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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butenolide
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Accession:CHEBI:50523 term browser browse the term
Definition:A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.
Synonyms:exact_synonym: furan-2-one
 related_synonym: 2-furanone;   Formula=C4H4O2;   butenolides
 alt_id: CHEBI:22960;   CHEBI:38121
 xref_mesh: MESH:C004511
 xref: Wikipedia:Butenolide


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(Z)-ligustilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
ISO ligustilide results in increased activity of AHR protein
[butylidenephthalide co-treated with ligustilide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; ligustilide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD PMID:29191726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of AKT1 protein CTD PMID:23973442 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO ligustilide results in decreased expression of APP protein CTD PMID:23973442 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ligustilide results in increased expression of BAX mRNA; ligustilide results in increased expression of BAX protein CTD PMID:31765699 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ligustilide results in decreased expression of BCL2 mRNA; ligustilide results in decreased expression of BCL2 protein CTD PMID:31765699 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO ligustilide results in increased activity of CASP3 protein
ligustilide results in increased cleavage of CASP3 protein
CTD PMID:30243965, PMID:31765699 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO ligustilide results in increased cleavage of CASP9 protein CTD PMID:31765699 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO ligustilide results in increased expression of and results in increased activity of CAT protein CTD PMID:23973442 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO ligustilide results in increased expression of CCNB1 protein CTD PMID:31765699 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO ligustilide results in increased expression of CCND1 protein CTD PMID:31765699 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ligustilide results in increased expression of CDKN1A protein CTD PMID:31765699 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO ligustilide results in increased expression of CYCS protein CTD PMID:31765699 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO ligustilide results in increased expression of CYP1A1 mRNA
ligustilide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:29191726 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of FOXO1 protein CTD PMID:23973442 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO ligustilide results in increased expression of HMOX1 mRNA; ligustilide results in increased expression of HMOX1 protein CTD PMID:23441843, PMID:30243965 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization EXP ligustilide affects the localization of HSF1 protein CTD PMID:26212861 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases phosphorylation ISO ligustilide results in decreased phosphorylation of IGF1R protein CTD PMID:23973442 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of IRS1 protein CTD PMID:23973442 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kl Klotho increases expression ISO ligustilide results in increased expression of KL mRNA; ligustilide results in increased expression of KL protein CTD PMID:23973442 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP ligustilide results in increased phosphorylation of MAPK1 protein CTD PMID:26212861 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP ligustilide results in increased phosphorylation of MAPK3 protein CTD PMID:26212861 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau decreases phosphorylation ISO ligustilide results in decreased phosphorylation of MAPT protein CTD PMID:23973442 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases methylation
affects response to substance
increases methylation
multiple interactions
ISO ligustilide results in decreased methylation of NFE2L2 promoter
NFE2L2 protein affects the susceptibility to ligustilide
ligustilide results in increased methylation of NFE2L2 promoter
ligustilide results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:23441843, PMID:30243965 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO ligustilide results in increased expression of NQO1 mRNA; ligustilide results in increased expression of NQO1 protein CTD PMID:23441843, PMID:30243965 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO ligustilide results in increased activity of NR1I2 protein
[ligustilide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO ligustilide results in increased expression of and results in increased activity of SOD2 protein CTD PMID:23973442 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO ligustilide results in decreased expression of and results in increased phosphorylation of TP53 protein CTD PMID:31765699 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ligustilide results in increased expression of UGT1A1 protein
ligustilide results in increased expression of UGT1A1 mRNA
CTD PMID:23441843, PMID:30243965 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh13 cadherin 13 affects response to substance ISO CDH13 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103
JBrowse link
G Cdyl2 chromodomain Y-like 2 affects response to substance ISO CDYL2 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr19:49,087,131...49,222,528
Ensembl chr19:49,093,355...49,198,073
JBrowse link
G Dner delta/notch-like EGF repeat containing affects response to substance ISO DNER gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
JBrowse link
