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Pathways
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VASOPRESSIN SIGNALING PATHWAY (PW:0000491)

View Ontology Report

Description
Vasopressin (Avp) acts as an antidiuretic hormone and as a neuromodulator and neurotransmitter. Avp exerts its actions by binding to two receptor types, G-protein coupled receptors coupling to particular G alpha subunits of heterotrimeric G proteins. Avp plays important roles in the cardiovascular and autonomic function by signaling via receptor type 1a (Avpr1a). The receptor couples to Gq alpha subunit leading to stimulation of phospholipase C beta isoforms, subsequent generation of seco

Pathway Diagram:

Ariadne Genomics Inc. vasopressin signaling pathway via receptor type 2 G protein mediated signaling pathway via Galphas family vasopressin signaling pathway via receptor type 1 G protein mediated signaling pathway via Galphaq family protein kinase A (PKA) signaling pathway Avpr1a Avpr2 vasoconstriction autonomic functions protein kinase A (PKA) signaling pathway --+> Aqp2 expression Avp Aqp2 expression ---> water reabsorption Aqp2 translocation ---> water reabsorption protein kinase A (PKA) signaling pathway --+> Aqp2 translocation Aqp2 expression Aqp2 translocation Avpr2 --+> protein kinase A (PKA) signaling pathway Avpr1a --+> vasoconstriction Avp ---- Avpr2 Avp ---- Avpr1a water reabsorption second messengers generation [Ca] elevation behavioral effects
GO TO:

Genes in Pathway:
show annotations for term's descendants           Sort by:
vasopressin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy6 adenylate cyclase 6 IMP
ISO
IDA		 RGD PMID:18971210 PMID:18431594 PMID:15579502 RGD:2312654, RGD:2312656, RGD:2313211 NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Akap7 A-kinase anchoring protein 7 IDA
ISO		 RGD PMID:15037626 PMID:18431594 RGD:1303982, RGD:2312656 NCBI chr 1:21,906,503...22,168,663
Ensembl chr 1:20,087,373...20,217,797 		JBrowse link
G Aqp2 aquaporin 2 IDA
TAS
IMP		 RGD PMID:15037626 PMID:18431594 PMID:15579502 PMID:18971210 RGD:1303982, RGD:2312656, RGD:2313211, RGD:2312654 NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Avp arginine vasopressin TAS
ISO
IMP		 RGD PMID:12942143 PMID:18431594 PMID:14624682 PMID:18299204 RGD:1358326, RGD:2312656, RGD:1579891, RGD:2301920 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A TAS
ISO		 RGD PMID:12942143 PMID:14624682 RGD:1358326, RGD:1579891 NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO
TAS
IDA		 RGD PMID:14624682 PMID:7624319 PMID:19047484 RGD:1579891, RGD:61542, RGD:2312649 NCBI chr13:45,598,116...45,611,680
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Avpr2 arginine vasopressin receptor 2 TAS
ISO
IMP		 RGD PMID:11882591 PMID:18431594 PMID:14624682 PMID:18971210 RGD:628560, RGD:2312656, RGD:1579891, RGD:2312654 NCBI chr  X:156,785,009...156,787,477
Ensembl chr  X:151,633,522...151,635,989 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:14624682 RGD:1579891 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gnas GNAS complex locus IMP
ISO
IDA		 RGD PMID:18971210 PMID:18431594 PMID:15579502 PMID:14624682 RGD:2312654, RGD:2312656, RGD:2313211, RGD:1579891 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Myo5b myosin Vb IMP
TAS		 RGD PMID:17156409 PMID:18431594 RGD:2312655, RGD:2312656 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745 		JBrowse link
G Pde4d phosphodiesterase 4D ISO RGD PMID:18431594 RGD:2312656 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO RGD PMID:17156409 PMID:18431594 RGD:2312655, RGD:2312656 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 ISO RGD PMID:17156409 PMID:18431594 RGD:2312655, RGD:2312656 NCBI chr 1:268,908,825...269,080,691
Ensembl chr 1:258,923,873...259,093,752 		JBrowse link
