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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:3347
Term: candesartan
Definition: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.
Chemical ID: MESH:C081643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepincreases response to substanceEXP 6480464CTDLEP protein results in increased susceptibility to candesartanPMID:21287150
Lepdecreases expressionISOLEP (Homo sapiens)6480464CTDcandesartan results in decreased expression of LEPPMID:19059660
Lepmultiple interactionsISOLEP (Homo sapiens)6480464CTDcandesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]PMID:17483542
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