Itpr2 (inositol 1,4,5-trisphosphate receptor, type 2) - Rat Genome Database

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Gene: Itpr2 (inositol 1,4,5-trisphosphate receptor, type 2) Rattus norvegicus
Analyze
Symbol: Itpr2
Name: inositol 1,4,5-trisphosphate receptor, type 2
RGD ID: 69649
Description: Enables calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-gated calcium channel activity. Involved in cellular response to hypoxia and release of sequestered calcium ion into cytosol. Located in axon; endoplasmic reticulum membrane; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor type 2; inositol 1,4,5-triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2; inositol 145-triphosphate receptor type 2; inositol triphosphate receptor type 2; insP3R2; IP3 receptor; IP3R 2; LOC102553163; type 2 inositol 1,4,5-trisphosphate receptor; type 2 InsP3 receptor; uncharacterized LOC102553163
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84180,759,325 - 181,165,361 (-)NCBIGRCr8
mRatBN7.24179,028,594 - 179,434,657 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4179,027,281 - 179,404,164 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4185,313,424 - 185,690,245 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04181,097,944 - 181,474,767 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04179,718,376 - 180,095,194 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04180,423,452 - 180,800,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4180,538,389 - 180,722,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04244,585,711 - 244,960,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44183,677,606 - 184,066,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14183,922,730 - 184,311,254 (-)NCBI
Celera4167,526,971 - 167,901,481 (-)NCBICelera
RH 3.4 Map41070.3RGD
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetazolamide  (ISO)
Adenophostin A  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
antimony trichloride  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium oxalate  (EXP)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
glyoxylic acid  (EXP)
lead(0)  (EXP)
losartan  (EXP)
mercury dibromide  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-hexadecanoylsphingosine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
potassium chromate  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vorinostat  (ISO)
xestospongin C  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors. Adkins CE, etal., Biochem J. 2000 Jan 15;345 Pt 2(Pt 2):357-63.
2. Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation. Cardenas C, etal., J Cell Sci. 2005 Jul 15;118(Pt 14):3131-40.
3. Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. Drawnel FM, etal., J Cell Biol. 2012 Nov 26;199(5):783-98. doi: 10.1083/jcb.201111095. Epub 2012 Nov 19.
4. Organelles containing inositol trisphosphate receptor type 2 in adrenal medullary cells. Endo Y, etal., J Physiol Sci. 2006 Dec;56(6):415-23. Epub 2006 Nov 3.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hirata K, etal., Hepatology 2002 Aug;36(2):284-96.
8. Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum. Jurkovicova D, etal., Pflugers Arch. 2007 Jun;454(3):415-25. Epub 2007 Feb 7.
9. Expression profiles of three isoforms of inositol 1,4,5-trisphosphate receptor in brown adipose tissue of the rat. Kajimoto K, etal., Biochem Pharmacol 2003 Mar 15;65(6):995-8.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Characterization of inositol 1,4,5-trisphosphate receptor isoform mRNA expression and regulation in rat pancreatic islets, RINm5F cells and betaHC9 cells. Lee B, etal., J Mol Endocrinol 1998 Aug;21(1):31-9.
12. Immobilization stress elevates IP(3) receptor mRNA in adult rat hearts in a glucocorticoid-dependent manner. Lencesova L, etal., FEBS Lett 2002 Nov 20;531(3):432-6.
13. Modulation of inositol 1,4,5-trisphosphate receptor type 2 channel activity by Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation. Maxwell JT, etal., J Biol Chem. 2012 Nov 16;287(47):39419-28. doi: 10.1074/jbc.M112.374058. Epub 2012 Sep 26.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Single-channel function of recombinant type 2 inositol 1,4, 5-trisphosphate receptor. Ramos-Franco J, etal., Biophys J. 2000 Sep;79(3):1388-99.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. Schulman JJ, etal., J Biol Chem. 2013 Aug 30;288(35):25340-9. doi: 10.1074/jbc.M113.496570. Epub 2013 Jul 24.
22. Structure of a novel InsP3 receptor. Sudhof TC, etal., EMBO J 1991 Nov;10(11):3199-206.
23. Signaling proteins in the axoglial apparatus of sciatic nerve nodes of Ranvier. Toews JC, etal., Glia. 2007 Jan 15;55(2):202-13.
24. Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Tu H, etal., Biophys J. 2005 Feb;88(2):1046-55. Epub 2004 Nov 8.
25. ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. van Es MA, etal., Lancet Neurol. 2007 Oct;6(10):869-77.
26. Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation. Vanderheyden V, etal., Biochim Biophys Acta. 2009 Jun;1793(6):959-70. doi: 10.1016/j.bbamcr.2008.12.003. Epub 2008 Dec 16.
27. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
28. Differential regulation of the InsP₃ receptor type-1 and -2 single channel properties by InsP₃, Ca²⁺ and ATP. Wagner LE and Yule DI, J Physiol. 2012 Jul 15;590(14):3245-59. doi: 10.1113/jphysiol.2012.228320. Epub 2012 Apr 30.
Additional References at PubMed
PMID:8063813   PMID:9858485   PMID:10191279   PMID:10828023   PMID:11163362   PMID:11285228   PMID:11587548   PMID:11722588   PMID:11782428   PMID:12112377   PMID:12820984   PMID:12893684  
PMID:17284437   PMID:17327232   PMID:17636122   PMID:18026983   PMID:18068335   PMID:19120137   PMID:19549843   PMID:19946888   PMID:20189985   PMID:21071436   PMID:21436055   PMID:21748767  
PMID:23137780   PMID:23382219   PMID:24415751   PMID:28327356   PMID:36645057  


Genomics

Comparative Map Data
Itpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84180,759,325 - 181,165,361 (-)NCBIGRCr8
mRatBN7.24179,028,594 - 179,434,657 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4179,027,281 - 179,404,164 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4185,313,424 - 185,690,245 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04181,097,944 - 181,474,767 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04179,718,376 - 180,095,194 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04180,423,452 - 180,800,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4180,538,389 - 180,722,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04244,585,711 - 244,960,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44183,677,606 - 184,066,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14183,922,730 - 184,311,254 (-)NCBI
Celera4167,526,971 - 167,901,481 (-)NCBICelera
RH 3.4 Map41070.3RGD
Cytogenetic Map4q44NCBI
ITPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,335,352 - 26,833,194 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,335,352 - 26,833,194 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,488,285 - 26,986,127 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,379,552 - 26,877,398 (-)NCBINCBI36Build 36hg18NCBI36
Build 341226,381,611 - 26,877,398NCBI
Celera1231,634,797 - 32,132,275 (-)NCBICelera
Cytogenetic Map12p11.23NCBI
HuRef1226,258,420 - 26,756,231 (-)NCBIHuRef
CHM1_11226,453,424 - 26,951,168 (-)NCBICHM1_1
T2T-CHM13v2.01226,207,897 - 26,705,197 (-)NCBIT2T-CHM13v2.0
Itpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396146,009,797 - 146,403,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6146,009,797 - 146,403,721 (-)EnsemblGRCm39 Ensembl
GRCm386146,108,299 - 146,502,258 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6146,108,299 - 146,502,223 (-)EnsemblGRCm38mm10GRCm38
MGSCv376146,060,002 - 146,450,434 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366146,068,650 - 146,459,082 (-)NCBIMGSCv36mm8
Celera6149,142,524 - 149,540,657 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.7NCBI
Itpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541321,291,110 - 21,719,303 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541321,289,673 - 21,719,610 (-)NCBIChiLan1.0ChiLan1.0
ITPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21069,981,191 - 70,487,626 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11269,978,015 - 70,484,024 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01259,478,206 - 59,984,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11262,093,208 - 62,596,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1262,092,241 - 62,596,018 (+)Ensemblpanpan1.1panPan2
ITPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12720,806,670 - 21,278,638 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2720,805,842 - 21,350,083 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2725,103,914 - 25,581,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02721,001,355 - 21,474,042 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2721,001,392 - 21,471,311 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12720,812,377 - 21,283,928 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02720,834,447 - 21,306,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02725,271,849 - 25,744,599 (-)NCBIUU_Cfam_GSD_1.0
Itpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494582,723,135 - 83,198,963 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936548645,925 - 1,121,888 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936548646,019 - 1,120,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl546,935,932 - 47,464,125 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1546,935,923 - 47,465,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2550,482,341 - 50,738,864 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11126,089,480 - 26,574,621 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1126,089,484 - 26,574,950 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660698,498,077 - 8,981,050 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475212,360,740 - 12,822,287 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475212,360,796 - 12,820,042 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itpr2
