GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Itpr2 | affects methylation | ISO | ITPR2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of ITPR2 intron; Benzo(a)pyrene affects the methylation of ITPR2 promoter | PMID:27901495 PMID:30157460 | Itpr2 | decreases expression | ISO | ITPR2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of ITPR2 mRNA; Benzo(a)pyrene results in decreased expression of ITPR2 protein | PMID:20064835 PMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291 PMID:32717239 | Itpr2 | decreases expression | ISO | Itpr2 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of ITPR2 mRNA | PMID:19770486 PMID:21715664 | Itpr2 | decreases methylation | ISO | ITPR2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of ITPR2 3' UTR | PMID:27901495 | Itpr2 | increases methylation | ISO | Itpr2 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of ITPR2 exon; Benzo(a)pyrene results in increased methylation of ITPR2 intron | PMID:27901495 | Itpr2 | multiple interactions | ISO | Itpr2 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene promotes the reaction [AHR protein binds to ITPR2 promoter] | PMID:19654925 | |
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