CALCIUM TRANSPORT PATHWAY (PW:0001139)

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Description

Calcium permeates almost every aspect of cellular processes and the pathways associated with them - from proliferation to cell death, contraction and gene expression, hormone and neurotransmitter release, metabolism and synaptic plasticity. Movement of calcium ions in and outside of the cell is paramount to the maintenance of a calcium gradient four order of magnitudes between the extracellular environment and the cytoplasmic concentration of resting cells. The steep gradient allows for fast lo

Pathway Diagram:

Elsevier Inc. Stim1 Na+ ---> Na+ in (3) Mcu complex Ca2+ outside ---> Ca2+ Ca2+ Ca2+ ---> Ca2+ stored Ca2+ stored ---> Ca2+ released Na+ ---> Na+ in (4) calcium/calcium-mediated signaling pathway RYRs ITPRs NCKXs NCXs PMCAs ROCs ORAIs CNGs TRPs VOCs NAADP cADPr IP3 Ca2+ outside Ca2+ ---> CA2+ pumped out Ca2+ exchanged CA2+ pumped out Atp2c2 Tpcn2 ---> Ca2+ released Tpcn1 ---> Ca2+ released Ca2+ stored ORAIs ---- Stim2 Ca2+ ---- ITPRs IP3 ---- ITPRs ORAIs ---- Stim1 Na+ Ca2+ ---- RYRs Na+ in (3) Na+ in (4) cADPr ---- RYRs NAADP ---- Tpcn1 NAADP ---- Tpcn2 Mcoln1 ---> Ca2+ released Ca2+ released Atp2c1 Tpcn1 Tpcn2 Mcoln1 Stim2 Slc24a6 Ca2+ ---> Ca2+ exchanged Stim1 --+> ORAIs SERCAs
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Genes in Pathway:

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calcium transport pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 JBrowse link 1 197,855,912 197,875,038 RGD:7204695
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 39,553,903 39,603,326 RGD:7204695
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 JBrowse link 10 59,528,849 59,560,440 RGD:7204695
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:7204695
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 JBrowse link 4 145,704,779 145,948,997 RGD:7204695
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 JBrowse link X 157,236,400 157,312,028 RGD:7204695
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 JBrowse link 13 50,091,644 50,153,808 RGD:7204695
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 JBrowse link 8 113,953,959 114,039,965 RGD:7204695
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 JBrowse link 19 52,347,480 52,404,608 RGD:7204695
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:7204688
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:7204688
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:7204688
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:7204688
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:7204688
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:7204688
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:7204688
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:7204688
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:7204688
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:7204688
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:7204688
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:7204688
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:7204688
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 3 37,950,846 38,211,478 RGD:7204688
G Cnga1 cyclic nucleotide gated channel alpha 1 JBrowse link 14 38,155,771 38,171,107 RGD:6893549
G Cnga2 cyclic nucleotide gated channel alpha 2 JBrowse link 16 69,878,513 69,899,075 RGD:6893549
G Cnga3 cyclic nucleotide gated channel alpha 3 JBrowse link 9 43,807,412 43,858,225 RGD:6893549