2778 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:536
Count of miRNA genes:260
Interacting mature miRNAs:356
Transcripts:ENSRNOT00000040645
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat

Markers in Region
D4Mgh12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24179,293,830 - 179,293,946 (+)MAPPERmRatBN7.2
Rnor_6.04180,689,009 - 180,689,124NCBIRnor6.0
Rnor_5.04244,849,397 - 244,849,512UniSTSRnor5.0
RGSC_v3.44183,954,704 - 183,954,820RGDRGSC3.4
RGSC_v3.44183,954,705 - 183,954,820UniSTSRGSC3.4
RGSC_v3.14184,199,829 - 184,199,944RGD
Celera4167,791,605 - 167,791,720UniSTS
RH 3.4 Map41076.3UniSTS
RH 3.4 Map41076.3RGD
Cytogenetic Map4q44UniSTS
D4Got297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24179,306,094 - 179,306,252 (+)MAPPERmRatBN7.2
Rnor_6.04180,701,272 - 180,701,429NCBIRnor6.0
Rnor_5.04244,861,660 - 244,861,817UniSTSRnor5.0
RGSC_v3.44183,966,968 - 183,967,125UniSTSRGSC3.4
Celera4167,803,868 - 167,804,024UniSTS
Cytogenetic Map4q44UniSTS
RH133051  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24179,193,874 - 179,194,068 (+)MAPPERmRatBN7.2
Rnor_6.04180,588,969 - 180,589,162NCBIRnor6.0
Rnor_5.04244,750,238 - 244,750,431UniSTSRnor5.0
RGSC_v3.44183,851,398 - 183,851,591UniSTSRGSC3.4
Celera4167,693,028 - 167,693,221UniSTS
RH 3.4 Map41070.3UniSTS
Cytogenetic Map4q44UniSTS
BE110085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24179,031,636 - 179,031,796 (+)MAPPERmRatBN7.2
Rnor_6.04180,425,378 - 180,425,537NCBIRnor6.0
Rnor_5.04244,587,637 - 244,587,796UniSTSRnor5.0
RGSC_v3.44183,679,532 - 183,679,691UniSTSRGSC3.4
Celera4167,528,897 - 167,529,056UniSTS
RH 3.4 Map41070.3UniSTS
Cytogenetic Map4q44UniSTS
AU046614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24179,122,021 - 179,122,202 (+)MAPPERmRatBN7.2
Rnor_6.04180,517,272 - 180,517,452NCBIRnor6.0
Rnor_5.04244,678,915 - 244,679,095UniSTSRnor5.0
RGSC_v3.44183,775,106 - 183,775,286UniSTSRGSC3.4
Celera4167,621,203 - 167,621,379UniSTS
Cytogenetic Map4q44UniSTS
BE100309  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24179,278,276 - 179,278,427 (+)MAPPERmRatBN7.2
Rnor_6.04180,673,476 - 180,673,626NCBIRnor6.0
Rnor_5.04244,833,770 - 244,833,920UniSTSRnor5.0
RGSC_v3.44183,938,620 - 183,938,770UniSTSRGSC3.4
Celera4167,776,080 - 167,776,230UniSTS
RH 3.4 Map41070.3UniSTS
Cytogenetic Map4q44UniSTS
Itpr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24179,235,304 - 179,236,096 (+)MAPPERmRatBN7.2
Rnor_6.04180,630,279 - 180,631,070NCBIRnor6.0
Rnor_5.04244,791,039 - 244,791,830UniSTSRnor5.0
RGSC_v3.44183,893,167 - 183,893,958UniSTSRGSC3.4
Celera4167,734,499 - 167,735,290UniSTS
RH 3.4 Map41070.3UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000040255   ⟹   ENSRNOP00000043615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4179,029,714 - 179,404,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000040645   ⟹   ENSRNOP00000047905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4179,082,013 - 179,404,164 (-)Ensembl
Rnor_6.0 Ensembl4180,538,389 - 180,722,358 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086465   ⟹   ENSRNOP00000072117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4179,029,714 - 179,108,199 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103103   ⟹   ENSRNOP00000077641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4179,029,714 - 179,404,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109175   ⟹   ENSRNOP00000096862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4179,027,281 - 179,404,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118898   ⟹   ENSRNOP00000077632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4179,086,247 - 179,404,164 (-)Ensembl
RefSeq Acc Id: NM_031046   ⟹   NP_112308
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,760,442 - 181,134,867 (-)NCBI
mRatBN7.24179,029,711 - 179,404,164 (-)NCBI
Rnor_6.04180,423,452 - 180,800,088 (-)NCBI
Rnor_5.04244,585,711 - 244,960,429 (-)NCBI
RGSC_v3.44183,677,606 - 184,066,130 (-)RGD
Celera4167,526,971 - 167,901,481 (-)RGD
Sequence:
RefSeq Acc Id: XM_039108425   ⟹   XP_038964353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,759,325 - 181,165,361 (-)NCBI
mRatBN7.24179,028,594 - 179,434,657 (-)NCBI
RefSeq Acc Id: XM_039108427   ⟹   XP_038964355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,759,325 - 181,165,315 (-)NCBI
mRatBN7.24179,028,594 - 179,434,606 (-)NCBI
RefSeq Acc Id: XM_039108428   ⟹   XP_038964356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,759,325 - 181,134,987 (-)NCBI
mRatBN7.24179,028,594 - 179,404,267 (-)NCBI
RefSeq Acc Id: XM_039108429   ⟹   XP_038964357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,759,325 - 181,165,315 (-)NCBI
mRatBN7.24179,028,594 - 179,434,606 (-)NCBI
RefSeq Acc Id: XM_039108430   ⟹   XP_038964358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,759,325 - 181,165,315 (-)NCBI
mRatBN7.24179,028,594 - 179,434,606 (-)NCBI
RefSeq Acc Id: XM_063286748   ⟹   XP_063142818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,759,325 - 181,165,338 (-)NCBI
RefSeq Acc Id: NP_112308   ⟸   NM_031046
- UniProtKB: Q6W3E4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047905   ⟸   ENSRNOT00000040645
RefSeq Acc Id: XP_038964353   ⟸   XM_039108425
- Peptide Label: isoform X1
- UniProtKB: Q6W3E4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964355   ⟸   XM_039108427
- Peptide Label: isoform X2
- UniProtKB: Q6W3E4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964357   ⟸   XM_039108429
- Peptide Label: isoform X4
- UniProtKB: Q6W3E4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964358   ⟸   XM_039108430
- Peptide Label: isoform X4
- UniProtKB: Q6W3E4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964356   ⟸   XM_039108428
- Peptide Label: isoform X3
- UniProtKB: F1LNT1 (UniProtKB/TrEMBL),   Q6W3E4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000043615   ⟸   ENSRNOT00000040255
Ensembl Acc Id: ENSRNOP00000096862   ⟸   ENSRNOT00000109175
Ensembl Acc Id: ENSRNOP00000077641   ⟸   ENSRNOT00000103103
Ensembl Acc Id: ENSRNOP00000077632   ⟸   ENSRNOT00000118898
Ensembl Acc Id: ENSRNOP00000072117   ⟸   ENSRNOT00000086465
RefSeq Acc Id: XP_063142818   ⟸   XM_063286748
- Peptide Label: isoform X1
Protein Domains
Ion transport   MIR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69649 AgrOrtholog
BioCyc Gene G2FUF-42433 BioCyc
Ensembl Genes ENSRNOG00000001804 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040255.6 UniProtKB/TrEMBL
  ENSRNOT00000040645.6 UniProtKB/TrEMBL
  ENSRNOT00000086465.2 UniProtKB/TrEMBL
  ENSRNOT00000103103.1 UniProtKB/TrEMBL
  ENSRNOT00000109175.1 UniProtKB/TrEMBL
  ENSRNOT00000118898.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IP3 receptor type 1 binding core, RIH domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  InsP3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanodine_IP3_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81678 UniProtKB/Swiss-Prot
NCBI Gene 81678 ENTREZGENE
PANTHER INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ins145_P3_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itpr2 PhenoGen
PRINTS INSP3RECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001804 RatGTEx
SMART MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K260_RAT UniProtKB/TrEMBL
  A0A8I5Y6K8_RAT UniProtKB/TrEMBL
  A0A8I5ZKC4_RAT UniProtKB/TrEMBL
  A0A8I6ARS8_RAT UniProtKB/TrEMBL
  A6IN17_RAT UniProtKB/TrEMBL
  F1LNT1 ENTREZGENE, UniProtKB/TrEMBL
  F1LQR8_RAT UniProtKB/TrEMBL
  ITPR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6W3E4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q99P56 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Itpr2  inositol 1,4,5-trisphosphate receptor, type 2  LOC102553163  uncharacterized LOC102553163  Data merged from RGD:7717500 737654 PROVISIONAL
2013-12-18 LOC102553163  uncharacterized LOC102553163      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-08-02 Itpr2  inositol 1,4,5-trisphosphate receptor, type 2  Itpr2  inositol 1,4,5-triphosphate receptor, type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Itpr2  inositol 1,4,5-triphosphate receptor, type 2  Itpr2  inositol 1,4,5-triphosphate receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Itpr2  inositol 1,4,5-triphosphate receptor 2    inositol 1,4,5-triphosphate receptor type 2  Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Itpr2  inositol 1,4,5-triphosphate receptor type 2      Name updated 70585 PROVISIONAL
2002-02-26 Itpr2  inositol 1,4,5-triphosphate receptor 2      Name updated 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression predominantly expressed in brown adipose tissue 727515
gene_function intracellular Ca2+ channel, receptor for Insp3 (inositol 1,4,5-triphosphate) that causes the release of Ca ++ from intracellular stores 68894
gene_function intracellular Ca2+ channel, receptor for Insp3 (inositol 1,4,5-triphosphate) that causes the release of Ca ++ from intracellular stores 69501
gene_process plays a role in the regulation of insulin secretion 68894
gene_process plays a role in the regulation of insulin secretion 69501
gene_regulation mRNA expression elevated in cardiac atria and ventricles by stress 729245