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ONTOLOGY REPORT - ANNOTATIONS


Term:focal segmental glomerulosclerosis
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Accession:DOID:1312 term browser browse the term
Definition:A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
Synonyms:exact_synonym: FGS;   FSGS;   Focal Glomerulosclerosis;   Focal Sclerosing Glomerulonephritides;   Focal Sclerosing Glomerulonephritis;   Segmental Glomerular Hyalinosis;   Segmental Hyalinosis;   focal glomerular sclerosis
 narrow_synonym: FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DILATED CARDIOMYOPATHY
 primary_id: MESH:D005923
 alt_id: RDO:0004418
 xref: GARD:6517;   NCI:C37308;   OMIM:PS603278
For additional species annotation, visit the Alliance of Genome Resources.


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focal segmental glomerulosclerosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:11554173
G Actn4 actinin alpha 4 JBrowse link 1 87,078,012 87,147,347 RGD:1598731
RGD:11554173
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:2292230
RGD:11575049
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:5129175
RGD:11554173
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:5129175
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:5129175
G Angpt2 angiopoietin 2 JBrowse link 16 75,966,480 76,016,147 RGD:2314213
G Anln anillin, actin binding protein JBrowse link 8 23,336,455 23,397,122 RGD:11554173
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:7175321
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:13782344
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:7205647
G Ccl11 C-C motif chemokine ligand 11 JBrowse link 10 69,434,965 69,439,566 RGD:7247740
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:7241818
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:11554173
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:1600628
RGD:11554173
RGD:8554872
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:7242704
G Col4a1 collagen type IV alpha 1 chain JBrowse link 16 83,522,162 83,632,153 RGD:11554173
G Crb2 crumbs cell polarity complex component 2 JBrowse link 3 22,037,812 22,061,247 RGD:11554173
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:11554173
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:11554173
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:11554173
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:11554173
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:10402764
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7175321
G Inf2 inverted formin, FH2 and WH2 domain containing JBrowse link 6 137,162,593 137,180,198 RGD:11554173
RGD:8554872
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:6907385
G Lamb2 laminin subunit beta 2 JBrowse link 8 117,268,335 117,280,517 RGD:8554872
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:2308781
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:2308781
G Mir193a microRNA 193a JBrowse link 10 67,065,885 67,065,996 RGD:13592920
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:2325738
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:2325738
G Mpv17 mitochondrial inner membrane protein MPV17 JBrowse link 6 26,585,713 26,600,265 RGD:11554173
G Myh10 myosin heavy chain 10 JBrowse link 10 55,274,910 55,406,738 RGD:11554173
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:6903254
RGD:11554173
G Myo1e myosin IE JBrowse link 8 76,644,715 76,840,240 RGD:11554173
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:11554173
G Nphs1 NPHS1 adhesion molecule, nephrin JBrowse link 1 88,922,346 88,950,560 RGD:8554872
RGD:11554173
G Nphs2 NPHS2 stomatin family member, podocin JBrowse link 13 73,929,136 73,941,522 RGD:11554173
G Nxf7 nuclear RNA export factor 7 JBrowse link X 106,049,075 106,066,334 RGD:8554872
G Pax2 paired box 2 JBrowse link 1 264,493,579 264,585,073 RGD:11554173
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:11554173
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:8693412
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:13515117
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:13515117
G Rap1gap Rap1 GTPase-activating protein JBrowse link 5 156,008,868 156,074,350 RGD:9835343
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11554173
RGD:13208548
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:12859042
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:7245511
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:7245511
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:7245511