G Cnga4 cyclic nucleotide gated channel alpha 4 JBrowse link 1 170,238,959 170,246,858 RGD:6893549
G Cngb1 cyclic nucleotide gated channel beta 1 JBrowse link 19 10,142,440 10,206,618 RGD:6893549
G Cngb3 cyclic nucleotide gated channel beta 3 JBrowse link 5 33,097,353 33,507,467 RGD:6893549
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:7204693
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:7204693
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 JBrowse link 20 5,645,894 5,711,702 RGD:7204693
G Mcoln1 mucolipin 1 JBrowse link 12 2,054,629 2,068,682 RGD:7204689
G Mcu mitochondrial calcium uniporter JBrowse link 20 29,037,452 29,199,224 RGD:7204696
G Orai1 ORAI calcium release-activated calcium modulator 1 JBrowse link 12 38,981,903 38,995,570 RGD:7204692
G Orai2 ORAI calcium release-activated calcium modulator 2 JBrowse link 12 23,544,483 23,564,602 RGD:7204692
G Orai3 ORAI calcium release-activated calcium modulator 3 JBrowse link 1 199,217,504 199,222,363 RGD:7204692
G Ryr1 ryanodine receptor 1 JBrowse link 1 87,959,596 88,066,252 RGD:7204694
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:7204694
G Ryr3 ryanodine receptor 3 JBrowse link 3 104,117,307 104,665,151 RGD:7204694
G Slc24a1 solute carrier family 24 member 1 JBrowse link 8 70,409,683 70,438,352 RGD:7204698
G Slc24a2 solute carrier family 24 member 2 JBrowse link 5 105,336,287 105,579,959 RGD:7204698
G Slc24a3 solute carrier family 24 member 3 JBrowse link 3 139,333,942 139,835,728 RGD:7204698
G Slc24a4 solute carrier family 24 member 4 JBrowse link 6 126,015,799 126,158,727 RGD:7204698
G Slc8a1 solute carrier family 8 member A1 JBrowse link 6 4,244,076 4,564,262 RGD:7204698
G Slc8a2 solute carrier family 8 member A2 JBrowse link 1 78,029,555 78,054,042 RGD:7204698
G Slc8a3 solute carrier family 8 member A3 JBrowse link 6 104,889,500 105,099,408 RGD:7204698
G Slc8b1 solute carrier family 8 member B1 JBrowse link 12 41,566,980 41,590,294 RGD:7204696
G Stim1 stromal interaction molecule 1 JBrowse link 1 167,373,894 167,533,412 RGD:7204692
G Stim2 stromal interaction molecule 2 JBrowse link 14 59,198,180 59,323,947 RGD:7204692
G Tpcn1 two pore segment channel 1 JBrowse link 12 41,507,784 41,566,847 RGD:7204697
G Tpcn2 two pore segment channel 2 JBrowse link 1 218,419,182 218,448,902 RGD:7204697
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 JBrowse link 4 70,947,615 70,974,004 RGD:7204689
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 JBrowse link 4 70,918,631 70,934,291 RGD:7204689

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassCNGscyclic nucleotide gated channels
Functional ClassITPRsinositol 1,4,5-trisphophate receptors
ComplexMcu complexmitochondrial calcium uniporter
Functional ClassPMCAsplasma membrane pumps of the ATP2B family
Functional ClassSERCAsRE/SR pumps of the ATP2A family
Functional ClassROCsreceptor operated channels
Functional ClassRYRsryanodine receptors
Functional ClassNCXsodium/calcium exchangers of the SLC8 family
Functional ClassNCKXsodium/calcium-potassium excahngers of the SLC24 family
Functional ClassORAIsstore operated ORAI calcium channels
Functional ClassTRPstransient receptor potential channels
Functional ClassVOCsvoltage operated calcium channels

Pathway Gene Annotations

Disease Annotations Associated with Genes in the calcium transport pathway
Disease TermsGene Symbols
ANHIDROSIS, FAMILIAL GENERALIZED, WITH ABNORMAL OR ABSENT SWEAT GLANDS Itpr2
Abnormalities, MultipleCacna1c , Cacna1g , Itpr1
Achromatopsia 1Cnga3 , Cngb3
Achromatopsia 2Cnga3
