Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hex-4-enoic acid
go back to main search page
Accession:CHEBI:38355 term browser browse the term
Definition:A hexenoic acid with the double bond at position 4.
Synonyms:related_synonym: 4-hexenoic acid;   4-hexenoic acids;   Formula=C6H10O2;   InChI=1S/C6H10O2/c1-2-3-4-5-6(7)8/h2-3H,4-5H2,1H3,(H,7,8);   InChIKey=NIDHFQDUBOVBKZ-UHFFFAOYSA-N;   SMILES=[H]C(C)=CCCC(O)=O;   gamma-hexenoic acid;   gamma-hexenoic acids;   hex-4-enoic acids
 xref: Beilstein:1720995;   LIPID_MAPS_instance:LMFA01030010


show annotations for term's descendants           Sort by:
mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 nephrosis 1, nephrin multiple interactions ISO Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 7:30,157,259...30,188,048
Ensembl chr 7:30,157,740...30,186,648 		JBrowse link
mycophenolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A530064D06Rik RIKEN cDNA A530064D06 gene decreases expression ISO Mycophenolic Acid results in decreased expression of NCR2 CTD PMID:20736080 NCBI chr17:48,459,064...48,474,425
Ensembl chr17:48,456,296...48,474,443 		JBrowse link
G Abcf1 ATP-binding cassette, sub-family F member 1 increases expression EXP Mycophenolic Acid results in increased expression of ABCF1 mRNA CTD PMID:19818335 NCBI chr17:36,267,711...36,280,642
Ensembl chr17:36,267,711...36,280,653 		JBrowse link
G Adm adrenomedullin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15063164 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027 		JBrowse link
G Agt angiotensinogen decreases expression ISO Mycophenolic Acid results in decreased expression of AGT protein alternative form CTD PMID:15213268 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression
multiple interactions		 ISO Mycophenolic Acid results in decreased expression of AIF1 mRNA
[Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA		 CTD PMID:10688038 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression EXP Mycophenolic Acid results in increased expression of AIMP1 mRNA CTD PMID:19818335 NCBI chr 3:132,366,259...132,390,151
Ensembl chr 3:132,366,242...132,390,131 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases expression ISO Mycophenolic Acid results in increased expression of AKT1 protein CTD PMID:21396949 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin affects binding ISO Mycophenolic Acid binds to ALB protein CTD PMID:26892221 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Ar androgen receptor multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein] CTD PMID:20302854 NCBI chr15:100,125,729...100,159,129
Ensembl chr15:100,125,700...100,159,125 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Mycophenolic Acid results in increased expression of BAK1 protein CTD PMID:16505121 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein CTD PMID:21396949 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 ISO [Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein; Mycophenolic Acid inhibits the reaction [BCL2 protein results in decreased susceptibility to Dexamethasone]; schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of BCL2 protein] CTD PMID:16505121 PMID:21396949 PMID:35321622 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp1 caspase 1 increases expression EXP Mycophenolic Acid results in increased expression of CASP1 mRNA CTD PMID:19818335 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage		 ISO Mycophenolic Acid results in increased activity of CASP3 protein
[Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased cleavage of CASP3 protein]		 CTD PMID:16059982 PMID:16505121 PMID:21396949 PMID:35321622 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression EXP Mycophenolic Acid results in increased expression of CCL19 mRNA CTD PMID:19818335 NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] CTD PMID:17624267 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression
increases expression		 EXP Mycophenolic Acid results in decreased expression of CCL20 mRNA
Mycophenolic Acid results in increased expression of CCL20 mRNA		 CTD PMID:19818335 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression EXP Mycophenolic Acid results in increased expression of CCL22 mRNA CTD PMID:19818335 NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 increases expression EXP Mycophenolic Acid results in increased expression of CCL25 mRNA CTD PMID:19818335 NCBI chr 8:4,375,207...4,410,020
Ensembl chr 8:4,375,210...4,410,020 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression EXP Mycophenolic Acid results in decreased expression of CCL4 mRNA CTD PMID:19818335 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression		 ISO [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of CCL5 mRNA
Mycophenolic Acid results in decreased expression of CCL5 mRNA		 CTD PMID:10688038 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression
decreases expression		 EXP Mycophenolic Acid results in increased expression of CCL6 mRNA
Mycophenolic Acid results in decreased expression of CCL6 mRNA		 CTD PMID:19818335 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression EXP Mycophenolic Acid results in decreased expression of CCL7 mRNA CTD PMID:19818335 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351 		JBrowse link
G Ccr10 C-C motif chemokine receptor 10 increases expression EXP Mycophenolic Acid results in increased expression of CCR10 mRNA CTD PMID:19818335 NCBI chr11:101,063,824...101,066,269
