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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
(+)-conocarpan  
(-)-beta-caryophyllene 
(-)-cubebin 
(-)-larreatricin 
(-)-microperfuranone 
(2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 
(2S)-2-[[(2S)-2-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylpentoxy]-1-oxo-3-phenylpropyl]amino]-4-methylsulfonylbutanoic acid propan-2-yl ester 
(2S)-2-[[(2S)-2-[(2S,3R)-2-[(2-amino-3-mercaptopropyl)amino]-3-methylpentoxy]-1-oxo-3-phenylpropyl]amino]-4-methylsulfonylbutanoic acid propan-2-yl ester 
(2S)-2-[[2-[(2S,3S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylpentoxy]-1-oxo-3-phenylpropyl]amino]-4-methylsulfonylbutanoic acid propan-2-yl ester 
(2S,3S)-2,3-dihydro-3-hydroxymethyl-2-(4-hydroxyphenyl)-5-(E)-propenylbenzofuran 
(5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate 
(5E)-5-[(4-methoxyphenyl)methylidene]-1,1-dioxo-2,3-diphenyl-1,3-thiazolidin-4-one 
(5Z)-3-(4-chlorophenyl)-4-hydroxy-5-(naphthalen-1-ylmethylidene)furan-2(5H)-one 
(E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside 
(E)-3-tosylacrylonitrile 
(E)-ascladiol 
(R)-ketamine 
(R)-ketorolac +   
(RS)-mallotophilippen E 
(S)-etodolac 
(S)-ketorolac +   
(Z)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-furanone 
(Z)-6,6',7,3'a-Diligustilide 
(Z)-ligustilide  
1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone 
1-(\{1-ethyl-4-[3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl]-1H-pyrazol-5-yl\}oxy)ethyl methyl carbonate +  
1-(all-cis-docosa-7,10,13,16-tetraenoyl)glycerol 
1-phenyl-3-(phenylsulfonyl)-2-propen-1-one 
13,14,15,16-tetranorlabdane-8alpha,12,18-triol 
2,2',5,5'-tetrachloro-4,4'-bis(methylsulfonyl)biphenyl 
2,5-Dichloro-carboxymethylenebut-2-en-4-olide 
2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran 
2-(2-hydroxy-4-methoxyphenyl)-5-(3-hydroxypropyl)benzofuran 
2-(4-hydroxyphenyl)-5-(E)-propenylbenzofuran 
2-(benzenesulfonyl)benzaldehyde oxime 
2-\{2-chloro-4-(methylsulfonyl)-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl\}cyclohexane-1,3-dione +  
2-bromo-1-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-propanone 
2-bromo-2-\{[(4-methylphenyl)sulfonyl]methyl\}-1-indanone 
2-chloro-4-carboxy(chloro)methylenebut-2-en-4-olide 
2-chloro-4-carboxymethylenebut-2-en-1,4-olide +  
2-Chloro-5-methyl-cis-dienelactone 
2-cyano-3-cyclopropyl-1-(2-mesyl-4-trifluoromethylphenyl)propan-1,3-dione 
2-oxo-3-(5-oxofuran-2-ylidene)propanoic acid 
3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 
3-(\{[(2S)-5-oxopyrrolidin-2-yl]methyl\}sulfonyl)-N-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alanin[N-(1-cyanocyclopropyl)]amide 
3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl alpha-D-galactosyl-(1->4)-beta-D-galactoside 
3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucoside 
3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside 
3-[2-chloro-4-(methylsulfonyl)benzoyl]-4-(phenylthio)bicyclo[3.2.1]oct-3-en-2-one +  
3-[2-chloro-4-(methylsulfonyl)benzoyl]-4-hydroxybicyclo[3.2.1]oct-3-en-2-one +  
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone  
3-hydroxymethyl-4-methyl-furan-2(5H)-one 
3-o-Ethyl-L-ascorbic acid 
4,4'-dihydroxybenzyl sulfone 
4,4'-sulfonyldiphenol  
4-(methylamino)antipyrine 
4-aminoantipyrine 
4-carboxymethylenebut-2-en-4-olide +  
4-Fluoromuconolactone 
5-(3-hydroxypropyl)-2-(2-methoxy-4-hydroxyphenyl)benzofuran 
5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone 
5-Fluoromuconolactone 
5-hydroxy-4-methoxy-5-(1-methylethenyl)-2-furanone 
5-methoxy-8-(2'-hydroxy-3'-buthoxy-3'-methylbutyloxy)psoralen 
5-oxo-2-furylacetic acid +  
6-[(5-chloro-3-methyl-1-benzofuran-2-yl)sulfonyl]pyridazin-3(2H)-one 
6-chloro-N-[(2S)-3-(1,1-dioxidothiomorpholin-4-yl)-3-oxo-2-\{[(1-pyridin-4-ylpiperidin-4-yl)methyl]amino\}propyl]naphthalene-2-sulfonamide 
