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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zardaverine
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Accession:CHEBI:46548 term browser browse the term
Definition:A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.
Synonyms:exact_synonym: 6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one
 related_synonym: 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone;   6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE;   Formula=C12H10F2N2O3;   InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17);   InChIKey=HJMQDJPMQIHLPB-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1;   zardaverina;   zardaverinum
 xref: CAS:101975-10-4;   LINCS:LSM-2833
 xref_mesh: MESH:C066436
 xref: PDBeChem:ZAR;   PMID:12387865;   PMID:12952271;   PMID:1426207;   PMID:1648920;   PMID:1665311;   PMID:1700309;   PMID:1723951;   PMID:1787170;   PMID:7644776;   PMID:7684572;   PMID:7925141;   PMID:8035322;   PMID:8369979;   PMID:8381357;   PMID:8392340


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zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link

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  CHEBI ontology 19775
    role 19722
      application 19411
        anti-asthmatic agent 9232
          anti-asthmatic drug 8603
            zardaverine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19775
    subatomic particle 19774
      composite particle 19774
        hadron 19774
          baryon 19774
            nucleon 19774
              atomic nucleus 19774
                atom 19774
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19584
                        carbon atom 19574
                          organic molecular entity 19574
                            organic molecule 19508
                              organic cyclic compound 19338
                                organic heterocyclic compound 18567
                                  organic heteromonocyclic compound 17073
                                    diazines 12263
                                      pyridazines 121
                                        pyridazinone 118
                                          zardaverine 3
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