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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrazoles
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Accession:CHEBI:35689 term browser browse the term
Definition:An azole in which the five-membered heterocyclic aromatic skeleton contains four N atoms and one C atom.
Synonyms:xref_mesh: MESH:D013777


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tetrazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO [Tetrazoles analog binds to and results in increased activity of HCAR2 protein] which results in decreased abundance of Fatty Acids, Nonesterified; Tetrazoles analog binds to and results in increased activity of HCAR2 protein CTD PMID:20363624 NCBI chr12:32,726,252...32,728,238
Ensembl chr12:32,726,184...32,728,504 		JBrowse link
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO thiazolyl blue results in decreased activity of ABCB1 protein CTD PMID:15451006 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Aco2 aconitase 2 multiple interactions ISO [Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue CTD PMID:12548706 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Casp3 caspase 3 increases activity ISO thiazolyl blue results in increased activity of CASP3 protein CTD PMID:22401948 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 increases reduction
multiple interactions		 ISO NQO2 protein results in increased reduction of thiazolyl blue
resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]		 CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
azosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions		 ISO azosemide results in decreased activity of SLC12A2 protein
azosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:15517342 PMID:29959396 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
candesartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects expression EXP candesartan affects the expression of ACE mRNA CTD PMID:18796534 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression EXP candesartan results in decreased expression of ACE2 mRNA CTD PMID:18796534 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
decreases expression		 ISO [candesartan co-treated with Fenofibrate] results in increased expression of ADIPOQ protein; candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ]
candesartan results in increased expression of ADIPOQ; candesartan results in increased expression of ADIPOQ protein
candesartan results in decreased expression of ADIPOQ		 CTD PMID:16443859 PMID:17483542 PMID:19059660 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP		 candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Nitric Oxide]; candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Reactive Oxygen Species]
candesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; candesartan inhibits the reaction [AGT protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; candesartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
candesartan inhibits the reaction [AGT protein modified form results in increased expression of COL1A2 protein]; candesartan inhibits the reaction [AGT results in increased expression of NOS3 protein]; candesartan inhibits the reaction [AGT results in increased expression of PTGS2 protein]; candesartan inhibits the reaction [AGT results in increased expression of VEGFA protein]		 CTD PMID:10525314 PMID:11729239 PMID:12065685 PMID:15539634 PMID:15728788 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression		 ISO
EXP		 candesartan binds to and results in decreased activity of AGTR1 protein
candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
candesartan results in decreased expression of AGTR1A mRNA		 CTD PMID:15728788 PMID:18796534 PMID:21474964 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
decreases expression		 ISO
EXP		 [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]
candesartan results in decreased expression of AGTR2 mRNA		 CTD PMID:18551021 PMID:18796534 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akap11 A-kinase anchoring protein 11 increases expression EXP candesartan results in increased expression of AKAP11 mRNA CTD PMID:14871019 NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases expression EXP candesartan results in decreased expression of AKR1B1 mRNA CTD PMID:14871019 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP candesartan results in decreased phosphorylation of AKT1 protein CTD PMID:17922026 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP candesartan inhibits the reaction [Galactose results in decreased expression of ATG5 mRNA] CTD PMID:34906534 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP candesartan inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 protein] CTD PMID:16723803 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP candesartan results in increased expression of BAX mRNA; candesartan results in increased expression of BAX protein CTD PMID:11409658 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bdkrb2 bradykinin receptor B2 decreases expression EXP candesartan results in decreased expression of BDKRB2 mRNA CTD PMID:18796534 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Becn1 beclin 1 multiple interactions EXP candesartan inhibits the reaction [Galactose results in decreased expression of BECN1 mRNA] CTD PMID:34906534 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO candesartan results in decreased activity of CA1 protein CTD PMID:11196069 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]; candesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; candesartan inhibits the reaction [Gentamicins results in increased expression of CASP3 protein] CTD PMID:23300732 PMID:30368989 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP candesartan inhibits the reaction [Galactose results in decreased activity of CAT protein] CTD PMID:34906534 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP candesartan results in decreased expression of CCN2 mRNA CTD PMID:16685210 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression
increases expression		 ISO
EXP		 T 0070907 inhibits the reaction [candesartan results in increased expression of CD36 mRNA]
candesartan results in decreased expression of CD36 mRNA		 CTD PMID:14871019 PMID:22124178 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases expression		 ISO candesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein] CTD PMID:16443859 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO candesartan inhibits the reaction [AGT protein modified form results in increased expression of COL1A2 protein] CTD PMID:11729239 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 decreases expression EXP candesartan results in decreased expression of CRISPLD2 mRNA CTD PMID:14871019 NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465 		JBrowse link
G Crp C-reactive protein multiple interactions
decreases expression		 ISO candesartan promotes the reaction [Fenofibrate results in decreased expression of CRP protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CRP protein] CTD PMID:14620923 PMID:16443859 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP candesartan inhibits the reaction [Indomethacin results in increased expression of CXCL1 protein] CTD PMID:17763956 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions		 ISO
EXP		 candesartan results in decreased expression of CYBA protein
candesartan results in decreased expression of CYBA; candesartan results in decreased expression of CYBA mRNA
Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA]; candesartan inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA]		 CTD PMID:16139267 PMID:16685210 PMID:18551021 PMID:21107329 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression		 EXP Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB]
candesartan results in decreased expression of CYBB; candesartan results in decreased expression of CYBB mRNA		 CTD PMID:16685210 PMID:21107329 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance
decreases expression		 ISO
EXP		 CYP11B2 protein polymorphism affects the susceptibility to candesartan
candesartan results in decreased expression of CYP11B2 mRNA		 CTD PMID:12065207 PMID:18796534 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Eng endoglin multiple interactions EXP candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Faslg Fas ligand multiple interactions EXP candesartan inhibits the reaction [Daunorubicin results in increased expression of FASLG protein] CTD PMID:16324756 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP candesartan inhibits the reaction [[Acetaldehyde co-treated with Cyanamide] results in increased expression of FOS protein]; candesartan inhibits the reaction [Acetaldehyde promotes the reaction [Cyanamide results in increased expression of FOS protein]] CTD PMID:26298003 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein] CTD PMID:21255808 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gcg glucagon multiple interactions ISO [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein] CTD PMID:21255808 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP candesartan inhibits the reaction [Galactose results in decreased expression of GDNF mRNA] CTD PMID:34906534 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression EXP candesartan results in decreased expression of HSPE1 mRNA CTD PMID:14871019 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP candesartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:16139267 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression EXP candesartan results in decreased expression of ID1 mRNA CTD PMID:14871019 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of IL1B protein]; candesartan inhibits the reaction [Gentamicins results in increased expression of IL1B protein] CTD PMID:30368989 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP candesartan inhibits the reaction [AGT protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; candesartan inhibits the reaction [AGT protein results in increased expression of IL6 protein] CTD PMID:10525314 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein] CTD PMID:21255808 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 decreases expression ISO candesartan decreases expression of KCNN4 mRNA and protein in CD4-positive, alpha-beta T cell RGD PMID:29388859 RGD:329955575 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Klk1 kallikrein 1 decreases expression EXP candesartan results in decreased expression of KLK1 mRNA CTD PMID:18796534 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Lep leptin multiple interactions
increases response to substance
decreases expression		 ISO
EXP		 candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]
LEP protein results in increased susceptibility to candesartan
candesartan results in decreased expression of LEP		 CTD PMID:17483542 PMID:19059660 PMID:21287150 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:23300732 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23300732 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein] CTD PMID:20562518 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP candesartan results in increased expression of MMP13 protein CTD PMID:19047581 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp15 matrix metallopeptidase 15 increases expression EXP candesartan results in increased expression of MMP15 mRNA CTD PMID:19047581 NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP candesartan results in decreased expression of MMP9 mRNA; candesartan results in decreased expression of MMP9 protein CTD PMID:19047581 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP candesartan inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:17763956 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP candesartan inhibits the reaction [Streptozocin results in increased expression of NOS2 protein] CTD PMID:16139267 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO
EXP		 [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]
candesartan inhibits the reaction [Streptozocin results in increased expression of NOS3 mRNA]; candesartan inhibits the reaction [Streptozocin results in increased expression of NOS3 protein]
candesartan inhibits the reaction [AGT results in increased expression of NOS3 protein]		 CTD PMID:12065685 PMID:16139267 PMID:18551021 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
decreases expression		 EXP Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox4 NADPH oxidase 4 decreases expression
multiple interactions		 ISO
EXP		 candesartan results in decreased expression of NOX4 protein
Amlodipine promotes the reaction [candesartan results in decreased expression of NOX4]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4]		 CTD PMID:18551021 PMID:21107329 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nppa natriuretic peptide A increases expression
increases secretion		 EXP candesartan results in increased expression of NPPA mRNA; candesartan results in increased expression of NPPA protein
candesartan results in increased secretion of NPPA protein		 CTD PMID:14639023 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects expression EXP candesartan affects the expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pln phospholamban multiple interactions EXP candesartan inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein] CTD PMID:16723803 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pmch pro-melanin-concentrating hormone decreases expression EXP candesartan results in decreased expression of PMCH mRNA CTD PMID:21287150 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression EXP candesartan results in decreased expression of PTGIS mRNA CTD PMID:14871019 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO candesartan inhibits the reaction [AGT results in increased expression of PTGS2 protein] CTD PMID:12065685 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased phosphorylation of RELA protein]; candesartan inhibits the reaction [Gentamicins results in increased phosphorylation of RELA protein] CTD PMID:30368989 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions
increases expression
decreases activity		 ISO
EXP		 candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
candesartan results in increased expression of REN mRNA
