RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
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Adcy8
adenylate cyclase 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19691954
NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
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Adcy9
adenylate cyclase 9
no_association
ISO
DNA:polymorphisms:repeat,cds:
RGD
PMID:11840511
RGD:1358365
NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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Ambp
alpha-1-microglobulin/bikunin precursor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29987918
NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
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Avpr1b
arginine vasopressin receptor 1B
no_association
ISO
DNA:SNP: :rs28373064, 35369693, rs28632197 (human) DNA:SNP: :rs28536160 (human)
RGD
PMID:23962971 PMID:23962971
RGD:11528373 , RGD:11528373
NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792
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Bdnf
brain-derived neurotrophic factor
treatment
ISO
RGD
PMID:34078872
RGD:405850253
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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C3
complement C3
ISO
RGD
PMID:17321106
RGD:408418723
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Dctn1
dynactin subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19136952
NCBI chr 4:115,671,024...115,703,824
Ensembl chr 4:115,661,638...115,703,815
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Hcn1
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
IMP
RGD
PMID:22884333
RGD:9686419
NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29921868
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Polg
DNA polymerase gamma, catalytic subunit
ISO ISS
MouseDO RGD
PMID:16619054
RGD:8694301
NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
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Rara
retinoic acid receptor, alpha
ISO
RGD
PMID:19596122
RGD:2314250
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Slc6a4
solute carrier family 6 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19878141
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Sst
somatostatin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25600109
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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Ace
angiotensin I converting enzyme
IEA
GAD
PMID:15118671
RGD:1331525
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Adcy2
adenylate cyclase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236
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Add3
adducin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
protein:increased expression:plasma
RGD
PMID:22137759
RGD:5686381
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Agt
angiotensinogen
ISO
GAD
PMID:15118671
RGD:1331525
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Akap11
A-kinase anchoring protein 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35410376
NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605
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Akt1
AKT serine/threonine kinase 1
ISO
DNA:SNP, haplotype: :multiple (human)
RGD
PMID:20214684
RGD:5509071
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Ank3
ankyrin 3
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNS:SNPs:multiple:(human)
CTD RGD
PMID:18711365 PMID:21926974 PMID:31043756 PMID:33729739
RGD:153344594
NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
ISO ISS
MouseDO RGD
PMID:9646882
RGD:1358437
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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Avpr1b
arginine vasopressin receptor 1B
ISO
DNA:SNP: :rs28536160 (human)
RGD
PMID:24012103
RGD:14700651
NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792
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Bdnf
brain-derived neurotrophic factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030 PMID:19018715 PMID:15118671
RGD:1331525
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bhlhe40
basic helix-loop-helix family, member e40
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25395965
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Bmal1
basic helix-loop-helix ARNT like 1
sexual_dimorphism
ISO
associated with Alcohol-related disorders;DNA:SNP::(rs11600996) (Human)
RGD
PMID:30121446
RGD:405866353
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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Brd1
bromodomain containing 1
susceptibility
ISO
DNA,SNP,haplotype:3'UTR:
RGD
PMID:16924267
RGD:9586096
NCBI chr 7:119,774,187...119,822,032
Ensembl chr 7:119,774,188...119,822,031
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18711365 PMID:21926972 PMID:21926974 PMID:31043756
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Cacna1d
calcium voltage-gated channel subunit alpha1 D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28194001
NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
ISS
MouseDO
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Ccl2
C-C motif chemokine ligand 2
ISO
RGD
PMID:15034225
RGD:1358456
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cd47
Cd47 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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Cdc42
cell division cycle 42
ISO
RGD
PMID:18391128
RGD:5688274
NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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Chrm2
cholinergic receptor, muscarinic 2
ISO
DNA:SNP: :rs324650 (human) protein:decreased expression:cerebral cortex
RGD
PMID:20351719 PMID:19103464
RGD:5509579 , RGD:5509584
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrnb3
cholinergic receptor nicotinic beta 3 subunit
susceptibility
ISO
DNA:SNPs: : rs4952,rs4953 (human)
RGD
PMID:21191315
RGD:405849396
NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
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Clock
clock circadian regulator
ISS
MouseDO
NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
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Comt
catechol-O-methyltransferase
ISO
CTD Direct Evidence: marker/mechanism DNA:promoter:Hypomethylation
CTD RGD
PMID:11772685 PMID:16984965
RGD:401940146
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Cplx1
complexin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr14:1,184,677...1,216,392
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Cplx2
complexin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855
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Cs
citrate synthase
treatment
IEP
protein decreased expression:prefrontal cortex protein decreased expression:brain
RGD
PMID:20372980 PMID:17367908 PMID:24359811
RGD:329337348 , RGD:329337351 , RGD:329337349
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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Ddc
dopa decarboxylase
ISO
DNA:deletions:5' utr, intron:g.-601delG, g.722_725delGAGA (human)
RGD
PMID:12555230
RGD:1358586
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Disc1
DISC1 scaffold protein
susceptibility
ISO
DNA;SNPs: :rs2738864,rs16841582 (human) DNA:SNPs: :rs1538979, rs821577, rs821633 (human) DNA:SNPs: :multiple
RGD
PMID:21222298 PMID:18317464 PMID:15386212
RGD:5509829 , RGD:5509836 , RGD:5509833
NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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Dixdc1
DIX domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27752079
NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
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Drd1
dopamine receptor D1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19153942
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd5
dopamine receptor D5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774
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Erbb4
erb-b2 receptor tyrosine kinase 4
IEP
RGD
PMID:34189720
RGD:405650687
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
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Fads2
fatty acid desaturase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
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Fstl5
follistatin-like 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 2:160,857,989...161,526,589
Ensembl chr 2:160,856,291...161,526,589
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Gabra3
gamma-aminobutyric acid type A receptor subunit alpha 3
ISO
DNA:repeat:intron:IVS8CA (human)
RGD
PMID:11840313
RGD:1358391
NCBI chr X:150,244,745...150,501,566
Ensembl chr X:150,261,607...150,501,559
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Gabra5
gamma-aminobutyric acid type A receptor subunit alpha 5
ISO
RGD
PMID:9514592
RGD:1358630
NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
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Gad1
glutamate decarboxylase 1
ISO
