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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rofecoxib
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Accession:CHEBI:8887 term browser browse the term
Definition:A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Synonyms:exact_synonym: 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
 related_synonym: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone;   Ceoxx;   Formula=C17H14O4S;   InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3;   InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N;   SMILES=CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1;   Vioxx;   rofecoxibum
 xref: CAS:162011-90-7;   DrugBank:DB00533;   Drug_Central:2397;   KEGG:C07590;   KEGG:D00568;   LINCS:LSM-2482
 xref_mesh: MESH:C116926
 xref: PMID:10859630;   PMID:11014111;   PMID:12069696;   PMID:16934051;   PMID:20162413;   PMID:28166217;   Reaxys:8269007;   Wikipedia:Rofecoxib


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rofecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 affects expression ISO rofecoxib affects the expression of ADAMTS8 mRNA CTD PMID:17070997 NCBI chr 8:29,349,078...29,368,413
Ensembl chr 8:29,349,114...29,368,404 		JBrowse link
G Adgrf1 adhesion G protein-coupled receptor F1 affects expression ISO rofecoxib affects the expression of ADGRF1 mRNA CTD PMID:17070997 NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704 		JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 affects expression ISO rofecoxib affects the expression of ADGRG6 mRNA CTD PMID:17070997 NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123 		JBrowse link
G Afdn afadin, adherens junction formation factor affects expression ISO rofecoxib affects the expression of AFDN mRNA CTD PMID:17070997 NCBI chr 1:53,905,344...54,034,216
Ensembl chr 1:53,905,373...54,034,216 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B affects expression ISO rofecoxib affects the expression of ALOX15B mRNA CTD PMID:17070997 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
G Angpt1 angiopoietin 1 decreases expression ISO rofecoxib results in decreased expression of ANGPT1 mRNA CTD PMID:17070997 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO rofecoxib results in decreased expression of ANGPTL1 mRNA CTD PMID:17070997 NCBI chr13:68,963,186...68,981,649
Ensembl chr13:68,962,991...68,992,570 		JBrowse link
G Anxa1 annexin A1 affects expression ISO rofecoxib affects the expression of ANXA1 mRNA CTD PMID:17070997 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa3 annexin A3 increases expression ISO rofecoxib results in increased expression of ANXA3 mRNA CTD PMID:17070997 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Anxa9 annexin A9 decreases expression ISO rofecoxib results in decreased expression of ANXA9 mRNA CTD PMID:17070997 NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374 		JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression ISO rofecoxib results in decreased expression of AOX1 mRNA CTD PMID:17070997 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO rofecoxib results in decreased expression of ARHGAP29 mRNA CTD PMID:17070997 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028 		JBrowse link
G C3 complement C3 increases expression ISO rofecoxib results in increased expression of C3 mRNA CTD PMID:17070997 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 decreases expression ISO rofecoxib results in decreased expression of CACNA2D3 mRNA CTD PMID:17070997 NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP rofecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of CALCA protein] CTD PMID:16690336 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cat catalase multiple interactions EXP rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] CTD PMID:20043943 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO rofecoxib results in increased expression of CCL2 mRNA CTD PMID:17070997 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions
increases expression		 ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein]
rofecoxib results in increased expression of CCL20 mRNA; rofecoxib results in increased expression of CCL20 protein		 CTD PMID:17667525 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO rofecoxib results in increased expression of CCL3 mRNA; rofecoxib results in increased expression of CCL3 protein
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL3 protein]		 CTD PMID:17667525 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression		 ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein]
rofecoxib results in increased expression of CCL5 mRNA; rofecoxib results in increased expression of CCL5 protein		 CTD PMID:17667525 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO rofecoxib inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 protein] CTD PMID:17565644 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cdh2 cadherin 2 affects expression ISO rofecoxib affects the expression of CDH2 mRNA CTD PMID:17070997 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdh3 cadherin 3 increases expression ISO rofecoxib results in increased expression of CDH3 mRNA CTD PMID:17070997 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Cdsn corneodesmosin affects expression ISO rofecoxib affects the expression of CDSN mRNA CTD PMID:17070997 NCBI chr20:3,179,432...3,184,252
