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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pimobendan
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Accession:CHEBI:32003 term browser browse the term
Definition:A pyridazinone that has formula C19H18N4O2.
Synonyms:exact_synonym: 6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
 related_synonym: Acardi;   Formula=C19H18N4O2;   InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24);   InChIKey=GLBJJMFZWDBELO-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1)-c1nc2cc(ccc2[nH]1)C1=NNC(=O)CC1C;   dl-Pimobendan;   pimobendane;   pimobendanum
 xref: Beilstein:4207330;   CAS:74150-27-9;   Drug_Central:2171;   KEGG:D01133
 xref_mesh: MESH:C041648
 xref: Patent:DE2837161;   Patent:US4361563;   VSDB:1890



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pimobendan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation ISO CYP1A2 protein results in decreased methylation of pimobendan CTD PMID:10611143 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation ISO CYP3A4 protein results in decreased methylation of pimobendan CTD PMID:10611143 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO pimobendan promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
pimobendan results in decreased expression of IL1B protein
CTD PMID:9004165 PMID:10193745 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO pimobendan results in decreased expression of IL6 protein
pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:9004165 PMID:10193745 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO pimobendan results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO pimobendan results in decreased expression of NOS2 mRNA
[pimobendan results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide
CTD PMID:10193745 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
pimobendan results in decreased expression of TNF protein
CTD PMID:9004165 PMID:10193745 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            cardiovascular drug 7726
              vasodilator agent 5846
                pimobendan 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteromonocyclic compound 17151
                                    diazines 12358
                                      pyridazines 123
                                        pyridazinone 120
                                          pimobendan 7
paths to the root