6-diazo-5-oxo-L-norleucine 
8alpha,19-dihydroxylabd-13E-ene-15-oic acid 
[4-(6-methylheptanoyl)-5-oxo-2,5-dihydrofuran-3-yl]methyl phosphate 
[5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid 
aceclofenac  
acedapsone 
acemetacin  
acetosyringone +  
acetylsalicylic acid +   
adapalene  
adenosine +   
agglomerin F 
aglaiabbreviatin A 
aglaiabbreviatin B 
ajugaciliatin A 
ajugaciliatin B 
ajugaciliatin C 
ajugaciliatin D 
ajugaciliatin E 
ajugaciliatin F 
ajugaciliatin G 
ajugaciliatin H 
ajugaciliatin I 
ajugaciliatin J 
ajugacumbin A 
ajugacumbin A chlorohydrin 
ajugacumbin F 
ajugalide B 
ajugalide C 
ajugamarin A1 
ajugamarin A1 chlorohydrin 
ajugamarin A2 
ajugamarin A2 chlorohydrin 
ajugamarin B1 
ajugamarin G1 
ajugamarin H1 
ajuganipponin A 
ajuganipponin B 
ajugapantin A 
Ajugarin I 
ajugatakasin A 
ajugatakasin B 
alclofenac  
Aldoxycarb 
alisiaquninone C 
alminoprofen 
almotriptan +   
almotriptan malate 
alpha-angelica lactone 
amantadine  
amfenac +   
amfenac sodium hydrate 
aminophenazone  
amisulpride  
amlexanox  
amodiaquine +   
ampiroxicam 
Anemonin  
antipyrine +   
apazone  
apigenin 7-O-beta-D-glucoside  
apigenin 7-O-beta-D-glucoside(1-) 
aplysinoplide A 
aplysinoplide B 
aplysinoplide C 
apocynin  
apremilast 
arasertaconazole +   
ascidiathiazone A 
ascidiathiazone B 
aspirin-triggered resolvin D1 
aspulvinone +  
azadiradionolide 
baicalin  
balsalazide +   
balsalazide disodium 
balsaminolate 
bauhinoxepin F 
bauhinoxepin I 
BE-23372M 
bendazac 
benoxaprofen  
benzoylmesaconine  
benzydamine  
beta-angelica lactone +  
betulin +   
biotin sulfone 
biphenyl-4-ylacetic acid +  
bromfenac  
bromfenac sodium salt +  
bromfenac sodium salt sesquihydrate 
bufexamac 
bumadizone 
bumadizone calcium +  
bumadizone calcium hemihydrate 
bunodosine 391 
but-2-en-4-olide +   
but-3-en-4-olide +  
butalbital 
cafenstrole  
carbamazepine +   
cardenolides +   
carlosic acid +  
carlosic acid methyl ester 
carprofen +   
cassiatannin A 
celecoxib  
centaureidin 
ceritinib  
chlormezanone +  
cimetidine +   
cimicoxib 
cinnamtannin B-1 
cinnamtannin D-1 
cis-trans-nepetalactone 
clofazimine  
clonixin 
clonixin lysine salt 
corilagin  
crisaborole 
daibulactone A, (rel)- 
daibulactone B, (rel)- 
dapsone +   
DAS645 
decursinol 
dehydrocostus lactone  
Demeton-S-methylsulphon 
deracoxib 
dexibuprofen 
dexketoprofen 
dexmedetomidine +   
diazoxide  
dibenzothiophene sulfone 
diclofenac +   
difenpiramide 
diflunisal  
Dimethipin 
dinitrogen oxide  
diphenyl sulfone +   
dithiosalicylic acid 
divinyl sulfone  
droxicam 
dysolenticin B 
dysolenticin C 
ecgonine methyl ester +   
elaeodendroside B 
elaeodendroside F 
elaeodendroside G 
elaeodendroside T 
eletriptan  
eletriptan hydrobromide 
enprofylline +  
esketamine +  
esketamine hydrochloride 
etodolac +   
etoricoxib  
eutypoid B 
eutypoid C 
eutypoid D 
eutypoid E 
fenbufen  
fendosal 
fenoprofen  
fenoprofen calcium 
fenoprofen calcium (anhydrous) +  
fipronil-sulfone  
firocoxib 
florfenicol 
fluensulfone  
flufenamate 
flufenamic acid  
flunixin  
flunixin meglumine  
flunoxaprofen 
fluoxetine  
fluoxetine hydrochloride 
flupyradifurone 
flurbiprofen +   
fomitopinic acid A 
fomitoside E 
fomitoside F 
gallic acid +   
garenoxacin 
gigantetronenin 
gigantrionenin 
ginkgetin  
glafenine  
glucocheirolin 
glucoerysolin 
GW 501516 sulfone 
hallactone B 
hedychilactone D 
humulone 
ibufenac  
ibuprofen +   
ibuproxam 
impatienol 
impatienolate 
indometacin +   
indoprofen  
ipomotaoside A 
Isomuronic acid 
isoxaflutole 
isoxicam 
JWH-133 
kebuzone 
ketamine +   
ketamine hydrochloride +  
ketoprofen  
ketorolac  
ketorolac tromethamine 
leflunomide  
leucosesterlactone 
Lichesterinic acid 
lifitegrast 
linderalactone 
LM-1685  
lonazolac 
lonazolac calcium 
lornoxicam  
