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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | activation of MAPK activity | | IDA | | 728220 | | RGD | | antigen processing and presentation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3041278|PMID:11754812 | RGD | MGI:MGI:3041278 PMID:11754812 | antigen processing and presentation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3033762|PMID:7985028 | RGD | MGI:MGI:3033762 PMID:7985028 | antigen processing and presentation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927530 | RGD | MGI:MGI:3033881 PMID:9432982 | antigen processing and presentation of exogenous peptide antigen via MHC class II | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:79110 PMID:8598040 | antigen processing and presentation of exogenous peptide antigen via MHC class II | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | antigen processing and presentation of exogenous peptide antigen via MHC class II | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:52620 PMID:7679955 | cell proliferation | | IDA | | 728220 | | RGD | | cell proliferation | | ISS | UniProtKB:P04233 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | cell proliferation | | ISO | RGD:1350471 | 1624291 | PMID:12782713 | RGD | PMID:12782713 | chaperone mediated protein folding requiring cofactor | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3033762|PMID:7985028 | RGD | MGI:MGI:3033762 PMID:7985028 | chaperone mediated protein folding requiring cofactor | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | chaperone mediated protein folding requiring cofactor | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:52620 PMID:7679955 | defense response | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927544 | RGD | MGI:MGI:1927451 PMID:8294875 | defense response | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | defense response | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927530 | RGD | MGI:MGI:1927452 PMID:8098731 | immunoglobulin mediated immune response | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:52620 PMID:7679955 | immunoglobulin mediated immune response | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | intracellular protein transport | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3041278|PMID:11754812 | RGD | MGI:MGI:3041278 PMID:11754812 | intracellular protein transport | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | intracellular protein transport | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:52620 PMID:7679955 | intracellular protein transport | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3054306|PMID:15294975 | RGD | MGI:MGI:3054306 PMID:15294975 | macrophage migration inhibitory factor signaling pathway | | ISO | RGD:1553657 | 1624291 | MGI:MGI:4943655|PMID:19413900 | RGD | MGI:MGI:4943655 PMID:19413900 | macrophage migration inhibitory factor signaling pathway | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | negative regulation of apoptotic process | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3690285|PMID:17045821 | RGD | MGI:MGI:3690285 PMID:17045821 | negative regulation of apoptotic process | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | negative regulation of apoptotic process | | ISS | UniProtKB:P04233 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | negative regulation of apoptotic process | | ISO | RGD:1350471 | 1624291 | PMID:17045821 | RGD | PMID:17045821 | negative regulation of apoptotic process | | ISO | RGD:1350471 | 1624291 | PMID:12782713 | RGD | PMID:12782713 | negative regulation of DNA damage response, signal transduction by p53 class mediator | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3690285|PMID:17045821 | RGD | MGI:MGI:3690285 PMID:17045821 | negative regulation of DNA damage response, signal transduction by p53 class mediator | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | negative regulation of DNA damage response, signal transduction by p53 class mediator | | ISO | RGD:1350471 | 1624291 | PMID:17045821 | RGD | PMID:17045821 | negative regulation of mature B cell apoptotic process | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3773489|PMID:18056708 | RGD | MGI:MGI:3773489 PMID:18056708 | negative regulation of mature B cell apoptotic process | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | negative regulation of peptide secretion | | ISO | RGD:1350471 | 1624291 | PMID:19849849 | RGD | PMID:19849849 | negative regulation of peptide secretion | | IEA | Ensembl:ENSP00000009530 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of T cell differentiation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:52620 PMID:7679955 | negative regulation of T cell differentiation | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative thymic T cell selection | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:52620 PMID:7679955 | negative thymic T cell selection | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of B cell