Achromatopsia 3Cngb3
AdenomaAtp2a3 , Atp2b3 , Cacna1d
Adrenocortical AdenomaAtp2b3
Aland Island Eye DiseaseCacna1f
Alzheimer DiseaseItpr1
Amelogenesis Imperfecta, Hypomaturation Type, IIA5Slc24a4
Amyotrophic Lateral SclerosisItpr2
ANHIDROSIS, ISOLATED, WITH NORMAL SWEAT GLANDSItpr2
Aniridia cerebellar ataxia mental deficiencyItpr1
Arrhythmias, CardiacCacna1c , Cacnb2 , Ryr2
Arrhythmogenic Right Ventricular DysplasiaRyr2
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1Ryr2
Arrhythmogenic Right Ventricular Dysplasia, Familial, 2Ryr2
Arthritis, JuvenileStim1
AsthmaItpr1
AtaxiaCacna1a , Cacnb4 , Itpr1
Autism Spectrum DisorderRyr2
Autistic DisorderCacna1c , Cacna1h
Axial Myopathy, Late-OnsetRyr1
Bipolar DisorderCacna1c
BlepharoptosisRyr1
Brain IschemiaSlc8a1 , Slc8a2 , Slc8a3
Brody MyopathyAtp2a1
Brugada SyndromeCacna1c , Cacnb2
Brugada Syndrome 3Cacna1c
Brugada Syndrome 4Cacnb2
Carcinoma, Adenoid CysticSlc24a3
Carcinoma, Ductal, BreastCacna1c , Cacna1h
Carcinoma, Renal CellRyr1
Cardiac Complexes, PrematureCacna1c , Cacnb2 , Ryr2
Cardiac Conduction Defect, NonspecificCacnb2
CardiomegalyAtp2a2 , Itpr2 , Slc8a1
CardiomyopathiesRyr2
Cardiomyopathy, DilatedItpr1 , Ryr2
Cardiomyopathy, Dilated, with Left Ventricular NoncompactionRyr2
Cardiomyopathy, HypertrophicRyr2
Cardiomyopathy, Hypertrophic, FamilialRyr2
Cardiomyopathy, RestrictiveCacna1c
CataractAtp2b1
Cerebral HemorrhageSlc24a1 , Slc8b1
ClubfootRyr1
Color Vision DefectsCnga3 , Cngb3
Cone-Rod Dystrophy, X-Linked, 3Cacna1f
Corneal OpacityMcoln1
Coronary Artery DiseaseAtp2b1
Darier DiseaseAtp2a2
Darier Disease, Acral Hemorrhagic TypeAtp2a2
Darier Disease, SegmentalAtp2a2
DeafnessCacna1d
Deafness, Autosomal Recessive 12Atp2b2
Death, Sudden, CardiacCacna1c , Ryr2
Developmental DisabilitiesCacna1a
Diabetes MellitusItpr1
Diabetes Mellitus, ExperimentalAtp2a2 , Atp2a3 , Ryr2 , Slc8a1
Diabetes Mellitus, Type 1Itpr3
Diabetes Mellitus, Type 2Atp2a2 , Atp2a3
Diabetic CardiomyopathiesAtp2a2 , Ryr2
Diastolic DysfunctionRyr2
Drug-Induced Liver InjuryItpr1
DwarfismRyr1
DysarthriaCacna1a
Dyskinesia, Drug-InducedCacna1d
DystoniaAtp2b4
Dystonia 23Cacna1b
Encephalomyelitis, Autoimmune, ExperimentalCacna1b
Epilepsies, PartialCacna1h
EpilepsyCacna1c , Itpr1
Epilepsy, AbsenceCacna1a , Cacna1h
Epilepsy, GeneralizedCacna1a , Cacnb4
Epilepsy, Idiopathic GeneralizedCacnb4
Epilepsy, Temporal LobeCacna1a
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 42Cacna1a
Episodic AtaxiaCacnb4
Episodic Ataxia with NystagmusCacna1a
Episodic Ataxia, Type 5Cacnb4
Exfoliation SyndromeCacna1a
Genetic Diseases, InbornAtp2b3 , Cacna1a , Cacna1c , Cacna1e , Cacna1g , Itpr1 , Ryr1 , Ryr2 , Ryr3
Heart ArrestCacnb2 , Itpr1 , Ryr2
Heart DiseasesAtp2a2 , Ryr2
Heart FailureAtp2a1 , Atp2a2 , Ryr2 , Slc8a1
Hemiplegic Migraine, Familial Type 1Cacna1a
Hip Dislocation, CongenitalRyr1
HirsutismCacna1g
Huntington DiseaseItpr1
HyperaldosteronismAtp2b3 , Cacna1d , Cacna1h
HYPERALDOSTERONISM, FAMILIAL, TYPE IVCacna1h
HyperalgesiaCacna1b , Cacna1h
HyperglycemiaCacna1e
HypertensionAtp2a3 , Atp2b1 , Atp2b3 , Cacna1c , Orai1 , Slc8a1 , Stim1
Hypertension, PulmonarySlc8a1
Hypertrophy, Left VentricularCacna1g
HypoglycemiaCacna1c
Hypokalemic Periodic ParalysisCacna1s
Hypokalemic Periodic Paralysis, Type 1Cacna1s
HypothyroidismAtp2a2
Hypoxia, BrainItpr1 , Itpr2
Immune Dysfunction with T-Cell Inactivation due to Calcium Entry Defect 1Orai1
Immune Dysfunction with T-Cell Inactivation due to Calcium Entry Defect 2Stim1
Immunologic Deficiency SyndromesCacna1c
Infant DeathRyr2
Intellectual DisabilityCacna1g , Mcoln1