candesartan results in decreased activity of REN protein		 CTD PMID:18679781 PMID:18796534 PMID:19047581 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein] CTD PMID:16723803 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein CTD PMID:19487956 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; candesartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of TGFB1 mRNA] CTD PMID:16778335 PMID:19487956 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbd thrombomodulin multiple interactions EXP candesartan inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein] CTD PMID:16778335 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression EXP candesartan results in decreased expression of TIMP2 mRNA CTD PMID:19047581 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression EXP candesartan results in decreased expression of TIMP3 mRNA CTD PMID:19047581 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 candesartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; candesartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; T 0070907 inhibits the reaction [candesartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
candesartan results in decreased expression of TNF mRNA
[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of TNF protein]; candesartan inhibits the reaction [Galactose results in increased expression of TNF mRNA]; candesartan inhibits the reaction [Gentamicins results in increased expression of TNF protein]		 CTD PMID:22124178 PMID:30368989 PMID:34906534 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP candesartan results in increased expression of TP53 mRNA; candesartan results in increased expression of TP53 protein CTD PMID:11409658 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression
multiple interactions		 EXP
ISO		 candesartan results in decreased expression of UCP2 mRNA
candesartan inhibits the reaction [Palmitic Acid results in increased expression of UCP2 mRNA]		 CTD PMID:16685210 PMID:20667613 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP candesartan inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein] CTD PMID:16139267 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 ISO candesartan results in decreased expression of VEGFA
candesartan inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
candesartan inhibits the reaction [AGT results in increased expression of VEGFA protein]		 CTD PMID:12065685 PMID:16202860 PMID:16675585 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Ybx3 Y box binding protein 3 decreases expression EXP candesartan results in decreased expression of YBX3 mRNA CTD PMID:14871019 NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161 		JBrowse link
cefazolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases activity ISO Cefazolin results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression		 ISO Cefazolin results in increased expression of and results in decreased activity of GSR protein
Cefazolin results in increased expression of GSR mRNA		 CTD PMID:32196862 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G RT1-DOa RT1 class II, locus DOa affects expression ISO Cefazolin affects the expression of HLA-DOA mRNA CTD PMID:25811541 NCBI chr20:4,753,587...4,756,590
Ensembl chr20:4,753,598...4,756,577 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Cefazolin affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake ISO SLC22A8 protein results in increased uptake of Cefazolin CTD PMID:16098483 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Cefazolin binds to and results in decreased activity of SLC25A20 protein; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
cilostazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO cilostazol increases expression of abca1 protein in liver
cilostazol reverses the reaction [palmitate decreases expression of abca1 protein in hepatoma cells]		 RGD PMID:26362727 PMID:26362727 RGD:21408552, RGD:21408552 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in decreased expression of ABL1 protein CTD PMID:35920412 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization ISO cilostazol results in increased localization of AIFM1 protein CTD PMID:20131233 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [Meloxicam co-treated with Cilostazol] results in decreased phosphorylation of AKT1 protein; Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]
cilostazol results in increased phosphorylation of AKT1 protein		 CTD PMID:12807996 PMID:15978173 PMID:18556572 PMID:35920412 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of AMH protein] CTD PMID:32456565 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects expression		 ISO (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]
cilostazol affects the expression of APP protein		 CTD PMID:24254769 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression EXP cilostazol affects the expression of ATP2A2 mRNA; cilostazol affects the expression of ATP2A2 protein CTD PMID:18088389 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
affects expression
multiple interactions		 ISO
EXP		 Cilostazol results in increased expression of BAX mRNA; Cilostazol results in increased expression of BAX protein
cilostazol affects the expression of BAX protein
[Cilostazol co-treated with Meloxicam] results in increased expression of BAX mRNA; Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]		 CTD PMID:15978173 PMID:16822680 PMID:20131233 PMID:35920412 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression		 ISO
EXP		 cilostazol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]
cilostazol affects the expression of BCL2 protein
cilostazol results in decreased expression of BCL2 protein		 CTD PMID:15978173 PMID:16822680 PMID:20131233 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in decreased expression of BID protein modified form]; cilostazol inhibits the reaction [Nitroprusside results in increased cleavage of and results in increased localization of BID protein] CTD PMID:18311796 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 [Meloxicam co-treated with Cilostazol] results in increased activity of CASP3 protein; KT 5720 inhibits the reaction [Cilostazol results in increased activity of CASP3 protein]
Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]; Cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP3 protein]		 CTD PMID:18311796 PMID:20131233 PMID:32456565 PMID:35920412 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP7 protein] CTD PMID:18311796 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein] CTD PMID:18311796 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO [Meloxicam co-treated with Cilostazol] results in increased activity of CASP9 protein
Cilostazol results in increased activity of CASP9 protein		 CTD PMID:35920412 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]] CTD PMID:19967051 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cilostazol results in decreased expression of CCNA2 protein CTD PMID:15723965 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cilostazol results in increased expression of CDKN1A protein CTD PMID:10642304 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity		 ISO cilostazol promotes the reaction [CFTR protein affects the secretion of Chlorides]
cilostazol results in increased activity of CFTR protein		 CTD PMID:12714375 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 ISO
EXP		 Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]
cilostazol results in increased phosphorylation of CREB1 protein		 CTD PMID:12807996 PMID:15978173 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases phosphorylation
multiple interactions		 ISO cilostazol results in increased phosphorylation of CSNK2A1 protein
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein]; CSNK2A1 protein affects the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein]		 CTD PMID:24254769 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO cilostazol results in decreased expression of E2F1 protein CTD PMID:15723965 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO cilostazol results in decreased expression of E2F2 protein CTD PMID:15723965 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G Ep300 E1A binding protein p300 affects expression
multiple interactions		 ISO cilostazol affects the expression of EP300 protein
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol affects the expression of EP300 protein]; KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein]; SIRT1 protein affects the reaction [cilostazol affects the expression of EP300 protein]; sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]		 CTD PMID:24254769 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of FSHB protein] CTD PMID:32456565 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects phosphorylation
multiple interactions		 ISO cilostazol affects the phosphorylation of GSK3B protein
SIRT1 protein affects the reaction [cilostazol affects the phosphorylation of GSK3B protein]		 CTD PMID:24254769 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
increases expression
multiple interactions		 ISO
EXP		 HMOX1 results in increased susceptibility to cilostazol
cilostazol results in increased expression of HMOX1 mRNA; cilostazol results in increased expression of HMOX1 protein
copper protoporphyrin IX inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; HMOX1 protein promotes the reaction [cilostazol results in increased activity of PPARG protein]; NFE2L2 mutant form inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]
Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 mRNA]; Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Cilostazol inhibits the reaction [Nitroprusside results in decreased expression of HMOX1 protein]		 CTD PMID:18311796 PMID:20131233 PMID:21256160 PMID:21660147 PMID:32456565 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]
cilostazol results in decreased expression of IL1B protein		 CTD PMID:20131233 PMID:32456565 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL5 protein] CTD PMID:15169552 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of IL6 mRNA]
cilostazol results in decreased expression of IL6 protein		 CTD PMID:20131233 PMID:32456565 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of LHB protein] CTD PMID:32456565 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein; SIRT1 protein affects the reaction [cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein] CTD PMID:24254769 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in decreased expression of MYC protein CTD PMID:35920412 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
increases response to substance		 ISO
EXP		 cilostazol results in increased expression of NFE2L2 protein
Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 mRNA]; Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]]
NFE2L2 results in increased susceptibility to cilostazol
NFE2L2 mutant form inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]		 CTD PMID:20131233 PMID:30295103 PMID:32456565 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions		 ISO cilostazol results in increased expression of NFKBIA protein
zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of NFKBIA protein]		 CTD PMID:20131233 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO cilostazol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:21256160 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation		 ISO cilostazol inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Paclitaxel results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Sirolimus results in decreased expression of NOS3 protein]
cilostazol results in increased phosphorylation of NOS3 protein		 CTD PMID:18556572 PMID:19520256 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]] CTD PMID:30295103 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO cilostazol results in decreased expression of PCNA protein CTD PMID:15723965 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pln phospholamban affects expression EXP cilostazol affects the expression of PLN mRNA; cilostazol affects the expression of PLN protein CTD PMID:18088389 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions		 ISO cilostazol results in increased activity of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [cilostazol results in increased activity of PPARG protein]; HMOX1 protein promotes the reaction [cilostazol results in increased activity of PPARG protein]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased activity of PPARG protein]		 CTD PMID:21660147 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in increased expression of and results in increased phosphorylation of PRKAA1 protein CTD PMID:35920412 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
decreases phosphorylation		 ISO
EXP		 Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]
cilostazol results in decreased phosphorylation of PTEN protein		 CTD PMID:12807996 PMID:15978173 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21256160 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]] CTD PMID:20131233 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases phosphorylation
affects expression
increases expression		 ISO cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein]
cilostazol results in increased phosphorylation of SIRT1 protein
cilostazol affects the expression of SIRT1 mRNA
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; cilostazol affects the expression of and affects the activity of SIRT1 protein; cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]; CSNK2A1 protein affects the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; SIRT1 protein affects the reaction [cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein]; SIRT1 protein affects the reaction [cilostazol affects the expression of EP300 protein]; SIRT1 protein affects the reaction [cilostazol affects the phosphorylation of GSK3B protein]; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]
cilostazol results in increased expression of SIRT1 protein		 CTD PMID:18556572 PMID:19520256 PMID:24254769 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO cilostazol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO cilostazol inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]; cilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine] CTD PMID:28041785 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Verapamil co-treated with Cilostazol] inhibits the reaction [Thioacetamide results in decreased activity of SOD1 protein]; Cilostazol inhibits the reaction [Thioacetamide results in decreased activity of SOD1 protein] CTD PMID:30295103 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
decreases expression		 ISO
EXP		 [Cilostazol co-treated with Probucol] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]; Cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]; Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]; Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]; Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; HMOX1 mutant form inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]; zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Cilostazol results in decreased susceptibility to TNF protein]
Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of TNF mRNA]
cilostazol results in decreased susceptibility to TNF protein
cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of TNF protein]; cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