G Sipa1 signal-induced proliferation-associated 1 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 1:212,367,867...212,379,952
Ensembl chr 1:202,938,580...202,950,591 		JBrowse link
G Snap23 synaptosome associated protein 23 TAS RGD PMID:18431594 RGD:2312656 NCBI chr 3:127,966,184...127,999,929
Ensembl chr 3:107,514,131...107,544,320 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 ISO RGD PMID:18431594 RGD:2312656 NCBI chr10:54,292,423...54,296,657
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
vasopressin signaling pathway via receptor type 1 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin ISO RGD PMID:14624682 RGD:1579891 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:14624682 RGD:1579891 NCBI chr13:45,598,116...45,611,680
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:14624682 RGD:1579891 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
vasopressin signaling pathway via receptor type 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00322 NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:34,375,895...34,822,236 		JBrowse link
G Adcy3 adenylate cyclase 3 IEA KEGG rno:04962 NCBI chr 6:32,819,602...32,923,174
Ensembl chr 6:27,124,828...27,203,686 		JBrowse link
G Adcy6 adenylate cyclase 6 ISO
IEA
IMP
IDA		 KEGG
RGD		 PMID:18431594 PMID:18971210 PMID:15579502 rno:04962, RGD:2312656, RGD:2312654, RGD:2313211 NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Adcy9 adenylate cyclase 9 IEA KEGG rno:04962 NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Akap7 A-kinase anchoring protein 7 ISO
IDA		 RGD PMID:18431594 PMID:15037626 RGD:2312656, RGD:1303982 NCBI chr 1:21,906,503...22,168,663
Ensembl chr 1:20,087,373...20,217,797 		JBrowse link
G Aqp2 aquaporin 2 TAS
IEA
IDA
IMP		 KEGG
RGD		 PMID:18431594 PMID:15037626 PMID:18971210 PMID:15579502 rno:04962, RGD:2312656, RGD:1303982, RGD:2312654, RGD:2313211 NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) IEA KEGG rno:04962 NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Aqp4 aquaporin 4 IEA KEGG rno:04962 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha IEA KEGG rno:04962 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta IEA KEGG rno:04962 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658 		JBrowse link
G Avp arginine vasopressin TAS
IEA
ISO		 KEGG
RGD		 PMID:18431594 PMID:14624682 rno:04962, RGD:2312656, RGD:1579891 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Avpr2 arginine vasopressin receptor 2 TAS
ISO
IEA
IMP		 SMPDB
KEGG
RGD		 PMID:18431594 PMID:18971210 PMID:14624682 SMP:00322 rno:04962, RGD:2312656, RGD:2312654, RGD:1579891 NCBI chr  X:156,785,009...156,787,477
Ensembl chr  X:151,633,522...151,635,989 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IEA KEGG rno:04962 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 IEA KEGG rno:04962 NCBI chr 3:98,408,240...98,449,104
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 IEA KEGG rno:04962 NCBI chr 4:66,874,623...66,990,962
Ensembl chr 4:65,907,655...66,023,763 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 IEA KEGG rno:04962 NCBI chr 7:9,273,320...9,281,755
Ensembl chr 7:8,622,614...8,631,048 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 IEA KEGG rno:04962 NCBI chr 2:177,987,981...177,994,568
Ensembl chr 2:175,690,335...175,695,932 		JBrowse link
G Dctn1 dynactin subunit 1 IEA KEGG rno:04962 NCBI chr 4:115,671,024...115,703,824
Ensembl chr 4:115,661,638...115,703,815 		JBrowse link
G Dctn2 dynactin subunit 2 IEA KEGG rno:04962 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543 		JBrowse link
G Dctn4 dynactin subunit 4 IEA KEGG rno:04962 NCBI chr18:53,982,355...54,009,409
Ensembl chr18:53,982,358...54,009,399 		JBrowse link
G Dctn5 dynactin subunit 5 IEA KEGG rno:04962 NCBI chr 1:186,120,415...186,137,146