King Denborough SyndromeRyr1
Lambert-Eaton Myasthenic SyndromeCacna1b
Language Development DisordersMcoln1
Leukomalacia, PeriventricularMcoln1
Limb Deformities, CongenitalCacna1c
Long QT SyndromeCacna1c , Cacnb2 , Ryr2
Malformations of Cortical Development, Group IICacna1f
Malignant HyperthermiaCacna1s , Ryr1
Malignant Hyperthermia Susceptibility Type 1Cacna1s , Ryr1
Malignant Hyperthermia Susceptibility Type 5Cacna1s
Malignant hypothermiaRyr1
MegacolonSlc8a1
MelanomaCacna1c , Cacna1s , Cnga3 , Ryr1 , Ryr2
Melanoma, Cutaneous Malignant, Susceptibility To, 1Cacna1c , Cacna1s , Cnga3 , Ryr1 , Ryr2
Memory DisordersCacna1d
Mesothelioma, MalignantRyr2
Migraine DisordersCacna1a
Migraine with AuraCacna1a
Migraine, Sporadic HemiplegicCacna1a
Minicore Myopathy with External OphthalmoplegiaRyr1
MucolipidosesMcoln1
Multiple SclerosisCacna1b
Muscle WeaknessRyr1
Muscular DiseasesRyr1
Muscular DystrophiesRyr1
Muscular Dystrophy, Congenital, Producing ArthrogryposisRyr1
Myasthenic Syndromes, CongenitalRyr1
Myocardial IschemiaRyr2 , Slc8a1
Myocardial Reperfusion InjuryAtp2a2 , Slc8a1
Myocardial StunningAtp2a2
Myoclonic Epilepsy, JuvenileCacnb4
Myopathies, Structural, CongenitalOrai1 , Ryr1 , Stim1
Myopathy, Central CoreRyr1
Myopathy, Congenital, with Fiber-Type DisproportionRyr1
Myopathy, Mitochondrial Progressive, with Congenital Cataract, Hearing Loss, and Developmental DelayRyr1
MyopiaCacna1f
Myotonia CongenitaRyr1
Neurodegenerative DiseasesItpr1
Neurodevelopmental DisordersItpr1
Neuromuscular Disease, Congenital, with Uniform Type 1 FiberRyr1
Niemann-Pick Disease, Type AItpr1
Night Blindness, Congenital StationaryCacna1f , Slc24a1
Night Blindness, Congenital Stationary, Type 1DSlc24a1
Night Blindness, Congenital Stationary, Type 2ACacna1f
Nystagmus, PathologicCngb3
OligospermiaTpcn1
Ovarian CystsCacnb3
Paroxysmal ventricular fibrillationCacna1c , Cacnb2 , Ryr2
Pemphigus, Benign FamilialAtp2c1
Peripheral Nervous System DiseasesCacna1b
Pleomorphic Xanthoastrocytoma Orai2
Polycystic Ovary SyndromeTrpv6
Polymorphic Catecholergic Ventricular TachycardiaRyr2
PresbycusisCacna1d
Primary Aldosteronism, Seizures, and Neurologic AbnormalitiesCacna1d
Prostatic NeoplasmsAtp2b4 , Cacna1d , Cnga1 , Itpr1 , Slc8a3
Reperfusion InjuryItpr1 , Slc8a1 , Slc8a2 , Slc8a3
Respiratory InsufficiencyCacna1s , Ryr1
Retinal DystrophiesCnga1 , Cnga3 , Cngb1 , Cngb3
Retinitis PigmentosaCnga1 , Cngb1
Retinitis Pigmentosa 45Cngb1
Retinitis Pigmentosa 49Cnga1 , Cngb1
Rigid Spine SyndromeRyr1
Sacral Defect and Anterior Sacral MeningoceleRyr1
Salivary Gland NeoplasmsSlc24a3
SchizophreniaAtp2a1 , Cacna1c , Cacna1h
Schizophrenia, ChildhoodRyr2
Sciatic NeuropathyCacna1d
ScoliosisRyr1
SeizuresCacna1a , Slc8a1 , Slc8a3
Short Qt SyndromeCacna1c , Cacnb2
Sinoatrial Node Dysfunction and DeafnessCacna1d
Skin/Hair/Eye Pigmentation, Variation In, 10Tpcn2
Skin/Hair/Eye Pigmentation, Variation In, 6Slc24a4
Smith-Magenis SyndromeCacna1g , Cacnb1
Spastic Paraplegia 39, Autosomal RecessiveMcoln1
Spastic Paraplegia, HereditaryMcoln1
Spinocerebellar Ataxia 15Itpr1
Spinocerebellar Ataxia 29Itpr1
SPINOCEREBELLAR ATAXIA 42Cacna1g
Spinocerebellar Ataxia, X-Linked 1Atp2b3
Spinocerebellar AtaxiasCacna1a , Itpr1
Stargardt Disease 1Cngb3
Status EpilepticusAtp2a2 , Slc8a1 , Slc8a2 , Slc8a3
Stormorken SyndromeStim1
TachycardiaRyr2
Tachycardia, VentricularCacna1c , Ryr2
Thyrotoxic Periodic ParalysisCacna1s
Thyrotoxic Periodic Paralysis, Susceptibility To, 1Cacna1s
Timothy SyndromeCacna1c
Ventricular Dysfunction, LeftAtp2a2