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:7247440
RGD:11554173
RGD:8554872
RGD:7247581
RGD:7247580
RGD:7247445
RGD:7247444
G Vldlr very low density lipoprotein receptor JBrowse link 1 245,236,819 245,273,688 RGD:2324671
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:7207031
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:11554173
focal segmental glomerulosclerosis 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:12880006
G Actn4 actinin alpha 4 JBrowse link 1 87,078,012 87,147,347 RGD:7240710
RGD:8554872
G Arhgap24 Rho GTPase activating protein 24 JBrowse link 14 8,383,211 8,600,526 RGD:8554872
focal segmental glomerulosclerosis 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:7240710
RGD:8554872
Focal Segmental Glomerulosclerosis 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:7240710
RGD:8554872
focal segmental glomerulosclerosis 5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Inf2 inverted formin, FH2 and WH2 domain containing JBrowse link 6 137,162,593 137,180,198 RGD:7240710
RGD:8554872
focal segmental glomerulosclerosis 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myo1e myosin IE JBrowse link 8 76,644,715 76,840,240 RGD:7240710
RGD:8554872
focal segmental glomerulosclerosis 7 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pax2 paired box 2 JBrowse link 1 264,493,579 264,585,073 RGD:8554872
RGD:7240710
focal segmental glomerulosclerosis 8 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anln anillin, actin binding protein JBrowse link 8 23,336,455 23,397,122 RGD:8554872
RGD:7240710
focal segmental glomerulosclerosis 9 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crb2 crumbs cell polarity complex component 2 JBrowse link 3 22,037,812 22,061,247 RGD:8554872
RGD:7240710
nephrotic syndrome type 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa5 annexin A5 JBrowse link 2 123,162,477 123,194,730 RGD:7242031
G Avil advillin JBrowse link 7 70,292,565 70,310,588 RGD:8554872
G Axdnd1 axonemal dynein light chain domain containing 1 JBrowse link 13 73,950,422 74,025,237 RGD:8554872
G Nphs2 NPHS2 stomatin family member, podocin JBrowse link 13 73,929,136 73,941,522 RGD:7240710
RGD:8554872
RGD:11554173
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:7174729
G Nup205 nucleoporin 205 JBrowse link 4 62,703,779 62,773,931 RGD:11554173
G Nup93 nucleoporin 93 JBrowse link 19 11,159,769 11,263,980 RGD:11554173
G Pla2g7 phospholipase A2 group VII JBrowse link 9 19,935,754 19,978,013 RGD:7248793
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:7257521
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:7247446
G Tsfm Ts translation elongation factor, mitochondrial JBrowse link 7 70,311,948 70,319,389 RGD:8554872
G Xpo5 exportin 5 JBrowse link 9 17,125,201 17,163,170 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15626
    disease of anatomical entity 14956
      Immune & Inflammatory Diseases 3100
        Inflammation 2040
          nephritis 418
            glomerulonephritis 365
              focal segmental glomerulosclerosis 107
                Focal Segmental Glomerulosclerosis 3 1
                Focal Segmental Glomerulosclerosis 4 0
                focal segmental glomerulosclerosis 1 3
                focal segmental glomerulosclerosis 2 1
                focal segmental glomerulosclerosis 5 1
                focal segmental glomerulosclerosis 6 1
                focal segmental glomerulosclerosis 7 1
                focal segmental glomerulosclerosis 8 1
                focal segmental glomerulosclerosis 9 1
                nephrotic syndrome type 2 12
Path 2
Term Annotations click to browse term
  disease 15626
    disease of anatomical entity 14956
      Urogenital Diseases 3965
        urinary system disease 2039
          kidney disease 1826
            nephritis 418
              glomerulonephritis 365
                glomerulosclerosis 121
                  focal segmental glomerulosclerosis 107
                    Focal Segmental Glomerulosclerosis 3 1
                    Focal Segmental Glomerulosclerosis 4 0
                    focal segmental glomerulosclerosis 1 3
                    focal segmental glomerulosclerosis 2 1
                    focal segmental glomerulosclerosis 5 1
                    focal segmental glomerulosclerosis 6 1
                    focal segmental glomerulosclerosis 7 1
                    focal segmental glomerulosclerosis 8 1
                    focal segmental glomerulosclerosis 9 1
                    nephrotic syndrome type 2 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.