Prr7 (proline rich 7 (synaptic)) - Rat Genome Database

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Gene: Prr7 (proline rich 7 (synaptic)) Rattus norvegicus
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Symbol: Prr7
Name: proline rich 7 (synaptic)
RGD ID: 1561898
Description: Predicted to enable long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of protein ubiquitination and postsynapse to nucleus signaling pathway. Located in neuron projection; nucleus; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human PRR7 (proline rich 7, synaptic); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: proline rich 7; proline-rich protein 7; synaptic proline-rich membrane protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,164,375 - 9,173,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,165,269 - 9,172,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,181,390 - 9,182,514 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01710,711,423 - 10,712,547 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0179,177,778 - 9,178,902 (-)NCBIRnor_WKY
Rnor_6.0179,693,274 - 9,702,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,694,168 - 9,695,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,803,146 - 11,811,418 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,209,243 - 15,210,367 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera179,243,777 - 9,244,901 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. Kravchick DO, etal., EMBO J. 2016 Sep 1;35(17):1923-34. doi: 10.15252/embj.201593070. Epub 2016 Jul 25.
2. Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor. Murata Y, etal., Biochem Biophys Res Commun. 2005 Feb 4;327(1):183-91.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21460222   PMID:22871113   PMID:27657535   PMID:36150742  


Genomics

Comparative Map Data
Prr7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,164,375 - 9,173,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,165,269 - 9,172,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,181,390 - 9,182,514 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01710,711,423 - 10,712,547 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0179,177,778 - 9,178,902 (-)NCBIRnor_WKY
Rnor_6.0179,693,274 - 9,702,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,694,168 - 9,695,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,803,146 - 11,811,418 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,209,243 - 15,210,367 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera179,243,777 - 9,244,901 (-)NCBICelera
Cytogenetic Map17p14NCBI
PRR7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,445,995 - 177,456,286 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5177,446,445 - 177,456,286 (+)EnsemblGRCh38hg38GRCh38
GRCh375176,872,996 - 176,883,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,806,400 - 176,815,889 (+)NCBINCBI36Build 36hg18NCBI36
Build 345176,806,401 - 176,815,889NCBI
Celera5171,618,357 - 171,627,632 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,794,261 - 171,803,535 (+)NCBIHuRef
CHM1_15176,307,202 - 176,316,315 (+)NCBICHM1_1
T2T-CHM13v2.05177,989,257 - 177,999,332 (+)NCBIT2T-CHM13v2.0
Prr7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,612,080 - 55,620,968 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,612,080 - 55,620,967 (+)EnsemblGRCm39 Ensembl
GRCm381355,464,267 - 55,473,162 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,464,267 - 55,473,154 (+)EnsemblGRCm38mm10GRCm38
MGSCv371355,565,628 - 55,574,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,481,647 - 55,482,774 (+)NCBIMGSCv36mm8
Celera1356,518,298 - 56,527,198 (+)NCBICelera
Cytogenetic Map13B1NCBI
Prr7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,692,004 - 29,695,113 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,685,254 - 29,695,113 (+)NCBIChiLan1.0ChiLan1.0
PRR7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15179,818,184 - 179,820,471 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,818,184 - 179,821,479 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05172,748,020 - 172,757,989 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRR7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,913,300 - 35,923,823 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,913,472 - 35,943,221 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,880,991 - 35,882,194 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,280,009 - 36,281,212 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,280,090 - 36,281,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,105,275 - 36,106,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,291,229 - 36,292,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,800,703 - 36,801,904 (-)NCBIUU_Cfam_GSD_1.0
Prr7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,701,213 - 122,710,382 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,726,070 - 1,735,343 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365971,726,143 - 1,735,295 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRR7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,496,106 - 80,505,430 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,496,105 - 80,508,825 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRR7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,458,347 - 79,467,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,466,186 - 79,467,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,650,015 - 10,659,071 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prr7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,632,309 - 12,633,729 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,632,297 - 12,633,521 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prr7
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:61
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000036162
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat

Markers in Region
D17Rat106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,175,224 - 9,175,368 (+)MAPPERmRatBN7.2
Rnor_6.0179,704,124 - 9,704,267NCBIRnor6.0
Rnor_5.01711,813,108 - 11,813,251UniSTSRnor5.0
RGSC_v3.41715,219,199 - 15,219,342UniSTSRGSC3.4
RGSC_v3.41715,219,198 - 15,219,342RGDRGSC3.4
RGSC_v3.11715,219,199 - 15,219,342RGD
Celera179,253,733 - 9,253,877UniSTS
RH 3.4 Map1779.2RGD
RH 3.4 Map1779.2UniSTS
RH 2.0 Map1742.9RGD
SHRSP x BN Map178.3RGD
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 58 15
Low 3 34 36 20 18 20 3 5 16 24 26 10 3
Below cutoff 9 20 20 20 4 5 11 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036162   ⟹   ENSRNOP00000038274
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,165,269 - 9,172,536 (-)Ensembl
Rnor_6.0 Ensembl179,694,168 - 9,695,292 (-)Ensembl
RefSeq Acc Id: NM_001109116   ⟹   NP_001102586
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,165,269 - 9,166,393 (-)NCBI
Rnor_6.0179,694,168 - 9,695,292 (-)NCBI
Rnor_5.01711,803,146 - 11,811,418 (-)NCBI
RGSC_v3.41715,209,243 - 15,210,367 (-)RGD
Celera179,243,777 - 9,244,901 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253652   ⟹   XP_006253714
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,164,375 - 9,173,669 (-)NCBI
Rnor_6.0179,693,274 - 9,702,518 (-)NCBI
Rnor_5.01711,803,146 - 11,811,418 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102586 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253714 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93984 (Get FASTA)   NCBI Sequence Viewer  
  P0C6T3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102586   ⟸   NM_001109116
- UniProtKB: P0C6T3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253714   ⟸   XM_006253652
- Peptide Label: isoform X1
- UniProtKB: P0C6T3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038274   ⟸   ENSRNOT00000036162

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C6T3-F1-model_v2 AlphaFold P0C6T3 1-269 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561898 AgrOrtholog
BioCyc Gene G2FUF-10206 BioCyc
Ensembl Genes ENSRNOG00000021447 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000038274 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036162 ENTREZGENE, UniProtKB/Swiss-Prot
KEGG Report rno:498704 UniProtKB/Swiss-Prot
NCBI Gene 498704 ENTREZGENE
PhenoGen Prr7 PhenoGen
UniProt P0C6T3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Prr7  proline rich 7 (synaptic)  Prr7  proline rich 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Prr7  proline rich 7      Symbol and Name status set to provisional 70820 PROVISIONAL