protein:decreased expression:prefrontal cortex layers 2-5 (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15560956 PMID:18534564
RGD:6480428
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gad2
glutamate decarboxylase 2
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15560956 PMID:34189720
RGD:405650687
NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
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Gch1
GTP cyclohydrolase 1
ISO
DNA:polymorphism
RGD
PMID:15909293
RGD:1601281
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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Grik2
glutamate ionotropic receptor kainate type subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18332879
NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
ISO
DNA:repeat:promoter:(GT)18-33 (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:31043756 PMID:12809987
RGD:1358644
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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Grin2b
glutamate ionotropic receptor NMDA type subunit 2B
ISO
RGD
PMID:16549338
RGD:1642201
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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Grk3
G protein-coupled receptor kinase 3
ISO
mRNA, protein:decreased expression:frontal cortex (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12808434 PMID:19400979
RGD:5685029
NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
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Grn
granulin precursor
ISO
protein:decreased expression:plasma
RGD
PMID:24581833
RGD:10401641
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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Gsk3a
glycogen synthase kinase 3 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20357757
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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Gsk3b
glycogen synthase kinase 3 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20357757 PMID:17357145 PMID:16397405
RGD:1641929 , RGD:1641931
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Hdac5
histone deacetylase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
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Htr2a
5-hydroxytryptamine receptor 2A
IEA ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030 PMID:15118671
RGD:1331525
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Htr2c
5-hydroxytryptamine receptor 2C
ISO
DNA:missense mutation:cds:p.C23S (human)
RGD
PMID:8823764
RGD:1358737
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Impa2
inositol monophosphatase 2
susceptibility
ISO
DNA:SNPs:promoter:-461C>T, -207T>C(human)
RGD
PMID:9322233 PMID:11673796 PMID:14699425
RGD:6480265 , RGD:6480269 , RGD:6480267
NCBI chr18:60,834,206...60,867,575
Ensembl chr18:60,834,246...60,865,641
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Ins2
insulin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:5506046
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Itih1
inter-alpha trypsin inhibitor, heavy chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363
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Kat6b
lysine acetyltransferase 6B
ISO
DNA:mutations:multiple (human)
RGD
PMID:24444492
RGD:9588521
NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
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L1cam
L1 cell adhesion molecule
ISO
associated with Depressive Disorder; mRNA:increased expression:blood (human)
RGD
PMID:18430502
RGD:6483084
NCBI chr X:151,597,270...151,623,776
Ensembl chr X:151,597,277...151,623,857
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Lman2l
lectin, mannose-binding 2-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 9:38,661,709...38,685,244
Ensembl chr 9:38,661,712...38,685,337
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Mbl2
mannose binding lectin 2
susceptibility
ISO
DNA:haplotype: :
RGD
PMID:24856568
RGD:12910826
NCBI chr 1:228,016,439...228,024,736
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Mrps33
mitochondrial ribosomal protein S33
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:68,596,729...68,605,428
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Mt-nd1
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
ISO
DNA:missense mutation:cds:m.3644T>C (human)
RGD
PMID:15533721
RGD:5490261
NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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Mthfr
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17074966
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Ncam1
neural cell adhesion molecule 1
ISO
DNA:snps:introns:IVS6+32T>C, IVS7+11G>C, IVS12+21C>A (human)
RGD
PMID:15050861
RGD:1358750
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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Ncan
neurocan
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
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Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
ISO
protein:decreased expression:prefrontal cortex (human)
RGD
PMID:20368511
RGD:6484696
NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
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Ndufv2
NADH:ubiquinone oxidoreductase core subunit V2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19135101
NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
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Ngf
nerve growth factor
sexual_dimorphism
ISO
DNA:SNPs,haplotypes: :multiple
RGD
PMID:21294249
RGD:401965386
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nrg1
neuregulin 1
ISO IEP
DNA:SNP:enhancer: (rs35753505)
RGD
PMID:18585932 PMID:34189720
RGD:39131291 , RGD:405650687
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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Ntng1
netrin G1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17507910
NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
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Ntng2
netrin G2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17507910
NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890
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Ntrk1
neurotrophic receptor tyrosine kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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Ntrk2
neurotrophic receptor tyrosine kinase 2
ISO
protein:decreased expression:cerebellum CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19018715 PMID:21612826
RGD:5684549
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Pacs1
phosphofurin acidic cluster sorting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 1:202,437,503...202,569,473
Ensembl chr 1:202,437,505...202,569,473
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Pc
pyruvate carboxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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Pde4b
phosphodiesterase 4B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18394866
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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Per3
period circadian regulator 3
sexual_dimorphism
ISO
associated with Alcohol-Related Disorders; DNA:SNP::(rs228642) (Human)
RGD
PMID:30121446
RGD:405866353
NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
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Plekho1
pleckstrin homology domain containing O1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785
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Polg
DNA polymerase gamma, catalytic subunit
ISS
MouseDO
NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
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Pomc
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:2843795 PMID:9664777
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Pou3f2
POU class 3 homeobox 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 5:36,077,930...36,083,838
Ensembl chr 5:36,077,930...36,083,838
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Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
ISO
DNA, mRNA:SNPs, haplotype, splice variant:multiple
RGD
PMID:23295814
RGD:13515076
NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
mRNA, protein:decreased expression:prefrontal cortex
RGD
PMID:20038946
RGD:5688160
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
mRNA, protein:increased expression:prefrontal cortex
RGD
PMID:20038946
RGD:5688160
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pvalb
parvalbumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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Rap1gap
Rap1 GTPase-activating protein
ISO
mRNA, protein:increased expression:dorsolateral prefrontal cortex (human)
RGD
PMID:16687443
RGD:5490162
NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253
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Reln
reelin
ISO
protein:decreased expression:hippocampus (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:11126396 PMID:14708030 PMID:15560956 PMID:11126396
RGD:2324681
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Rims1
regulating synaptic membrane exocytosis 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631
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Rps6ka2
ribosomal protein S6 kinase A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
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RT1-Da
RT1 class II, locus Da
ISO
RGD
PMID:16687443
RGD:5490162
NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
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S100b
S100 calcium binding protein B
IEP ISO
protein:increased expression:cerebrospinal fluid CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15581912 PMID:16476148 PMID:15581912
RGD:5508853
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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Scn2a
sodium voltage-gated channel alpha subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
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Serpina1
serpin family A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17659342
NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
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Shank2
SH3 and multiple ankyrin repeat domains 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
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Slc18a1
solute carrier family 18 member A1
ISO
DNA:SNPs:5' utr, cds:g.-584A>G (rs988713), p.T136I (rs1390938) (human)
RGD
PMID:16936705
RGD:5131197
NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051
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Slc5a3
solute carrier family 5 member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16420717
NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
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Slc6a4
solute carrier family 6 member 4
ISO
CTD Direct Evidence: marker/mechanism DNA:repeats:promoter:
CTD RGD
PMID:11772685 PMID:16395126 PMID:10484962
RGD:36947381
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Snap25
synaptosome associated protein 25
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
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Snca
synuclein alpha
ISO
RGD
PMID:19198857
RGD:6478716
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sp4
Sp4 transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19401786
NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
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Srpk2
SRSF protein kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 4:11,464,684...11,655,993
Ensembl chr 4:11,464,674...11,655,990
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Srsf3
serine and arginine rich splicing factor 3
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:18281098
RGD:11039413
NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078
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Ssbp2
single-stranded DNA binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 2:22,650,488...22,938,669
Ensembl chr 2:22,651,258...22,933,696
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Sstr5
somatostatin receptor 5
ISO
DNA:SNP, missense mutations, haplotype: :573G>A, p.L48M, p.P335L (human)
RGD
PMID:12192619
RGD:1358589
NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946
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Stard9
StAR-related lipid transfer domain containing 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 3:107,581,097...107,672,746
Ensembl chr 3:107,581,164...107,673,898
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Stk4
serine/threonine kinase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
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Syne1
spectrin repeat containing nuclear envelope protein 1
susceptibility
ISO
DNA:SNPs:promoter,intron:
RGD
PMID:28178086
RGD:13209005
NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322
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Tac1
tachykinin, precursor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15845098
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tacr1
tachykinin receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19204064
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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Tenm4
teneurin transmembrane protein 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21926972
NCBI chr 1:149,895,097...151,263,315
Ensembl chr 1:150,780,381...151,259,144
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Thsd7a
thrombospondin type 1 domain containing 7A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 4:40,461,124...40,899,345
Ensembl chr 4:40,460,814...40,899,583
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Tnfrsf11b
TNF receptor superfamily member 11B
ISO
protein:increased expression:plasma
RGD
PMID:20861651
RGD:7205488
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
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Tph2
tryptophan hydroxylase 2
ISO
mRNA:increased expression:frontal association cortex ClinVar Annotator: match by term: Bipolar affective disorder, susceptibility to
ClinVar RGD
PMID:17905754 PMID:18347598 PMID:19319927 PMID:25741868 PMID:16240163
RGD:5686358
NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
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Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 8:111,275,973...111,355,491
Ensembl chr 8:111,276,354...111,355,092
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Trpc3
transient receptor potential cation channel, subfamily C, member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23602965
NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
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Trpm2
transient receptor potential cation channel, subfamily M, member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23602965
NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
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Tshb
thyroid stimulating hormone subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:6455462
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Vwf
von Willebrand factor
ISO
protein:increased expression:plasma
RGD
PMID:19839997
RGD:7207027
NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
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Zcchc2
zinc finger CCHC-type containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr13:22,118,677...22,193,626
Ensembl chr13:22,119,568...22,166,373
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Zfp592
zinc finger protein 592
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31043756
NCBI chr 1:134,951,286...135,002,443
Ensembl chr 1:134,967,783...135,002,443
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Abat
4-aminobutyrate aminotransferase
IMP
RGD
PMID:21914462
RGD:9588556
NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
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Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
ISO
protein:increased expression, increased phosphorylation:hippocampus (mouse)
RGD
PMID:31396300
RGD:126908003
NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
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Acsl4
acyl-CoA synthetase long-chain family member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15108178
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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Adora2a
adenosine A2a receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26860412
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Adra1a
adrenoceptor alpha 1A
ISO
RGD
PMID:19540213
RGD:5688369
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Adra2a
adrenoceptor alpha 2A
IMP
RGD
PMID:20047711
RGD:6480482
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9029664
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Atp5pd
ATP synthase peripheral stalk subunit d
treatment
IDA
RGD
PMID:25641667
RGD:13800885
NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
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Avpr1b
arginine vasopressin receptor 1B
treatment no_association
ISO IMP
associated with bipolar disorder;DNA:SNP: :multiple
RGD
PMID:26700241 PMID:24654684 PMID:23068076
RGD:14700672 , RGD:14700666 , RGD:14700671
NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792
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Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:21308783
RGD:10054142
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
treatment
IEP
RGD
PMID:21308783
RGD:10054142
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bdnf
brain-derived neurotrophic factor
treatment
IEP ISO
protein:decreased expression:brain CTD Direct Evidence: marker/mechanism|therapeutic mRNA, protein:decreased expression:lymphocyte, platelet
CTD RGD
PMID:16330021 PMID:21945287 PMID:20920483 PMID:24128869 PMID:22097208 PMID:20227453 More...
RGD:4891127 , RGD:10059357 , RGD:5684923 , RGD:4891139
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Becn1
beclin 1
disease_progression treatment
ISO
RGD
PMID:25386878 PMID:25386878
RGD:11561930 , RGD:11561930
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Cadm1
cell adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22113448
NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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Cat
catalase
ISO
associated with gastric adenocarcinoma; protein:decreased expression:blood serum (human)
RGD
PMID:31396300
RGD:126908003
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cdk5
cyclin-dependent kinase 5
treatment
IDA
RGD
PMID:21682945
RGD:13782377
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
NOT
IEP
RGD
PMID:21682945
RGD:13782377
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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Chat
choline O-acetyltransferase
IEP IMP
mRNA:decreased expression:habenula:
RGD
PMID:28420875 PMID:28420875
RGD:151347550 , RGD:151347550
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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Chrm2
cholinergic receptor, muscarinic 2
IEP
mRNA:increased expression:brain
RGD
PMID:20830301
RGD:5509587
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrna3
cholinergic receptor nicotinic alpha 3 subunit
IEP
mRNA:decreased expression:habenula:
RGD
PMID:28420875
RGD:151347550
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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Chrnb3
cholinergic receptor nicotinic beta 3 subunit
IEP ISO
mRNA:decreased expression:habenula:
RGD
PMID:28420875 PMID:28420875
RGD:151347550 , RGD:151347550
NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
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Chrnb4
cholinergic receptor nicotinic beta 4 subunit
IEP
mRNA:decreased expression:habenula:
RGD
PMID:28420875
RGD:151347550
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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Cnr2
cannabinoid receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18286196
NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
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Creb1
cAMP responsive element binding protein 1
treatment
IEP IDA
protein:increased expression:nucleus accumbens
RGD
PMID:26762379 PMID:31257291
RGD:401959608 , RGD:401960862
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Crh
corticotropin releasing hormone
IEP ISO
mRNA:increased expression:paraventricular nucleus, dorsal raphe nucleus (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12438692 PMID:18698320 PMID:20860876
RGD:5147490
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crhbp
corticotropin releasing hormone binding protein
ISO IEP
DNA:snps:intron, 3' utr:g.10661T>C, g.16113T>C (human) protein:increased expression:hippocampus, frontal cortex (rat)
RGD
PMID:14573312 PMID:19631474
RGD:1358530 , RGD:5508785
NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
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Crhr1
corticotropin releasing hormone receptor 1
IEP
RGD
PMID:20860876
RGD:5147490
NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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Crhr2
corticotropin releasing hormone receptor 2
IEP
RGD
PMID:20860876
RGD:5147490
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
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Crp
C-reactive protein
ISO
associated with kidney failure, chronic; protein:increased expression:plasma
RGD
PMID:22972567
RGD:6904211
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Csf3
colony stimulating factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9018096
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
IEP
RGD
PMID:20595028
RGD:4892242
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
IEP
RGD
PMID:20595028
RGD:4892242
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
IEP
RGD
PMID:20595028
RGD:4892242
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2d1
cytochrome P450, family 2, subfamily d, polypeptide 1
IEP
RGD
PMID:20595028
RGD:4892242
NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
IEP
protein:increased expression:liver
RGD
PMID:20595028
RGD:4892242
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
IEP
RGD
PMID:20595028
RGD:4892242
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Dbh
dopamine beta-hydroxylase
IEP
protein:decreased expression:frontal cortex (rat)
RGD
PMID:19120095
RGD:5129527
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Disc1
DISC1 scaffold protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29643356
NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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Dixdc1
DIX domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27752079
NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
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Dnmt3a
DNA methyltransferase 3 alpha
ISO
mRNA:increased expression:nucleus accumbens:
RGD
PMID:20729844
RGD:9589061
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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Drd1
dopamine receptor D1
IEP
mRNA:increased expression:caudate putamen (rat)
RGD
PMID:17558292
RGD:2311588
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd2
dopamine receptor D2
ISO IEP
DNA:snp:cds:p.H313H (human) mRNA:decreased expression:striatum
RGD
PMID:9513185 PMID:21596067
RGD:1358603 , RGD:6907449
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Drd5
dopamine receptor D5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774
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Esr2
estrogen receptor 2
treatment
IDA
RGD
PMID:24128867
RGD:10045672
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Fadd
Fas associated via death domain
treatment
IEP
RGD
PMID:30138765
RGD:13792497
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fgf2
fibroblast growth factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16861106
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Fgfr1
Fibroblast growth factor receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16861106
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
treatment
IEP
RGD
PMID:34431619
RGD:405650599
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
ISO
protein:decreased expression: hippocampus (human)
RGD
PMID:27494187
RGD:401851061
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
G
Fth1
ferritin heavy chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17063146
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
G
Ftl1
ferritin light chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17063146
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
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Gabra5
gamma-aminobutyric acid type A receptor subunit alpha 5
ISO
DNA:repeat:: (human)
RGD
PMID:9267853
RGD:1358629
NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
G
Gata1
GATA binding protein 1
ISO IEP
mRNA:increased expression:prefrontal cortex
RGD
PMID:22885997 PMID:25340772 PMID:22885997
RGD:6892958 , RGD:11049534 , RGD:6892958
NCBI chr X:14,529,706...14,537,530
Ensembl chr X:14,529,702...14,537,530
G
Gata2
GATA binding protein 2
ISO
RGD
PMID:25340772
RGD:11049534
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
G
Gdnf
glial cell derived neurotrophic factor
ISO
DNA:SNP: :rs884344
RGD
PMID:24022000
RGD:405849398
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
G
Ghrl
ghrelin and obestatin prepropeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19272368
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
G
Glo1
glyoxalase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22113448
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
G
Gnb1
G protein subunit beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22113448
NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
G
Gnb3
G protein subunit beta 3
susceptibility
ISO
DNA:SNP:cds: 825C>T (human)
RGD
PMID:12634518
RGD:1358639
NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
G
Gpx1
glutathione peroxidase 1
ISO
RGD
PMID:23707456
RGD:11352766
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gpx3
glutathione peroxidase 3
treatment
IEP
RGD
PMID:33935736
RGD:401827871
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
G
Gria1
glutamate ionotropic receptor AMPA type subunit 1
treatment
ISO
RGD
PMID:32048672
RGD:405849038
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
G
Gsk3a
glycogen synthase kinase 3 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20357757
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
G
Gsk3b
glycogen synthase kinase 3 beta
treatment
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20357757 PMID:20534517 PMID:19815943
RGD:10045564
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Hdac5
histone deacetylase 5
IEP
protein:increased expression:hippocampus:
RGD
PMID:24495952
RGD:9681459
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
G
Htr1a
5-hydroxytryptamine receptor 1A
ISO
RGD
PMID:21512427 PMID:10578452
RGD:5683629 , RGD:5683634
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
G
Htr2a
5-hydroxytryptamine receptor 2A
treatment
IEA IEP IDA
GAD RGD
PMID:15118671 PMID:18239281 PMID:30628811
RGD:1331525 , RGD:401901207 , RGD:401900757
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
G
Htr3b
5-hydroxytryptamine receptor 3B
susceptibility
ISO
RGD
PMID:16487942
RGD:6480662
NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444
G
Htr7
5-hydroxytryptamine receptor 7
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21859099 PMID:16828124
RGD:6482189
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
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Igf1
insulin-like growth factor 1
ISO
associated with alcohol dependence;protein:increased expression:plasma
RGD
PMID:26792039
RGD:401976547
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Il1b
interleukin 1 beta
IEP ISO
protein:increased expression:frontal cortex, hippocampus, hypothalamus (rat) protein:increased expression:serum, hippocampus (mouse) associated with gastric adenocarcinoma; protein:increased expression:blood serum (human)
RGD
PMID:15000880 PMID:31396300 PMID:31396300
RGD:1626681 , RGD:126908003 , RGD:126908003
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rn
interleukin 1 receptor antagonist
ISO
associated with Status Epilepticus; rat model treated with human protein
RGD
PMID:22427156
RGD:7174694
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
G
Il6
interleukin 6
treatment
IEP ISO
mRNA:increased expression:colon protein:increased expression:serum, hippocampus (mouse) associated with gastric adenocarcinoma; protein:increased expression:blood serum (human) associated with Chronic Hepatitis C; DNA:insertion/deletion:promoter: associated with Hepatitis C, Chronic;DNA:SNP:promoter:-174G>C (human) CTD Direct Evidence: marker/mechanism protein:increased expression:hippocampus (rat)
CTD RGD
PMID:18458677 PMID:23589140 PMID:31396300 PMID:31396300 PMID:23571152 PMID:28083615 PMID:27106565 More...
RGD:10402829 , RGD:126908003 , RGD:126908003 , RGD:38676480 , RGD:14975286 , RGD:11062144
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Il6r
interleukin 6 receptor
IEP
mRNA:increased expression:colon
RGD
PMID:23589140
RGD:10402829
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
G
Ins1
insulin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34352274
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
IEP
protein:increased expression:basolateral amygdala
RGD
PMID:10719210
RGD:2290593
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Kcnk2
potassium two pore domain channel subfamily K member 2
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21871532 PMID:16906152
RGD:9831184
NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
G
Kmo
kynurenine 3-monooxygenase
IEP
protein:decreased activity:plasma
RGD
PMID:29217494
RGD:13703051
NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
G
L1cam
L1 cell adhesion molecule
IEP
mRNA:decreased expression:hippocampus (rat)
RGD
PMID:20018220
RGD:6483073
NCBI chr X:151,597,270...151,623,776
Ensembl chr X:151,597,277...151,623,857
G
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
treatment
ISO
RGD
PMID:25386878
RGD:11561930
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
G
Mapk1
mitogen activated protein kinase 1
ISO
RGD
PMID:21070506
RGD:401966883
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mc4r
melanocortin 4 receptor
treatment
IMP
associated with alcohol use disorder; associated with alcohol withdrawal syndrome
RGD
PMID:18499089
RGD:407572521
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
G
Mfn1
mitofusin 1
treatment
ISO
RGD
PMID:22244747
RGD:13204844
NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
G
Mfn2
mitofusin 2
treatment
IEP
RGD
PMID:22244747
RGD:13204844
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
G
Mif
macrophage migration inhibitory factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20177408
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 Ensembl chr 4:12,790,902...12,799,504
G
Mir382
microRNA 382
treatment
IEP
RGD
PMID:32982244
RGD:408364963
NCBI chr 6:128,748,539...128,748,618
G
Mre11
MRE11 homolog, double strand break repair nuclease
ISO
ClinVar Annotator: match by term: Mental depression
ClinVar
PMID:25741868 PMID:26467025 PMID:26878173 PMID:26898890 PMID:27878467 PMID:28492532 PMID:31159747 PMID:31353207 PMID:33471991 More...
NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
G
Mt-co2
mitochondrially encoded cytochrome c oxidase II
ISO
protein:increased expression:blood serum, hippocampus (mouse)
RGD
PMID:31396300
RGD:126908003
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
G
Mthfr
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17074966
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
G
Ncam1
neural cell adhesion molecule 1
treatment
IEP
RGD
PMID:29217494
RGD:13703051
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
G
Ndufb7
NADH:ubiquinone oxidoreductase subunit B7
susceptibility
IEP
RGD
PMID:22311638
RGD:13801196
NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579
G
Nefl
neurofilament light chain
IEP
protein:decreased expression:dentate gyrus, hippocampus CA3
RGD
PMID:17683840
RGD:2299053
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
G
Nfkb1
nuclear factor kappa B subunit 1
ISO
protein:increased phosphorylation:hippocampus (mouse)
RGD
PMID:31396300
RGD:126908003
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Ngf
nerve growth factor
IEP
mRNA:decreased expression:hippocampus
RGD
PMID:19129380
RGD:2303796
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
G
Ngfr
nerve growth factor receptor
ISO
DNA:SNP:CDS:p.S205L, minor (L) allele appears protective (human)
RGD
PMID:15274039
RGD:5508376
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
G
Nos1
nitric oxide synthase 1
treatment
ISO IDA
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17854383 PMID:20571741
RGD:13824995
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
G
Nos1ap
nitric oxide synthase 1 adaptor protein
treatment
IDA
RGD
PMID:19587612
RGD:7327168
NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949
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Notch3
notch receptor 3
ISO
ClinVar Annotator: match by term: Depression
ClinVar
PMID:15364702 PMID:16009764 PMID:21616505 PMID:28492532 PMID:32581362
NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
G
Nppc
natriuretic peptide C
ISO
DNA:SNP:CDS:multiple (human)
RGD
PMID:35642741
RGD:401854249
NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
G
Npy
neuropeptide Y
treatment
ISO IEP IDA
DNA:snp, missense mutation:promoter, cds:g.-399T>C, p.L7P (human) CTD Direct Evidence: marker/mechanism|therapeutic mRNA:decreased expression:hippocampus, prefrontal cortex
CTD RGD
PMID:9729278 PMID:17572454 PMID:14757324 PMID:22406386 PMID:19623606
RGD:1358535 , RGD:10448940 , RGD:10448937
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Npy1r
neuropeptide Y receptor Y1
treatment
IMP ISO IDA
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:9729278 PMID:17265460 PMID:19623606 PMID:21803058
RGD:1642308 , RGD:10448937 , RGD:10448284
NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
G
Npy2r
neuropeptide Y receptor Y2
treatment
IMP
RGD
PMID:21803058
RGD:10448284
NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024
G
Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP
RGD
PMID:28763303
RGD:13439713
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
treatment sexual_dimorphism
IEP IMP ISO
mRNA:decreased expression:hippocampus (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14708030 PMID:21837980 PMID:27221032 PMID:31329100 PMID:32982244
RGD:5686290 , RGD:408364988 , RGD:407571699 , RGD:408364963
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Nr3c1em1Kuan
nuclear receptor subfamily 3, group C, member 1; CRISPR/Cas9 induced mutant1, Kuan
sexual_dimorphism
IMP
RGD
PMID:31329100
RGD:407571699
G
Ntrk2
neurotrophic receptor tyrosine kinase 2
ISO IEP
RGD
PMID:20956301 PMID:22097208
RGD:5684782 , RGD:5684923
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
G
Nts
neurotensin
ISO
DNA:SNP:CDS:multiple (human)
RGD
PMID:35642741
RGD:401854249
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
G
Ogdhl
oxoglutarate dehydrogenase L
ISO
ClinVar Annotator: match by term: Depression
ClinVar
PMID:28017472
NCBI chr16:7,578,343...7,604,385
Ensembl chr16:7,578,367...7,604,386
G
Oprk1
opioid receptor, kappa 1
severity
ISO
associated with alcohol use disorder;DNA:SNP: :rs963549 (human)
RGD
PMID:37177778
RGD:401850581
NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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Panx1
Pannexin 1
ISO
DNA:SNP:CDS:multiple (human)
RGD
PMID:35642741
RGD:401854249
NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774
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Pawr
pro-apoptotic WT1 regulator
IEP
mRNA:decreased expression:striatum
RGD
PMID:21596067
RGD:6907449
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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Pde4d
phosphodiesterase 4D
IMP
RGD
PMID:22487514
RGD:7327149
NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
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Pdyn
prodynorphin
IMP
RGD
PMID:24816773
RGD:401850568
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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Pla2g2a
phospholipase A2 group IIA
ISO
mRNA:increased expression:blood
RGD
PMID:22331023
RGD:6482716
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
G
Pomc
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18201294
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Pon1
paraoxonase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19272368
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
treatment
IDA
RGD
PMID:27457507
RGD:13514054
NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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Prep
prolyl endopeptidase
IEP
protein:altered activity:frontal cortex, striatum, hypothalamus (rat)
RGD
PMID:17415460
RGD:1626457
NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466
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Prl
prolactin
ameliorates
ISO
associated with withdrawal disorder and alcohol dependence
RGD
PMID:3757769
RGD:401959379
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19356723
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Reln
reelin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Ren
renin
ISO
Associated with hypertension;protein:decreased activity:blood (human)
RGD
PMID:29960014
RGD:125097507
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Rnf103
ring finger protein 103
IDA
RGD
PMID:11071867
RGD:634523
NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:103,526,502...103,555,919
G
S100a10
S100 calcium binding protein A10
IEP ISO IDA
mRNA,protein:decreased expression:prefrontal cortex: CTD Direct Evidence: marker/mechanism DNA:hypermethylated:promoter:
CTD RGD
PMID:21682946 PMID:21682946 PMID:21682946
RGD:9588311 , RGD:9588311
NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
G
S100b
S100 calcium binding protein B
IEP
protein:increased expression:hippocampus
RGD
PMID:21843601
RGD:5508824
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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Selp
selectin P
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25451969
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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Slc18a2
solute carrier family 18 member A2
ISO
RGD
PMID:17898223
RGD:5131168
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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Slc5a7
solute carrier family 5 member 7
ISO
mRNA:decreased expression:habenula:
RGD
PMID:28420875
RGD:151347550
NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258
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Slc6a2
solute carrier family 6 member 2
IEP
RGD
PMID:18800064
RGD:6218960
NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
G
Slc6a4
solute carrier family 6 member 4
susceptibility severity treatment
ISO IMP
associated with Pulmonary Disease, Chronic Obstructive;DNA:SNP: :rs3794808 (human) associated with Chronic Hepatitis C; DNA:insertion/deletion:promoter: associated with Coronary Disease;DNA:repeats:promoter: associated with breast cancer;DNA:repeat:promoter: DNA:hypomethylation:promoter associated with Radiation Injuries;DNA:repeats:promoter: CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12898347 PMID:18458677 PMID:18686203 PMID:21843009 PMID:20981038 PMID:23571152 PMID:23096047 PMID:22134442 PMID:20664233 PMID:20808944 PMID:30582858 PMID:18295409 More...
RGD:4889426 , RGD:38676480 , RGD:38456010 , RGD:36947877 , RGD:36947869 , RGD:36947395 , RGD:36947387 , RGD:4889509
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Slc6a4m1Hubr
solute carrier family 6 member 4; ZFN induced mutant1, Hubr
IMP
RGD
PMID:18295409
RGD:4889509
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Snap25
synaptosome associated protein 25
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14708030
NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
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Snca
synuclein alpha
IEP ISO
RGD
PMID:18800064 PMID:19198857
RGD:6218960 , RGD:6478716
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sncg
synuclein, gamma
IEP
RGD
PMID:18800064
RGD:6218960
NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
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Sod1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19605942
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Stat3
signal transducer and activator of transcription 3
ISO
protein:increased phosphorylation:hippocampus (mouse)
RGD
PMID:31396300
RGD:126908003
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stk33
serine/threonine kinase 33
ISO
DNA:SNP:CDS:multiple (human)
RGD
PMID:35642741
RGD:401854249
NCBI chr 1:163,276,176...163,458,580
Ensembl chr 1:163,276,340...163,458,627
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Tg
thyroglobulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30373627
NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
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Th
tyrosine hydroxylase
IEP
mRNA,protein:decreased expression:hippocampus:
RGD
PMID:24495952
RGD:9681459
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tph1
tryptophan hydroxylase 1
ISO IEP
mRNA,protein:decreased expression:hippocampus: DNA:SNPs, haplotype:intron:218A>C, 779A>C (human)
RGD
PMID:16165107 PMID:24495952 PMID:17134762
RGD:1580459 , RGD:9681459 , RGD:5686354
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Tph2
tryptophan hydroxylase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17950541
NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
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Trem1
triggering receptor expressed on myeloid cells 1
treatment
IEP
RGD
PMID:32009956
RGD:127284856
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Uqcrb
ubiquinol-cytochrome c reductase binding protein
IEP
RGD
PMID:22311638
RGD:13801196
NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
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Xirp2
xin actin-binding repeat containing 2
ISO
DNA:SNP:CDS:multiple (human)
RGD
PMID:35642741
RGD:401854249
NCBI chr 3:52,126,213...52,213,094
Ensembl chr 3:51,870,092...52,213,091
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Xbp1
X-box binding protein 1
susceptibility
ISO
ClinVar Annotator: match by term: Major affective disorder 7 CTD Direct Evidence: marker/mechanism
OMIM ClinVar CTD
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Adcy3
adenylate cyclase 3
ISS
OMIM:608520 | OMIM:608691
MouseDO
NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
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Apoa1
apolipoprotein A1
susceptibility
IEP
protein: increased expression: cerebrospinal fluid
RGD
PMID:20580919
RGD:5128563
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apoa4
apolipoprotein A4
IEP
protein:increased expression:blood serum (rat)
RGD
PMID:20580919
RGD:5128563
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Arrb1
arrestin, beta 1
severity
ISO
protein:decreased expression:blood, mononuclear cell
RGD
PMID:15514408
RGD:1578803
NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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Bdnf
brain-derived neurotrophic factor
ISO
RGD
PMID:21803060
RGD:8655887
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28696432
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Calm2
calmodulin 2
ISO
mRNA:decreased expression:frontal association cortex
RGD
PMID:22885997
RGD:6892958
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Car1
carbonic anhydrase 1
ISS
OMIM:608520 | OMIM:608691
MouseDO
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Cat
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20471444
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Chrm2
cholinergic receptor, muscarinic 2
ISO
DNA:SNP:3' utr:1890A>T (human) protein:decreased expression:cerebral cortex
RGD
PMID:12116189 PMID:19103464
RGD:1358507 , RGD:5509584
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrnb3
cholinergic receptor nicotinic beta 3 subunit
ISO
mRNA:decreased expression:habenula:
RGD
PMID:28420875
RGD:151347550
NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
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Cntnap2
contactin associated protein 2
susceptibility
ISO
DNA:SNPs: : rs2710102,rs2710117(human)
RGD
PMID:23123147
RGD:13450917
NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027
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Crhr1
corticotropin releasing hormone receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23529111
NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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Crtc1
CREB regulated transcription coactivator 1
ISS
OMIM:608520 | OMIM:608691
MouseDO
NCBI chr16:18,988,197...19,046,914
Ensembl chr16:18,988,250...19,043,381
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Ctnnd2
catenin delta 2
susceptibility
ISO
DNA:polymorphism:multiple (human)
RGD
PMID:24256404
RGD:40902831
NCBI chr 2:81,168,525...82,016,495
Ensembl chr 2:81,167,117...82,015,764
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
treatment
ISO
associated with alcoholic psychosis;DNA:polymorphism: :1846G.A (rs3892097)(human)
RGD
PMID:34117140
RGD:401901273
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Disc1
DISC1 scaffold protein
susceptibility
ISO
DNA:SNP:Cds:p.S704C(human) protein:altered expression:orbitofrontal cortex
RGD
PMID:16959794 PMID:15657124
RGD:5509832 , RGD:5509834
NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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Dusp1
dual specificity phosphatase 1
ISO
mRNA:increased expression:dentated gyrus, hippocampus A1
RGD
PMID:20953200
RGD:7771583
NCBI chr10:16,680,478...16,683,275
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Edn1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29175309
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Eif4b
eukaryotic translation initiation factor 4B
ISO
protein:decreased expression:prefrontal cortex
RGD
PMID:21635931
RGD:11049139
NCBI chr 7:133,206,637...133,228,436
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Fkbp5
FKBP prolyl isomerase 5
susceptibility
ISO
associated with Trauma and Stressor Related Disorders; DNA:SNPs,haplotypes:multiple CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Major depressive disorder, increased recurrence of depressive episodes in, susceptibility to
OMIM CTD ClinVar RGD
PMID:15565110 PMID:20090668
RGD:401976504
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Foxp2
forkhead box P2
no_association
ISO
DNA:SNP: :rs10447760 (human) DNA:SNPs: :multiple
RGD
PMID:22404659 PMID:22404659
RGD:11535994 , RGD:11535994
NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
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Frem3
FRAS1 related extracellular matrix 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26441752
NCBI chr19:27,308,469...27,366,771
Ensembl chr19:27,308,469...27,366,771
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Gad1
glutamate decarboxylase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15560956
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gad2
glutamate decarboxylase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15560956
NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
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Gal
galanin and GMAP prepropeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27940914
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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Galr1
galanin receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27940914
NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577
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Galr2
galanin receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27940914
NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176
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Galr3
galanin receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27940914
NCBI chr 7:110,603,525...110,608,429
Ensembl chr 7:110,605,226...110,607,685
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Gata1
GATA binding protein 1
ISO
mRNA:increased expression:dorsolateral prefrontal cortex
RGD
PMID:22885997
RGD:6892958
NCBI chr X:14,529,706...14,537,530
Ensembl chr X:14,529,702...14,537,530
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Hspa1a
heat shock protein family A (Hsp70) member 1A
ISO
DNA:SNP: :rs1043618 (human)
RGD
PMID:17428599
RGD:5147598
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa1l
heat shock protein family A (Hsp70) member 1 like
ISO
DNA:SNPs: :rs2075799, rs2227956 (human)
RGD
PMID:17428599
RGD:5147598
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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Htr1b
5-hydroxytryptamine receptor 1B
sexual_dimorphism susceptibility
ISO
associated with attention deficit hyperactivity disorder;DNA:SNP: :rs11568817(human) associated with disease of mental health; DNA:SNP: :861G>C(human)
RGD
PMID:28923721 PMID:12496953
RGD:405650695 , RGD:405818271
NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
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Htr2a
5-hydroxytryptamine receptor 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD OMIM
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Htr2c
5-hydroxytryptamine receptor 2C
treatment
IDA
mRNA:increased editing
RGD
PMID:16005997
RGD:1624993
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Ifi44l
interferon-induced protein 44-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29175309
NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
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Il10
interleukin 10
ISO
associated with Hepatitis C, Chronic;DNA:SNPs, haplotype:promoter:-592C>A, -���819C>T, -1082G>A (human)
RGD
PMID:30734130
RGD:14975122
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il2
interleukin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12635532
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il3
interleukin 3
ISO
mRNA: increased expression: BA10: frontal cortex
RGD
PMID:20479761
RGD:5686897
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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Il5
interleukin 5
ISO
protein: increased expression: serum
RGD
PMID:22230487
RGD:5687135
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Il6
interleukin 6
ISO
associated with Hepatitis C, Chronic;DNA:SNP, haplotype:promoter:-174G>C (human)
RGD
PMID:30734130
RGD:14975122
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Isg15
ISG15 ubiquitin-like modifier
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29175309
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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Mc1r
melanocortin 1 receptor
ISO
DNA:SNP:cds: rs885479,R163Q
RGD
PMID:21052032
RGD:5687198
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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Med12
mediator complex subunit 12
ISO
DNA:mutation:multiple
RGD
PMID:12216017
RGD:1358728
NCBI chr X:66,404,807...66,427,775
Ensembl chr X:66,404,760...66,428,387
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Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20471444
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nos1
nitric oxide synthase 1
IEP
RGD
PMID:25001963
RGD:13825137
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
DNA:SNP:intron:IVS2+646C>G (human)
RGD
PMID:18246526
RGD:7174717
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29175309
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nrg1
neuregulin 1
ISO
mRNA:increased expression:prefrontal cortex
RGD
PMID:29295823
RGD:41404730
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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Ntrk2
neurotrophic receptor tyrosine kinase 2
severity
ISO
mRNA:decreased expression:depression DNA:SNPs: :rs2289657, rs56142442 (human) DNA:SNPs: : (human)
RGD
PMID:21223646 PMID:19844206 PMID:20124106
RGD:5684778 , RGD:5684911 , RGD:5684909
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Pawr
pro-apoptotic WT1 regulator
ISO
protein:decreased expression:brain:
RGD
PMID:20067857
RGD:9835359
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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Pdyn
prodynorphin
ISO
mRNA:decreased expression:periamygdaloid cortex associated with heroin dependence or alcohol use disorder;DNA:repeat:promoter:rs35286251 (human)
RGD
PMID:24231353 PMID:35271823
RGD:401850554 , RGD:401850556
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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Pten
phosphatase and tensin homolog
ISO
protein:increased expression:occipital cortex (human)
RGD
PMID:12969265
RGD:127285604
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Reln
reelin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11126396
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Slc5a7
solute carrier family 5 member 7
ISO
mRNA:decreased expression:habenula:
RGD
PMID:28420875
RGD:151347550
NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258
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Slc6a4
solute carrier family 6 member 4
treatment susceptibility no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:repeats:promotor: DNA:repeats:promoter: DNA:hypomethylation:promoter: DNA:SNPs, haplotypes:multiple
CTD RGD
PMID:16055263 PMID:12955294 PMID:15812265 PMID:24679990 PMID:19844206 PMID:27439447 PMID:12872203 More...
RGD:39128240 , RGD:38456009 , RGD:36947871 , RGD:5684911 , RGD:36947384 , RGD:36947382
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20471444
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Syn1
synapsin I
ISO
mRNA:decreased expression:dorsolateral prefrontal cortex
RGD
PMID:22885997
RGD:6892958
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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Tac1
tachykinin, precursor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15845098
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tph2
tryptophan hydroxylase 2
susceptibility
ISO
ClinVar Annotator: match by term: Major depressive disorder CTD Direct Evidence: marker/mechanism
ClinVar CTD OMIM
PMID:17905754 PMID:18347598 PMID:19319927 PMID:25741868
NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
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Xdh
xanthine dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20471444
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Disc1
DISC1 scaffold protein
ISS
OMIM:608516
MouseDO
NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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Hap1
huntingtin-associated protein 1
ISS
OMIM:608516
MouseDO
NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126
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Morc1
MORC family CW-type zinc finger 1
ISS
OMIM:608516
MouseDO
NCBI chr11:52,178,769...52,384,255
Ensembl chr11:52,178,769...52,384,255
G
Tph2
tryptophan hydroxylase 2
ISS
OMIM:608516
MouseDO
NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
G
Gabrd
gamma-aminobutyric acid type A receptor subunit delta
ISS
MouseDO
NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
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Il10
interleukin 10
IEP
RGD
PMID:17033197
RGD:1598630
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Tph1
tryptophan hydroxylase 1
ISO
RGD
PMID:15544576
RGD:1580465
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Serpine1
serpin family E member 1
treatment
IDA
RGD
PMID:26286041
RGD:11073724
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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