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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:736161 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AMH mRNA | CTD | PMID:22079256 | 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane | increases expression | EXP | | 6480464 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of AMH protein | CTD | PMID:17170213 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of AMH mRNA | CTD | PMID:15834898 | 17beta-estradiol | increases expression | ISO | RGD:736161 | 6480464 | Estradiol results in increased expression of AMH mRNA | CTD | PMID:21826169 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | multiple interactions | ISO | RGD:736161 | 6480464 | AMH protein inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA] | CTD | PMID:16740653 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AMH mRNA | CTD | PMID:15590112 | 2-methylcholine | affects expression | ISO | RGD:736161 | 6480464 | beta-methylcholine affects the expression of AMH mRNA | CTD | PMID:21179406 | 4-vinylcyclohexene dioxide | decreases expression | EXP | | 6480464 | 4-vinyl-1-cyclohexene dioxide results in decreased expression of AMH protein; more ... | CTD | PMID:20816688 | 5-aza-2'-deoxycytidine | decreases expression | ISO | RGD:736161 | 6480464 | decitabine results in decreased expression of AMH mRNA | CTD | PMID:19363521 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:736161 | 6480464 | TP53 protein affects the reaction [decitabine results in decreased expression of AMH mRNA] | CTD | PMID:19363521 | 6-propyl-2-thiouracil | multiple interactions | ISO | RGD:10152 | 6480464 | AKT1 protein mutant form promotes the reaction [Propylthiouracil results in increased expression of AMH mRNA] | CTD | PMID:20951798 | 6-propyl-2-thiouracil | increases expression | ISO | RGD:10152 | 6480464 | Propylthiouracil results in increased expression of AMH mRNA | CTD | PMID:20951798 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of AMH mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:10152 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to AMH promoter] | CTD | PMID:19654925 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:10152 | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of AMH protein; more ... | CTD | PMID:22828881 | bisphenol A | increases expression | ISO | RGD:736161 | 6480464 | bisphenol A results in increased expression of AMH mRNA | CTD | PMID:21826169 | bisphenol A | multiple interactions | ISO | RGD:10152 | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of AMH mRNA; more ... | CTD | PMID:22828881 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of AMH promoter | CTD | PMID:22457795 | carmustine | decreases expression | ISO | RGD:736161 | 6480464 | Carmustine results in decreased expression of AMH mRNA | CTD | PMID:15980968 | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of AMH mRNA | CTD | PMID:17898221 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of AMH mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of AMH protein | CTD | PMID:17379624 | heptadecafluorononanoic acid | increases expression | EXP | | 6480464 | perfluoro-n-nonanoic acid results in increased expression of AMH mRNA; more ... | CTD | PMID:20580666 | methoxychlor | increases expression | EXP | | 6480464 | Methoxychlor results in increased expression of AMH protein | CTD | PMID:17170213 | methoxychlor | increases expression | EXP | | 6480464 | Methoxychlor results in increased expression of AMH protein | CTD | PMID:17170213 PMID:18848953 | methoxychlor | increases expression | EXP | | 6480464 | Methoxychlor results in increased expression of AMH protein | CTD | PMID:17170213 more ... | mono(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:736161 | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of AMH mRNA | CTD | PMID:19165384 | mono(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of AMH protein | CTD | PMID:19440488 | paracetamol | decreases expression | ISO | RGD:736161 | 6480464 | Acetaminophen results in decreased expression of AMH mRNA | CTD | PMID:22230336 | testosterone | multiple interactions | ISO | RGD:10152 | 6480464 | AMH protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Testosterone] | CTD | PMID:14630719 | testosterone | decreases expression | ISO | RGD:10152 | 6480464 | Testosterone results in decreased expression of AMH mRNA | CTD | PMID:22138414 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Hippo signaling pathway | |
| TGF-beta signaling pathway | |
| Pathway Interaction Database | ALK2 signaling events (PID:200160) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Hippo signaling pathway | |
| TGF-beta signaling pathway | |
| Pathway Interaction Database | ALK2 signaling events (PID:200160) |
References - curated| 1. |
Bayrak A, etal., Fertil Steril. 2007 Jan 12;. |
| 2. |
Bedecarrats GY, etal., Proc Natl Acad Sci U S A 2003 Aug 5;100(16):9348-53. Epub 2003 Jul 23. |
| 3. |
Carlsson IB, etal., Hum Reprod. 2006 Sep;21(9):2223-7. Epub 2006 May 23. |
| 4. |
Carre-Eusebe D, etal., Hum Genet. 1992 Dec;90(4):389-94. |
| 5. |
Chang HL, etal., Gynecol Oncol. 2009 Jul;114(1):57-60. Epub 2009 Apr 8. |
| 6. |
Dorgan JF, etal., J Natl Cancer Inst. 2009 Nov 4;101(21):1501-9. Epub 2009 Oct 9. |
| 7. |
Freeman EW, etal., Fertil Steril. 2007 Jan;87(1):101-6. Epub 2006 Nov 15. |
| 8. |
GOA data from the GO Consortium |
| 9. |
Haqq C, etal., Genomics 1992 Apr;12(4):665-9. |
| 10. |
Ikeda Y, etal., Endocrinology 2002 Jan;143(1):304-12. |
| 11. |
McGee EA, etal., Biol Reprod. 2001 Jan;64(1):293-8. |
| 12. |
MGD data from the GO Consortium |
| 13. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 14. |
Pieretti-Vanmarcke R, etal., Clin Cancer Res. 2006 Mar 1;12(5):1593-8. |
| 15. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 16. |
