Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | multiple interactions | EXP | | 6480464 | [piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein] | CTD | PMID:12806184 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases expression | EXP | | 6480464 | Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein | CTD | PMID:15075188 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | affects expression | EXP | | 6480464 | Puromycin Aminonucleoside affects the expression of SLC9A3 protein | CTD | PMID:12191963 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:730978 | 6480464 | decitabine results in increased expression of SLC9A3 mRNA | CTD | PMID:21856257 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SLC9A3 mRNA | CTD | PMID:16483693 | choline | multiple interactions | ISO | RGD:11319 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC9A3 gene | CTD | PMID:20938992 | cimetidine | multiple interactions | EXP | | 6480464 | [piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein] | CTD | PMID:12806184 | clofibrate | multiple interactions | EXP | | 6480464 | Clofibrate inhibits the reaction [Dietary Fats results in increased expression of SLC9A3 protein] | CTD | PMID:16339392 | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of SLC9A3 protein | CTD | PMID:18400872 | dexamethasone | increases expression | ISO | RGD:730978 | 6480464 | Dexamethasone results in increased expression of SLC9A3 protein | CTD | PMID:16564041 | folic acid | multiple interactions | ISO | RGD:11319 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC9A3 gene | CTD | PMID:20938992 | indomethacin | increases expression | EXP | | 6480464 | Indomethacin results in increased expression of SLC9A3 protein | CTD | PMID:15053815 | L-methionine | multiple interactions | ISO | RGD:11319 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC9A3 gene | CTD | PMID:20938992 | lithium atom | increases expression | EXP | | 6480464 | Lithium results in increased expression of SLC9A3 protein | CTD | PMID:10966935 | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of SLC9A3 mRNA | CTD | PMID:18692542 | resveratrol | multiple interactions | ISO | RGD:730978 | 6480464 | [resveratrol results in increased expression of SLC9A3 protein] which results in increased uptake of Sodium Chloride | CTD | PMID:21191669 | resveratrol | increases expression | ISO | RGD:730978 | 6480464 | resveratrol results in increased expression of SLC9A3 protein | CTD | PMID:21191669 | sodium atom | increases uptake | EXP | | 6480464 | SLC9A3 protein results in increased uptake of Sodium | CTD | PMID:10710541 | sodium atom | multiple interactions | EXP | | 6480464 | [3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride results in decreased activity of SLC9A3 protein] which results in decreased transport of Sodium | CTD | PMID:10710541 | sodium chloride | multiple interactions | ISO | RGD:730978 | 6480464 | [resveratrol results in increased expression of SLC9A3 protein] which results in increased uptake of Sodium Chloride | CTD | PMID:21191669 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SLC9A3 protein | CTD | PMID:15673309 PMID:16192424 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SLC9A3 protein | CTD | PMID:16192424 PMID:15673309 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SLC9A3 protein | CTD | PMID:16192424 | trans-resveratrol | multiple interactions | ISO | RGD:730978 | 6480464 | [resveratrol results in increased expression of SLC9A3 protein] which results in increased uptake of Sodium Chloride | CTD | PMID:21191669 | trans-resveratrol | increases expression | ISO | RGD:730978 | 6480464 | resveratrol results in increased expression of SLC9A3 protein | CTD | PMID:21191669 | tunicamycin | decreases expression | ISO | RGD:11319 | 6480464 | Tunicamycin results in decreased expression of SLC9A3 mRNA | CTD | PMID:17127020 | valproic acid | increases expression | ISO | RGD:730978 | 6480464 | Valproic Acid results in increased expression of SLC9A3 mRNA | CTD | PMID:19101580 | zinc atom | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of SLC9A3 mRNA | CTD | PMID:11717422 | zinc(0) | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of SLC9A3 mRNA | CTD | PMID:11717422 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Bile secretion |
| Mineral absorption | |
| Protein digestion and absorption | |
| Proximal tubule bicarbonate reclamation | |
| Pathway Interaction Database | Endothelins (PID:200005) |
| RhoA signaling pathway (PID:200009) | |
Disease Annotations
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
| External Database Links | |
| KEGG Pathway | Bile secretion |
| Mineral absorption | |
| Protein digestion and absorption | |
| Proximal tubule bicarbonate reclamation | |
| Pathway Interaction Database | Endothelins (PID:200005) |
| RhoA signaling pathway (PID:200009) | |
References - curatedReferences - uncuratedRGD Disease Portals| Slc9a3 has been annotated in the following RGD Disease Portals. |
|||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
Candidate Gene StatusComparative Map Data| Slc9a3 (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| SLC9A3 (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Slc9a3 (Mus musculus) |
|
Position Markers| RH94714 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_012654 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036786 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_036786 | (Get FASTA) |
| GenBank Protein | AAA41702 | (Get FASTA) |
| AAB06704 | (Get FASTA) | |
| P26433 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015159 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000020711 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000020711 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 24784 | ENTREZGENE |
| Germonline | ENSRNOG00000015159 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55804 | ENTREZGENE |
| InterPro | Cation/H_exchanger | UniProtKB/Swiss-Prot |
| Cation/H_exchanger_cons-reg | UniProtKB/Swiss-Prot | |
| Na/H_exchanger_3/5_cons-reg | UniProtKB/Swiss-Prot | |
| NaH_exchanger_subfam | UniProtKB/Swiss-Prot | |
| Reg_factor_effector_bac | UniProtKB/Swiss-Prot | |
| IPI | IPI00193371 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24784 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Cation/H_exchanger_cons-reg | UniProtKB/Swiss-Prot |
| Pfam | Na_H_Exchanger | UniProtKB/Swiss-Prot |
| PRINTS | NAHEXCHNGR | UniProtKB/Swiss-Prot |
| NAHEXCHNGR3 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Bac_reg_effector | UniProtKB/Swiss-Prot |
| TIGRFAMs | b_cpa1 | UniProtKB/Swiss-Prot |
| UniGene | Rn.9706 | ENTREZGENE |
| UniProt | G3V7Y7_RAT | UniProtKB/TrEMBL |
| Q6LCL2_RAT | UniProtKB/TrEMBL | |
| SL9A3_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-10-16 | Slc9a3 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 | Slc9a3 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Slc9a3 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 | solute carrier family 9, member 3 | Name updated | 10779 | APPROVED | |
| 2003-04-09 | Slc9a3 | solute carrier family 9, member 3 | Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive) | Name updated | 2575 | APPROVED | |
| 2002-06-10 | Slc9a3 | Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive) | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | associated with chronic metabolic acidosis | 628393 |
| gene_disease | decreased localization to the renal proximal tubule apical brush border is associated with a model of acute hypertension | 737665 |
| gene_drugs | administration of the antiestrogen ICI 182,780 decreases the levels of mRNA and protein | 628393 |
| gene_drugs | selective inhibitor S3226 blocks activity and growth response in young uninephrectomized rats | 628393 |
| gene_expression | expressed in the proximal tubule of the kidney | 628393 |
| gene_expression | expressed in the small and large intestine | 628393 |
| gene_process | facilitates increased absorption of NaCl in the intestine | 625757 |
| gene_process | facilitates the hyperplastic/hypertrophic response in different cell types | 628529 |
| gene_process | mediates fluid and electrolyte reabsorption in the efferent ductules | 628393 |
| gene_regulation | estrogen receptor (ER) is required for the expression and function | 628393 |
| gene_regulation | activity is regulated by physiological stimuli, glucorticoids, aldosterone, and other neurohormones and also by signal transduction pathways that involve protein kinase C, cAMP, cGMP, intracellular calcium and accessory proteins such as NHE regulatory fac | 628393 |
| gene_regulation | increased acidosis reported in rats after 6 days of treatment with ammonium chloride resulted in enhanced exchanger activity | 628393 |
| gene_regulation | significant increase in the mRNA is observed in the uninephrectomized rats | 628393 |
| gene_regulation | after the removal of the renal mass the activity of the apical membrane exchanger is increased | 628393 |
| More on Slc9a3 | |
|
Entrez Gene |
|
Ensembl Gene |
| Genome Browser |
|
NCBI Map Viewer |
|
Vista |
|
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3720 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.