cilostazol results in decreased expression of TNF protein		 CTD PMID:12807996 PMID:15169552 PMID:19967051 PMID:20131233 PMID:21256160 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO
EXP		 cilostazol results in increased expression of TP53 protein
cilostazol inhibits the reaction [Nitroprusside results in increased phosphorylation of TP53 protein]		 CTD PMID:10642304 PMID:18311796 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]] CTD PMID:19967051 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
irbesartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO irbesartan results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ace2 angiotensin converting enzyme 2 affects response to substance ISO ACE2 gene polymorphism affects the susceptibility to irbesartan CTD PMID:11593098 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein CTD PMID:15149348 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen affects response to substance
multiple interactions
increases expression		 ISO
EXP		 AGT gene polymorphism affects the susceptibility to irbesartan; AGT gene SNP affects the susceptibility to irbesartan
irbesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]
irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
irbesartan results in increased expression of AGT protein
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGT protein]		 CTD PMID:10082498 PMID:11910301 PMID:14639093 PMID:15614026 PMID:16794485 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects response to substance
multiple interactions		 ISO AGTR1 gene polymorphism affects the susceptibility to irbesartan
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA]
irbesartan binds to and results in decreased activity of AGTR1 protein		 CTD PMID:11910301 PMID:12022239 PMID:19028402 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of AKT1 protein] CTD PMID:19028402 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of ALB protein] CTD PMID:31967706 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apob apolipoprotein B affects response to substance ISO APOB gene SNP affects the susceptibility to irbesartan CTD PMID:15453913 PMID:15614026 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 irbesartan inhibits the reaction [ioversol results in increased expression of BAX mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in increased expression of BAX protein]		 CTD PMID:16828304 PMID:31967706 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 irbesartan inhibits the reaction [ioversol results in decreased expression of BCL2 mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]		 CTD PMID:16828304 PMID:31967706 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 exon polymorphism affects the susceptibility to irbesartan CTD PMID:12640257 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO irbesartan results in decreased activity of CA1 protein CTD PMID:11196069 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Irbesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Irbesartan inhibits the reaction [Indomethacin results in increased expression of CASP3 mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]		 CTD PMID:23300732 PMID:29523851 PMID:31967706 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 protein] CTD PMID:19028402 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases response to substance ISO CYP11B2 gene SNP results in increased susceptibility to irbesartan CTD PMID:12022239 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO irbesartan results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein] CTD PMID:31967706 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in decreased expression of DDAH1 mRNA] CTD PMID:29523851 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339 		JBrowse link
G Edn1 endothelin 1 affects response to substance ISO EDN1 gene polymorphism affects the susceptibility to irbesartan CTD PMID:15188945 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of EGFR mRNA] CTD PMID:29523851 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 affects response to substance ISO ERAP1 gene polymorphism affects the susceptibility to irbesartan CTD PMID:13678427 NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of F3 protein CTD PMID:21229253 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:31967706 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ifng interferon gamma decreases expression ISO irbesartan results in decreased expression of IFNG protein CTD PMID:15210574 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 protein] CTD PMID:19028402 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein]
Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]		 CTD PMID:33380422 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of MMP9 protein] CTD PMID:29523851 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 protein] CTD PMID:19028402 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of NFKB1 protein] CTD PMID:19028402 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased phosphorylation of NFKBIB protein] CTD PMID:19028402 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nppa natriuretic peptide A increases expression ISO irbesartan results in increased expression of NPPA protein CTD PMID:12035877 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA] CTD PMID:29523851 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of RAC1 mRNA] CTD PMID:19028402 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of RELA protein] CTD PMID:19028402 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases expression ISO irbesartan results in increased expression of REN protein CTD PMID:14639093 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Ret ret proto-oncogene increases expression ISO irbesartan results in increased expression of RET protein CTD PMID:16164579 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions
affects expression		 EXP [benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein
irbesartan affects the expression of SMAD2 mRNA; irbesartan affects the expression of SMAD2 protein		 CTD PMID:16635409 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
affects expression		 EXP [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein
irbesartan affects the expression of SMAD3 mRNA; irbesartan affects the expression of SMAD3 protein		 CTD PMID:16635409 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein CTD PMID:21229253 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects response to substance
multiple interactions
affects expression
decreases expression		 ISO
EXP		 TGFB1 gene SNP affects the susceptibility to irbesartan
[benazepril co-treated with irbesartan] affects the expression of TGFB1 mRNA
irbesartan affects the expression of TGFB1 mRNA
irbesartan results in decreased expression of TGFB1 mRNA		 CTD PMID:11352773 PMID:15049387 PMID:16635409 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 irbesartan results in decreased expression of TNF protein
Irbesartan inhibits the reaction [Indomethacin results in increased expression of TNF protein]
Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF mRNA]; Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF protein]; Irbesartan inhibits the reaction [Acetaminophen results in increased expression of TNF protein]		 CTD PMID:15210574 PMID:19028402 PMID:29523851 PMID:31967706 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 protein] CTD PMID:19028402 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Losartan results in decreased activity of ABCB11 protein
Losartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Losartan results in decreased expression of ACE protein		 CTD PMID:25511041 PMID:25655897 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions
increases activity
increases expression		 EXP
ISO		 Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]
Losartan results in increased activity of ACE2 protein
Losartan results in increased expression of ACE2 protein
Losartan results in increased expression of ACE2 mRNA; Losartan results in increased expression of ACE2 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]		 CTD PMID:15897343 PMID:16176966 PMID:16221218 PMID:20178811 PMID:22009550 More... NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of ACTA2 mRNA; Losartan results in decreased expression of ACTA2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:15100363 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP Losartan results in decreased expression of ACTG2 mRNA CTD PMID:15100363 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Losartan results in increased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects expression EXP Losartan affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen multiple interactions
increases secretion
decreases activity
decreases expression
increases expression
decreases response to substance		 ISO
EXP		 [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [pyruvamide binds to AGT protein modified form]]; Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Losartan inhibits the reaction [AGT protein promotes the reaction [[Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased secretion of PRL protein]]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of CXCL8 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of MMP2 protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]
Losartan results in increased secretion of AGT protein; Losartan results in increased secretion of AGT protein alternative form
Losartan results in decreased activity of AGT protein
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of DES protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA; [Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the localization of Calcium]; Losartan inhibits the reaction [AGT protein affects the localization of Lipids]; Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]; Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased abundance of Fatty Acids, Nonesterified]; Losartan inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Triglycerides]; Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Ethanol results in increased secretion of AGT protein alternative form]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]; Losartan inhibits the reaction [Folic Acid results in increased localization of AGT protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AGT protein]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]
Losartan results in decreased expression of AGT protein; Losartan results in decreased expression of AGT protein alternative form; Losartan results in decreased expression of AGT protein modified form
Losartan results in increased expression of AGT protein
Losartan results in decreased activity of AGT protein; Losartan results in decreased activity of AGT protein modified form
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein; Losartan results in decreased activity of AGT protein		 CTD PMID:1387008 PMID:7965263 PMID:8403307 PMID:8952583 PMID:9124547 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
increases expression
decreases activity		 ISO
EXP		 [Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]
Losartan results in decreased expression of AGTR1 protein; Losartan results in decreased expression of AGTR1A mRNA; Losartan results in decreased expression of AGTR1A protein
Losartan results in increased expression of AGTR1 mRNA; Losartan results in increased expression of AGTR1A mRNA
[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]		 CTD PMID:9124547 PMID:9533614 PMID:10821809 PMID:11893553 PMID:12930639 More... NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression
decreases expression		 EXP
ISO		 [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]
Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein]
Losartan results in increased expression of AGTR2 protein
Losartan results in decreased expression of AGTR2 mRNA		 CTD PMID:9336375 PMID:11967826 PMID:15331931 PMID:18300857 PMID:25511041 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein] CTD PMID:28578904 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Alb albumin affects binding ISO Losartan binds to ALB protein; Losartan binds to ALB protein modified form CTD PMID:27470663 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Losartan results in decreased expression of ALOX15 mRNA; Losartan results in decreased expression of ALOX15 protein CTD PMID:15100363 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression EXP Losartan results in decreased expression of ALOX5 protein CTD PMID:21377515 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions		 ISO Losartan results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]		 CTD PMID:16303729 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Losartan results in increased expression of ATP1A2 mRNA; Losartan results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Losartan results in decreased expression of ATP1A3 mRNA; Losartan results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA] CTD PMID:15502641 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression		 EXP Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]
Losartan results in increased expression of BAX protein
Losartan results in decreased expression of BAX mRNA		 CTD PMID:12623880 PMID:12845756 PMID:15502641 PMID:17784886 PMID:19298698 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
increases expression
decreases expression		 EXP Losartan promotes the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA]
Losartan affects the expression of BCL2 protein
Losartan results in increased expression of BCL2 protein
Losartan results in decreased expression of BCL2 protein		 CTD PMID:12623880 PMID:15502641 PMID:19298698 PMID:21153712 PMID:22000973 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein] CTD PMID:27412937 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO [KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein] CTD PMID:25103225 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp3 caspase 3 increases cleavage
decreases activity
multiple interactions		 EXP Losartan results in increased cleavage of CASP3 protein
Losartan results in decreased activity of CASP3 protein
Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]		 CTD PMID:12623880 PMID:23300732 PMID:23875703 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases activity EXP Losartan results in decreased activity of CASP8 protein CTD PMID:23875703 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage EXP Losartan results in increased cleavage of CASP9 protein CTD PMID:12623880 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
multiple interactions		 EXP Losartan results in decreased expression of CAT protein
