Mrtfb (myocardin related transcription factor B) - Rat Genome Database

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Gene: Mrtfb (myocardin related transcription factor B) Rattus norvegicus
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Symbol: Mrtfb
Name: myocardin related transcription factor B
RGD ID: 1560833
Description: Predicted to enable DNA-binding transcription factor activity; actin binding activity; and transcription coactivator activity. Involved in regulation of modification of postsynaptic structure. Is active in glutamatergic synapse; postsynapse; and presynapse. Orthologous to human MRTFB (myocardin related transcription factor B); INTERACTS WITH 17beta-estradiol; bisphenol A; valproic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100912459; LOC497850; MKL/myocardin-like 2; MKL/myocardin-like protein 2; MKL/myocardin-like protein 2-like; MKL1/myocardin like 2; Mkl2; myocardin like 2; myocardin-related transcription factor B; RGD1560833; similar to myocardin-related transcription factor B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,623,887 - 1,789,658 (+)NCBIGRCr8
mRatBN7.2101,116,315 - 1,278,106 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,116,310 - 1,277,897 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0101,151,163 - 1,273,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01011,829,918 - 11,951,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10180,081 - 341,402 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology. Kaneda M, etal., Sci Rep. 2018 Jan 15;8(1):727. doi: 10.1038/s41598-017-18905-7.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12397177   PMID:14565952   PMID:15798203   PMID:16204380   PMID:17183527   PMID:17991879   PMID:18945672   PMID:20534669   PMID:21776010   PMID:25468996   PMID:30244496  


Genomics

Comparative Map Data
Mrtfb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,623,887 - 1,789,658 (+)NCBIGRCr8
mRatBN7.2101,116,315 - 1,278,106 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,116,310 - 1,277,897 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0101,151,163 - 1,273,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01011,829,918 - 11,951,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10180,081 - 341,402 (+)NCBICelera
Cytogenetic Map10q11NCBI
MRTFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381613,994,774 - 14,266,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1614,071,319 - 14,266,773 (+)EnsemblGRCh38hg38GRCh38
GRCh371614,164,919 - 14,360,636 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,072,697 - 14,268,131 (+)NCBINCBI36Build 36hg18NCBI36
Build 341614,072,696 - 14,268,130NCBI
Celera1614,340,460 - 14,536,766 (+)NCBICelera
Cytogenetic Map16p13.12NCBI
HuRef1614,082,327 - 14,277,730 (+)NCBIHuRef
CHM1_11614,165,144 - 14,360,614 (+)NCBICHM1_1
T2T-CHM13v2.01614,032,048 - 14,304,042 (+)NCBIT2T-CHM13v2.0
Mrtfb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,073,913 - 13,235,393 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,074,345 - 13,235,393 (+)EnsemblGRCm39 Ensembl
GRCm381613,256,056 - 13,417,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,256,481 - 13,417,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv371613,256,574 - 13,417,622 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,272,217 - 13,326,281 (+)NCBIMGSCv36mm8
Celera1613,859,728 - 14,019,765 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.24NCBI
Mrtfb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,547,829 - 4,733,724 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,542,700 - 4,733,646 (-)NCBIChiLan1.0ChiLan1.0
MRTFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21814,606,916 - 14,803,226 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11618,389,744 - 18,586,024 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01612,999,165 - 13,195,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11614,427,091 - 14,619,198 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1614,493,351 - 14,613,860 (+)Ensemblpanpan1.1panPan2
MRTFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,902,749 - 29,113,448 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,918,350 - 29,098,220 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha630,265,501 - 30,476,132 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0629,066,342 - 29,277,006 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl629,077,199 - 29,271,056 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1628,868,907 - 29,079,923 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,756,781 - 28,967,376 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0629,174,173 - 29,385,094 (-)NCBIUU_Cfam_GSD_1.0
Mrtfb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,317,026 - 114,480,361 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365012,468,345 - 2,567,234 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365012,414,696 - 2,571,627 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRTFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl328,968,215 - 29,167,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1328,964,758 - 29,240,125 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MRTFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1513,530,313 - 13,725,359 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl513,609,016 - 13,720,022 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606816,331,363 - 16,528,431 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrtfb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247824,217,522 - 4,408,175 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247824,217,620 - 4,416,161 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrtfb
593 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat

Markers in Region
RH137809  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2101,192,347 - 1,192,590 (+)MAPPERmRatBN7.2
Rnor_6.0101,226,185 - 1,226,427NCBIRnor6.0
Rnor_5.01011,904,423 - 11,904,665UniSTSRnor5.0
RGSC_v3.4101,129,248 - 1,129,490UniSTSRGSC3.4
Celera10255,959 - 256,201UniSTS
RH 3.4 Map10518.79UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003752284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide FQ223205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000097507   ⟹   ENSRNOP00000091163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,116,310 - 1,277,897 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098625   ⟹   ENSRNOP00000087546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,235,228 - 1,277,897 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109289   ⟹   ENSRNOP00000088170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,125,651 - 1,277,897 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115774   ⟹   ENSRNOP00000088346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,211,645 - 1,277,897 (+)Ensembl
RefSeq Acc Id: NM_001427624   ⟹   NP_001414553
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,623,953 - 1,789,658 (+)NCBI
RefSeq Acc Id: XM_039087007   ⟹   XP_038942935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,623,887 - 1,785,017 (+)NCBI
mRatBN7.2101,116,680 - 1,278,106 (+)NCBI
RefSeq Acc Id: XM_039087009   ⟹   XP_038942937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,623,887 - 1,785,017 (+)NCBI
mRatBN7.2101,116,680 - 1,278,106 (+)NCBI
RefSeq Acc Id: XM_039087011   ⟹   XP_038942939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,693,829 - 1,785,017 (+)NCBI
mRatBN7.2101,211,558 - 1,278,106 (+)NCBI
RefSeq Acc Id: XM_063268241   ⟹   XP_063124311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,623,887 - 1,785,017 (+)NCBI
RefSeq Acc Id: XM_063268242   ⟹   XP_063124312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,623,887 - 1,785,017 (+)NCBI
RefSeq Acc Id: XP_038942937   ⟸   XM_039087009
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7A3 (UniProtKB/TrEMBL),   A6K4E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942935   ⟸   XM_039087007
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7A3 (UniProtKB/TrEMBL),   A6K4E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942939   ⟸   XM_039087011
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A614 (UniProtKB/TrEMBL),   A6K4E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091163   ⟸   ENSRNOT00000097507
RefSeq Acc Id: ENSRNOP00000088170   ⟸   ENSRNOT00000109289
RefSeq Acc Id: ENSRNOP00000088346   ⟸   ENSRNOT00000115774
RefSeq Acc Id: ENSRNOP00000087546   ⟸   ENSRNOT00000098625
RefSeq Acc Id: XP_063124311   ⟸   XM_063268241
- Peptide Label: isoform X2
- UniProtKB: A6K4E0 (UniProtKB/TrEMBL),   A0A8I6GJE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124312   ⟸   XM_063268242
- Peptide Label: isoform X2
- UniProtKB: A6K4E0 (UniProtKB/TrEMBL),   A0A8I6GJE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414553   ⟸   NM_001427624
- UniProtKB: A6K4E0 (UniProtKB/TrEMBL),   A0A8I6GJE3 (UniProtKB/TrEMBL)
Protein Domains
SAP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560833 AgrOrtholog
BioCyc Gene G2FUF-26247 BioCyc
Ensembl Genes ENSRNOG00000066694 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097507.1 UniProtKB/TrEMBL
  ENSRNOT00000098625.1 UniProtKB/TrEMBL
  ENSRNOT00000109289.1 UniProtKB/TrEMBL
  ENSRNOT00000115774.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  6.10.140.2040 UniProtKB/TrEMBL
  6.10.150.10 UniProtKB/TrEMBL
InterPro Myocardin-like UniProtKB/TrEMBL
  RPEL_repeat UniProtKB/TrEMBL
  SAP_dom UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
NCBI Gene Mrtfb ENTREZGENE
PANTHER MYOCARDIN-RELATED TRANSCRIPTION FACTOR B UniProtKB/TrEMBL
  PTHR22793 UniProtKB/TrEMBL
Pfam RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
PhenoGen Mrtfb PhenoGen
PROSITE RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000066694 RatGTEx
SMART RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/TrEMBL
UniProt A0A8I6A614 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7A3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8X1_RAT UniProtKB/TrEMBL
  A0A8I6GJE3 ENTREZGENE, UniProtKB/TrEMBL
  A6K4E0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Mrtfb  myocardin related transcription factor B  Mrtfb  myocardin related transcription factor B  Data merged from RGD:149736406 737654 PROVISIONAL
2021-08-09 Mrtfb  myocardin related transcription factor B      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Mrtfb  myocardin related transcription factor B  LOC100912459  MKL/myocardin-like protein 2-like  Data merged from RGD:6487121 737654 PROVISIONAL
2018-06-29 Mrtfb  myocardin related transcription factor B  Mkl2  MKL1/myocardin like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-04-19 Mkl2  MKL1/myocardin like 2  Mkl2  myocardin like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-29 Mkl2  myocardin like 2  Mkl2  MKL/myocardin-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-25 Mkl2  MKL/myocardin-like 2  RGD1560833  similar to myocardin-related transcription factor B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912459  MKL/myocardin-like protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-02 RGD1560833  similar to myocardin-related transcription factor B  LOC100362470  MKL/myocardin-like 2  Data merged from RGD:2318118 1643240 APPROVED
2010-05-05 LOC100362470  MKL/myocardin-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1560833  similar to myocardin-related transcription factor B   RGD1560833_predicted  similar to myocardin-related transcription factor B (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560833_predicted  similar to myocardin-related transcription factor B (predicted)  LOC497850  similar to myocardin-related transcription factor B  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC497850  similar to myocardin-related transcription factor B      Symbol and Name status set to provisional 70820 PROVISIONAL