Ensembl chr 1:176,689,156...176,705,906 		JBrowse link
G Dctn6 dynactin subunit 6 IEA KEGG rno:04962 NCBI chr16:58,077,595...58,096,604
Ensembl chr16:58,077,585...58,096,968 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 IEA KEGG rno:04962 NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:129,609,397...129,680,883 		JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 IEA KEGG rno:04962 NCBI chr 4:34,819,313...35,132,647
Ensembl chr 4:33,852,927...34,166,149 		JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 IEA KEGG rno:04962 NCBI chr 3:76,441,621...76,492,782
Ensembl chr 3:56,033,917...56,085,080 		JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 IEA KEGG rno:04962 NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:114,376,662...114,410,934 		JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 IEA KEGG rno:04962 NCBI chr19:538,207...561,110
Ensembl chr19:531,812...554,670 		JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 IEA KEGG rno:04962 NCBI chr 8:4,189,067...4,412,183
Ensembl chr 8:4,189,257...4,412,183 		JBrowse link
G Dync2li1 dynein cytoplasmic 2 light intermediate chain 1 IEA KEGG rno:04962 NCBI chr 6:15,745,350...15,778,166
Ensembl chr 6:9,992,541...10,025,336 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 IEA KEGG rno:04962 NCBI chr12:46,945,291...46,976,867
Ensembl chr12:41,312,367...41,314,741 		JBrowse link
G Dynll2 dynein light chain LC8-type 2 IEA KEGG rno:04962 NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805 		JBrowse link
G Fshr follicle stimulating hormone receptor ISO SMPDB SMP:00322 NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Gnas GNAS complex locus ISO
IEA
IMP
IDA		 SMPDB
KEGG
RGD		 PMID:18431594 PMID:18971210 PMID:15579502 PMID:14624682 SMP:00322 rno:04962, RGD:2312656, RGD:2312654, RGD:2313211, RGD:1579891 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gnb1 G protein subunit beta 1 ISO SMPDB SMP:00322 NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:166,075,629...166,142,124 		JBrowse link
G Gng12 G protein subunit gamma 12 ISO SMPDB SMP:00322 NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:96,010,952...96,134,712 		JBrowse link
G Myo5b myosin Vb TAS RGD PMID:18431594 RGD:2312656 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase IEA KEGG rno:04962 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
G Pde4d phosphodiesterase 4D ISO RGD PMID:18431594 RGD:2312656 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha IEA KEGG rno:04962 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta IEA
ISO		 KEGG
SMPDB		 SMP:00322 rno:04962 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit IEA KEGG rno:04962 NCBI chr  X:45,701,747...45,745,210
Ensembl chr  X:41,823,355...41,866,669 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO
IEA		 KEGG
RGD		 PMID:18431594 rno:04962, RGD:2312656 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:14,521,368...14,534,593 		JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 1:268,908,825...269,080,691
Ensembl chr 1:258,923,873...259,093,752 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 9:6,720,057...6,749,456
Ensembl chr 9:6,484,469...6,512,873 		JBrowse link
G Rab5b RAB5B, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 7:1,693,971...1,712,936
Ensembl chr 7:1,109,454...1,128,268 		JBrowse link
G Rab5c RAB5C, member RAS oncogene family IEA KEGG rno:04962 NCBI chr10:86,142,872...86,166,449
Ensembl chr10:85,642,809...85,666,103 		JBrowse link
G Sipa1 signal-induced proliferation-associated 1 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 1:212,367,867...212,379,952
Ensembl chr 1:202,938,580...202,950,591 		JBrowse link
G Snap23 synaptosome associated protein 23 TAS RGD PMID:18431594 RGD:2312656 NCBI chr 3:127,966,184...127,999,929