Losartan inhibits the reaction [Streptozocin results in decreased activity of CAT protein]		 CTD PMID:23875703 PMID:30958922 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Losartan inhibits the reaction [glyoxylic acid results in increased expression of CCL2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]
Losartan results in decreased expression of CCL2 mRNA; Losartan results in decreased expression of CCL2 protein		 CTD PMID:10925121 PMID:16284884 PMID:17922026 PMID:19553526 PMID:28578904 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP Losartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd36 CD36 molecule increases expression
decreases expression
multiple interactions		 ISO Losartan results in increased expression of CD36 mRNA
Losartan results in decreased expression of CD36 mRNA
Losartan promotes the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA]
T 0070907 inhibits the reaction [Losartan results in increased expression of CD36 mRNA]		 CTD PMID:18302760 PMID:22124178 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd44 CD44 molecule multiple interactions EXP Losartan inhibits the reaction [glyoxylic acid results in increased expression of CD44 protein] CTD PMID:37454925 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd74 CD74 molecule decreases expression EXP Losartan results in decreased expression of CD74 mRNA CTD PMID:15100363 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]		 CTD PMID:28578904 PMID:33007385 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of COL1A1 mRNA
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL1A1 mRNA]		 CTD PMID:15100363 PMID:18300870 PMID:23585870 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of COL3A1 mRNA
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]		 CTD PMID:15100363 PMID:16539842 PMID:23585870 PMID:25233898 PMID:28578904 More... NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression EXP Losartan results in decreased expression of COL4A1 mRNA CTD PMID:16191423 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA] CTD PMID:19109942 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein] CTD PMID:15728788 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]		 CTD PMID:28578904 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cubn cubilin multiple interactions EXP Losartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein] CTD PMID:24093454 NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Losartan results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Losartan results in increased expression of CYP1A1 mRNA CTD PMID:9860486 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dcn decorin decreases expression EXP Losartan results in decreased expression of DCN mRNA CTD PMID:15100363 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Des desmin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of DES protein] CTD PMID:28578904 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 ISO
EXP		 Losartan results in decreased expression of EDN1 protein
Losartan results in decreased expression of EDN1 mRNA; Losartan results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]		 CTD PMID:11369837 PMID:12901495 PMID:16191423 PMID:17666345 PMID:18971572 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions
decreases expression		 EXP Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA] CTD PMID:23091284 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein] CTD PMID:25398788 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eln elastin decreases expression EXP Losartan results in decreased expression of ELN mRNA CTD PMID:15100363 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Eng endoglin multiple interactions
increases expression		 EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]
Losartan results in increased expression of ENG mRNA; Losartan results in increased expression of ENG protein		 CTD PMID:15539634 PMID:32947957 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions		 ISO Losartan results in decreased expression of F3 mRNA; Losartan results in decreased expression of F3 protein
Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]		 CTD PMID:18060435 PMID:22188725 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Faslg Fas ligand decreases expression EXP Losartan results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA] CTD PMID:19109942 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO Losartan results in decreased expression of FLT1 mRNA; Losartan results in decreased expression of FLT1 protein CTD PMID:19771429 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases expression ISO Losartan results in decreased expression of FLT4 mRNA CTD PMID:19771429 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Losartan results in decreased expression of FN1 mRNA; Losartan results in decreased expression of FN1 protein CTD PMID:16191423 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]; Losartan inhibits the reaction [Polyethylene Glycols results in increased expression of FOS protein] CTD PMID:11463773 PMID:15528393 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Losartan results in increased expression of GJA1 protein CTD PMID:18971572 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]		 CTD PMID:15573910 PMID:29859236 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein] CTD PMID:22982863 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Losartan inhibits the reaction [Cadmium results in increased expression of HAVCR1] CTD PMID:24093454 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA] CTD PMID:19109942 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression		 EXP
ISO		 Losartan results in increased activity of HMOX1 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]
Losartan results in increased expression of HMOX1 mRNA
cobaltiprotoporphyrin promotes the reaction [Losartan results in increased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Losartan results in increased expression of HMOX1 mRNA]		 CTD PMID:19804535 PMID:28578904 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein] CTD PMID:25398788 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases secretion		 ISO Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]
Losartan results in decreased secretion of ICAM1 protein		 CTD PMID:10517737 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 EXP Losartan results in increased expression of IFNG protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]; Losartan inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]		 CTD PMID:23875703 PMID:34590760 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases expression EXP Losartan results in increased expression of IL10 mRNA CTD PMID:18971572 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]
Losartan results in decreased expression of IL1A protein		 CTD PMID:17299153 PMID:23875703 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Vitamin D co-treated with Losartan] inhibits the reaction [Amiodarone results in increased expression of IL4 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of IL4 protein] CTD PMID:34590760 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions		 ISO
EXP		 Losartan results in decreased expression of IL6 mRNA
Losartan results in increased expression of IL6 protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]		 CTD PMID:16284884 PMID:21479465 PMID:23875703 PMID:30677511 PMID:32947957 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga3 integrin subunit alpha 3 decreases expression EXP Losartan results in decreased expression of ITGA3 protein CTD PMID:15100363 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression EXP Losartan results in decreased expression of ITGA6 protein CTD PMID:15100363 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions EXP Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR1 protein] CTD PMID:37454925 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions EXP Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR2 protein] CTD PMID:37454925 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver] RGD PMID:22613986 RGD:127285667 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein] CTD PMID:34590760 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kng1 kininogen 1 multiple interactions EXP Losartan inhibits the reaction [bisphenol A results in increased expression of KNG1 protein] CTD PMID:38027817 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]; Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lox lysyl oxidase decreases expression EXP Losartan results in decreased expression of LOX mRNA CTD PMID:15100363 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lum lumican decreases expression EXP Losartan results in decreased expression of LUM mRNA CTD PMID:15100363 NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK1 protein]; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]
Losartan results in increased activity of MAPK1 protein
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression
multiple interactions		 EXP Losartan results in decreased expression of MAPK14 protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]		 CTD PMID:28091615 PMID:34590760 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity		 ISO
EXP		 Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
Losartan results in increased phosphorylation of MAPK3 protein
Losartan results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK3 protein]; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:22982863 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mgp matrix Gla protein decreases expression EXP Losartan results in decreased expression of MGP mRNA CTD PMID:15100363 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO		 Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of MMP2 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]		 CTD PMID:12930639 PMID:16251426 PMID:23585870 PMID:29859236 PMID:36682589 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp23 matrix metallopeptidase 23 decreases expression EXP Losartan results in decreased expression of MMP23 mRNA CTD PMID:15100363 NCBI chr 5:166,239,643...166,242,734
Ensembl chr 5:166,239,644...166,242,433 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]] CTD PMID:28578904 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of MMP9 mRNA
Losartan inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]		 CTD PMID:18971572 PMID:23585870 PMID:25233898 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects expression EXP Losartan affects the expression of MYC protein CTD PMID:22000973 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh11 myosin heavy chain 11 decreases expression EXP Losartan results in decreased expression of MYH11 mRNA CTD PMID:15100363 NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 protein] CTD PMID:15362513 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Mylk myosin light chain kinase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein] CTD PMID:18511912 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP		 Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]
Losartan inhibits the reaction [Ethanol affects the localization of NCF1 protein]		 CTD PMID:22306536 PMID:22497828 PMID:22982071 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of NFE2L2 mRNA
Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]		 CTD PMID:18765277 PMID:28578904 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO		 Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]		 CTD PMID:16284884 PMID:29859236 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos1 nitric oxide synthase 1 increases phosphorylation
multiple interactions		 EXP Losartan results in increased phosphorylation of NOS1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of NOS1 protein]		 CTD PMID:20056918 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 affects expression
decreases expression
increases expression		 EXP Losartan affects the expression of NOS2 mRNA
Losartan results in decreased expression of NOS2 mRNA; Losartan results in decreased expression of NOS2 protein
Losartan results in increased expression of NOS2 protein		 CTD PMID:12198324 PMID:16191423 PMID:18390819 PMID:21377515 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 affects expression
increases expression
multiple interactions
increases phosphorylation		 EXP Losartan affects the expression of NOS3 mRNA
Losartan results in increased expression of NOS3 mRNA
[Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]
Losartan results in increased phosphorylation of NOS3 protein		 CTD PMID:12198324 PMID:18390819 PMID:18971572 PMID:20232302 PMID:23091284 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression		 EXP Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Losartan results in decreased expression of NPPA protein		 CTD PMID:12198334 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression		 EXP [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Losartan results in decreased expression of NPPB mRNA; Losartan results in decreased expression of NPPB protein		 CTD PMID:12198334 PMID:15969258 PMID:17666919 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Npr1 natriuretic peptide receptor 1 affects response to substance ISO NPR1 protein mutant form affects the susceptibility to Losartan CTD PMID:20881240 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP Losartan results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP Losartan results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]
Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]		 CTD PMID:15502880 PMID:21613793 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form] CTD PMID:12431451 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] CTD PMID:12930639 PMID:17043664 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfd platelet derived growth factor D multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA] CTD PMID:17043664 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA] CTD PMID:17043664 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP Losartan results in decreased expression of PDLIM3 mRNA CTD PMID:15100363 NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Losartan results in decreased expression of PECAM1 mRNA CTD PMID:19771429 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plat plasminogen activator, tissue type decreases expression EXP Losartan results in decreased expression of PLAT mRNA CTD PMID:15100363 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Podxl podocalyxin-like multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899 		JBrowse link
G Postn periostin multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]
Losartan results in decreased expression of POSTN mRNA		 CTD PMID:15121739 PMID:21641384 PMID:32947957 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA] CTD PMID:19109942 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]
Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]		 CTD PMID:18302760 PMID:19109942 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression		 EXP Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]
Losartan results in increased expression of PPARGC1A mRNA		 CTD PMID:18765277 PMID:18971572 PMID:19109942 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP Losartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein] CTD PMID:22497828 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prl prolactin multiple interactions EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]
Losartan inhibits the reaction [AGT protein promotes the reaction [[Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased secretion of PRL protein]]		 CTD PMID:14722030 PMID:36682589 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
Losartan results in decreased expression of PTGS2 mRNA; Losartan results in decreased expression of PTGS2 protein		 CTD PMID:17244722 PMID:18267125 PMID:21377515 PMID:28578904 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP Losartan inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]; Losartan inhibits the reaction [Gentamicins results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Gentamicins results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA] CTD PMID:27798352 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 Losartan inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]
Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]		 CTD PMID:15157388 PMID:28578904 PMID:29859236 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions
increases expression
increases activity		 ISO
EXP		 [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]
Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]
Losartan results in increased expression of REN mRNA; Losartan results in increased expression of REN protein
Losartan results in increased activity of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]		 CTD PMID:1387008 PMID:7965263 PMID:8382237 PMID:8403307 PMID:9124547 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression EXP Losartan results in decreased expression of RT1-DA mRNA CTD PMID:15100363 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 decreases expression EXP Losartan results in decreased expression of RT1-S3 mRNA CTD PMID:15100363 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein] CTD PMID:27412937 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein] CTD PMID:28578904 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein] CTD PMID:29609002 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA] CTD PMID:18302760 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Sdc2 syndecan 2 decreases expression EXP Losartan results in decreased expression of SDC2 mRNA; Losartan results in decreased expression of SDC2 protein CTD PMID:15100363 NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081 		JBrowse link
G Selp selectin P multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein] CTD PMID:19553526 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases response to substance EXP SFRP2 protein results in decreased susceptibility to Losartan CTD PMID:23875703 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases activity
affects response to substance
decreases expression
multiple interactions		 ISO Losartan results in decreased activity of SLC22A12 protein
SLC22A12 protein affects the susceptibility to Losartan
Losartan results in decreased expression of SLC22A12 mRNA
[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid		 CTD PMID:18670416 PMID:20486468 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] CTD PMID:19587147 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions ISO Losartan inhibits the reaction [Ammonium Chloride results in increased expression of NHE3 protein] CTD PMID:18287403 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]] CTD PMID:28578904 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Losartan results in decreased activity of SOD2 protein CTD PMID:18765277 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein] CTD PMID:10400907 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression EXP Losartan results in decreased expression of SPARC mRNA CTD PMID:15100363 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Losartan inhibits the reaction [glyoxylic acid results in increased expression of SPP1 protein] CTD PMID:37454925 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein] CTD PMID:19109942 PMID:25398788 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Losartan results in decreased phosphorylation of STAT3 protein CTD PMID:33380422 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions
decreases activity
decreases expression
increases expression		 ISO
EXP		 Losartan results in decreased secretion of TGFB1 protein
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein; Losartan results in decreased expression of TGFB1 protein modified form
Losartan results in increased expression of TGFB1 protein
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]		 CTD PMID:11369837 PMID:12930639 PMID:12937228 PMID:15331931 PMID:15573910 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression		 EXP Losartan inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA] CTD PMID:20137537 PMID:25233898 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression
multiple interactions		 EXP Losartan results in decreased expression of TIMP2 mRNA
Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]		 CTD PMID:20137537 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Losartan results in decreased expression of TJP1 protein CTD PMID:18400868 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnc tenascin C decreases expression EXP
ISO		 Losartan results in decreased expression of TNC mRNA CTD PMID:15100363 PMID:32947957 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 Losartan affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; T 0070907 inhibits the reaction [Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]
Losartan results in decreased expression of TNF protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Losartan inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]		 CTD PMID:15573910 PMID:17299153 PMID:18060435 PMID:22124178 PMID:23875703 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression EXP Losartan results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198 		JBrowse link
G Tp53 tumor protein p53 affects expression EXP Losartan affects the expression of TP53 protein CTD PMID:22000973 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA] CTD PMID:26464165 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression
multiple interactions		 ISO
EXP		 Losartan results in decreased expression of UCP2 mRNA; Losartan results in decreased expression of UCP2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]		 CTD PMID:17508912 PMID:19109942 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA] CTD PMID:19109942 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of VCAM1 protein] CTD PMID:19553526 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Losartan results in decreased expression of VEGFA mRNA; Losartan results in decreased expression of VEGFA protein		 CTD PMID:12110003 PMID:17299153 PMID:17481528 PMID:22188725 PMID:25511041 More... NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Losartan results in decreased expression of VEGFC mRNA CTD PMID:19771429 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vim vimentin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]		 CTD PMID:28578904 PMID:33007385 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wnt1 Wnt family member 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein] CTD PMID:28578904 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
olmesartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO olmesartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
olmesartan results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport ISO ABCC2 protein affects the transport of olmesartan CTD PMID:19505989 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression EXP olmesartan results in increased expression of ACE2 mRNA; olmesartan results in increased expression of ACE2 protein CTD PMID:19171689 PMID:28656296 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]] CTD PMID:24144775 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions		 EXP
ISO		 olmesartan results in decreased expression of AGT protein modified form
[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]		 CTD PMID:16003179 PMID:19171689 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases activity ISO olmesartan results in decreased activity of AGTR1 protein CTD PMID:17208988 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Pravastatin co-treated with olmesartan] results in increased phosphorylation of AKT1 protein CTD PMID:17170375 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin decreases oxidation ISO olmesartan results in decreased oxidation of ALB protein CTD PMID:17587751 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO olmesartan results in decreased expression of BAX protein CTD PMID:17208988 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO olmesartan results in decreased expression of and results in decreased activity of CASP3 protein CTD PMID:17208988 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Crp C-reactive protein decreases expression ISO olmesartan results in decreased expression of CRP protein CTD PMID:18360012 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP olmesartan results in decreased expression of CYBA protein CTD PMID:17170375 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Daxx death-domain associated protein decreases expression ISO olmesartan results in decreased expression of DAXX protein CTD PMID:17208988 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dhfr dihydrofolate reductase increases expression EXP olmesartan results in increased expression of DHFR protein CTD PMID:17170375 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO olmesartan results in decreased expression of FAS protein CTD PMID:17208988 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il6 interleukin 6 decreases expression ISO olmesartan results in decreased expression of IL6 protein CTD PMID:18360012 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases activity ISO olmesartan results in decreased activity of JUN protein CTD PMID:17208988 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions EXP Olmesartan inhibits the reaction [Angiotensin II increases phosphorylation of Map3k7 protein in the heart] RGD PMID:26706286 RGD:155791673 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO olmesartan results in increased expression of MAPK1 protein modified form CTD PMID:17208988 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO olmesartan results in increased expression of MAPK3 protein modified form CTD PMID:17208988 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
decreases activity		 ISO olmesartan results in decreased expression of MAPK8 protein modified form
olmesartan results in decreased activity of MAPK8 protein		 CTD PMID:17208988 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression
decreases activity		 ISO olmesartan results in decreased expression of MAPK9 protein modified form
olmesartan results in decreased activity of MAPK9 protein		 CTD PMID:17208988 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor increases expression EXP olmesartan results in increased expression of MAS1 mRNA; olmesartan results in increased expression of MAS1 protein CTD PMID:28656296 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]] CTD PMID:24144775 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP olmesartan promotes the reaction [NOS3 protein binds to NOS3 protein]; olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein; Pravastatin promotes the reaction [olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein] CTD PMID:17170375 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression ISO Olmesartan increases expression of Nphs1 protein in kidney RGD PMID:17229913 RGD:38599164 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]] CTD PMID:24144775 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]] CTD PMID:24144775 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
tomelukast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death increases expression EXP LY 171883 results in increased expression of BAD protein CTD PMID:12065618 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP LY 171883 results in increased expression of BAX protein CTD PMID:12065618 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO [LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B4; LY 171883 binds to and results in decreased activity of CYSLTR1 protein
LY 171883 binds to and results in increased activity of CYSLTR1 protein; LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]		 CTD PMID:8014878 PMID:14718577 NCBI chr  X:71,661,421...71,690,012
Ensembl chr  X:71,663,821...71,690,121 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO LY 171883 binds to and results in increased activity of PPARA protein CTD PMID:15491415 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO LY 171883 results in increased activity of [PPARG protein co-treated with RXRA protein] CTD PMID:8700121 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO LY 171883 results in increased activity of [PPARG protein co-treated with RXRA protein] CTD PMID:8700121 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
valsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions EXP [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; Valsartan inhibits the reaction [Purines analog results in decreased expression of MRP4 protein] CTD PMID:35114312 PMID:36464070 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP Valsartan inhibits the reaction [Purines analog results in decreased expression of ABCG2 protein] CTD PMID:36464070 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
decreases expression		 EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]
Valsartan results in decreased expression of ACE mRNA		 CTD PMID:23733546 PMID:31023080 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions EXP
ISO		 Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]
Valsartan inhibits the reaction [Glucose results in decreased expression of ACE2 protein]		 CTD PMID:16176966 PMID:29266779 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein] CTD PMID:35114312 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA] CTD PMID:19225232 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Agt angiotensinogen multiple interactions
increases expression		 ISO
EXP		 [benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
Valsartan results in increased expression of AGT protein; Valsartan results in increased expression of AGT protein modified form