Ventricular FibrillationCacnb2 , Ryr2
Ventricular Fibrillation, Paroxysmal Familial, 1Cacna1c , Ryr2
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1Ryr2
Ventricular Tachycardia, FamilialRyr2
Weight GainStim2
Pathway Annotations Associated with Genes in the calcium transport pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
alfentanil pharmacodynamics pathwayCacna1a , Cacnb1
altered visual phototransduction pathwayCnga1 , Cngb1
Alzheimer disease pathwayAtp2a1 , Atp2a2 , Atp2a3 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Itpr1 , Itpr2 , Itpr3 , Ryr3
amiodarone pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
amlodipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
arrhythmogenic right ventricular cardiomyopathy pathwayAtp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Ryr2 , Slc8a1
atenolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
betaxolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
bisoprolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
bupivacaine pharmacodynamics pathwayCacna1a , Cacnb1
bupranolol drug pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
bupranolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
buprenorphine pharmacodynamics pathwayCacna1a , Cacnb1
calcium transport pathwayAtp2a1 , Atp2a2 , Atp2a3 , Atp2b1 , Atp2b2 , Atp2b3 , Atp2b4 , Atp2c1 , Atp2c2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Cnga1 , Cnga2 , Cnga3 , Cnga4 , Cngb1 , Cngb3 , Itpr1 , Itpr2 , Itpr3 , Mcoln1 , Mcu , Orai1 , Orai2 , Orai3 , Ryr1 , Ryr2 , Ryr3 , Slc24a1 , Slc24a2 , Slc24a3 , Slc24a4 , Slc8a1 , Slc8a2 , Slc8a3 , Slc8b1 , Stim1 , Stim2 , Tpcn1 , Tpcn2 , Trpv5 , Trpv6
calcium/calcium-mediated signaling pathwayAtp2a1 , Atp2a2 , Atp2a3 , Atp2b1 , Atp2b2 , Atp2b3 , Atp2b4 , Atp2c1 , Atp2c2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Cnga1 , Cnga2 , Cnga3 , Cnga4 , Cngb1 , Cngb3 , Itpr1 , Itpr2 , Itpr3 , Mcoln1 , Mcu , Orai1 , Orai2 , Orai3 , Ryr1 , Ryr2 , Ryr3 , Slc24a1 , Slc24a2 , Slc24a3 , Slc24a4 , Slc8a1 , Slc8a2 , Slc8a3 , Slc8b1 , Stim1 , Stim2 , Tpcn1 , Tpcn2 , Trpv5 , Trpv6
calcium/calmodulin dependent kinase 2 signaling pathwayCacna1c , Cacnb2 , Ryr2
carvedilol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
chloroprocaine pharmacodynamics pathwayCacna1a , Cacnb1
citalopram pharmacodynamics pathwayCacna1a , Cacnb1
cocaine pharmacodynamics pathwayCacna1a , Cacnb1
codeine and morphine pharmacodynamics pathwayCacna1a , Cacnb1
desipramine pharmacodynamics pathwayCacna1a , Cacnb1
dilated cardiomyopathy pathwayAtp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Ryr2 , Slc8a1
diltiazem pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
diphenoxylate pharmacodynamics pathwayCacna1a , Cacnb1
disopyramide pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
dobutamine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
escitalopram pharmacodynamics pathwayCacna1a , Cacnb1
esmolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
ethylmorphine pharmacodynamics pathwayCacna1a , Cacnb1
felodipine pharmacokinetics pathwayCacna1c , Cacnb1
fentanyl pharmacodynamics pathwayCacna1a , Cacnb1
flecainde pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
fluoxetine pharmacodynamics pathwayCacna1a , Cacnb1
fosphenytoin pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
gliclazide pharmacodynamics pathwayCacna1a , Cacnb1
glutamate signaling pathwayCacna1a , Cacna1c , Cacna1d , Itpr1 , Itpr2 , Itpr3
glyburide pharmacodynamics pathwayCacna1a , Cacnb1
gonadotropin-releasing hormone signaling pathwayCacna1c , Cacna1d , Cacna1f , Cacna1s , Itpr1 , Itpr2 , Itpr3