Ensembl chr20:3,179,438...3,184,250 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 affects expression ISO rofecoxib affects the expression of CEACAM1 mRNA CTD PMID:17070997 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Clu clusterin increases expression ISO rofecoxib results in increased expression of CLU mRNA CTD PMID:17070997 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col14a1 collagen type XIV alpha 1 chain decreases expression ISO rofecoxib results in decreased expression of COL14A1 mRNA CTD PMID:17070997 NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214 		JBrowse link
G Colec12 collectin sub-family member 12 decreases expression ISO rofecoxib results in decreased expression of COLEC12 mRNA CTD PMID:17070997 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618 		JBrowse link
G Crisp3 cysteine-rich secretory protein 3 increases expression ISO rofecoxib results in increased expression of CRISP3 mRNA CTD PMID:17070997 NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CX3CL1 mRNA CTD PMID:17070997 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]
rofecoxib results in decreased activity of CYP1A2 protein		 CTD PMID:15834531 PMID:16934051 PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Defb5 defensin beta 5 increases expression ISO rofecoxib results in increased expression of DEFB4 mRNA CTD PMID:17070997 NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467 		JBrowse link
G Dsc1 desmocollin 1 affects expression ISO rofecoxib affects the expression of DSC1 mRNA CTD PMID:17070997 NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB] CTD PMID:12126971 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO rofecoxib results in decreased expression of EPHA3 mRNA CTD PMID:17070997 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900 		JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO rofecoxib results in decreased expression of EPHB6 mRNA CTD PMID:17070997 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230 		JBrowse link
G Etv5 ETS variant transcription factor 5 decreases expression ISO rofecoxib results in decreased expression of ETV5 mRNA CTD PMID:17070997 NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO rofecoxib results in decreased expression of FABP4 mRNA CTD PMID:17070997 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Faf1 Fas associated factor 1 affects expression ISO rofecoxib affects the expression of FAF1 mRNA CTD PMID:17070997 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO rofecoxib results in decreased expression of FAIM2 mRNA CTD PMID:17070997 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168 		JBrowse link
G Flnb filamin B increases expression ISO rofecoxib results in increased expression of FLNB mRNA CTD PMID:17070997 NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006 		JBrowse link
G Foxd1 forkhead box D1 decreases expression ISO rofecoxib results in decreased expression of FOXD1 mRNA CTD PMID:17070997 NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:29,702,558...29,704,978 		JBrowse link
G Frzb frizzled-related protein affects expression ISO rofecoxib affects the expression of FRZB mRNA CTD PMID:17070997 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO rofecoxib results in decreased expression of GATA3 mRNA CTD PMID:17070997 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO rofecoxib results in decreased expression of HGF mRNA CTD PMID:17070997 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression ISO rofecoxib results in decreased expression of HPGD mRNA CTD PMID:17070997 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Il1a interleukin 1 alpha affects expression
decreases expression		 ISO rofecoxib affects the expression of IL1A mRNA
rofecoxib results in decreased expression of IL1A mRNA		 CTD PMID:17070997 PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
rofecoxib promotes the reaction [Acetic Acid results in increased expression of IL1B protein]		 CTD PMID:11376495 PMID:12126971 PMID:14762100 PMID:15705740 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO rofecoxib results in increased expression of IL1RN mRNA CTD PMID:17070997 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 increases expression ISO rofecoxib results in increased expression of IL6 mRNA; rofecoxib results in increased expression of IL6 protein CTD PMID:17070997 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insm1 INSM transcriptional repressor 1 decreases expression ISO rofecoxib results in decreased expression of INSM1 mRNA CTD PMID:17070997 NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003 		JBrowse link
G Itgbl1 integrin subunit beta like 1 affects expression ISO rofecoxib affects the expression of ITGBL1 mRNA CTD PMID:17070997 NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733 		JBrowse link
G Klf12 KLF transcription factor 12 affects expression ISO rofecoxib affects the expression of KLF12 mRNA CTD PMID:17070997 NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP rofecoxib inhibits the reaction [Dimethoate results in increased expression of LHB protein] CTD PMID:19579042 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO rofecoxib results in decreased expression of LIFR mRNA CTD PMID:17070997 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha increases expression ISO rofecoxib results in increased expression of LMX1A mRNA CTD PMID:17070997 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253 		JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO rofecoxib results in increased expression of MAL mRNA CTD PMID:17070997 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO rofecoxib results in decreased expression of MAPRE2 mRNA CTD PMID:17070997 NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044 		JBrowse link
G Mbtd1 mbt domain containing 1 decreases expression ISO rofecoxib results in decreased expression of MBTD1 mRNA CTD PMID:17070997 NCBI chr10:78,839,140...78,895,413
Ensembl chr10:78,839,036...78,893,720 		JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression ISO rofecoxib affects the expression of MEF2C mRNA CTD PMID:17070997 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Meox2 mesenchyme homeobox 2 decreases expression ISO rofecoxib results in decreased expression of MEOX2 mRNA CTD PMID:17070997 NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO rofecoxib results in increased expression of MMP1 mRNA CTD PMID:16580899 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO rofecoxib results in increased expression of MMP3 mRNA CTD PMID:16580899 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO rofecoxib affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Mta2 metastasis associated 1 family, member 2 decreases expression ISO rofecoxib results in decreased expression of MTA2 mRNA CTD PMID:17070997 NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946 		JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO rofecoxib results in decreased expression of NAALADL2 mRNA CTD PMID:17070997 NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689 		JBrowse link
G Nfasc neurofascin decreases expression ISO rofecoxib results in decreased expression of NFASC mRNA CTD PMID:17070997 NCBI chr13:43,997,223...44,183,863
Ensembl chr13:43,997,224...44,183,880 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein] CTD PMID:16879691 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO rofecoxib affects the expression of NOS1 mRNA CTD PMID:17070997 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:16879691 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP rofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; rofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 PMID:25596430 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Npas3 neuronal PAS domain protein 3 increases expression ISO rofecoxib results in increased expression of NPAS3 mRNA CTD PMID:17070997 NCBI chr 6:70,702,773...71,527,928
Ensembl chr 6:70,703,170...71,524,884 		JBrowse link
G Npr2 natriuretic peptide receptor 2 decreases expression ISO rofecoxib results in decreased expression of NPR2 mRNA CTD PMID:17070997 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression ISO rofecoxib affects the expression of NQO1 mRNA CTD PMID:17070997 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha decreases expression ISO rofecoxib results in decreased expression of PI4KA mRNA CTD PMID:17070997 NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080 		JBrowse link
G Pla2g2a phospholipase A2 group IIA affects expression ISO rofecoxib affects the expression of PLA2G2A mRNA CTD PMID:17070997 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO rofecoxib results in increased expression of PLAT mRNA CTD PMID:16580899 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pml PML nuclear body scaffold increases expression ISO rofecoxib results in increased expression of PML mRNA CTD PMID:17070997 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Postn periostin affects expression ISO rofecoxib affects the expression of POSTN mRNA CTD PMID:17070997 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Prrx1 paired related homeobox 1 affects expression ISO rofecoxib affects the expression of PRRX1 mRNA CTD PMID:17070997 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866 		JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO rofecoxib results in decreased expression of PTGER3 mRNA CTD PMID:17070997 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO rofecoxib results in decreased expression of PTGIS mRNA CTD PMID:17175104 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression		 ISO rofecoxib analog results in decreased activity of PTGS1 protein; rofecoxib results in decreased activity of PTGS1 protein
rofecoxib results in decreased expression of PTGS1 mRNA		 CTD PMID:16141368 PMID:17175104 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases response to substance
multiple interactions
decreases activity
increases expression
decreases expression		 ISO
EXP		 PTGS2 promoter SNP results in increased susceptibility to rofecoxib
[rofecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
rofecoxib results in increased expression of PTGS2 mRNA
PTGS2 inhibits the reaction [rofecoxib results in increased uptake of Hexoses]
rofecoxib results in decreased expression of PTGS2 mRNA
[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Lipopolysaccharides; Dinoprostone results in decreased susceptibility to [rofecoxib results in decreased activity of PTGS2 protein]		 CTD PMID:10594344 PMID:11245490 PMID:11321505 PMID:11703585 PMID:12110471 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rasa1 RAS p21 protein activator 1 affects expression ISO rofecoxib affects the expression of RASA1 mRNA CTD PMID:17070997 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rnf144b ring finger protein 144B increases expression ISO rofecoxib results in increased expression of RNF144B mRNA CTD PMID:17070997 NCBI chr17:17,431,271...17,580,687
Ensembl chr17:17,432,786...17,562,760 		JBrowse link
G Rorc RAR-related orphan receptor C decreases expression ISO rofecoxib results in decreased expression of RORC mRNA CTD PMID:17070997 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO rofecoxib results in increased expression of SCD mRNA CTD PMID:17070997 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO rofecoxib results in increased expression of SERPINA3 mRNA CTD PMID:17070997 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Sh2d1a SH2 domain containing 1A decreases expression ISO rofecoxib results in decreased expression of SH2D1A mRNA CTD PMID:17070997 NCBI chr  X:121,373,693...121,401,923 JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO SLC2A1 inhibits the reaction [rofecoxib results in increased uptake of Hexoses] CTD PMID:16447059 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions		 ISO rofecoxib results in increased expression of SLC2A4 mRNA; rofecoxib results in increased expression of SLC2A4 protein
[rofecoxib results in increased expression of SLC2A4 protein] which results in increased uptake of Hexoses		 CTD PMID:16447059 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO rofecoxib results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO rofecoxib results in increased expression of SOCS3 mRNA; rofecoxib results in increased expression of SOCS3 protein CTD PMID:17070997 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO rofecoxib results in increased expression of SOD2 mRNA CTD PMID:17070997 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO rofecoxib results in increased expression of STAT3 mRNA CTD PMID:17070997 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO rofecoxib results in increased expression of TAC1 protein CTD PMID:16449370 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tead4 TEA domain transcription factor 4 increases expression ISO rofecoxib results in increased expression of TEAD4 mRNA CTD PMID:17070997 NCBI chr 4:161,474,122...161,572,837
Ensembl chr 4:161,497,851...161,572,323 		JBrowse link
G Tfrc transferrin receptor affects expression ISO rofecoxib affects the expression of TFRC mRNA CTD PMID:17070997 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO rofecoxib results in decreased expression of TIMP3 mRNA CTD PMID:16580899 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO rofecoxib results in increased expression of TMPRSS4 mRNA CTD PMID:17070997 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409 		JBrowse link
G Tnc tenascin C increases expression ISO rofecoxib results in increased expression of TNC mRNA CTD PMID:17070997 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 rofecoxib promotes the reaction [Acetic Acid results in increased expression of TNF protein]
rofecoxib results in decreased expression of TNF protein		 CTD PMID:11376495 PMID:17878525 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trim17 tripartite motif-containing 17 affects expression ISO rofecoxib affects the expression of TRIM17 mRNA CTD PMID:17070997 NCBI chr10:43,743,111...43,750,929
Ensembl chr10:43,740,604...43,750,919 		JBrowse link
G Tspan2 tetraspanin 2 decreases expression ISO rofecoxib results in decreased expression of TSPAN2 mRNA CTD PMID:17070997 NCBI chr 2:190,177,717...190,234,994
Ensembl chr 2:190,177,741...190,219,660 		JBrowse link
G Vcan versican decreases expression ISO rofecoxib results in decreased expression of VCAN mRNA CTD PMID:17070997 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        pharmacological role 19090
          analgesic 14766
            rofecoxib 110
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  ester 17477
                                    carboxylic ester 16735
                                      lactone 13290
                                        gamma-lactone 6849
                                          butenolide 6384
                                            rofecoxib 110
paths to the root