Ensembl chr11:101,063,823...101,066,269 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression EXP Mycophenolic Acid results in increased expression of CCR2 mRNA CTD PMID:19818335 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 increases expression EXP Mycophenolic Acid results in increased expression of CCR3 mRNA CTD PMID:19818335 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression EXP Mycophenolic Acid results in increased expression of CCR6 mRNA CTD PMID:19818335 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973 		JBrowse link
G Ccr9 C-C motif chemokine receptor 9 increases expression EXP Mycophenolic Acid results in increased expression of CCR9 mRNA CTD PMID:19818335 NCBI chr 9:123,596,276...123,612,522
Ensembl chr 9:123,507,504...123,613,395 		JBrowse link
G Cd40lg CD40 ligand increases expression EXP Mycophenolic Acid results in increased expression of CD40LG mRNA CTD PMID:19818335 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] CTD PMID:12193749 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein] CTD PMID:20302854 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Mycophenolic Acid results in increased expression of CX3CL1 mRNA CTD PMID:19818335 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression EXP Mycophenolic Acid results in increased expression of CXCL12 mRNA CTD PMID:19818335 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
decreases expression
increases secretion
multiple interactions		 EXP
ISO		 Mycophenolic Acid results in increased expression of CXCL15 mRNA; Mycophenolic Acid results in increased expression of CXCL5 mRNA
Mycophenolic Acid results in decreased expression of CXCL5 mRNA
Mycophenolic Acid results in increased secretion of CXCL8 protein
Mycophenolic Acid results in increased expression of CXCL8 mRNA
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased secretion of CXCL8 protein]		 CTD PMID:19818335 PMID:20302854 PMID:29408666 PMID:29594315 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Mycophenolic Acid results in increased expression of CXCL2 protein CTD PMID:19818335 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
increases expression		 EXP Mycophenolic Acid results in decreased expression of CXCL1 mRNA
Mycophenolic Acid results in increased expression of CXCL1 mRNA		 CTD PMID:19818335 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression EXP Mycophenolic Acid results in increased expression of CXCR2 mRNA CTD PMID:19818335 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression EXP Mycophenolic Acid results in increased expression of CXCR3 mRNA CTD PMID:19818335 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875 		JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 increases expression EXP Mycophenolic Acid results in increased expression of CXCR5 mRNA CTD PMID:19818335 NCBI chr 9:44,423,084...44,437,741
Ensembl chr 9:44,423,084...44,473,174 		JBrowse link
G Cycs cytochrome c, somatic increases secretion ISO Mycophenolic Acid results in increased secretion of CYCS protein CTD PMID:16505121 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO Mycophenolic Acid results in increased expression of CYP1A1 mRNA
Mycophenolic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]		 CTD PMID:25929522 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] CTD PMID:25929522 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases methylation ISO CYP2C8 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases methylation ISO CYP3A5 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Des desmin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Mycophenolic Acid results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein] CTD PMID:20302854 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hspa5 heat shock protein 5 decreases expression ISO Mycophenolic Acid results in decreased expression of HSPA5 mRNA CTD PMID:24356939 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions		 ISO Mycophenolic Acid results in decreased expression of IFNG mRNA
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA		 CTD PMID:11562063 PMID:29594315 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 decreases expression ISO Mycophenolic Acid results in decreased expression of IL10 mRNA CTD PMID:11562063 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il10ra interleukin 10 receptor, alpha increases expression EXP Mycophenolic Acid results in increased expression of IL10RA mRNA CTD PMID:19818335 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447 		JBrowse link
G Il10rb interleukin 10 receptor, beta increases expression EXP Mycophenolic Acid results in increased expression of IL10RB mRNA CTD PMID:19818335 NCBI chr16:91,203,166...91,222,718
Ensembl chr16:91,203,052...91,222,722 		JBrowse link
G Il11 interleukin 11 increases expression EXP Mycophenolic Acid results in increased expression of IL11 mRNA CTD PMID:19818335 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858 		JBrowse link
G Il12rb2 interleukin 12 receptor, beta 2 decreases expression ISO Mycophenolic Acid results in decreased expression of IL12RB2 mRNA CTD PMID:11562063 NCBI chr 6:67,263,914...67,353,277
Ensembl chr 6:67,268,302...67,353,172 		JBrowse link
G Il13 interleukin 13 increases expression EXP Mycophenolic Acid results in increased expression of IL13 mRNA CTD PMID:19818335 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il15 interleukin 15 increases expression EXP Mycophenolic Acid results in increased expression of IL15 mRNA CTD PMID:19818335 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Il16 interleukin 16 increases expression EXP Mycophenolic Acid results in increased expression of IL16 mRNA CTD PMID:19818335 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934 		JBrowse link
G Il18 interleukin 18 decreases expression EXP Mycophenolic Acid results in decreased expression of IL18 mRNA CTD PMID:19818335 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1r1 interleukin 1 receptor, type I increases expression EXP Mycophenolic Acid results in increased expression of IL1R1 mRNA CTD PMID:19818335 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417 		JBrowse link
G Il1r2 interleukin 1 receptor, type II increases expression EXP Mycophenolic Acid results in increased expression of IL1R2 mRNA CTD PMID:19818335 NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391 		JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression		 ISO [Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]
Mycophenolic Acid results in decreased expression of IL2 mRNA		 CTD PMID:11562063 PMID:12193749 PMID:29594315 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il2rb interleukin 2 receptor, beta chain increases expression EXP Mycophenolic Acid results in increased expression of IL2RB mRNA CTD PMID:19818335 NCBI chr15:78,363,456...78,396,569
Ensembl chr15:78,363,456...78,379,471 		JBrowse link
G Il2rg interleukin 2 receptor, gamma chain increases expression EXP Mycophenolic Acid results in increased expression of IL2RG mRNA CTD PMID:19818335 NCBI chr  X:100,307,991...100,311,861
Ensembl chr  X:100,307,984...100,311,861 		JBrowse link
G Il3 interleukin 3 increases expression EXP Mycophenolic Acid results in increased expression of IL3 mRNA CTD PMID:19818335 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Mycophenolic Acid results in decreased expression of IL4 mRNA CTD PMID:11562063 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5ra interleukin 5 receptor, alpha increases expression EXP Mycophenolic Acid results in increased expression of IL5RA mRNA CTD PMID:19818335 NCBI chr 6:106,687,336...106,725,998
Ensembl chr 6:106,687,318...106,725,998 		JBrowse link
G Il6 interleukin 6 increases expression ISO Mycophenolic Acid results in increased expression of IL6 protein CTD PMID:11981085 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha increases expression EXP Mycophenolic Acid results in increased expression of IL6RA mRNA CTD PMID:19818335 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Il6st interleukin 6 signal transducer increases expression EXP Mycophenolic Acid results in increased expression of IL6ST mRNA CTD PMID:19818335 NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 increases expression ISO Mycophenolic Acid results in increased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 9:108,437,635...108,442,776
Ensembl chr 9:108,437,485...108,442,783 		JBrowse link
G Itgam integrin alpha M increases expression EXP Mycophenolic Acid results in increased expression of ITGAM mRNA CTD PMID:19818335 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Klrk1 killer cell lectin-like receptor subfamily K, member 1 decreases expression ISO Mycophenolic Acid results in decreased expression of KLRK1 CTD PMID:20736080 NCBI chr 6:129,587,286...129,600,863
Ensembl chr 6:129,587,286...129,600,827 		JBrowse link
G Krcc1 lysine-rich coiled-coil 1 decreases expression ISO Mycophenolic Acid results in decreased expression of KRCC1 mRNA CTD PMID:24356939 NCBI chr 6:71,248,661...71,263,809
Ensembl chr 6:71,248,661...71,262,303 		JBrowse link
G Lrrc37 leucine rich repeat containing 37 decreases expression ISO Mycophenolic Acid results in decreased expression of LRRC37A3 mRNA CTD PMID:24356939 NCBI chr11:103,425,403...103,512,309
Ensembl chr11:103,425,403...103,511,966 		JBrowse link
G Lta lymphotoxin A increases expression EXP Mycophenolic Acid results in increased expression of LTA mRNA CTD PMID:19818335 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327 		JBrowse link
G Ltb lymphotoxin B increases expression EXP Mycophenolic Acid results in increased expression of LTB mRNA CTD PMID:19818335 NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein CTD PMID:15604220 NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases expression
increases phosphorylation		 ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK1 protein]
Mycophenolic Acid results in decreased expression of MAPK1 protein modified form		 CTD PMID:20302854 PMID:35321622 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases expression
increases phosphorylation		 ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK3 protein]
Mycophenolic Acid results in decreased expression of MAPK3 protein modified form		 CTD PMID:20302854 PMID:35321622 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
decreases expression
increases phosphorylation		 ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK8 protein]
Mycophenolic Acid results in decreased expression of MAPK8 protein modified form		 CTD PMID:20302854 PMID:35321622 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases expression		 ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]
Mycophenolic Acid results in decreased expression of MAPK9 protein modified form		 CTD PMID:20302854 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Mycophenolic Acid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) increases expression EXP Mycophenolic Acid results in increased expression of MIF mRNA CTD PMID:19818335 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 increases expression ISO Mycophenolic Acid results in increased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr19:60,744,425...60,748,352
Ensembl chr19:60,744,425...60,748,352 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 decreases expression ISO Mycophenolic Acid results in decreased expression of NCR1 CTD PMID:20736080 NCBI chr 7:4,340,714...4,348,183
Ensembl chr 7:4,340,723...4,348,163 		JBrowse link
G Ncr3-ps natural cytotoxicity triggering receptor 3, pseudogene decreases expression ISO Mycophenolic Acid results in decreased expression of NCR3 CTD PMID:20736080 NCBI chr17:35,399,512...35,403,785
Ensembl chr17:35,399,511...35,403,638 		JBrowse link
G Nphs1 nephrosis 1, nephrin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein] CTD PMID:17624267 NCBI chr 7:30,157,259...30,188,048
Ensembl chr 7:30,157,740...30,186,648 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Mycophenolic Acid results in increased activity of NR1I2 protein
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Ocln occludin multiple interactions
decreases expression		 ISO schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of OCLN protein] CTD PMID:35321622 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Mycophenolic Acid results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Prkca protein kinase C, alpha increases expression ISO Mycophenolic Acid results in increased expression of PRKCA protein CTD PMID:21396949 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:17950325 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases expression
multiple interactions		 ISO Mycophenolic Acid results in decreased expression of RELA protein modified form
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]		 CTD PMID:20302854 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Mycophenolic Acid results in increased expression of RGS2 mRNA CTD PMID:24356939 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein CTD PMID:15604220 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Mycophenolic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 decreases expression ISO Mycophenolic Acid results in decreased expression of SLC7A11 mRNA CTD PMID:24356939 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Mycophenolic Acid results in increased expression of SPP1 mRNA CTD PMID:19818335 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein CTD PMID:15604220 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Mycophenolic Acid results in decreased expression of TGFB1 mRNA CTD PMID:11562063 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions		 ISO Mycophenolic Acid results in decreased expression of TJP1 protein
schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of TJP1 protein]		 CTD PMID:35321622 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
multiple interactions		 ISO
EXP		 Mycophenolic Acid results in decreased expression of TNF mRNA
Mycophenolic Acid results in increased expression of TNF mRNA; Mycophenolic Acid results in increased expression of TNF protein
Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased secretion of TNF protein]		 CTD PMID:11562063 PMID:11912253 PMID:19818335 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a increases expression EXP Mycophenolic Acid results in increased expression of TNFRSF1A mRNA CTD PMID:19818335 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b increases expression EXP Mycophenolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:19818335 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Trp53 transformation related protein 53 affects activity ISO Mycophenolic Acid affects the activity of TP53 protein CTD PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tspoap1 TSPO associated protein 1 decreases expression ISO Mycophenolic Acid results in decreased expression of TSPOAP1 mRNA CTD PMID:24356939 NCBI chr11:87,649,022...87,676,754
Ensembl chr11:87,651,367...87,676,754 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation
multiple interactions
affects metabolic processing		 ISO UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid
4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; [UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide
UGT1A9 gene SNP affects the metabolism of Mycophenolic Acid		 CTD PMID:18498916 PMID:18816295 PMID:31742356 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    chemical entity 22209
      atom 22202
        nonmetal atom 22086
          carbon atom 21861
            organic molecular entity 21861
              lipid 18917
                fatty acid 17245
                  medium-chain fatty acid 5934
                    hexenoic acid 112
                      hex-4-enoic acid 112
                        2-oxohex-4-enoic acid + 0
                        cis-hex-4-enoic acid + 0
                        mycophenolic acid + 112
                        trans-hex-4-enoic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            heteroorganic entity 21517
                              organochalcogen compound 21006
                                organooxygen compound 20847
                                  carbon oxoacid 19634
                                    carboxylic acid 19630
                                      monocarboxylic acid 19007
                                        fatty acid 17245
                                          unsaturated fatty acid 1092
                                            monounsaturated fatty acid 599
                                              hexenoic acid 112
                                                hex-4-enoic acid 112
                                                  2-oxohex-4-enoic acid + 0
                                                  cis-hex-4-enoic acid + 0
                                                  mycophenolic acid + 112
                                                  trans-hex-4-enoic acid + 0
paths to the root