heroin pharmacodynamics pathwayCacna1a , Cacnb1
Huntington disease pathwayItpr1
hydrocodone pharmacodynamics pathwayCacna1a , Cacnb1
hydromorphone pharmacodynamics pathwayCacna1a , Cacnb1
hypertrophic cardiomyopathy pathwayAtp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Ryr2 , Slc8a1
ibutilide pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
imipramine pharmacodynamics pathwayCacna1a , Cacnb1
insulin secretion pathwayCacna1a , Cacna1c , Cacna1d
isoprenaline pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
isradipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
levacetylmethadol pharmacodynamics pathwayCacna1a , Cacnb1
levobunolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
levobupivacaine phgarmacodynamics pathwayCacna1a , Cacnb1
levorphanol pharmacodynamics pathwayCacna1a , Cacnb1
lidocaine pharmacodynamics pathwayAtp2a2 , Cacna1a , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
long term depressionCacna1a , Itpr1 , Itpr2 , Itpr3
long term potentiationCacna1c , Itpr1 , Itpr2 , Itpr3
mepivacaine pharmacodynamics pathwayCacna1a , Cacnb1
methadone pharmacodynamics pathwayCacna1a , Cacnb1
metoprolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
mexiletine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
mitogen activated protein kinase signaling pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4
nadolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nalbuphine pharmacodynamics pathwayCacna1a , Cacnb1
naloxone pharmacodynamics pathwayCacna1a , Cacnb1
naltrexone pharmacodynamics pathwayCacna1a , Cacnb1
nebivolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nicotine pharmacodynamics pathwayCacna1a , Cacnb1
nifedipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nimodipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nisoldipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nitrendipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
oxybuprocaine pharmacodynamics pathwayCacna1a , Cacnb1
oxycodone pharmacodynamics pathwayCacna1a , Cacnb1
oxymorphone pharmacodynamics pathwayCacna1a , Cacnb1
penbutolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
pentazocine pharmacodynamics pathwayCacna1a , Cacnb1
phenytoin pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
phosphatidylinositol 3-kinase signaling pathwayItpr1 , Itpr2 , Itpr3
pindolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
potassium channel inhibitors pharmacodynamics pathwayCacna1a , Cacnb1
prilocaine pharmacodynamics pathwayCacna1a , Cacnb1
procainamide pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
procaine pharmacodynamics pathwayCacna1a , Cacnb1
propranolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
quinidine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
remifentanil pharmacodynamics pathwayCacna1a , Cacnb1
retinitis pigmentosa pathwayCnga1 , Cngb1
ropivacaine pharmacodynamics pathwayCacna1a , Cacnb1
sotalol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
timolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
tramadol pharmacodynamics pathwayCacna1a , Cacnb1
type 2 diabetes mellitus pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g
verapamil pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
visual phototransduction pathwayCnga1 , Cnga3 , Cngb1 , Cngb3 , Slc24a1 , Slc24a2
Phenotype Annotations Associated with Genes in the calcium transport pathway

References Associated with the calcium transport pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: