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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionEXP 6480464CTDLosartan results in decreased expression of CCL2 mRNA; Losartan results in decreased expression of CCL2 proteinPMID:10925121 PMID:17922026
Ccl2multiple interactionsEXP 6480464CTDLosartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Losartan inhibits the reaction [glyoxylic acid results in increased expression of CCL2 protein]PMID:16284884 PMID:19553526 PMID:37454925
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDLosartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]PMID:28578904
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDLosartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]PMID:28578904
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