Ensembl chr 3:107,514,131...107,544,320 		JBrowse link
G Stx4 syntaxin 4 IEA KEGG rno:04962 NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:182,451,117...182,459,979 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 ISO
IEA		 KEGG
RGD		 PMID:18431594 rno:04962, RGD:2312656 NCBI chr10:54,292,423...54,296,657
Ensembl chr10:53,793,923...53,797,809 		JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayprotein kinase A (PKA) signaling pathwayprotein kinase A (PKA) signaling pathway
Pathwayvasopressin signaling pathway via receptor type 2vasopressin signaling pathway via receptor type 2

Pathway Gene Annotations

Disease Annotations Associated with Genes in the vasopressin signaling pathway
Disease TermsGene Symbols
acrodysostosisPde4d
Acrodysostosis 2, with or without Hormone ResistancePde4d
acromegalyGnas
ACTH-independent macronodular adrenal hyperplasiaGnas
ACTH-independent macronodular adrenal hyperplasia 1Gnas
ACTH-secreting pituitary adenomaAvpr1b
acute kidney failureAvp , Avpr1a
Adrenal Gland NeoplasmsGnas
adrenoleukodystrophyAvpr2
Aicardi-Goutieres Syndrome 3Sipa1
AlbuminuriaGnaq
alcohol dependenceAvp , Avpr1b
alcohol use disorderAvp
alcohol withdrawal syndromeAvp
Alzheimer's diseaseGnas
amnestic disorderAvp
amphetamine abuseMyo5b , Pde4d
amyotrophic lateral sclerosis type 8Gnas
Angina PectorisAvp
anxiety disorderAvp , Avpr1b
asthmaPde4d
autism spectrum disorderAvpr1a , Avpr1b
autistic disorderAvp , Avpr1a , Avpr1b , Avpr2
Autoinflammatory Disease, Familial, Behcet-Like-3Sipa1
autosomal dominant hypocalcemia 2Gna11
autosomal hemophilia AAvpr2
B-Cell Chronic Lymphocytic LeukemiaGnas
Bardet-Biedl syndromeSipa1
Barth syndromeAvpr2
bipolar disorderAvpr1b
blood coagulation diseaseGnaq
Bloom syndromeRab11a , Snap23
brachydactylyGnas
brain edemaAvpr1a
Brain InjuriesAvpr1a , Pde4d
Cafe-au-Lait SpotsGnas
Cardiac ArrhythmiasAvp
CardiomegalyAvpr1a , Gnaq
cardiomyopathyAqp2 , Avp , Avpr2
Cardiovascular AbnormalitiesGnaq
cerebral creatine deficiency syndrome 1Avpr2
Chemical and Drug Induced Liver InjuryAvp
ChloracneRab11a
cholangiocarcinomaGnas
Chromosome Xq28 Duplication SyndromeAvpr2
chronic myeloid leukemiaSipa1
CLOVES syndromeGna11
cocaine dependenceAvp
colorectal cancerRab11a , Snap23
common variable immunodeficiencyVamp2
congenital adrenal hyperplasiaAvpr1a , Avpr2
congenital heart diseaseGna11 , Gnaq
congestive heart failureAvp , Avpr2 , Gnaq
Craniofacial AbnormalitiesGna11 , Gnaq
Crohn's diseaseMyo5b
Cushing SyndromeAvpr1b , Gnas
DehydrationAvp
depressive disorderAvpr1b , Pde4d
diabetes insipidusAqp2 , Avp
diabetic ketoacidosisAqp2
Diabetic NephropathiesAqp2
Diamond-Blackfan anemiaVamp2
diarrheaMyo5b
dilated cardiomyopathyGnaq
Drug OverdoseAvp
Duane retraction syndromeGnas
dyskeratosis congenitaAvpr2 , Vamp2
DysmenorrheaAvp
Emery-Dreifuss muscular dystrophyAvpr2
endocrine system diseaseGnas
esophageal atresiaPde4d , Sipa1
Experimental Diabetes MellitusAqp2 , Avp
Experimental Liver CirrhosisSnap23
ExsanguinationAvp
factor VIII deficiencyAvpr2
familial adult myoclonic epilepsy 5Avpr1b
familial hypocalciuric hypercalcemia 2Gna11
familial multiple nevi flammeiGna11 , Gnaq
favismAvpr2
Febrile SeizuresAvp
fetal alcohol spectrum disorderAvp
focal segmental glomerulosclerosisGnaq
GallstonesGnas
Gastrointestinal HemorrhageAvp
gastrointestinal stromal tumorAvpr1b
genetic diseaseAdcy6 , Aqp2 , Avp , Avpr2 , Gna11 , Gnaq , Gnas , Myo5b , Pde4d , Vamp2
glycogen storage disease VSipa1
Growth DisordersAvpr2
growth hormone secreting pituitary adenomaGnas
HemorrhageAvpr1a
hemorrhagic diseaseGnas
hepatocellular carcinomaGnas
hereditary spastic paraplegia 4Gnas
Heterotopic OssificationGnas
Huntington's disease-like 1Avp
hydronephrosisAqp2
HyperalgesiaAvp
hyperglycemiaAvp
