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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:adenosine signaling pathway
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Accession:PW:0000998 term browser browse the term
Definition:Adenosine signaling is involved in the regulation of several physiological processes. It uses four receptors of the GPCR family that activate the Gaphas or Galphai types of G proteins to increase or decrease the levels of cAMP. The adenosine receptors are a class of purinergic or purinoreceptors.
Synonyms:related_synonym: SMP:00320;   SMP:00321

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adenosine signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236
JBrowse link
G Adora2a adenosine A2a receptor ISO SMPDB SMP:00320 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adora2b adenosine A2B receptor ISO SMPDB SMP:00321 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 ISO SMPDB SMP:00320 SMP:00321 NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697
JBrowse link
G Atf2 activating transcription factor 2 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Bad BCL2-associated agonist of cell death ISO SMPDB SMP:00320 SMP:00321 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO SMPDB SMP:00320 SMP:00321 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Cdc42 cell division cycle 42 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO SMPDB SMP:00320 SMP:00321 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Elk1 ETS transcription factor ELK1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Gnas GNAS complex locus ISO SMPDB SMP:00320 SMP:00321 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnb1 G protein subunit beta 1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
JBrowse link
G Gng12 G protein subunit gamma 12 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO SMPDB SMP:00320 SMP:00321 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO SMPDB SMP:00320 SMP:00321 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO SMPDB SMP:00320 SMP:00321 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO SMPDB SMP:00320 SMP:00321 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO SMPDB SMP:00320 SMP:00321 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO SMPDB SMP:00320 SMP:00321 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO SMPDB SMP:00320 SMP:00321 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO SMPDB SMP:00320 SMP:00321 NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO SMPDB SMP:00320 SMP:00321 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO SMPDB SMP:00320 SMP:00321 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Prkcz protein kinase C, zeta ISO SMPDB SMP:00320 SMP:00321 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO SMPDB SMP:00320 SMP:00321 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO SMPDB SMP:00320 SMP:00321 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link

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  pathway 6098
    signaling pathway 2648
      nucleoside and nucleotide mediated signaling pathway 39
        adenosine signaling pathway 39
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