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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1558200 | 6480464 | Ethinyl Estradiol affects the expression of ANG1 mRNA | CTD | PMID:17555576 | 17beta-estradiol | increases expression | ISO | RGD:1349500 | 6480464 | Estradiol results in increased expression of ANG mRNA | CTD | PMID:19619570 PMID:19429434 | 17beta-estradiol | increases expression | ISO | RGD:1349500 | 6480464 | Estradiol results in increased expression of ANG mRNA | CTD | PMID:19429434 PMID:19619570 | 17beta-estradiol | decreases expression | ISO | RGD:1349500 | 6480464 | Estradiol results in decreased expression of ANG mRNA | CTD | PMID:20106945 | 17beta-estradiol | multiple interactions | ISO | RGD:1349500 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ANG mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ANG1 mRNA | CTD | PMID:16495355 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1558200 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ANG mRNA | CTD | PMID:12167310 PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1349500 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ANG mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1349500 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ANG mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1349500 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ANG mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1558200 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ANG mRNA | CTD | PMID:12167310 | 5-fluorouracil | affects response to substance | ISO | RGD:1349500 | 6480464 | ANG protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | aflatoxin B1 | affects expression | ISO | RGD:1349500 | 6480464 | Aflatoxin B1 affects the expression of ANG protein | CTD | PMID:20106945 | benzo[a]pyrene | multiple interactions | ISO | RGD:1558200 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of ANG mRNA | CTD | PMID:21715664 | caffeine | decreases expression | ISO | RGD:1349500 | 6480464 | Caffeine results in decreased expression of ANG mRNA | CTD | PMID:11793227 | ciglitazone | multiple interactions | ISO | RGD:1349500 | 6480464 | [ciglitazone binds to PPARG protein alternative form] which results in increased expression of ANG mRNA | CTD | PMID:16197558 | cisplatin | increases expression | ISO | RGD:1349500 | 6480464 | Cisplatin results in increased expression of ANG mRNA | CTD | PMID:19561079 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ANG1 mRNA | CTD | PMID:17602206 | cobalt dichloride | multiple interactions | ISO | RGD:1349500 | 6480464 | zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANG mRNA] | CTD | PMID:22202117 | cobalt dichloride | increases secretion | ISO | RGD:1349500 | 6480464 | cobaltous chloride results in increased secretion of ANG protein | CTD | PMID:16490744 | cobalt dichloride | increases expression | ISO | RGD:1349500 | 6480464 | cobaltous chloride results in increased expression of ANG mRNA | CTD | PMID:22202117 | copper(2+) sulfate | decreases expression | ISO | RGD:1349500 | 6480464 | Copper Sulfate results in decreased expression of ANG mRNA | CTD | PMID:19549813 | cyclosporin A | affects expression | ISO | RGD:1349500 | 6480464 | Cyclosporine affects the expression of ANG mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:1349500 | 6480464 | Cyclosporine results in increased expression of ANG mRNA | CTD | PMID:21632981 PMID:22147139 | cyclosporin A | increases expression | ISO | RGD:1349500 | 6480464 | Cyclosporine results in increased expression of ANG mRNA | CTD | PMID:22147139 | diazoxide | increases expression | ISO | RGD:1558200 | 6480464 | Isoproterenol results in increased expression of ANG mRNA | CTD | PMID:20003209 | diazoxide | increases expression | ISO | RGD:1558200 | 6480464 | Isoproterenol results in increased expression of ANG1 mRNA | CTD | PMID:18089841 | diazoxide | multiple interactions | ISO | RGD:1558200 | 6480464 | Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG1 mRNA] | CTD | PMID:18089841 | dioxygen | increases secretion | ISO | RGD:1349500 | 6480464 | Oxygen deficiency results in increased secretion of ANG protein | CTD | PMID:16490744 | dioxygen | increases expression | ISO | RGD:1349500 | 6480464 | Oxygen deficiency results in increased expression of ANG mRNA | CTD | PMID:16490744 | disodium selenite | increases expression | ISO | RGD:1349500 | 6480464 | Sodium Selenite results in increased expression of ANG mRNA | CTD | PMID:18175754 | doxycycline | multiple interactions | ISO | RGD:1558200 | 6480464 | Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG1 mRNA] | CTD | PMID:18089841 | enalapril | decreases expression | ISO | RGD:1349500 | 6480464 | Enalapril results in decreased expression of ANG protein | CTD | PMID:3038326 | furosemide | affects expression | EXP | | 6480464 | Furosemide affects the expression of ANG mRNA | CTD | PMID:16526316 | isoprenaline | increases expression | ISO | RGD:1558200 | 6480464 | Isoproterenol results in increased expression of ANG1 mRNA | CTD | PMID:18089841 | isoprenaline | increases expression | ISO | RGD:1558200 | 6480464 | Isoproterenol results in increased expression of ANG mRNA | CTD | PMID:20003209 | isoprenaline | multiple interactions | ISO | RGD:1558200 | 6480464 | Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG1 mRNA] | CTD | PMID:18089841 | menadione | affects expression | ISO | RGD:1349500 | 6480464 | Vitamin K 3 affects the expression of ANG mRNA | CTD | PMID:20044591 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ANG1 mRNA | CTD | PMID:17602206 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of ANG1 mRNA | CTD | PMID:19638242 | paracetamol | decreases expression | ISO | RGD:1349500 | 6480464 | Acetaminophen results in decreased expression of ANG mRNA | CTD | PMID:11793227 | paracetamol | affects expression | ISO | RGD:1349500 | 6480464 | Acetaminophen affects the expression of ANG mRNA | CTD | PMID:21420995 | paracetamol | affects expression | ISO | RGD:1558200 | 6480464 | Acetaminophen affects the expression of ANG mRNA | CTD | PMID:17562736 | pirinixic acid | decreases expression | ISO | RGD:1558200 | 6480464 | pirinixic acid results in decreased expression of ANG mRNA | CTD | PMID:20059764 | pirinixic acid | multiple interactions | ISO | RGD:1558200 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ANG mRNA] | CTD | PMID:20059764 | pirinixic acid | increases expression | ISO | RGD:1558200 | 6480464 | pirinixic acid results in increased expression of ANG mRNA | CTD | PMID:17426115 | progesterone | affects expression | ISO | RGD:1558200 | 6480464 | Progesterone affects the expression of ANG1 mRNA | CTD | PMID:17251523 | propiconazole | decreases expression | ISO | RGD:1558200 | 6480464 | propiconazole results in decreased expression of ANG1 mRNA | CTD | PMID:21278054 | quercetin | decreases expression | ISO | RGD:1349500 | 6480464 | Quercetin results in decreased expression of ANG mRNA | CTD | PMID:21632981 | raloxifene | increases expression | ISO | RGD:1349500 | 6480464 | Raloxifene results in increased expression of ANG mRNA | CTD | PMID:19429434 | thioacetamide | decreases expression | ISO | RGD:1349500 | 6480464 | Thioacetamide results in decreased expression of ANG mRNA | CTD | PMID:11793227 | valproic acid | increases expression | ISO | RGD:1349500 | 6480464 | Valproic Acid results in increased expression of ANG mRNA | CTD | PMID:19101580 | zinc dichloride | multiple interactions | ISO | RGD:1349500 | 6480464 | zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANG mRNA] | CTD | PMID:22202117 | | 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Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
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Bodner-Adler B, etal., Anticancer Res. 2001 Jan-Feb;21(1B):809-12. |
| 3. |
Campo L, etal., J Pathol. 2005 Apr;205(5):585-91. |
| 4. |
Chopra V, etal., Cancer J Sci Am. 1996 Sep-Oct;2(5):279-85. |
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Chopra V, etal., J Cancer Res Clin Oncol. 1997;123(3):167-72. |
| 6. |
Corrado L, etal., J Neurol Sci. 2007 Jul 15;258(1-2):123-7. Epub 2007 Apr 25. |
| 7. |
Eissa S, etal., Clin Biochem. 2004 Sep;37(9):803-10. |
| 8. |
Greenway MJ, etal., Nat Genet. 2006 Apr;38(4):411-3. Epub 2006 Feb 26. |
| 9. |
Huang L, etal., Eur Neurol. 2007;58(4):224-7. Epub 2007 Sep 7. |
| 10. |
Huang L, etal., J Neurol Sci. 2009 Oct 15;285(1-2):220-3. Epub 2009 Aug 8. |
| 11. |
Hwang KS, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):e23-6. |
| 12. |
Ibaragi S, etal., Clin Cancer Res. 2009 Mar 15;15(6):1981-8. Epub 2009 Mar 10. |
| 13. |
Kim YN and Kim do H, Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):116-20. Epub 2012 Mar 15. |