hypertensionAqp2 , Avp , Avpr1a , Avpr2 , Gnas
Hypokalemic Periodic Paralysis, Type 1Avpr1b
HyponatremiaAvp
HypotensionAvp
HypoxiaGnas
immunodeficiency 33Avpr2
inappropriate ADH syndromeAvp
inflammatory bowel disease 1Myo5b
inherited metabolic disorderMyo5b
Inosine Triphosphatase DeficiencyAvp
Insulin ResistanceGnas
intellectual disabilityGnas , Myo5b , Rab11a , Sipa1
intestinal diseaseMyo5b
ischemiaAvp
Kabuki syndromeAdcy6
Klippel-Trenaunay syndromeGnaq
Lethal Congenital Contracture Syndrome 8Adcy6
Li-Fraumeni syndromeVamp2
Liver NeoplasmsMyo5b
lung non-small cell carcinomaGnaq
lung small cell carcinomaAvp
McCune Albright syndromeGnas
melanomaGna11 , Gnaq , Sipa1
Memory DisordersAvp
Metabolic Bone DiseasesGnas
microcephalyRab11a
microvillus inclusion diseaseMyo5b
mood disorderAvpr1b
morphine withdrawal syndromeAvp
myocardial infarctionAvpr1a
Myocardial IschemiaSnap23
nemaline myopathy 6Rab11a
nephrogenic diabetes insipidusAqp2 , Avpr2
nephrogenic diabetes insipidus type 2Aqp2
nephrogenic syndrome of inappropriate antidiuresisAvpr2
Neu-Laxova syndrome 2Gnaq
neuroblastomaGnas
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND AUTISTIC FEATURES WITH OR WITHOUT HYPERKINETIC MOVEMENTSVamp2
Neurodevelopmental DisordersGna11 , Pde4d , Vamp2
neurohypophyseal diabetes insipidusAvp
neuronal ceroid lipofuscinosisRab11a
obesityGnas
OliguriaAvpr2
opiate dependenceAvp
opiate withdrawal syndromeAvp
Orthostatic HypotensionGnas
PainAvp
pancreatic cancerGnas
pantothenate kinase-associated neurodegenerationAvp
paraplegiaAvpr2
Parasitic Liver DiseasesGnas
parathyroid carcinomaAvpr1b
periventricular nodular heterotopiaAvpr2
pituitary adenomaAvpr1b
pituitary adenoma 3Gnas
Pituitary NeoplasmsGnas
polycystic kidney diseaseGnas
polycystic ovary syndromeGnas
PolyuriaAqp2 , Avp
Port-Wine StainGnaq
portal hypertensionAvp , Avpr1a
Precocious PubertyGnas
primary hyperaldosteronismGnas
primary microcephalyRab11a
Progressive Familial Intrahepatic Cholestasis 10Myo5b
progressive myoclonus epilepsy 9Gna11
progressive osseous heteroplasiaGnas
Prostatic NeoplasmsPde4d
pseudohypoaldosteronismGnas
pseudohypoparathyroidismGnas
pseudohypoparathyroidism type 1AGnas
pseudohypoparathyroidism type 1BGnas
pseudohypoparathyroidism type 1CGnas
pseudopseudohypoparathyroidismGnas
psychotic disorderAvp
RASopathyGna11
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsSipa1
renovascular hypertensionAvpr1a
Respiration DisordersGnas
schizophreniaAvp , Avpr1a , Gnas
Schwartz-Jampel syndrome 1Gna11
severe congenital encephalopathy due to MECP2 mutationAvpr2
sex cord-gonadal stromal tumorGnas
ShockAvp
Shy-Drager SyndromeAvp
Spinal Cord InjuriesPde4d
SplenomegalyAvpr2
StrokeAvp , Pde4d
Sturge-Weber syndromeGnaq
substance-related disorderAkap7
syndromic X-linked intellectual disability Lubs typeAvpr2
TachycardiaGnas
temporal lobe epilepsyAvp
transient cerebral ischemiaPde4d
type 1 diabetes mellitusAvp
type 2 diabetes mellitusAvp
ureteral obstructionAdcy6 , Avpr2
vascular dementiaAvp
very long chain acyl-CoA dehydrogenase deficiencyVamp2
Wernicke-Korsakoff syndromeAvp
withdrawal disorderAvp , Gnas
X-linked monogenic diseaseAvpr2
X-linked nephrogenic diabetes insipidusAqp2 , Avpr2
Pathway Annotations Associated with Genes in the vasopressin signaling pathway
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein familyGna11 , Gnaq
adenine phoshoribosyltransferase deficiency pathwayPde4d
adenosine monophosphate deaminase deficiency pathwayPde4d
adenosine signaling pathwayGnas
adenylosuccinate lyase deficiency pathwayPde4d
AICA-ribosuria pathwayPde4d
Alzheimer's disease pathwayGnaq
amiloride pharmacodynamics pathwayAqp2
angiotensin II signaling pathway via AT1 receptorGna11 , Gnaq
autophagy pathwayRab11a
azathioprine pharmacodynamics pathwayPde4d
bendroflumethiazide pharmacodynamics pathwayAqp2