[Valsartan co-treated with AGT protein] results in increased activity of LPL protein; Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]; Valsartan inhibits the reaction [Streptozocin results in decreased abundance of AGT protein modified form]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Streptozocin results in increased expression of AGT protein]
[Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of AGT protein; Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein]; Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [AGT protein results in decreased export of Sodium]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Oxygen]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Prostaglandins E]; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of AGT protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan inhibits the reaction [Purines analog results in increased secretion of AGT protein]; Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Glucose results in increased expression of AGT protein]; Valsartan promotes the reaction [Particulate Matter results in increased expression of AGT protein modified form]		 CTD PMID:9261183 PMID:10082498 PMID:11115077 PMID:11244025 PMID:11403356 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
multiple interactions		 EXP
ISO		 Valsartan results in decreased expression of AGTR1A mRNA
Valsartan binds to and results in decreased activity of AGTR1 protein
Valsartan promotes the reaction [Streptozocin results in increased expression of AGTR1 protein]		 CTD PMID:18403896 PMID:28973481 PMID:29266779 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 affects response to substance
multiple interactions
decreases expression
increases expression		 ISO
EXP		 AGTR2 affects the susceptibility to Valsartan
[PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]
Valsartan results in decreased expression of AGTR2 mRNA
Valsartan results in increased expression of AGTR2 protein
Valsartan inhibits the reaction [Streptozocin results in increased expression of AGTR2 protein]		 CTD PMID:11403356 PMID:12215461 PMID:16982965 PMID:18403896 PMID:29266779 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP		 Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:31009642 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions
decreases export		 EXP
ISO		 Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Valsartan results in decreased export of ALB protein		 CTD PMID:16872305 PMID:17664856 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein] CTD PMID:9261183 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Ang angiogenin decreases expression ISO Valsartan results in decreased expression of ANG mRNA CTD PMID:22768174 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Angpt1 angiopoietin 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein] CTD PMID:14638905 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] CTD PMID:14638905 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Apcs amyloid P component, serum decreases expression ISO Valsartan results in decreased expression of APCS protein CTD PMID:16129801 NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298 		JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein] CTD PMID:17785354 PMID:19603250 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP Valsartan inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP Valsartan inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 protein] CTD PMID:18192338 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Valsartan inhibits the reaction [Glucose results in increased expression of BAX protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of BAX protein]		 CTD PMID:29266779 PMID:32197949 PMID:34273911 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA] CTD PMID:32197949 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Valsartan inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Valsartan inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]		 CTD PMID:29266779 PMID:32197949 PMID:34273911 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA] CTD PMID:32197949 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Valsartan CTD PMID:16982965 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [icatibant results in decreased activity of BDKRB2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Valsartan CTD PMID:16982965 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA] CTD PMID:19225232 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions EXP Valsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta affects splicing EXP valsartan affects alternative mRNA splicing of camk2d protein in left ventricle of 2k1c rats with renovascular hypertension RGD PMID:26619200 RGD:401940196 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein] CTD PMID:23300732 PMID:32197949 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein] CTD PMID:32197949 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO Fluorouracil promotes the reaction [Valsartan results in decreased activity of CAT protein]; Valsartan promotes the reaction [Fluorouracil results in decreased activity of CAT protein] CTD PMID:35235860 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO
EXP		 [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Fluorouracil promotes the reaction [Valsartan results in decreased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of CCL2 mRNA]
Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]		 CTD PMID:15284299 PMID:16705055 PMID:17624267 PMID:18436887 PMID:19225232 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd163 CD163 molecule decreases expression ISO Valsartan results in decreased expression of CD163 mRNA CTD PMID:22768174 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd34 CD34 molecule decreases expression ISO Valsartan results in decreased expression of CD34 mRNA CTD PMID:22768174 NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832 		JBrowse link
G Cd68 Cd68 molecule decreases expression ISO Valsartan results in decreased expression of CD68 mRNA CTD PMID:22768174 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA] CTD PMID:19225232 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Valsartan results in decreased expression of CEBPA mRNA CTD PMID:22768174 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression		 ISO Fluorouracil promotes the reaction [Valsartan results in decreased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of COL1A1 mRNA] CTD PMID:31009642 PMID:35235860 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Valsartan inhibits the reaction [Glucose results in increased expression of COL3A1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of COL3A1 protein] CTD PMID:29266779 PMID:31009642 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a4 collagen type IV alpha 4 chain multiple interactions ISO Valsartan inhibits the reaction [Streptozocin results in increased expression of COL4A4 mRNA] CTD PMID:33631230 NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876 		JBrowse link
G Crem cAMP responsive element modulator decreases expression EXP Valsartan results in decreased expression of CREM mRNA CTD PMID:19027736 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Cst3 cystatin C multiple interactions EXP [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan] inhibits the reaction [adefovir results in increased expression of CST3 protein] CTD PMID:35114312 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] CTD PMID:23288202 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Ctss cathepsin S decreases expression ISO Valsartan results in decreased expression of CTSS mRNA CTD PMID:22768174 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression ISO Valsartan results in decreased expression of CXADR mRNA; Valsartan results in decreased expression of CXADR protein CTD PMID:20392896 NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein] CTD PMID:18716376 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein] CTD PMID:15643130 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Valsartan results in decreased expression of CYP11B2 mRNA; Valsartan results in decreased expression of CYP11B2 protein CTD PMID:16043663 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene affects the susceptibility to Valsartan CTD PMID:22149319 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein] CTD PMID:32197949 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Des desmin multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA] CTD PMID:19225232 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression EXP valsartan inhibits the reaction [renovascular hypertension and cardiomegaly increases expression of dyrk1a protein in left ventricle of 2k1c rats] RGD PMID:26619200 RGD:401940196 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA] CTD PMID:19225232 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein CTD PMID:11136700 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A decreases expression EXP Valsartan results in decreased expression of EDNRA mRNA CTD PMID:28951255 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]] CTD PMID:19225232 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32197949 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Eng endoglin multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein] CTD PMID:32197949 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Valsartan results in decreased expression of FABP4 mRNA CTD PMID:22768174 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf5 fibroblast growth factor 5 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA] CTD PMID:19225232 NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997 		JBrowse link
G Filip1l filamin A interacting protein 1-like multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA] CTD PMID:19225232 NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA] CTD PMID:18619357 PMID:18846332 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA] CTD PMID:19225232 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein] CTD PMID:32197949 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fzd2 frizzled class receptor 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA] CTD PMID:19225232 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Valsartan inhibits the reaction [Purines analog results in decreased expression of GPX1 protein] CTD PMID:36464070 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO		 Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein] CTD PMID:31009642 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA] CTD PMID:19225232 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions EXP
ISO		 Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein] CTD PMID:31009642 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac9 histone deacetylase 9 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA] CTD PMID:19225232 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein] CTD PMID:16115399 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hivep1 HIVEP zinc finger 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA] CTD PMID:19225232 NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein] CTD PMID:32197949 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Valsartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
Valsartan inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]		 CTD PMID:17724226 PMID:28973481 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA] CTD PMID:19225232 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Ier2 immediate early response 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA] CTD PMID:19225232 NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211 		JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA] CTD PMID:19225232 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Valsartan results in decreased expression of IL1B mRNA CTD PMID:28951255 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion		 EXP
ISO		 [Tacrolimus co-treated with Valsartan] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of IL6 protein
Fluorouracil promotes the reaction [Valsartan results in decreased secretion of IL6 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of IL6 protein]		 CTD PMID:16549154 PMID:29266779 PMID:35235860 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA] CTD PMID:19225232 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA] CTD PMID:18619357 PMID:18846332 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO
EXP		 Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 PMID:15005273 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kl Klotho increases expression EXP Valsartan results in increased expression of KL mRNA; Valsartan results in increased expression of KL protein CTD PMID:21051829 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Klf10 KLF transcription factor 10 multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]] CTD PMID:19225232 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994 		JBrowse link
G Klf9 KLF transcription factor 9 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA] CTD PMID:19225232 NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037 		JBrowse link
G Kng1 kininogen 1 increases expression
multiple interactions		 EXP Valsartan results in increased expression of KNG1 protein modified form
benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]		 CTD PMID:11509473 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein] CTD PMID:32197949 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]] CTD PMID:19225232 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases activity		 ISO [Valsartan co-treated with AGT protein] results in increased activity of LPL protein
Valsartan results in increased activity of LPL protein		 CTD PMID:18640387 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA] CTD PMID:19225232 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein] CTD PMID:17068200 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19041135 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19041135 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity		 ISO Fluorouracil promotes the reaction [Valsartan results in decreased activity of MMP2 protein]; Valsartan inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of MMP2 protein]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of MMP2 protein]; Valsartan promotes the reaction [Fluorouracil results in decreased activity of MMP2 protein] CTD PMID:29266779 PMID:35235860 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity		 EXP
ISO		 [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein
Valsartan results in decreased expression of MMP9 mRNA; Valsartan results in decreased expression of MMP9 protein
Fluorouracil promotes the reaction [Valsartan results in decreased activity of MMP9 protein]		 CTD PMID:21051829 PMID:35235860 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mn1 MN1 proto-oncogene, transcriptional regulator multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA] CTD PMID:19225232 NCBI chr12:45,181,794...45,220,959
Ensembl chr12:45,183,085...45,221,651 		JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression ISO Valsartan results in decreased expression of MRC1 mRNA CTD PMID:22768174 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 multiple interactions EXP Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
increases expression		 EXP
ISO		 [Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA
Valsartan results in increased expression of MYH6 mRNA
Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH6 protein]		 CTD PMID:11136700 PMID:31009642 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] CTD PMID:31009642 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA] CTD PMID:19225232 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP Valsartan results in decreased expression of NOS1 protein CTD PMID:31023080 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:32197949 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression		 EXP
ISO		 [fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]
Valsartan inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NOS3 protein]
Valsartan results in decreased expression of NOS3 protein		 CTD PMID:11897773 PMID:18436887 PMID:28951255 PMID:31023080 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Valsartan inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression		 EXP
ISO		 [Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]
Valsartan results in decreased expression of NPPA mRNA
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]		 CTD PMID:11136700 PMID:23288202 PMID:31009642 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression		 ISO
EXP		 Valsartan inhibits the reaction [CHOP protocol results in increased expression of NPPB protein]
Valsartan results in decreased expression of NPPB protein
[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
Valsartan results in decreased expression of NPPB mRNA
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]		 CTD PMID:11136700 PMID:12417542 PMID:16247790 PMID:31009642 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein] CTD PMID:32197949 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nup98 nucleoporin 98 and 96 precursor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA] CTD PMID:19225232 NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415 		JBrowse link
G Osr1 odd-skipped related transcription factor 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein] CTD PMID:20175999 NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817 		JBrowse link
G Pde3a phosphodiesterase 3A increases expression EXP Valsartan results in increased expression of PDE3A mRNA CTD PMID:19027736 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA] CTD PMID:19225232 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Postn periostin multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA] CTD PMID:17485602 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Valsartan results in decreased expression of PPARG mRNA CTD PMID:22768174 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA] CTD PMID:19225232 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP		 Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]
Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]		 CTD PMID:19145780 PMID:19225232 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 multiple interactions EXP Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Rbp4 retinol binding protein 4 decreases expression EXP valsartan decreases expression of Rbp4 protein in blood plasma RGD PMID:21365528 RGD:329853304 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA] CTD PMID:19225232 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of RELA protein] CTD PMID:32197949 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions
increases activity
increases expression		 ISO
EXP		 [benazepril co-treated with Valsartan] results in increased activity of REN protein
Valsartan results in increased activity of REN protein
[benazepril co-treated with Valsartan] results in increased activity of REN protein; Valsartan inhibits the reaction [Purines analog results in increased secretion of REN protein]
Valsartan results in increased expression of REN protein		 CTD PMID:8505092 PMID:10836730 PMID:11501062 PMID:36464070 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA] CTD PMID:19225232 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894 		JBrowse link
G Sele selectin E multiple interactions ISO Valsartan inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression		 ISO
EXP		 Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]
Valsartan results in decreased expression of SERPINE1 mRNA; Valsartan results in decreased expression of SERPINE1 protein		 CTD PMID:11244025 PMID:21051829 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP Valsartan inhibits the reaction [Purines analog results in decreased expression of SLC22A12 protein] CTD PMID:36464070 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of SLC22A6 protein; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein]; Valsartan inhibits the reaction [Purines analog results in decreased expression of SLC22A6 protein] CTD PMID:35114312 PMID:36464070 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases expression		 EXP
ISO		 [adefovir co-treated with Probenecid co-treated with Valsartan] results in increased expression of SLC22A8 protein; Valsartan inhibits the reaction [Purines analog results in decreased expression of SLC22A8 protein]
Valsartan results in increased expression of SLC22A8 protein		 CTD PMID:35114312 PMID:36464070 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc25a32 solute carrier family 25 member 32 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA] CTD PMID:19225232 NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]]; naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:12658023 PMID:17199717 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression		 EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Valsartan results in decreased expression of SMAD3 protein		 CTD PMID:15619341 PMID:16872305 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad7 SMAD family member 7 multiple interactions
increases expression		 EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]
Valsartan results in increased expression of SMAD7 protein		 CTD PMID:15619341 PMID:16872305 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Snn stannin multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA] CTD PMID:19225232 NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP		 [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein
Valsartan inhibits the reaction [Purines analog results in decreased expression of SOD1 protein]		 CTD PMID:20445533 PMID:36464070 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spmip11 sperm microtubule inner protein 11 multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein] CTD PMID:17624267 NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA] CTD PMID:19225232 NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Valsartan inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein] CTD PMID:34273911 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein] CTD PMID:12846741 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein] CTD PMID:12846741 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Syp synaptophysin multiple interactions ISO
EXP		 Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]		 CTD PMID:18487452 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA] CTD PMID:14638905 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 [benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
[Tacrolimus co-treated with Valsartan] results in increased expression of TGFB1 protein; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Ovalbumin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
Valsartan results in decreased expression of TGFB1 protein
Valsartan inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]		 CTD PMID:11798641 PMID:15619341 PMID:16115399 PMID:16549154 PMID:16872305 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions
decreases expression		 EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]
Valsartan results in decreased expression of TGFBR2 mRNA		 CTD PMID:15619341 PMID:16872305 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA] CTD PMID:19225232 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression		 ISO
EXP		 Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]
Valsartan results in decreased expression of TIMP1 mRNA; Valsartan results in decreased expression of TIMP1 protein		 CTD PMID:12846741 PMID:15504291 PMID:21051829 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 [Metformin co-treated with rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Valsartan inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]
Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]		 CTD PMID:16865780 PMID:18436887 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of TP53 protein] CTD PMID:32197949 PMID:34273911 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein] CTD PMID:17068200 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Tug1 taurine up-regulated 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of TUG1 mRNA] CTD PMID:32197949 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927 		JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 multiple interactions ISO
EXP		 Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Oxygen deficiency results in increased expression of UBE2V2 mRNA] CTD PMID:16769992 PMID:17068200 NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 ISO
EXP		 Valsartan results in decreased expression of VEGFA mRNA
Fluorouracil promotes the reaction [Valsartan results in decreased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of VEGFA mRNA]
Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]		 CTD PMID:11897773 PMID:14638905 PMID:14718351 PMID:17724226 PMID:22768174 More... NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      atom 19832
        nonmetal atom 19770
          nitrogen atom 18959
            nitrogen molecular entity 18959
              organonitrogen compound 18808
                organonitrogen heterocyclic compound 18152
                  azole 14379
                    tetrazoles 366
                      (5Z)-5-[(5-ethylfuran-2-yl)methylidene]-2-\{[(S)-(4-fluorophenyl)(1H-tetrazol-5-yl)methyl]amino\}-1,3-thiazol-4(5H)-one 0
                      1,5-diaminotetrazole 0
                      1-(2-benzofuranyl)-2-[[1-(2,4,6-trimethylphenyl)-5-tetrazolyl]thio]ethanone 0
                      1-(2-hydroxycyclohexyl)-5-\{4-[(2-oxo-1H-quinolin-6-yl)oxy]butyl\}-4H-1lambda5,2,3,4-tetrazol-1-ylium 0
                      1-(2-methoxy-5-methylphenyl)-5-(2-oxanylmethylthio)tetrazole 0
                      1-(2-methyl-6-propan-2-ylphenyl)-5-phenyltetrazole 0
                      1-(3-Isocyanatophenyl)-5-(methylsulfanyl)-1H-tetrazole 0
                      1-(4-chlorophenyl)-2-[5-(1-pyrrolidinyl)-2-tetrazolyl]ethanone oxime 0
                      1-(4-chlorophenyl)sulfonyl-N-[3-methoxy-4-(1-tetrazolyl)phenyl]-4-piperidinecarboxamide 0
                      1-(4-hydroxycyclohexyl)-5-\{4-[(2-oxo-1H-quinolin-6-yl)oxy]butyl\}-4H-1lambda5,2,3,4-tetrazol-1-ylium 0
                      1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-[5-[4-(dimethylamino)phenyl]-2-tetrazolyl]ethanone 0
                      1-Phenyl-5-mercaptotetrazole 0
                      1-Tetrazol-2-ylethanone 0
                      1-[2,5-diethoxy-4-(1-tetrazolyl)phenyl]sulfonyl-4-(4-fluorophenyl)-3,6-dihydro-2H-pyridine 0
                      1-[[2-[5-[3,5-bis(trifluoromethyl)phenyl]-2-tetrazolyl]-1-oxoethyl]amino]-3-(4-chlorophenyl)thiourea 0
                      2,4-dimethyl-5-[2-[[1-(4-methylphenyl)-5-tetrazolyl]thio]-1-oxoethyl]-1H-pyrrole-3-carboxylic acid ethyl ester 0
                      2,5-diethoxy-N-[2-(2-methylphenyl)ethyl]-4-(1-tetrazolyl)benzenesulfonamide 0
                      2-(1,3-benzothiazol-2-yl)-3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-6-yl)-5-[(E)-2-phenylethenyl]-2H-tetrazol-3-ium 0
                      2-(4-chlorophenyl)-5-(4-phenylbuta-1,3-dienyl)-2H-1,2,3,4-tetraazole 0
                      2-(4-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3,4-tetraazole 0
                      2-(5-amino-1-tetrazolyl)-N-[(1-ethyl-3,5-dimethyl-4-pyrazolyl)methylideneamino]acetamide 0
                      2-Cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one 0
                      2-[2-[[2-[[1-(2,4-dimethylphenyl)-5-tetrazolyl]thio]-1-oxoethyl]amino]-4-thiazolyl]acetic acid ethyl ester 0
                      2-[4-[(1-phenyl-5-tetrazolyl)oxy]phenyl]-1,3,4-oxadiazole 0
                      2-[5-(2-fluorophenyl)-2-tetrazolyl]-N-[2-(3-methylbutylamino)-2-oxoethyl]-N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 0
                      2-[5-(2-fluorophenyl)-2-tetrazolyl]-N-[2-oxo-2-[(phenylmethyl)amino]ethyl]-N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 0
                      2-[5-(3,4-diethoxyphenyl)-2-tetrazolyl]-N-(3-methoxyphenyl)acetamide 0
                      2-[5-(4-butoxyphenyl)-2-tetrazolyl]-N-(2-furanylmethyl)acetamide 0
                      2-[6-chloro-3-\{[2,2-difluoro-2-(1-oxidopyridin-2-yl)ethyl]amino\}-2-oxopyrazin-1(2H)-yl]-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]acetamide 0
                      2-[[(1-phenyl-5-tetrazolyl)thio]methyl]imidazo[1,2-a]pyrimidine 0
                      2-[[[1-(2-methoxy-5-methylphenyl)-5-tetrazolyl]thio]methyl]-1,3-benzothiazole 0
                      2-[cyclohexyl-[2-[5-(3,4-dimethoxyphenyl)-2-tetrazolyl]-1-oxoethyl]amino]-N-cyclopentylpropanamide 0
                      2-chloro-3-[2-(3,4-dichlorophenyl)-5-tetrazolyl]pyridine 0
                      2-chloro-3-[2-(4-methylphenyl)-5-tetrazolyl]pyridine 0
                      3-(2-phenyl-5-tetrazolyl)pyridine 0
                      3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium + 5
                      3-[(1-phenyl-5-tetrazolyl)thio]-2-oxolanone 0
                      3-[1-(3,5-dichlorophenyl)-5-tetrazolyl]-5-methylisoxazole 0
                      3-[1-(4-chlorophenyl)-5-tetrazolyl]-1-methyl-4-quinolinone 0
                      3-[2-(4-fluorophenyl)-5-tetrazolyl]-2-methoxypyridine 0
                      3-[2-(4-methylphenyl)-5-tetrazolyl]quinoline 0
                      3-[5-(4-ethylphenyl)-2-tetrazolyl]propanoic acid methyl ester 0
                      3-[[[1-(2,4-dimethylphenyl)-5-tetrazolyl]thio]methyl]-1,2,3-benzotriazin-4-one 0
                      4-(diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]piperidine 0
                      4-[2,2-bis(1-phenyl-5-tetrazolyl)ethenyl]-N,N-dimethylaniline 0
                      4-[2-(4-fluorophenyl)-5-tetrazolyl]quinoline 0
                      5-(3,4-dimethoxyphenyl)-2H-tetrazole 0
                      5-(4-methylphenyl)-2H-tetrazole 0
                      5-(4-propan-2-ylphenyl)-2H-tetrazole 0
                      5-[(2-chlorophenyl)methylsulfonyl]-1-(2,6-dimethylphenyl)tetrazole 0
                      5-[2-(2-methoxyphenoxy)ethylthio]-1-(4-methylphenyl)tetrazole 0
                      5-[3-(2,5-dimethyl-1-pyrrolyl)phenyl]-2H-tetrazole 0
                      5-[4-(1-imidazolyl)phenoxy]-1-phenyltetrazole 0
                      6-[[[1-(2,6-dimethylphenyl)-5-tetrazolyl]thio]methyl]-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine 0
                      6-[[[1-(2-methoxy-5-methylphenyl)-5-tetrazolyl]thio]methyl]-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine 0
                      6-[[[1-(4-chlorophenyl)-5-tetrazolyl]thio]methyl]-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine 0
                      6-[[[1-(4-propan-2-ylphenyl)-5-tetrazolyl]thio]methyl]-1,3,5-triazine-2,4-diamine 0
                      7-[[[1-(2-methylphenyl)-5-tetrazolyl]thio]methyl]-5-thiazolo[3,2-a]pyrimidinone 0
                      Cefteram pivoxil 0
                      Dasolampanel 0
                      F5231 0
                      Fentrazamide 0
                      Fentrazamide Metabolite 0
                      LSM-6257 0
                      N'-[2-(4-methylphenoxy)-1-oxoethyl]-2-(5-phenyl-2-tetrazolyl)acetohydrazide 0
                      N,N-bis(but-2-ynyl)-3-methoxy-4-(1-tetrazolyl)benzenesulfonamide 0
                      N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[1-(3,4-dimethoxyphenyl)-5-tetrazolyl]thio]acetamide 0
                      N-(2-methoxyphenyl)-2-[5-[2-[(4-methoxyphenyl)sulfonylamino]phenyl]-2-tetrazolyl]acetamide 0
                      N-(2-oxolanylmethyl)-3-(1-tetrazolyl)benzamide 0
                      N-(3-bicyclo[2.2.1]heptanyl)-2-[5-(4-chlorophenyl)-2-tetrazolyl]acetamide 0
                      N-(3-methoxyphenyl)-1-[4-(1-tetrazolyl)phenyl]sulfonyl-3-piperidinecarboxamide 0
                      N-(4-acetamidophenyl)-2-[[1-(4-ethylphenyl)-5-tetrazolyl]thio]acetamide 0
                      N-(5-chloro-2-pyridinyl)-2-[(1-phenyl-5-tetrazolyl)thio]propanamide 0
                      N-[2-(1-cyclohexenyl)ethyl]-1-phenyl-5-tetrazolamine 0
                      N-cyclohexyl-2-[3-methoxy-N-(1-oxo-2-thiophen-2-ylethyl)-4-(1-tetrazolyl)anilino]-2-(4-methylphenyl)acetamide 0
                      N-cyclopentyl-2-[[1-(2-methoxyphenyl)-5-tetrazolyl]thio]acetamide 0
                      N-cyclopentyl-2-[[2-[5-(4-fluorophenyl)-2-tetrazolyl]-1-oxoethyl]-(2-furanylmethyl)amino]hexanamide 0
                      N-tert-butyl-2-(N-[2-[5-(4-fluorophenyl)-2-tetrazolyl]-1-oxoethyl]-3-hydroxyanilino)-2-(1H-indol-3-yl)acetamide 0
                      N2,N2-dimethyl-6-[[(1-phenyl-5-tetrazolyl)thio]methyl]-1,3,5-triazine-2,4-diamine 0
                      N2-phenyl-6-[[(1-phenyl-5-tetrazolyl)thio]methyl]-1,3,5-triazine-2,4-diamine 0
                      [[2-[5-(2-chlorophenyl)-1-tetrazolyl]-6,8-dioxabicyclo[3.2.1]octan-4-ylidene]amino]thiourea 0
                      \{[5-(3-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}phenyl)-4-bromo-2-(2H-tetrazol-5-yl)thiophen-3-yl]oxy\}acetic acid 0
                      acitazanolast 0
                      azimsulfuron 0
                      azosemide 1
                      biphenylyltetrazole + 333
                      cefazolin 6
                      cefminox 0
                      cilostazol 52
                      forasartan 0
                      metyltetraprole 0
                      octyl 5-methyl-7-thiophen-2-yl-6,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate 0
                      picarbutrazox 0
                      sulukast 0
                      tedizolid 0
                      tedizolid phosphate 0
                      tetraniliprole 0
                      tetrazole + 0
                      tomelukast 6
                      zolasartan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            organic molecule 19680
                              organic cyclic compound 19493
                                organic heterocyclic compound 18871
                                  heteroarene 17142
                                    monocyclic heteroarene 14874
                                      azole 14379
                                        tetrazoles 366
                                          (5Z)-5-[(5-ethylfuran-2-yl)methylidene]-2-\{[(S)-(4-fluorophenyl)(1H-tetrazol-5-yl)methyl]amino\}-1,3-thiazol-4(5H)-one 0
                                          1,5-diaminotetrazole 0
                                          1-(2-benzofuranyl)-2-[[1-(2,4,6-trimethylphenyl)-5-tetrazolyl]thio]ethanone 0
                                          1-(2-hydroxycyclohexyl)-5-\{4-[(2-oxo-1H-quinolin-6-yl)oxy]butyl\}-4H-1lambda5,2,3,4-tetrazol-1-ylium 0
                                          1-(2-methoxy-5-methylphenyl)-5-(2-oxanylmethylthio)tetrazole 0
                                          1-(2-methyl-6-propan-2-ylphenyl)-5-phenyltetrazole 0
                                          1-(3-Isocyanatophenyl)-5-(methylsulfanyl)-1H-tetrazole 0
                                          1-(4-chlorophenyl)-2-[5-(1-pyrrolidinyl)-2-tetrazolyl]ethanone oxime 0
                                          1-(4-chlorophenyl)sulfonyl-N-[3-methoxy-4-(1-tetrazolyl)phenyl]-4-piperidinecarboxamide 0
                                          1-(4-hydroxycyclohexyl)-5-\{4-[(2-oxo-1H-quinolin-6-yl)oxy]butyl\}-4H-1lambda5,2,3,4-tetrazol-1-ylium 0
                                          1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-[5-[4-(dimethylamino)phenyl]-2-tetrazolyl]ethanone 0
                                          1-Phenyl-5-mercaptotetrazole 0
                                          1-Tetrazol-2-ylethanone 0
                                          1-[2,5-diethoxy-4-(1-tetrazolyl)phenyl]sulfonyl-4-(4-fluorophenyl)-3,6-dihydro-2H-pyridine 0
                                          1-[[2-[5-[3,5-bis(trifluoromethyl)phenyl]-2-tetrazolyl]-1-oxoethyl]amino]-3-(4-chlorophenyl)thiourea 0
                                          2,4-dimethyl-5-[2-[[1-(4-methylphenyl)-5-tetrazolyl]thio]-1-oxoethyl]-1H-pyrrole-3-carboxylic acid ethyl ester 0
                                          2,5-diethoxy-N-[2-(2-methylphenyl)ethyl]-4-(1-tetrazolyl)benzenesulfonamide 0
                                          2-(1,3-benzothiazol-2-yl)-3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-6-yl)-5-[(E)-2-phenylethenyl]-2H-tetrazol-3-ium 0
                                          2-(4-chlorophenyl)-5-(4-phenylbuta-1,3-dienyl)-2H-1,2,3,4-tetraazole 0
                                          2-(4-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3,4-tetraazole 0
                                          2-(5-amino-1-tetrazolyl)-N-[(1-ethyl-3,5-dimethyl-4-pyrazolyl)methylideneamino]acetamide 0
                                          2-Cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one 0
                                          2-[2-[[2-[[1-(2,4-dimethylphenyl)-5-tetrazolyl]thio]-1-oxoethyl]amino]-4-thiazolyl]acetic acid ethyl ester 0
                                          2-[4-[(1-phenyl-5-tetrazolyl)oxy]phenyl]-1,3,4-oxadiazole 0
                                          2-[5-(2-fluorophenyl)-2-tetrazolyl]-N-[2-(3-methylbutylamino)-2-oxoethyl]-N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 0
                                          2-[5-(2-fluorophenyl)-2-tetrazolyl]-N-[2-oxo-2-[(phenylmethyl)amino]ethyl]-N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 0
                                          2-[5-(3,4-diethoxyphenyl)-2-tetrazolyl]-N-(3-methoxyphenyl)acetamide 0
                                          2-[5-(4-butoxyphenyl)-2-tetrazolyl]-N-(2-furanylmethyl)acetamide 0
                                          2-[6-chloro-3-\{[2,2-difluoro-2-(1-oxidopyridin-2-yl)ethyl]amino\}-2-oxopyrazin-1(2H)-yl]-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]acetamide 0
                                          2-[[(1-phenyl-5-tetrazolyl)thio]methyl]imidazo[1,2-a]pyrimidine 0
                                          2-[[[1-(2-methoxy-5-methylphenyl)-5-tetrazolyl]thio]methyl]-1,3-benzothiazole 0
                                          2-[cyclohexyl-[2-[5-(3,4-dimethoxyphenyl)-2-tetrazolyl]-1-oxoethyl]amino]-N-cyclopentylpropanamide 0
                                          2-chloro-3-[2-(3,4-dichlorophenyl)-5-tetrazolyl]pyridine 0
                                          2-chloro-3-[2-(4-methylphenyl)-5-tetrazolyl]pyridine 0
                                          3-(2-phenyl-5-tetrazolyl)pyridine 0
                                          3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium + 5
                                          3-[(1-phenyl-5-tetrazolyl)thio]-2-oxolanone 0
                                          3-[1-(3,5-dichlorophenyl)-5-tetrazolyl]-5-methylisoxazole 0
                                          3-[1-(4-chlorophenyl)-5-tetrazolyl]-1-methyl-4-quinolinone 0
                                          3-[2-(4-fluorophenyl)-5-tetrazolyl]-2-methoxypyridine 0
                                          3-[2-(4-methylphenyl)-5-tetrazolyl]quinoline 0
                                          3-[5-(4-ethylphenyl)-2-tetrazolyl]propanoic acid methyl ester 0
                                          3-[[[1-(2,4-dimethylphenyl)-5-tetrazolyl]thio]methyl]-1,2,3-benzotriazin-4-one 0
                                          4-(diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]piperidine 0
                                          4-[2,2-bis(1-phenyl-5-tetrazolyl)ethenyl]-N,N-dimethylaniline 0
                                          4-[2-(4-fluorophenyl)-5-tetrazolyl]quinoline 0
                                          5-(3,4-dimethoxyphenyl)-2H-tetrazole 0
                                          5-(4-methylphenyl)-2H-tetrazole 0
                                          5-(4-propan-2-ylphenyl)-2H-tetrazole 0
                                          5-[(2-chlorophenyl)methylsulfonyl]-1-(2,6-dimethylphenyl)tetrazole 0
                                          5-[2-(2-methoxyphenoxy)ethylthio]-1-(4-methylphenyl)tetrazole 0
                                          5-[3-(2,5-dimethyl-1-pyrrolyl)phenyl]-2H-tetrazole 0
                                          5-[4-(1-imidazolyl)phenoxy]-1-phenyltetrazole 0
                                          6-[[[1-(2,6-dimethylphenyl)-5-tetrazolyl]thio]methyl]-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine 0
                                          6-[[[1-(2-methoxy-5-methylphenyl)-5-tetrazolyl]thio]methyl]-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine 0
                                          6-[[[1-(4-chlorophenyl)-5-tetrazolyl]thio]methyl]-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine 0
                                          6-[[[1-(4-propan-2-ylphenyl)-5-tetrazolyl]thio]methyl]-1,3,5-triazine-2,4-diamine 0
                                          7-[[[1-(2-methylphenyl)-5-tetrazolyl]thio]methyl]-5-thiazolo[3,2-a]pyrimidinone 0
                                          Cefteram pivoxil 0
                                          Dasolampanel 0
                                          F5231 0
                                          Fentrazamide 0
                                          Fentrazamide Metabolite 0
                                          LSM-6257 0
                                          N'-[2-(4-methylphenoxy)-1-oxoethyl]-2-(5-phenyl-2-tetrazolyl)acetohydrazide 0
                                          N,N-bis(but-2-ynyl)-3-methoxy-4-(1-tetrazolyl)benzenesulfonamide 0
                                          N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[1-(3,4-dimethoxyphenyl)-5-tetrazolyl]thio]acetamide 0
                                          N-(2-methoxyphenyl)-2-[5-[2-[(4-methoxyphenyl)sulfonylamino]phenyl]-2-tetrazolyl]acetamide 0
                                          N-(2-oxolanylmethyl)-3-(1-tetrazolyl)benzamide 0
                                          N-(3-bicyclo[2.2.1]heptanyl)-2-[5-(4-chlorophenyl)-2-tetrazolyl]acetamide 0
                                          N-(3-methoxyphenyl)-1-[4-(1-tetrazolyl)phenyl]sulfonyl-3-piperidinecarboxamide 0
                                          N-(4-acetamidophenyl)-2-[[1-(4-ethylphenyl)-5-tetrazolyl]thio]acetamide 0
                                          N-(5-chloro-2-pyridinyl)-2-[(1-phenyl-5-tetrazolyl)thio]propanamide 0
                                          N-[2-(1-cyclohexenyl)ethyl]-1-phenyl-5-tetrazolamine 0
                                          N-cyclohexyl-2-[3-methoxy-N-(1-oxo-2-thiophen-2-ylethyl)-4-(1-tetrazolyl)anilino]-2-(4-methylphenyl)acetamide 0
                                          N-cyclopentyl-2-[[1-(2-methoxyphenyl)-5-tetrazolyl]thio]acetamide 0
                                          N-cyclopentyl-2-[[2-[5-(4-fluorophenyl)-2-tetrazolyl]-1-oxoethyl]-(2-furanylmethyl)amino]hexanamide 0
                                          N-tert-butyl-2-(N-[2-[5-(4-fluorophenyl)-2-tetrazolyl]-1-oxoethyl]-3-hydroxyanilino)-2-(1H-indol-3-yl)acetamide 0
                                          N2,N2-dimethyl-6-[[(1-phenyl-5-tetrazolyl)thio]methyl]-1,3,5-triazine-2,4-diamine 0
                                          N2-phenyl-6-[[(1-phenyl-5-tetrazolyl)thio]methyl]-1,3,5-triazine-2,4-diamine 0
                                          [[2-[5-(2-chlorophenyl)-1-tetrazolyl]-6,8-dioxabicyclo[3.2.1]octan-4-ylidene]amino]thiourea 0
                                          \{[5-(3-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}phenyl)-4-bromo-2-(2H-tetrazol-5-yl)thiophen-3-yl]oxy\}acetic acid 0
                                          acitazanolast 0
                                          azimsulfuron 0
                                          azosemide 1
                                          biphenylyltetrazole + 333
                                          cefazolin 6
                                          cefminox 0
                                          cilostazol 52
                                          forasartan 0
                                          metyltetraprole 0
                                          octyl 5-methyl-7-thiophen-2-yl-6,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate 0
                                          picarbutrazox 0
                                          sulukast 0
                                          tedizolid 0
                                          tedizolid phosphate 0
                                          tetraniliprole 0
                                          tetrazole + 0
                                          tomelukast 6
                                          zolasartan 0
paths to the root