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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306393
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nipbl
Name: NIPBL, cohesin loading factor
Acc ID: CHEBI:32692
Term: 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one
Definition: A nitrosamine that has formula C10H13N3O2.
Chemical ID: MESH:C016583
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nipblincreases expressionISONIPBL (Homo sapiens)6480464CTD4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NIPBL mRNA alternative formPMID:35435490
Nipblincreases response to substanceISONIPBL (Homo sapiens)6480464CTDNIPBL mRNA alternative form results in increased susceptibility to 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonePMID:35435490
Nipblmultiple interactionsISONIPBL (Homo sapiens)6480464CTDNIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of FEN1 protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PARP1 protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PCNA protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of XRCC1 protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein modified form]PMID:35435490
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