bile acid transport pathwayAdcy6 , Gnas
bumetanide pharmacodynamics pathwayAqp2
calcium/calcium-mediated signaling pathwayAvpr1a , Avpr1b , Gna11 , Gnaq , Gnas
Chagas disease pathwayGna11 , Gnaq , Gnas
chemokine mediated signaling pathwayAdcy6
chlorothiazide pharmacodynamics pathwayAqp2
chlorthalidone pharmacodynamics pathwayAqp2
cilostazol pharmacodynamics pathwayPde4d
corticotropin-releasing hormone signaling pathwayGnas
cystinuria pathwayAqp2
dilated cardiomyopathy pathwayAdcy6 , Gnas
dipyridamole pharmacodyamics pathwayPde4d
dopamine signaling pathway via D1 family of receptorsGnas
eicosanoid signaling pathwayGna11 , Gnaq , Rab11a
endocytosis pathwayRab11a , Rab11fip2
endothelin signaling pathwayAdcy6 , Gna11 , Gnaq
Entamoebiasis pathwayGna11 , Gnaq , Gnas
epinephrine signaling pathway via adrenergic receptor betaGnas
eplerenone pharmacodynamics pathwayAqp2
etacrynic acid pharmacodynamics pathwayAqp2
follicle-stimulating hormone signaling pathwayGnas
furosemide pharmacodynamics pathwayAqp2
G protein mediated signaling pathway via Galphaq familyAvpr1a , Avpr1b , Gna11 , Gnaq
G protein mediated signaling pathway via Galphas familyAdcy6 , Avpr1b , Avpr2 , Gnas
glucagon signaling pathwayAdcy6 , Gnas
glutamate signaling pathwayAdcy6 , Gnaq , Gnas
gonadotropin-releasing hormone signaling pathwayAdcy6 , Gna11 , Gnaq , Gnas
Hartnup disease pathwayAqp2
histamine signaling pathway, immunologicalGnas
Huntington's disease pathwayGnaq
hydrochlorothiazide pharmacodynamics pathwayAqp2
hydroflumethiazide pharmacodynamics pathwayAqp2
iminoglycinuria pathwayAqp2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayMyo5b , Rab11a , Snap23 , Vamp2
insulin secretion pathwayVamp2
Kelley-Seegmiller syndrome pathwayPde4d
Lesch-Nyhan syndrome pathwayPde4d
long term depressionGna11 , Gnaq , Gnas
long term potentiationGnaq
luteinizing hormone signaling pathwayGnas
lysinuric protein intolerance pathwayAqp2
melanocortin system pathwayGnas
mercaptopurine pharmacodynamics pathwayPde4d
metolazone pharmacodynamics pathwayAqp2
molybdenum cofactor deficiency pathwayPde4d
Notch signaling pathwayRab11a
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1Gnaq
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnaq
oxytocin signaling pathwayGna11 , Gnaq
platelet-derived growth factor signaling pathwaySipa1
prostaglandin D2 signaling pathwayGnas
prostaglandin I2 signaling pathwayGnas
protein kinase A (PKA) signaling pathwayAdcy6 , Akap7 , Pde4d
purine metabolic pathwayAdcy6 , Pde4d
purine nucleoside phosphorylase deficiency pathwayPde4d
Rab family mediated signaling pathwayRab11a
serotonin signaling pathway via receptors engaging G alphas protein familyGnas
sleeping sickness pathwayGnaq
sphingosine 1-phosphate signaling pathwayGna11 , Gnaq
spironolactone pharmacodynamics pathwayAqp2
tioguanine pharmacodynamics pathwayPde4d
torasemide pharmacodynamics pathwayAqp2
triamterene pharmacodynamics pathwayAqp2
trichlormethiazide pharmacodynamics pathwayAqp2
vasopressin signaling pathwayAdcy6 , Akap7 , Aqp2 , Avp , Avpr1a , Avpr1b , Avpr2 , Gna11 , Gnaq , Gnas , Myo5b , Pde4d , Rab11a , Rab11fip2 , Sipa1 , Snap23 , Vamp2
vasopressin signaling pathway via receptor type 1Avp , Avpr1a , Avpr1b , Gna11 , Gnaq
vasopressin signaling pathway via receptor type 2Adcy6 , Akap7 , Aqp2 , Avp , Avpr2 , Gnas , Myo5b , Pde4d , Rab11a , Rab11fip2 , Sipa1 , Snap23 , Vamp2
water transport pathwayAqp2
xanthinuria type I pathwayPde4d
xanthinuria pathwayPde4d
xanthinuria type II pathwayPde4d
Phenotype Annotations Associated with Genes in the vasopressin signaling pathway
Phenotype TermsGene Symbols
polyuriaAvp

References Associated with the vasopressin signaling pathway:

Ontology Path Diagram:
paths to the root
paths to the root

Import into Pathway Studio: