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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733315
Species: Mus musculus
RGD Object: Gene
Symbol: Il2
Name: interleukin 2
Acc ID: CHEBI:168396
Term: mycophenolic acid
Definition: A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.
Chemical ID: MESH:D009173
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il2decreases expressionISOIl2 (Rattus norvegicus)6480464CTDMycophenolic Acid results in decreased expression of IL2 mRNAPMID:11562063
Il2multiple interactionsISOIL2 (Homo sapiens)6480464CTD[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]PMID:12193749 PMID:29594315
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