proliferation | | ISO | RGD:1350471 | 1624291 | PMID:12782713 | RGD | PMID:12782713 | positive regulation of B cell proliferation | | IEA | Ensembl:ENSP00000009530 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of chemokine (C-X-C motif) ligand 2 production | | ISO | RGD:1553657 | 1624291 | MGI:MGI:4943655|PMID:19413900 | RGD | MGI:MGI:4943655 PMID:19413900 | positive regulation of chemokine (C-X-C motif) ligand 2 production | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | positive regulation of cytokine-mediated signaling pathway | | ISO | RGD:1553657 | 1624291 | MGI:MGI:4419085|PMID:12782713 | RGD | MGI:MGI:4419085 PMID:12782713 | positive regulation of cytokine-mediated signaling pathway | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | positive regulation of cytokine-mediated signaling pathway | | ISO | RGD:1350471 | 1624291 | PMID:12782713 | RGD | PMID:12782713 | positive regulation of dendritic cell antigen processing and presentation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:4943392|PMID:18003616 | RGD | MGI:MGI:4943392 PMID:18003616 | positive regulation of dendritic cell antigen processing and presentation | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | positive regulation of ERK1 and ERK2 cascade | | ISO | RGD:1553657 | 1624291 | MGI:MGI:4419085|PMID:12782713 | RGD | MGI:MGI:4419085 PMID:12782713 | positive regulation of ERK1 and ERK2 cascade | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | positive regulation of ERK1 and ERK2 cascade | | ISO | RGD:1350471 | 1624291 | PMID:17045821 | RGD | PMID:17045821 | positive regulation of ERK1 and ERK2 cascade | | ISO | RGD:1350471 | 1624291 | PMID:12782713 | RGD | PMID:12782713 | positive regulation of fibroblast proliferation | | ISO | RGD:1350471 | 1624291 | PMID:12782713 | RGD | PMID:12782713 | positive regulation of fibroblast proliferation | | IEA | Ensembl:ENSP00000009530 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of macrophage cytokine production | | ISO | RGD:1553657 | 1624291 | MGI:MGI:4943655|PMID:19413900 | RGD | MGI:MGI:4943655 PMID:19413900 | positive regulation of macrophage cytokine production | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | positive regulation of neutrophil chemotaxis | | ISO | RGD:1553657 | 1624291 | MGI:MGI:4943655|PMID:19413900 | RGD | MGI:MGI:4943655 PMID:19413900 | positive regulation of neutrophil chemotaxis | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | positive regulation of peptidyl-tyrosine phosphorylation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3690285|PMID:17045821 | RGD | MGI:MGI:3690285 PMID:17045821 | positive regulation of peptidyl-tyrosine phosphorylation | | ISS | UniProtKB:P04441 | 1600115 | GO_REF:0000024 | BHF-UCL | GO_REF:0000024 | positive regulation of peptidyl-tyrosine phosphorylation | | ISO | RGD:1350471 | 1624291 | PMID:17045821 | RGD | PMID:17045821 | positive regulation of T cell differentiation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:79110 PMID:8598040 | positive regulation of T cell differentiation | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of T cell differentiation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927530 | RGD | MGI:MGI:3033881 PMID:9432982 | positive regulation of T cell differentiation | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:52620 PMID:7679955 | positive regulation of type 2 immune response | | ISO | RGD:1553657 | 1624291 | MGI:MGI:2158514|PMID:11823488 | RGD | MGI:MGI:2158514 PMID:11823488 | positive regulation of type 2 immune response | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive thymic T cell selection | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:79110 PMID:8598040 | positive thymic T cell selection | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive thymic T cell selection | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927205 | RGD | MGI:MGI:52620 PMID:7679955 | positive thymic T cell selection | | ISO | RGD:1553657 | 1624291 | MGI:MGI:1927530 | RGD | MGI:MGI:3033881 PMID:9432982 | prostaglandin biosynthetic process | | ISO | RGD:1350471 | 1624291 | PMID:12782713 | RGD | PMID:12782713 | prostaglandin biosynthetic process | | ISS | UniProtKB:P04233 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | protein complex assembly | | ISO | RGD:1553657 | 1624291 | MGI:MGI:3033762|PMID:7985028 | RGD | MGI:MGI:3033762 PMID:7985028 | protein complex assembly | | IEA | Ensembl:ENSMUSP00000095171 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | signal transduction | | ISO | RGD:1350471 | 1624291 | PMID:12782713 | RGD | PMID:12782713 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Antigen processing and presentation |
| Herpes simplex infection | |
| Tuberculosis | |
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Antigen processing and presentation |
| Herpes simplex infection | |
| Tuberculosis | |
References - curated| 1. |
Henkes W, etal., Nucleic Acids Res 1988 Dec 23;16(24):11822. |
| 2. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 3. |
