Gene: Pde3a (phosphodiesterase 3A, cGMP inhibited)
Rattus norvegicus
Symbol:
Pde3a
Name:
phosphodiesterase 3A, cGMP inhibited
Description:
ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity; cAMP binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; INVOLVED IN cAMP catabolic process; diterpenoid metabolic process; negative regulation of apoptotic process; PARTICIPATES IN protein kinase A (PKA) signaling pathway; insulin signaling pathway; purine metabolic pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental; Hypertension, Pulmonary; Insulin Resistance; FOUND IN cytosol; INTERACTS WITH 8-bromo-3',5'-cyclic AMP; ammonium chloride; diazinon
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cyclic GMP-inhibited phosphodiesterase A; cyclic nucleotide phosphodiesterase; phosphodiesterase 3A; phosphodiesterase 3a; phosphodiesterase 3A cGMP inhibited; phosphodiesterase 3A, cGMP inhibited ; RNPDE3A
Orthologs:
Homo sapiens : PDE3A
(phosphodiesterase 3A, cGMP-inhibited)
HGNC
Pde3a
(phosphodiesterase 3A, cGMP inhibited)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 4 q44 NCBI RGSC Genome Assembly v5.0 4 239,659,270 - 239,921,900 + NCBI RGSC Genome Assembly v3.4 4 178,658,896 - 178,930,417 + NCBI Rat Celera Assembly 4 162,714,211 - 162,977,642 + NCBI Genome Assembly 3.1 4 178,904,019 - 179,175,541 + NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol decreases expression ISO RGD:734436 6480464 Ethinyl Estradiol results in decreased expression of PDE3A mRNA CTD PMID:18936297 8-bromo-3',5'-cyclic AMP increases expression EXP 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PDE3A mRNA CTD PMID:12466227 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PDE3A mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression ISO RGD:734436 6480464 Benzo(a)pyrene results in decreased expression of PDE3A mRNA CTD PMID:22178795 calcitriol increases expression ISO RGD:734436 6480464 Calcitriol results in increased expression of PDE3A mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:734436 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of PDE3A mRNA CTD PMID:21592394 cobalt dichloride decreases expression ISO RGD:734436 6480464 cobaltous chloride results in decreased expression of PDE3A mRNA CTD PMID:19320972 dasatinib (anhydrous) increases expression ISO RGD:734436 6480464 dasatinib results in increased expression of PDE3A mRNA CTD PMID:20579391 diazinon affects expression EXP 6480464 Diazinon affects the expression of PDE3A mRNA CTD PMID:17452286 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of PDE3A mRNA CTD PMID:18692542 pirinixic acid multiple interactions ISO RGD:734436 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDE3A mRNA CTD PMID:19710929 testosterone multiple interactions ISO RGD:734436 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of PDE3A mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:734436 6480464 Testosterone results in increased expression of PDE3A mRNA CTD PMID:21592394 testosterone enanthate increases expression EXP 6480464 testosterone enanthate results in increased expression of PDE3A mRNA CTD PMID:21427060 PMID:20463352 testosterone enanthate increases expression EXP 6480464 testosterone enanthate results in increased expression of PDE3A mRNA CTD PMID:20463352 PMID:21427060 theophylline increases expression EXP 6480464 Theophylline results in increased expression of PDE3A mRNA CTD PMID:16651698 valsartan increases expression EXP 6480464 valsartan results in increased expression of PDE3A mRNA CTD PMID:19027736
2316958 Gluco58 Glucose level QTL 58 10 Glucose level postprandial 4 6690606 185398530 Rat 1576316 Ept5 Estrogen-induced pituitary tumorigenesis QTL 5 3.8 Gland mass pituitary 4 82700691 182307104 Rat 1549827 Scl46 Serum cholesterol level QTL 46 3.5 Lipid level baseline serum cholesterol 4 135601855 180601855 Rat 724558 Plsm2 Polydactyly-luxate syndrome (PLS) morphotypes QTL 2 .0003 Limb morphology hind feet phalanges number 4 135628567 180628567 Rat 61362 Oia2 Oil induced arthritis QTL 2 .001 Joint/bone inflammation arthritis severity 4 136668162 181668162 Rat 1298524 Oia8 Oil induced arthritis QTL 8 Joint/bone inflammation arthritis severity 4 136668162 181668162 Rat 2303623 Vencon2 Ventilatory control QTL 2 3.8 Ventilatory control re-oxygenation after hypoxia 4 138523557 183523557 Rat 1578674 Bmd12 Bone mineral density QTL 12 3.8 Bone mineral density femoral neck cortical vBMD 4 140398530 185398530 Rat 2293659 Bmd35 Bone mineral density QTL 35 4.5 .0001 Bone mineral density 4 140454608 186104310 Rat 1581561 Eae22 Experimental allergic encephalomyelitis QTL 22 Brain/spinal cord inflammation 4 145746752 187126005 Rat 6478693 Anxrr32 Anxiety related response QTL 32 .00092 Anxiety response response in light-dark box 4 148704454 187126005 Rat 6478700 Anxrr33 Anxiety related response QTL 33 .00896 Anxiety response response in light-dark box 4 148704454 187126005 Rat 6478718 Anxrr34 Anxiety related response QTL 34 .00896 Anxiety response response in light-dark box 4 148704454 187126005 Rat 6478748 Anxrr42 Anxiety related response QTL 42 .28008 Anxiety response pen field inner locomotion 4 148704454 187126005 Rat 6478754 Anxrr43 Anxiety related response QTL 43 .14035 Anxiety response pen field inner locomotion 4 148704454 187126005 Rat 634342 Cia24 Collagen induced arthritis QTL 24 4.5 Joint/bone inflammation type II collagen induced 4 149304432 179854843 Rat 1300109 Rf13 Renal function QTL 13 3.91 Renal function salt-loaded renal blood flow 4 161028988 184893756 Rat 1331738 Bp209 Blood pressure QTL 209 2.979 Blood pressure time series calculation 4 161454762 187126005 Rat
Gene-Chemical Interaction Annotations