| 14. |
Kristan SS, etal., Clin Exp Allergy. 2009 Mar;39(3):354-60. Epub 2009 Jan 22. |
| 15. |
Kristan SS, etal., Scand J Immunol. 2012 Jan;75(1):109-14. doi: 10.1111/j.1365-3083.2011.02623.x. |
| 16. |
Kurki EM, etal., Nutr Metab (Lond). 2012 Jun 29;9(1):64. |
| 17. |
Liote F, etal., Clin Exp Immunol. 2003 Apr;132(1):163-8. |
| 18. |
Liu XH, etal., Microvasc Res. 2008 May;76(1):23-30. Epub 2008 Mar 18. |
| 19. |
Lukesova S, etal., Folia Biol (Praha). 2008;54(4):134-40. |
| 20. |
Miyake H, etal., Cancer. 1999 Jul 15;86(2):316-24. |
| 21. |
Montero S, etal., Clin Cancer Res. 1998 Sep;4(9):2161-8. |
| 22. |
Moreau C, etal., Amyotroph Lateral Scler. 2009 Jun;10(3):175-81. |
| 23. |
Oikonomou KA, etal., Inflamm Bowel Dis. 2011 Apr;17(4):963-70. doi: 10.1002/ibd.21410. |
| 24. |
Olson KA, etal., Int J Cancer. 2002 Apr 20;98(6):923-9. |
| 25. |
Persad R, etal., J Pediatr Gastroenterol Nutr. 2012 Feb 10. |
| 26. |
Piccoli R, etal., Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4579-83. |
| 27. |
Reverter JL, etal., Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1378-82. Epub 2008 Oct 31. |
| 28. |
RGD automated data pipeline |
| 29. |
RGD automated import pipeline for gene-chemical interactions |
| 30. |
RGD Automated Pipelines |
| 31. |
RGD comprehensive gene curation |
| 32. |
Rodriguez-Munoz Y, etal., Aliment Pharmacol Ther. 2011 Oct;34(8):960-71. doi: 10.1111/j.1365-2036.2011.04807.x. Epub 2011 Aug 17. |
| 33. |
Shaarawy M, etal., Clin Chem Lab Med. 2003 Mar;41(3):306-10. |
| 34. |
Shimoyama S, etal., Cancer Res. 1996 Jun 15;56(12):2703-6. |
| 35. |
Steff AM, etal., Am J Reprod Immunol. 2004 Feb;51(2):166-73. |
| 36. |
Steidinger TU, etal., J Neurochem. 2011 Feb;116(3):334-41. doi: 10.1111/j.1471-4159.2010.07112.x. Epub 2010 Dec 22. |
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Suzumori N, etal., Fertil Steril. 2004 Jul;82(1):93-6. |
| 38. |
van Es MA, etal., Ann Neurol. 2011 Dec;70(6):964-73. doi: 10.1002/ana.22611. |
| 39. |
Weiner HL, etal., Science. 1987 Jul 17;237(4812):280-2. |
| 40. |
Zhao H, etal., Cancer. 2005 Jul 1;104(1):30-5. |
References - uncurated
RGD Disease Portals| Ang has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ang (Rattus norvegicus) |
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| ANG (Homo sapiens) |
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| Ang (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001006992 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06082827 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01082897 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY395869 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY665826 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001006992 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001006993 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001006993 | (Get FASTA) |
| GenBank Protein | AAR28758 | (Get FASTA) |
| AAV87193 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000043032 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000060200 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000064029 | UniProtKB/TrEMBL |
| Entrez Gene | 305843 | ENTREZGENE |
| Gene3D-CATH | RNaseA | UniProtKB/TrEMBL |
| InterPro | RNaseA | UniProtKB/TrEMBL |
| RNaseA_AS | UniProtKB/TrEMBL | |
| RNaseA_domain | UniProtKB/TrEMBL | |
| IPI | IPI00365861 | UniProtKB/TrEMBL |
| IPI00553855 | UniProtKB/TrEMBL | |
| KEGG Report | rno:305843 | ENTREZGENE, UniProtKB/TrEMBL |
| PANTHER | RNaseA | UniProtKB/TrEMBL |
| Pfam | RnaseA | UniProtKB/TrEMBL |
| PRINTS | RIBONUCLEASE | UniProtKB/TrEMBL |
| ProDom | RNaseA | UniProtKB/TrEMBL |
| PROSITE | RNASE_PANCREATIC | UniProtKB/TrEMBL |
| SMART | RNAse_Pc | UniProtKB/TrEMBL |
| Superfamily-SCOP | RNaseA | UniProtKB/TrEMBL |
| UniGene | Rn.217453 | ENTREZGENE |
| UniProt | Q5GAM6_RAT | UniProtKB/TrEMBL |
| Q5WRG2_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2010-04-20 | Ang | angiogenin, ribonuclease, RNase A family, 5 | Ang1 | angiogenin, ribonuclease A family, member 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-11-20 | Ang1 | angiogenin, ribonuclease A family, member 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Ang | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1594539 |
| Created: | 2006-11-20 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