RGD automated data pipeline |
| 17. |
RGD automated import pipeline for gene-chemical interactions |
| 18. |
RGD Automated Pipelines |
| 19. |
Segev DL, etal., J Biol Chem 2001 Jul 20;276(29):26799-806. |
| 20. |
Song JY, etal., Int J Oncol. 2009 Jun;34(6):1583-91. |
| 21. |
Tian XY, etal., Reproduction. 2001 Jun;121(6):873-80. |
| 22. |
Uzumcu M, etal., J Endocrinol. 2006 Dec;191(3):549-58. |
| 23. |
Yeh J, etal., Biochem Biophys Res Commun. 2006 Sep 22;348(2):337-44. Epub 2006 Jul 13. |
| 24. |
Yeh J, etal., Fertil Steril. 2007 May;87(5):1227-30. Epub 2007 Jan 12. |
References - uncuratedRGD Disease Portals| Amh has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Amh (Rattus norvegicus) |
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| AMH (Homo sapiens) |
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| Amh (Mus musculus) |
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Position Markers| PMC203309P1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012902 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06047715 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01047477 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474029 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S98336 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012902 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037034 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037034 | (Get FASTA) |
| GenBank Protein | AAB22104 | (Get FASTA) |
| EDL89230 | (Get FASTA) | |
| P49000 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000019377 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000026220 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000026220 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25378 | ENTREZGENE |
| Germonline | ENSRNOG00000019377 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 68060 | ENTREZGENE |
| InterPro | AMH_N | UniProtKB/Swiss-Prot |
| Muellerian-inhibiting_factor | UniProtKB/Swiss-Prot | |
| TGFb | UniProtKB/Swiss-Prot | |
| TGFb_CS | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:25378 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR15009 | UniProtKB/Swiss-Prot |
| Pfam | AMH_N | UniProtKB/Swiss-Prot |
| TGF_beta | UniProtKB/Swiss-Prot | |
| PIRSF | Muellerian-inhibiting_factor | UniProtKB/Swiss-Prot |
| PROSITE | TGF_BETA_1 | UniProtKB/Swiss-Prot |
| TGF_BETA_2 | UniProtKB/Swiss-Prot | |
| SMART | TGFB | UniProtKB/Swiss-Prot |
| UniGene | Rn.19121 | ENTREZGENE |
| UniProt | MIS_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-02-26 | Amh | anti-Mullerian hormone | anti-mullerian hormone | Symbol and Name status set to approved | 2225 | APPROVED | |
| 2002-06-10 | Amh | anti-mullerian hormone | Name updated | 1489 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | inhibits human breast cancer cell growth in vitro through interference with cell cycle progression and induction of apoptosis | 70295 |
| gene_disease | inhibits human breast cancer cell growth in vitro through interference with cell cycle progression and induction of apoptosis | 70576 |
| gene_expression | produced by Sertoli cells of the testis (males); in females, synthesized by granulosa cells of the ovary and persists until menopause | 70295 |
| gene_expression | produced by Sertoli cells of the testis (males); in females, synthesized by granulosa cells of the ovary and persists until menopause | 70576 |
| gene_expression | expressed in the granulosa small growing follicles in the ovary | 70295 |
| gene_expression | expressed in the granulosa small growing follicles in the ovary | 70576 |
| gene_expression | expression is high in the 1-day-postnatal testis and decreases to a low level in the adult testis | 1298546 |
| gene_function | testicular glycoprotein ligand for MIS receptor II that causes regression of Mullerian duct, the fallopian tubes and part of the vagina | 1298546 |
| gene_process | responsible for the regression of Mullerian duct in male embryos | 70295 |
| gene_process | responsible for the regression of Mullerian duct in male embryos | 70576 |
| gene_process | plays a key role in male sexual development and differentiation | 1298546 |
| gene_process | regulates such hypothalamic/pituitary/gonadal axis processes as steroidogenesis, breast and prostate growth, and ovarian follicle recruitment | 1298576 |
| gene_process | enhances the effect of gonadotropin-releasing hormone (GnRH) agonist on the FSHbeta gene promoter and synergizes with the GnRH agonist to stimulate LHbeta gene promoter activity | 1298576 |
| gene_process | regulates follicular growth | 70576 |
| gene_process | contributes to ovarian development | 70576 |
| gene_process | impedes cell cycle progression and apoptosis induction and thus breast cancer cell growth | 70295 |
| gene_process | induces NFkappaB to bind to its cognate DNA sequence | 70295 |
| gene_process | enhances IEX-1S mRNA expression in breast tissue | 70295 |
| gene_process | increases apoptosis in the mouse mammary ductal epithelium | 70295 |
| gene_process | potential endogenous hormonal regulator of NFkappaB signaling and growth in breast tissue | 70295 |
| gene_product | member of the transforming growth factor b family | |
| gene_regulation | mRNA and protein expression in ovary increased by E2 benzoate; reduction is correlated with the inhibotory effect of EB on the follicular stratification | 70295 |
| gene_regulation | mRNA and protein expression in ovary increased by E2 benzoate; reduction is correlated with the inhibotory effect of EB on the follicular stratification | 70576 |
| gene_regulation | transcription is estrogen responsive | 70576 |
| gene_regulation | activated by steroidogenic factor 1 | 70576 |
| More on Amh | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2108 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.