Nipbl (NIPBL, cohesin loading factor) - Rat Genome Database

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Gene: Nipbl (NIPBL, cohesin loading factor) Rattus norvegicus
Analyze
Symbol: Nipbl
Name: NIPBL, cohesin loading factor
RGD ID: 1306393
Description: Predicted to enable several functions, including chromo shadow domain binding activity; cohesin loader activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including chromosome organization; embryonic morphogenesis; and reproductive structure development. Predicted to act upstream of or within several processes, including embryonic cranial skeleton morphogenesis; fat cell differentiation; and positive regulation of ossification. Predicted to be located in chromatin and nucleus. Predicted to be part of Scc2-Scc4 cohesin loading complex and integrator complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome and Cornelia de Lange syndrome 1. Orthologous to human NIPBL (NIPBL cohesin loading factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: delangin; IDN3; Nipped-B homolog; Nipped-B homolog (Drosophila); nipped-B-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,126,676 - 59,314,841 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl259,126,676 - 59,293,277 (-)EnsemblGRCr8
mRatBN7.2257,399,443 - 57,586,770 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl257,399,445 - 57,565,899 (-)EnsemblmRatBN7.2
Rnor_6.0257,508,830 - 57,676,197 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl257,509,428 - 57,600,820 (-)Ensemblrn6Rnor6.0
Rnor_5.0278,992,721 - 79,160,884 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4257,908,828 - 58,099,422 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera253,014,297 - 53,179,686 (-)NCBICelera
RGSC_v3.1257,837,538 - 58,006,254 (-)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
choline  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
inulin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
maneb  (ISO)
methimazole  (EXP)
oxaliplatin  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological_process  (ND)
brain development  (IBA,IEA,ISO)
cellular response to X-ray  (IEA,ISO)
chromatin looping  (IEA)
chromatin remodeling  (IEA,ISO)
cognition  (IEA,ISO)
developmental growth  (IEA,ISO)
digestive tract development  (IBA)
DNA damage response  (IEA,ISO)
ear morphogenesis  (IEA,ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic digestive tract morphogenesis  (IEA,ISO)
embryonic forelimb morphogenesis  (IEA,ISO)
embryonic organ morphogenesis  (IEA)
embryonic viscerocranium morphogenesis  (IBA,IEA,ISO)
establishment of mitotic sister chromatid cohesion  (IBA)
establishment of protein localization to chromatin  (IBA)
external genitalia morphogenesis  (IEA,ISO)
eye morphogenesis  (IEA,ISO)
face morphogenesis  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
forelimb morphogenesis  (IEA,ISO)
gallbladder development  (IEA,ISO)
heart development  (IEA,ISO)
heart morphogenesis  (IBA,IEA,ISO)
intracellular protein localization  (IEA,ISO)
maintenance of mitotic sister chromatid cohesion  (IEA,ISO)
mitotic sister chromatid cohesion  (IEA,ISO)
mitotic sister chromatid segregation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of neuron migration  (IEA,ISO)
positive regulation of ossification  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of developmental growth  (IEA,ISO)
regulation of embryonic development  (IEA,ISO)
regulation of gene expression  (IEA)
regulation of hair cycle  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
replication-born double-strand break repair via sister chromatid exchange  (IBA)
sensory perception of sound  (IEA,ISO)
somatic stem cell population maintenance  (IEA)
stem cell population maintenance  (ISO)
uterus morphogenesis  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
cytosol  (IEA,ISO)
integrator complex  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
Scc2-Scc4 cohesin loading complex  (IBA,IEA,ISO)
SMC loading complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NIPBL expression levels in CdLS probands as a predictor of mutation type and phenotypic severity. Kaur M, etal., Am J Med Genet C Semin Med Genet. 2016 Jun;172(2):163-70. doi: 10.1002/ajmg.c.31495. Epub 2016 Apr 29.
3. Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. Kawauchi S, etal., PLoS Genet. 2009 Sep;5(9):e1000650. doi: 10.1371/journal.pgen.1000650. Epub 2009 Sep 18.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Intragenic and large NIPBL rearrangements revealed by MLPA in Cornelia de Lange patients. Russo S, etal., Eur J Hum Genet. 2012 Jul;20(7):734-41. doi: 10.1038/ejhg.2012.7. Epub 2012 Feb 22.
Additional References at PubMed
PMID:8291537   PMID:15146186   PMID:15882967   PMID:16100726   PMID:16682347   PMID:16802858   PMID:17468178   PMID:17577209   PMID:18854353   PMID:19056867   PMID:19242925   PMID:20720539  
PMID:22628566   PMID:23920377   PMID:28041881   PMID:29094699  


Genomics

Comparative Map Data
Nipbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,126,676 - 59,314,841 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl259,126,676 - 59,293,277 (-)EnsemblGRCr8
mRatBN7.2257,399,443 - 57,586,770 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl257,399,445 - 57,565,899 (-)EnsemblmRatBN7.2
Rnor_6.0257,508,830 - 57,676,197 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl257,509,428 - 57,600,820 (-)Ensemblrn6Rnor6.0
Rnor_5.0278,992,721 - 79,160,884 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4257,908,828 - 58,099,422 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera253,014,297 - 53,179,686 (-)NCBICelera
RGSC_v3.1257,837,538 - 58,006,254 (-)NCBI
Cytogenetic Map2q16NCBI
NIPBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38536,876,769 - 37,066,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl536,876,769 - 37,066,413 (+)Ensemblhg38GRCh38
GRCh37536,876,871 - 37,066,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36536,912,742 - 37,101,678 (+)NCBIBuild 36Build 36hg18NCBI36
Celera536,763,790 - 36,952,889 (+)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef536,829,492 - 37,018,602 (+)NCBIHuRef
CHM1_1536,879,597 - 37,068,738 (+)NCBICHM1_1
T2T-CHM13v2.0537,126,599 - 37,316,247 (+)NCBIT2T-CHM13v2.0
Nipbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,319,308 - 8,494,799 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,320,101 - 8,473,947 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38158,289,824 - 8,465,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,290,617 - 8,444,463 (-)Ensemblmm10GRCm38
MGSCv37158,241,225 - 8,394,463 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36158,238,440 - 8,391,678 (-)NCBIMGSCv36mm8
Celera158,136,258 - 8,289,610 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.82NCBI
Nipbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542621,666,857 - 21,841,515 (+)Ensembl
ChiLan1.0NW_00495542621,666,958 - 21,841,515 (+)NCBIChiLan1.0ChiLan1.0
NIPBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2473,270,202 - 73,457,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1571,423,834 - 71,611,174 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0573,306,527 - 73,491,367 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1578,585,649 - 78,772,665 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl578,585,649 - 78,698,184 (-)EnsemblpanPan2panpan1.1
NIPBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1471,583,118 - 71,780,986 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl471,583,732 - 71,780,852 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha471,193,245 - 71,390,556 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0472,093,046 - 72,290,807 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl472,093,358 - 72,290,830 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1471,840,270 - 72,037,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0471,962,190 - 72,159,916 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0472,493,866 - 72,691,524 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nipbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213226,330,734 - 226,501,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365184,869,546 - 4,969,450 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365184,870,686 - 5,041,099 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NIPBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1622,152,469 - 22,363,821 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11622,152,455 - 22,364,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21623,393,877 - 23,512,467 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NIPBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1435,748,112 - 35,940,075 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl435,829,386 - 35,941,271 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607126,085,896 - 26,277,759 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nipbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475917,899,152 - 17,999,295 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475917,899,152 - 18,078,213 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nipbl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13172,043,623 - 172,207,381 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nipbl
1169 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:30
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000021181, ENSRNOT00000065395
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
D2Rat385  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8259,250,223 - 59,250,466 (+)Marker Load Pipeline
mRatBN7.2257,522,996 - 57,523,239 (+)MAPPERmRatBN7.2
Rnor_6.0257,633,081 - 57,633,323NCBIRnor6.0
Rnor_5.0279,117,766 - 79,118,008UniSTSRnor5.0
RGSC_v3.4258,035,190 - 58,035,432UniSTSRGSC3.4
RGSC_v3.4258,035,189 - 58,035,432RGDRGSC3.4
Celera253,136,745 - 53,136,987UniSTS
RGSC_v3.1257,963,354 - 57,963,967RGD
SHRSP x BN Map224.0998RGD
SHRSP x BN Map224.0998UniSTS
Cytogenetic Map2q16UniSTS
D2Got310  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,501,761 - 57,501,956 (+)MAPPERmRatBN7.2
Rnor_6.0257,611,846 - 57,612,040NCBIRnor6.0
Rnor_5.0279,096,531 - 79,096,725UniSTSRnor5.0
RGSC_v3.4258,013,952 - 58,014,150UniSTSRGSC3.4
Celera253,115,573 - 53,115,767UniSTS
Cytogenetic Map2q16UniSTS
RH143372  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,399,777 - 57,399,949 (+)MAPPERmRatBN7.2
Rnor_6.0257,508,854 - 57,509,025NCBIRnor6.0
Rnor_5.0278,993,539 - 78,993,710UniSTSRnor5.0
RGSC_v3.4257,909,641 - 57,909,812UniSTSRGSC3.4
Celera253,014,321 - 53,014,492UniSTS
Cytogenetic Map2q16UniSTS
AW532132  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,569,595 - 57,569,785 (+)MAPPERmRatBN7.2
Rnor_6.0257,679,821 - 57,680,010NCBIRnor6.0
Rnor_5.0279,164,506 - 79,164,695UniSTSRnor5.0
RGSC_v3.4258,081,596 - 58,081,785UniSTSRGSC3.4
Celera253,183,313 - 53,183,502UniSTS
Cytogenetic Map2q16UniSTS
BE117972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,502,189 - 57,502,404 (+)MAPPERmRatBN7.2
Rnor_6.0257,612,274 - 57,612,488NCBIRnor6.0
Rnor_5.0279,096,959 - 79,097,173UniSTSRnor5.0
RGSC_v3.4258,014,384 - 58,014,598UniSTSRGSC3.4
Celera253,116,001 - 53,116,215UniSTS
RH 3.4 Map2331.7UniSTS
Cytogenetic Map2q16UniSTS
MARC_21845-21846:1025102921:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,483,006 - 57,483,771 (+)MAPPERmRatBN7.2
Rnor_6.0257,593,094 - 57,593,858NCBIRnor6.0
Rnor_5.0279,077,779 - 79,078,543UniSTSRnor5.0
RGSC_v3.4257,995,199 - 57,995,963UniSTSRGSC3.4
Celera253,096,825 - 53,097,589UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083247   ⟹   ENSRNOP00000071473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,126,676 - 59,293,277 (-)Ensembl
mRatBN7.2 Ensembl257,399,445 - 57,565,899 (-)Ensembl
Rnor_6.0 Ensembl257,509,428 - 57,600,820 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097994   ⟹   ENSRNOP00000078828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,126,676 - 59,293,277 (-)Ensembl
mRatBN7.2 Ensembl257,399,760 - 57,565,899 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110737   ⟹   ENSRNOP00000093925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,140,841 - 59,293,277 (-)Ensembl
mRatBN7.2 Ensembl257,399,445 - 57,489,347 (-)Ensembl
RefSeq Acc Id: NM_001427697   ⟹   NP_001414626
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,126,676 - 59,293,277 (-)NCBI
RefSeq Acc Id: NM_001427698   ⟹   NP_001414627
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,126,676 - 59,293,277 (-)NCBI
RefSeq Acc Id: XM_039103537   ⟹   XP_038959465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,126,987 - 59,314,841 (-)NCBI
mRatBN7.2257,400,349 - 57,586,770 (-)NCBI
RefSeq Acc Id: XM_039103539   ⟹   XP_038959467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,126,987 - 59,292,985 (-)NCBI
mRatBN7.2257,400,296 - 57,565,947 (-)NCBI
RefSeq Acc Id: XM_039103540   ⟹   XP_038959468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,126,987 - 59,216,351 (-)NCBI
mRatBN7.2257,399,443 - 57,489,124 (-)NCBI
RefSeq Acc Id: XM_063281521   ⟹   XP_063137591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,126,987 - 59,314,628 (-)NCBI
RefSeq Acc Id: XR_010063589
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,141,387 - 59,292,985 (-)NCBI
Ensembl Acc Id: ENSRNOP00000071473   ⟸   ENSRNOT00000083247
RefSeq Acc Id: XP_038959468   ⟸   XM_039103540
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AXR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959467   ⟸   XM_039103539
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AXR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959465   ⟸   XM_039103537
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AXR8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078828   ⟸   ENSRNOT00000097994
Ensembl Acc Id: ENSRNOP00000093925   ⟸   ENSRNOT00000110737
RefSeq Acc Id: NP_001414626   ⟸   NM_001427697
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AXR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414627   ⟸   NM_001427698
- Peptide Label: isoform 2
- UniProtKB: A0A8I5ZLR4 (UniProtKB/TrEMBL),   A0A8I6AXR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137591   ⟸   XM_063281521
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AXR8 (UniProtKB/TrEMBL)
Protein Domains
Sister chromatid cohesion C-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306393 AgrOrtholog
BioCyc Gene G2FUF-54119 BioCyc
Ensembl Genes ENSRNOG00000056907 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083247 ENTREZGENE
  ENSRNOT00000083247.3 UniProtKB/TrEMBL
  ENSRNOT00000097994 ENTREZGENE
  ENSRNOT00000097994.2 UniProtKB/TrEMBL
  ENSRNOT00000110737.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Cohesin_HEAT UniProtKB/TrEMBL
  Nipped-B_C UniProtKB/TrEMBL
  SCC2/Nipped-B UniProtKB/TrEMBL
NCBI Gene 294787 ENTREZGENE
PANTHER NIPPED-B-LIKE PROTEIN UniProtKB/TrEMBL
  PTHR21704 UniProtKB/TrEMBL
Pfam Cohesin_HEAT UniProtKB/TrEMBL
  Nipped-B_C UniProtKB/TrEMBL
PhenoGen Nipbl PhenoGen
RatGTEx ENSRNOG00000056907 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A0G2K0J4_RAT UniProtKB/TrEMBL
  A0A8I5ZLR4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AXR8 ENTREZGENE, UniProtKB/TrEMBL
  A6KGI1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-27 Nipbl  NIPBL, cohesin loading factor  Nipbl  Nipped-B homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Nipbl  Nipped-B homolog (Drosophila)  LOC681423  similar to delangin isoform A  Data merged from RGD:1595401 1643240 APPROVED
2010-01-27 Nipbl  Nipped-B homolog (Drosophila)  NIPBL  Nipped-B homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681423  similar to delangin isoform A      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 NIPBL  Nipped-B homolog (Drosophila)    delangin  Name updated 1299863 APPROVED
2005-12-06 NIPBL  delangin  NIPBL_predicted  delangin (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 NIPBL_predicted  delangin (predicted)      Symbol and Name status set to approved 70820 APPROVED