Gene: Irs2 (insulin receptor substrate 2) Rattus norvegicus
Symbol: Irs2
Name: insulin receptor substrate 2
Description: ENCODES a protein that exhibits 14-3-3 protein binding; insulin receptor binding; phosphatidylinositol 3-kinase binding; INVOLVED IN cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to peptide; PARTICIPATES IN insulin signaling pathway; erythropoietin signaling pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental; Fetal Growth Retardation; Non-alcoholic Fatty Liver Disease; FOUND IN cytosol (ortholog); plasma membrane (ortholog); protein complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 4PS; IRS-2; LOC207125; similar to aldolase; tyrosine kinase substrate
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01683,824,515 - 83,848,569 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01683,287,185 - 83,311,239 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41683,379,987 - 83,404,220 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11683,367,312 - 83,368,308 (+)NCBI
Celera1676,286,571 - 76,310,806 (+)NCBI
Cytogenetic Map16q12.5NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Irs2
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 69316
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2016-09-13
Status: ACTIVE