loxoprofen +   
loxoprofen sodium +  
loxoprofen sodium hydrate 
LSM-4499 
lumiracoxib  
lupulin A 
LY-221481 
magnesium sulfate +   
Maklamicin, (rel)- 
mallotophilippen C 
mallotophilippen D 
manoalide  
matsudone A 
mavacoxib 
meclofenamic acid  
mefenamic acid  
meloxicam  
mesalamine  
meso-3,3'-didemethoxynectandrin B 
mesotrione +   
mesylmethyl(benzyl)sulfone 
metamizole 
metamizole sodium  
methimazole S-oxide 
methionine sulfone +  
metiazinic acid 
miroprofen 
mitoxantrone +   
mofebutazone 
monoacetyldapsone 
MT-2153 +  
N-[(4-methylpiperazin-1-yl)carbonyl]-L-phenylalanin-(N-\{(1S)-3-phenyl-1-[2-(benzenesulfonyl)ethyl]propyl\})amide 
N-[2-methoxy-5-(\{[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl\}methyl)phenyl]glycine +  
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide +   
N-acetylmethionine sulfone 
N-butan-2-yl-3,8-dimethyl-2-oxo-1-oxaspiro[4.5]dec-3-ene-4-carboxamide 
N-phenylacetamide +   
nabumetone  
naproxcinod 
naproxen +   
naproxen sodium 
naproxol 
nedocromil  
nefazodone +   
nepafenac 
nimesulide  
nitroflurbiprofen  
nitroso-dapsone 
nitrosulindac 
non-narcotic analgesic +   
nortriptyline  
NS-398  
O-methylsalicylic acid +   
O-propanoylcarnitine +  
oleocanthal 
olsalazine 
olsalazine sodium 
opioid analgesic +   
oxametacin 
oxaprozin  
oxycarboxin 
oxyphenbutazone +   
oxyphenbutazone hydrate 
paracetamol +   
parameritannin A-1 
parecoxib  
parthenolide +   
patuletin 
penicillic acid 
PFE-PKIS 18 
PHA-665752  
phenylbutazone +   
pirfenidone  
piroxicam +   
probenazole 
proglumetacin +  
proglumetacin dimaleate 
propoxyphene 
propyphenazone 
protoanemonin 
pseudoneolinderane 
Pulvinic acid 
Pulvinic acid dilactone 
pyrasulfotole 
quercetin 4'-O-alpha-L-rhamnopyranosyl-3-O-beta-D-allopyranoside 
rataniaphenol I 
rataniaphenol II 
rataniaphenol III 
remazole black-GR 
remazole black-GR (4-) +  
remazole orange-3R 
remazole orange-3R(2-) +  
rimsulfuron 
Ro 41-5253  
robenacoxib 
rofecoxib  
A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
rosmarinic acid +   
RU 58668  
salicin +   
salsalate  
sarmentologenin +  
SC-58125  
SC560 
scutebarbatine C 
scutebarbatine D 
scutebarbatine E 
sertaconazole  
sertaconazole nitrate 
sodium (2-amino-3-benzoylphenyl)acetate +  
sodium gallate 
sodium meclofenamate monohydrate 
sotolone 
spiromesifen 
SR9243 
stattic  
strigolactone +  
sulcotrione 
sulfasalazine  
sulfolane 
sulfonyldimethane  
sulindac +   
sulindac sulfide  
sulindac sulfone  
suprofen  
suxibuzone  
tembotrione 
tenidap  
tenoxicam  
tepoxalin  
teriflunomide  
tetradifon  
thiamphenicol 
thiomarinol B 
tiaprofenic acid  
tilmacoxib 
tolfenamic acid  
tolmetin  
tolmetin sodium +  
tolmetin sodium dihydrate 
topramezone 
trans-cinnamyl methyl 2-tosylmalonate 
trilobacin 
triptonide  
U50488  
valdecoxib +   
vedaprofen 
venlafaxine +   
vismodegib  
viteagnusin I 
vitexilactone 
Vulpinic acid 
WAY-316606 
willow bark extract 
WIN 55212-2  
WLL-vs 
wogonin +   
ximoprofen 
xylazine  
xylazine hydrochloride 
yadanziolide V 
zileuton  
zomepirac  

Synonyms
Exact Synonyms: 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
Related Synonyms: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone ;   Ceoxx ;   Formula=C17H14O4S ;   InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3 ;   InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N ;   SMILES=CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1 ;   Vioxx ;   rofecoxibum
Xrefs: Beilstein:8269007 ;   CAS:162011-90-7 ;   DrugBank:DB00533 ;   Drug_Central:2397 ;   KEGG:C07590 ;   KEGG:D00568 ;   LINCS:LSM-2482
Xref Mesh: MESH:C116926
Xrefs: PMID:10859630 ;   PMID:11014111 ;   PMID:12069696 ;   PMID:16934051 ;   PMID:20162413 ;   PMID:28166217 ;   Reaxys:8269007 ;   Wikipedia:Rofecoxib

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.