Leng L, etal., J Exp Med 2003 Jun 2;197(11):1467-76. |
| 4. |
Meyer-Siegler KL and Vera PL, J Urol 2005 Feb;173(2):615-20. |
| 5. |
MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 10. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
References - uncurated
RGD Disease Portals| Cd74 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Cd74 (Rattus norvegicus) |
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| CD74 (Homo sapiens) |
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| Cd74 (Mus musculus) |
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Position Markers| RH94596 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013069 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06095407 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01095439 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC059152 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB611598 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB696567 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473971 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219430 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225098 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225666 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227357 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227455 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227561 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228116 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231756 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232412 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232423 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232867 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232996 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233568 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233706 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234457 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X13044 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X14254 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013069 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037201 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037201 | (Get FASTA) |
| GenBank Protein | AAH59152 | (Get FASTA) |
| CAA31450 | (Get FASTA) | |
| CAA32468 | (Get FASTA) | |
| EDM14561 | (Get FASTA) | |
| EDM14562 | (Get FASTA) | |
| EDM14563 | (Get FASTA) | |
| EDM14564 | (Get FASTA) | |
| EDM14565 | (Get FASTA) | |
| EDM14566 | (Get FASTA) | |
| EDM14567 | (Get FASTA) | |
| EDM14568 | (Get FASTA) | |
| EDM14569 | (Get FASTA) | |
| P10247 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018735 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000025342 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000025354 | UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000025344 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000025354 | UniProtKB/Swiss-Prot | |
| Entrez Gene | 25599 | ENTREZGENE |
| Gene3D-CATH | MHCII_invariant | UniProtKB/Swiss-Prot |
| Thyroglobulin_1 | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000018735 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 3209 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:6890709 | IMAGE-MGC_LOAD |
| InterPro | MHC_II-assoc_invar/CLIP_MHC-bd | UniProtKB/Swiss-Prot |
| MHC_II-assoc_invar_chain | UniProtKB/Swiss-Prot | |
| MHC_II-assoc_invariant_trimer | UniProtKB/Swiss-Prot | |
| Thyroglobulin_1 | UniProtKB/Swiss-Prot | |
| IPI | IPI00188697 | UniProtKB/Swiss-Prot |
| IPI00231232 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:25599 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:72926 | IMAGE-MGC_LOAD |
| PANTHER | PTHR14093 | UniProtKB/Swiss-Prot |
| Pfam | MHC2-interact | UniProtKB/Swiss-Prot |
| MHCassoc_trimer | UniProtKB/Swiss-Prot | |
| Thyroglobulin_1 | UniProtKB/Swiss-Prot | |
| PIRSF | CD74_antigen | UniProtKB/Swiss-Prot |
| PRINTS | CD74ANTIGEN | UniProtKB/Swiss-Prot |
| PROSITE | THYROGLOBULIN_1_1 | UniProtKB/Swiss-Prot |
| THYROGLOBULIN_1_2 | UniProtKB/Swiss-Prot | |
| SMART | SM00211 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | MHC_II-assoc_invariant_trimer | UniProtKB/Swiss-Prot |
| Thyroglobulin_1 | UniProtKB/Swiss-Prot | |
| TIGR | TC217441 | |
| UniGene | Rn.33804 | ENTREZGENE |
| UniProt | HG2A_RAT | UniProtKB/Swiss-Prot |
| Q6GT70_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-29 | Cd74 | Cd74 molecule, major histocompatibility complex, class II invariant chain | Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | CD74 antigen (invariant polpypeptide of major histocompatibility class II antigen-associated) | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Cd74 | CD74 antigen (invariant polpypeptide of major histocompatibility class II antigen-associated) | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Cd74 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2313 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