G Gna14 G protein subunit alpha 14 affects response to substance ISO GNA14 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr 1:235,165,775...235,347,986
Ensembl chr 1:235,166,718...235,347,937
JBrowse link
G Grip1 glutamate receptor interacting protein 1 affects response to substance ISO GRIP1 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr 7:64,672,723...64,854,939
Ensembl chr 7:64,672,722...64,864,404
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone results in increased mutagenesis of HPRT1 gene CTD PMID:17993254 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Mrtfb myocardin related transcription factor B affects response to substance ISO MRTFB gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr10:1,151,163...1,273,269 JBrowse link
G Plxna2 plexin A2 affects response to substance ISO PLXNA2 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648
JBrowse link
G Tp53 tumor protein p53 increases mutagenesis EXP 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone results in increased mutagenesis of TP53 gene CTD PMID:11152562 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
Anemonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos2 nitric oxide synthase 2 multiple interactions ISO anemonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; anemonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18281171 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
but-2-en-4-olide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO butenolide results in increased activity of NFE2L2 protein CTD PMID:30244016 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
cardenolides term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Cardenolides inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] CTD PMID:23104431 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
Cymarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Cymarine inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] CTD PMID:23104431 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
digitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Digitoxin
CTD PMID:23104431, PMID:26708294 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ar androgen receptor multiple interactions ISO Digitoxin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein CTD PMID:22037315 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 decreases expression ISO Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein CTD PMID:22037315 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein CTD PMID:22037315 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein CTD PMID:22037315 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] CTD PMID:19446813 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein
CTD PMID:22037315 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
CTD PMID:22037315 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein CTD PMID:22037315 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein CTD PMID:22037315 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein CTD PMID:22037315 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein CTD PMID:22037315 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein CTD PMID:22037315 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Digitoxin binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Digitoxin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] CTD PMID:24124520 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fanci FA complementation group I multiple interactions ISO Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] CTD PMID:24124520 NCBI chr 1:141,116,565...141,172,997
Ensembl chr 1:141,120,166...141,172,483
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] CTD PMID:19446813 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] CTD PMID:19446813 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] CTD PMID:19446813 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO Digitoxin results in decreased phosphorylation of NFKBIA protein CTD PMID:15136726 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases activity
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein] CTD PMID:19446813 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Digitoxin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Digitoxin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Digitoxin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein CTD PMID:22037315 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 multiple interactions ISO Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
affects uptake
increases uptake
multiple interactions
increases export
increases transport
affects secretion
increases expression
affects binding
decreases uptake
affects transport
ISO
EXP
ABCB1 gene SNP affects the abundance of Digoxin
ABCB1A protein affects the uptake of Digoxin
ABCB1 protein results in increased uptake of Digoxin
18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [citronellal results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Digoxin results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Elacridar results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Plant Extracts results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; ABCB1 protein binds to and affects the metabolism of Digoxin; abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; beta-pinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Capsaicin affects the reaction [ABCB1 protein results in increased export of Digoxin]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; citronellal inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; cyazofamid affects the reaction [ABCB1 protein results in increased uptake of Digoxin]; dehydroandrographolide inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Diltiazem inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; efonidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin]; gamma-terpinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; manidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Propranolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; rhodioloside affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]; sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; tangeretin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
Acetaminophen promotes the reaction [ABCB1 protein results in increased transport of Digoxin]
ABCB1A protein results in increased uptake of Digoxin
ABCB1 protein affects the secretion of Digoxin
Digoxin results in increased expression of ABCB1 mRNA; Digoxin results in increased expression of ABCB1 protein
Digoxin binds to ABCB1 protein
ABCB1 protein results in decreased uptake of Digoxin
ABCB1 gene SNP affects the transport of Digoxin; ABCB1 protein affects the transport of Digoxin
CTD PMID:10527640, PMID:10562306, PMID:10617675, PMID:10997946, PMID:11231118, PMID:11895100, PMID:15276087, PMID:15856409, PMID:15890377, PMID:15969931, PMID:16221533, PMID:16671962, PMID:16674925, PMID:16904803, PMID:17365992, PMID:18385293, PMID:19505989, PMID:19647009, PMID:19958760, PMID:21240898, PMID:21311904, PMID:21341280, PMID:23104431, PMID:23976943, PMID:24380838, PMID:25844889, PMID:26888941, PMID:30790579, PMID:32003934 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects uptake ISO ABCB1B protein affects the uptake of Digoxin CTD PMID:10562306 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO Digoxin results in decreased activity of ABCG2 protein CTD PMID:15365089 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression
multiple interactions
EXP Digoxin results in decreased expression of ATP1A2 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA]
CTD PMID:19687166 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression
multiple interactions
EXP Digoxin results in decreased expression of ATP1A3 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A3 mRNA]
CTD PMID:19687166 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Digoxin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Digoxin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Digoxin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] CTD PMID:24124520 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fanci FA complementation group I multiple interactions ISO Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] CTD PMID:24124520 NCBI chr 1:141,116,565...141,172,997
Ensembl chr 1:141,120,166...141,172,483
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Digoxin results in decreased activity of G6PD protein CTD PMID:26820767 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Digoxin results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Digoxin results in decreased activity of GSR protein CTD PMID:26820767 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
affects localization
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin affects the localization of HIF1A protein]; Digoxin results in increased phosphorylation of and results in increased expression of HIF1A protein; KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]
Digoxin results in increased activity of HIF1A protein
CTD PMID:19647009 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Digoxin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Ins2 insulin 2 decreases response to substance ISO
EXP
INS protein results in decreased susceptibility to Digoxin CTD PMID:22562035 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
affects response to substance
decreases expression
decreases activity
ISO Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein]
KCNH2 gene affects the susceptibility to Digoxin
Digoxin results in decreased expression of KCNH2 protein modified form
CTD PMID:19139152 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK1 protein] CTD PMID:19687166 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP Digoxin results in increased phosphorylation of MAPK3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK3 protein]
CTD PMID:19687166 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos3 nitric oxide synthase 3 decreases response to substance ISO NOS3 protein results in decreased susceptibility to Digoxin CTD PMID:11761419 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression
EXP N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of NPPA mRNA] CTD PMID:19687166 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B increases expression ISO Digoxin results in increased expression of NPPB protein CTD PMID:16032632 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Digoxin results in decreased activity of PGD protein CTD PMID:26820767 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Rorc RAR-related orphan receptor C decreases activity ISO Digoxin results in decreased activity of RORC protein CTD PMID:21441909 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc9a1 solute carrier family 9 member A1 increases expression
multiple interactions
EXP Digoxin results in increased expression of SLC9A1 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of SLC9A1 mRNA]
CTD PMID:19687166 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
increases uptake
decreases activity
affects transport
ISO
EXP
Elacridar affects the reaction [SLCO1A4 protein affects the transport of Digoxin]
SLCO1A4 protein results in increased uptake of Digoxin
Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]
Digoxin results in decreased activity of SLCO1A4 protein
CTD PMID:11883641, PMID:19833843 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digoxin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Helveticoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rorc RAR-related orphan receptor C increases expression ISO helveticoside results in increased expression of RORC mRNA CTD PMID:29981919 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
lanatoside C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO lanatoside C results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO lanatoside C results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO lanatoside C results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO lanatoside C results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO lanatoside C results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
manoalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin affects expression ISO Ouabain affects the expression of A2M protein CTD PMID:17268060 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein
CTD PMID:19647009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression ISO Ouabain affects the expression of ACAA2 protein CTD PMID:17268060 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Ace angiotensin I converting enzyme affects expression EXP Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein CTD PMID:16565308 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acta2 actin alpha 2, smooth muscle affects expression ISO Ouabain affects the expression of ACTA2 protein CTD PMID:17268060 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression ISO Ouabain affects the expression of ADH1C protein CTD PMID:17268060 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Agt angiotensinogen affects expression
increases expression
EXP Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein
CTD PMID:11768735, PMID:16565308 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
affects expression
EXP Ouabain results in decreased expression of AGTR1A protein
Ouabain affects the expression of AGTR1A mRNA
CTD PMID:16565308 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Ouabain results in increased expression of AIFM1 protein CTD PMID:31436044 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Anxa1 annexin A1 affects expression ISO Ouabain affects the expression of ANXA1 protein CTD PMID:17268060 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 affects expression ISO Ouabain affects the expression of ANXA2 protein CTD PMID:17268060 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Ouabain results in increased expression of APAF1 protein CTD PMID:31436044 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Ouabain results in decreased expression of ARAF mRNA CTD PMID:16412265 NCBI chr  X:1,369,534...1,391,603
Ensembl chr  X:1,379,194...1,390,873
JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO Ouabain results in decreased expression of ARIH1 mRNA CTD PMID:16412265 NCBI chr 8:64,166,359...64,268,555
Ensembl chr 8:64,166,360...64,268,555
JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 affects expression ISO Ouabain affects the expression of ARPC5 protein CTD PMID:17268060 NCBI chr13:70,174,970...70,183,879
Ensembl chr13:70,174,936...70,183,879
JBrowse link
G Arrb1 arrestin, beta 1 increases expression ISO Ouabain results in increased expression of ARRB1 mRNA CTD PMID:16412265 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 affects expression ISO Ouabain affects the expression of ASAH1 protein CTD PMID:17268060 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Atf6b activating transcription factor 6 beta increases expression ISO Ouabain results in increased expression of ATF6B protein CTD PMID:31436044 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Ouabain results in increased phosphorylation of ATM protein CTD PMID:31436044 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit multiple interactions ISO Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr15:36,561,306...36,590,171
Ensembl chr15:36,565,495...36,590,171
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions
increases expression
affects expression
affects binding
ISO
EXP
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein
CTD PMID:11768735, PMID:11834625, PMID:12479229, PMID:16716361, PMID:19995221 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding
ISO
EXP
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein
CTD PMID:11834625, PMID:12479229, PMID:15458945, PMID:16166162, PMID:16716361, PMID:18487447, PMID:19687166, PMID:19897708, PMID:19995221 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 increases expression
multiple interactions
decreases expression
affects expression
affects binding
ISO
EXP
Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein
CTD PMID:11204457, PMID:12479229, PMID:15276875, PMID:19687166, PMID:19995221, PMID:24631656 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions
increases expression
EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA] CTD PMID:11204457 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp4b ATPase H+/K+ transporting subunit beta multiple interactions ISO Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr16:81,136,218...81,145,131
Ensembl chr16:81,136,218...81,145,131
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects expression ISO Ouabain affects the expression of ATP5F1A protein CTD PMID:17268060 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atr ATR serine/threonine kinase decreases phosphorylation ISO Ouabain results in decreased phosphorylation of ATR protein CTD PMID:31436044 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bahd1 bromo adjacent homology domain containing 1 decreases expression ISO Ouabain results in decreased expression of BAHD1 mRNA CTD PMID:16412265 NCBI chr 3:110,708,790...110,732,038
Ensembl chr 3:110,723,481...110,732,060
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression
multiple interactions
ISO Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]
CTD PMID:17096883, PMID:18247327, PMID:31436044 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Ouabain results in decreased expression of BCL2 protein CTD PMID:31436044 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Ouabain results in decreased expression of BCL2L1 protein CTD PMID:31436044 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein] CTD PMID:19954800 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Ouabain results in decreased expression of BRCA1 protein CTD PMID:31436044 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Calb1 calbindin 1 decreases expression EXP Ouabain results in decreased expression of CALB1 protein CTD PMID:20105455 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Calml5 calmodulin-like 5 affects expression ISO Ouabain affects the expression of CALML5 protein CTD PMID:17268060 NCBI chr17:70,044,956...70,045,886 JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression ISO Ouabain results in increased expression of CAMK2B protein CTD PMID:31436044 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Canx calnexin increases expression ISO Ouabain results in increased expression of CANX protein CTD PMID:18247327 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
ISO
EXP
Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein
CTD PMID:11435898, PMID:17096883, PMID:18247327, PMID:20435043, PMID:31436044 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases expression ISO Ouabain results in increased expression of CASP4 protein CTD PMID:31436044 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Ouabain results in increased expression of and results in increased activity of CASP8 protein CTD PMID:31436044 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ouabain results in increased expression of and results in increased activity of CASP9 protein CTD PMID:31436044 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein] CTD PMID:20627318 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 decreases expression ISO Ouabain results in decreased expression of CAV1 mRNA CTD PMID:28795476 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccdc14 coiled-coil domain containing 14 decreases expression ISO Ouabain results in decreased expression of CCDC14 mRNA CTD PMID:16412265 NCBI chr11:69,281,000...69,316,897
Ensembl chr11:69,281,554...69,316,848
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein
CTD PMID:11340305 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO Ouabain results in decreased expression of CCNA1 mRNA CTD PMID:20460749 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Ouabain results in decreased expression of CCNA2 mRNA CTD PMID:21215801 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Ouabain results in decreased expression of CCND1 mRNA CTD PMID:28795476 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh1 cadherin 1 decreases expression
increases expression
ISO Ouabain results in decreased expression of CDH1 protein
Ouabain results in increased expression of CDH1 mRNA
CTD PMID:28795476 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein CTD PMID:28795476 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein CTD PMID:20460749, PMID:21215801, PMID:31436044 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Ouabain results in decreased expression of CDK6 protein CTD PMID:31436044 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
ISO Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein
CTD PMID:20460749, PMID:21215801, PMID:28795476, PMID:31436044 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ckb creatine kinase B decreases activity EXP Ouabain results in decreased activity of CKB protein CTD PMID:19911114 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Cldn1 claudin 1 decreases expression ISO Ouabain results in decreased expression of CLDN1 protein CTD PMID:18247327 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cnpy2 canopy FGF signaling regulator 2 affects expression ISO Ouabain affects the expression of CNPY2 protein CTD PMID:17268060 NCBI chr 7:2,737,674...2,744,321
Ensembl chr 7:2,737,765...2,742,369
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA] CTD PMID:26702050 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cs citrate synthase decreases activity EXP Ouabain results in decreased activity of CS protein CTD PMID:20372980 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO Ouabain results in decreased expression of and affects the localization of CYC1 protein CTD PMID:18247327 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Ouabain results in increased expression of DDIT3 protein CTD PMID:31436044 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit decreases expression ISO Ouabain results in decreased expression of DDOST mRNA CTD PMID:16412265 NCBI chr 5:156,668,924...156,676,036
Ensembl chr 5:156,668,712...156,676,035
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 increases expression ISO Ouabain results in increased expression of DNAJA3 mRNA CTD PMID:28795476 NCBI chr10:11,059,701...11,085,186
Ensembl chr10:11,060,313...11,085,210
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression
ISO
EXP
Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA
CTD PMID:19626329, PMID:20132239 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Dsg1 desmoglein 1 affects expression ISO Ouabain affects the expression of DSG1 protein CTD PMID:17268060 NCBI chr18:12,008,301...12,040,337
Ensembl chr18:12,008,759...12,038,053
JBrowse link
G Dut deoxyuridine triphosphatase affects expression ISO Ouabain affects the expression of DUT protein CTD PMID:17268060 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression ISO Ouabain results in increased expression of ECE1 protein CTD PMID:18247327 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 affects expression ISO Ouabain affects the expression of ECHS1 protein CTD PMID:17268060 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Edn1 endothelin 1 increases expression
decreases expression
EXP
ISO
Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA
CTD PMID:15477225, PMID:28795476 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A increases expression EXP Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein CTD PMID:15477225, PMID:16982439 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO Ouabain results in decreased phosphorylation of EGFR protein CTD PMID:28795476 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Ouabain results in increased expression of EIF2A protein CTD PMID:31436044 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:31436044 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K affects expression ISO Ouabain affects the expression of EIF3K protein CTD PMID:17268060 NCBI chr 1:87,927,142...87,937,033
Ensembl chr 1:87,927,141...87,937,516
JBrowse link
G Endog endonuclease G increases expression ISO Ouabain results in increased expression of ENDOG protein CTD PMID:31436044 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit decreases expression ISO Ouabain results in decreased expression of ERCC4 mRNA CTD PMID:24124520 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression ISO Ouabain results in decreased expression of ETS1 mRNA CTD PMID:28795476 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Fadd Fas associated via death domain increases expression ISO Ouabain results in increased expression of FADD protein CTD PMID:31436044 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions
decreases expression
ISO Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA
CTD PMID:24124520 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fancf FA complementation group F decreases expression ISO Ouabain results in decreased expression of FANCF mRNA CTD PMID:24124520 NCBI chr 1:107,229,516...107,232,321
Ensembl chr 1:107,231,292...107,232,305
JBrowse link
G Fanci FA complementation group I decreases expression
multiple interactions
ISO Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
CTD PMID:24124520 NCBI chr 1:141,116,565...141,172,997
Ensembl chr 1:141,120,166...141,172,483
JBrowse link
G Fars2 phenylalanyl-tRNA synthetase 2, mitochondrial increases expression ISO Ouabain results in increased expression of FARS2 mRNA CTD PMID:16412265 NCBI chr17:29,006,981...29,438,906
Ensembl chr17:29,006,988...29,438,668
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Ouabain results in increased expression of FAS protein CTD PMID:31436044 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO Ouabain results in increased expression of FASLG protein CTD PMID:31436044 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA] CTD PMID:21139329 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fh fumarate hydratase affects expression ISO Ouabain affects the expression of FH protein CTD PMID:17268060 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Fkbp7 FKBP prolyl isomerase 7 increases expression ISO Ouabain results in increased expression of FKBP7 mRNA CTD PMID:16412265 NCBI chr 3:63,522,480...63,535,835
Ensembl chr 3:63,522,403...63,535,991
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Ouabain results in decreased expression of FN1 mRNA CTD PMID:28795476 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gc GC, vitamin D binding protein affects expression ISO Ouabain affects the expression of GC protein CTD PMID:17268060 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
JBrowse link
G Glrb glycine receptor, beta increases expression ISO Ouabain results in increased expression of GLRB mRNA CTD PMID:16412265 NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Ouabain results in decreased expression of GRB2 protein CTD PMID:28795476 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Gtpbp6 GTP binding protein 6 (putative) increases expression ISO Ouabain results in increased expression of GTPBP6 mRNA CTD PMID:16412265 NCBI chr12:52,637,000...52,640,869
Ensembl chr12:52,637,000...52,640,839
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO Ouabain results in increased expression of HEY1 mRNA CTD PMID:28795476 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects localization
increases activity
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein
CTD PMID:19647009 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 affects expression ISO Ouabain affects the expression of HNRNPA2B1 protein CTD PMID:17268060 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Ouabain results in decreased expression of HNRNPDL mRNA CTD PMID:16412265 NCBI chr14:11,199,114...11,204,670
Ensembl chr14:11,198,896...11,202,669
JBrowse link
G Hpcal1 hippocalcin-like 1 affects expression ISO Ouabain affects the expression of HPCAL1 protein CTD PMID:17268060 NCBI chr 6:43,001,920...43,109,083
Ensembl chr 6:43,001,948...43,109,071
JBrowse link
G Hrg histidine-rich glycoprotein affects expression ISO Ouabain affects the expression of HRG protein CTD PMID:17268060 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Ouabain results in increased expression of HSPA5 protein CTD PMID:31436044 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 affects expression
multiple interactions
ISO Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein
CTD PMID:17268060, PMID:18247327 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Ouabain results in increased expression of ID2 mRNA CTD PMID:28795476 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Ouabain results in decreased expression of IL2RA mRNA CTD PMID:7593202 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il2rb interleukin 2 receptor subunit beta decreases expression ISO Ouabain results in decreased expression of IL2RB CTD PMID:7593202 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
JBrowse link
G Ilk integrin-linked kinase decreases expression ISO Ouabain results in decreased expression of ILK mRNA CTD PMID:28795476 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO Ouabain results in decreased expression of ITGAV mRNA CTD PMID:28795476 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
decreases phosphorylation
ISO Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein
CTD PMID:28795476 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 increases expression ISO
EXP
Ouabain results in increased expression of KCND2 mRNA CTD PMID:16412265 NCBI chr 4:48,309,283...48,816,804 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression
decreases activity
multiple interactions
ISO Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD PMID:19139152, PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Ouabain results in decreased expression of LEF1 mRNA CTD PMID:28795476 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Lgals1 galectin 1 affects expression
increases expression
ISO Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein
CTD PMID:17268060, PMID:18247327 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289
JBrowse link
G Limk1 LIM domain kinase 1 decreases expression ISO Ouabain results in decreased expression of LIMK1 mRNA CTD PMID:28795476 NCBI chr12:25,036,630...25,070,538
Ensembl chr12:25,036,605...25,070,539
JBrowse link
G Lss lanosterol synthase increases abundance ISO LSS protein results in increased abundance of Ouabain CTD PMID:21106941 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression ISO Ouabain results in increased expression of MAP2K6 mRNA CTD PMID:28795476 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein
CTD PMID:19687166, PMID:28795476 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein
CTD PMID:19687166, PMID:28795476 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions ISO Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein] CTD PMID:19716839 NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055
JBrowse link
G Mdh2 malate dehydrogenase 2 affects expression ISO Ouabain affects the expression of MDH2 protein CTD PMID:17268060 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein CTD PMID:31436044 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Ouabain results in decreased expression of MGMT protein CTD PMID:31436044 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir29b1 microRNA 29b-1 multiple interactions
decreases expression
EXP MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA
CTD PMID:26702050 NCBI chr 4:58,344,310...58,344,390
Ensembl chr 4:58,344,310...58,344,390
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO Ouabain results in decreased expression of MMP13 mRNA CTD PMID:28795476 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein
CTD PMID:28795476 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Ouabain results in decreased expression of MMP9 protein CTD PMID:28795476 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mras muscle RAS oncogene homolog decreases expression ISO Ouabain results in decreased expression of MRAS mRNA CTD PMID:28795476 NCBI chr 8:107,629,028...107,656,851
Ensembl chr 8:107,629,028...107,681,512
JBrowse link
G Mrtfa myocardin related transcription factor A decreases expression ISO Ouabain results in decreased expression of MRTFA mRNA CTD PMID:28795476 NCBI chr 7:122,233,196...122,403,661
Ensembl chr 7:122,234,012...122,403,667
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
increases expression
ISO Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein
CTD PMID:9653513, PMID:21215801 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl12a myosin light chain 12A increases expression ISO Ouabain results in increased expression of MYL12A protein CTD PMID:17268060 NCBI chr 9:119,325,282...119,333,012
Ensembl chr 9:119,325,283...119,332,967
JBrowse link
G Mylk myosin light chain kinase decreases expression ISO Ouabain results in decreased expression of MYLK mRNA CTD PMID:28795476 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
JBrowse link
G Nectin3 nectin cell adhesion molecule 3 decreases expression ISO Ouabain results in decreased expression of NECTIN3 mRNA CTD PMID:28795476 NCBI chr11:57,897,879...57,995,193
Ensembl chr11:57,897,879...57,993,548
JBrowse link
G Nectin4 nectin cell adhesion molecule 4 increases expression ISO Ouabain results in increased expression of NECTIN4 mRNA CTD PMID:28795476 NCBI chr13:89,755,665...89,774,185
Ensembl chr13:89,755,845...89,774,378
JBrowse link
G Nefl neurofilament light decreases expression ISO Ouabain results in decreased expression of NEFL mRNA CTD PMID:28795476 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression
increases expression
EXP Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein
CTD PMID:12384489, PMID:15097235 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
affects expression
increases expression
EXP 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein
CTD PMID:12384489, PMID:15477225 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 decreases expression ISO Ouabain results in decreased expression of NPC2 mRNA CTD PMID:16412265 NCBI chr 6:108,467,410...108,488,330
Ensembl chr 6:108,467,410...108,488,330
JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions
EXP Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:17266992, PMID:19687166 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases expression ISO Ouabain results in decreased expression of NRAS mRNA CTD PMID:28795476 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Park7 Parkinsonism associated deglycase affects response to substance ISO PARK7 affects the susceptibility to Ouabain CTD PMID:16624565 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] CTD PMID:24124520, PMID:31436044 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein CTD PMID:20460749, PMID:21215801 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdcd6 programmed cell death 6 increases expression ISO Ouabain results in increased expression of PDCD6 protein CTD PMID:18247327 NCBI chr 1:31,576,183...31,591,852
Ensembl chr 1:31,576,183...31,591,849
JBrowse link
G Pfdn5 prefoldin subunit 5 affects expression ISO Ouabain affects the expression of PFDN5 protein CTD PMID:17268060 NCBI chr 7:143,924,662...143,929,400
Ensembl chr 7:143,924,662...143,929,397
JBrowse link
G Pfn1 profilin 1 affects expression
decreases expression
ISO Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein
CTD PMID:17268060, PMID:18247327 NCBI chr10:57,273,003...57,275,708
Ensembl chr10:57,273,005...57,275,708
JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO Ouabain results in decreased expression of PLAUR mRNA CTD PMID:28795476 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plcg1 phospholipase C, gamma 1 decreases expression ISO Ouabain results in decreased expression of PLCG1 mRNA CTD PMID:28795476 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ppt2 palmitoyl-protein thioesterase 2 decreases expression ISO Ouabain results in decreased expression of PPT2 mRNA CTD PMID:16412265 NCBI chr20:4,381,455...4,401,638
Ensembl chr20:4,381,455...4,401,610
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO Ouabain results in decreased expression of PRKDC protein CTD PMID:31436044 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 affects expression ISO Ouabain affects the expression of PSMB6 protein CTD PMID:17268060 NCBI chr10:57,131,339...57,133,685
Ensembl chr10:57,131,386...57,133,637
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP [Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide CTD PMID:18976649 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 decreases expression ISO Ouabain results in decreased expression of PTPN2 mRNA CTD PMID:16412265 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Ouabain results in increased expression of RAB11B protein CTD PMID:18247327 NCBI chr 7:18,598,991...18,612,132
Ensembl chr 7:18,598,880...18,612,147
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO Ouabain results in decreased expression of RAF1 mRNA CTD PMID:28795476 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 decreases expression ISO Ouabain results in decreased expression of RASGRF1 mRNA CTD PMID:28795476 NCBI chr 8:97,277,250...97,405,095
Ensembl chr 8:97,277,456...97,405,102
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Ouabain results in decreased expression of RGS2 mRNA CTD PMID:28795476 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rhoh ras homolog family member H increases expression ISO Ouabain results in increased expression of RHOH mRNA CTD PMID:28795476 NCBI chr14:43,961,756...43,992,587
Ensembl chr14:43,961,756...43,992,587
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases cleavage
multiple interactions
ISO Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]
CTD PMID:20661774 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions
increases cleavage
ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein] CTD PMID:20661774 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rpa3 replication protein A3 affects expression ISO Ouabain affects the expression of RPA3 protein CTD PMID:17268060 NCBI chr 4:34,279,320...34,282,351
Ensembl chr 4:34,279,320...34,282,351
JBrowse link
G Rpgrip1l Rpgrip1-like decreases expression ISO Ouabain results in decreased expression of RPGRIP1L mRNA CTD PMID:16412265 NCBI chr19:17,115,266...17,208,055
Ensembl chr19:17,115,412...17,208,055
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 affects expression EXP Ouabain affects the expression of RPS6KB1 mRNA CTD PMID:28099878 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases response to substance
ISO K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain] CTD PMID:20080988 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G S100a13 S100 calcium binding protein A13 affects expression ISO Ouabain affects the expression of S100A13 protein CTD PMID:17268060 NCBI chr 2:189,906,022...189,912,516
Ensembl chr 2:189,906,022...189,912,516
JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Ouabain results in increased expression of S100B protein CTD PMID:15581912 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases expression
ISO Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA
CTD PMID:12590200, PMID:28795476 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 multiple interactions ISO Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 3:159,361,313...159,385,843
Ensembl chr 3:159,368,273...159,384,775
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 multiple interactions ISO Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 5:9,046,889...9,094,740
Ensembl chr 5:9,048,614...9,094,616
JBrowse link
G Shc3 SHC adaptor protein 3 increases expression ISO Ouabain results in increased expression of SHC3 mRNA CTD PMID:28795476 NCBI chr17:13,670,520...13,791,043
Ensembl chr17:13,670,520...13,791,043
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15284287 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12541134 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Slc8a1 solute carrier family 8 member A1 affects response to substance
increases expression
multiple interactions
ISO
EXP
SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]
CTD PMID:16166162, PMID:19897708 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions
increases expression
EXP N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA] CTD PMID:19687166 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Ouabain results in decreased expression of SMAD4 mRNA CTD PMID:28795476 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO Ouabain results in decreased expression of SOS1 protein CTD PMID:28795476 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 decreases expression ISO Ouabain results in decreased expression of SOS2 mRNA CTD PMID:28795476 NCBI chr 6:91,885,292...92,008,059
Ensembl chr 6:91,883,425...92,007,957
JBrowse link
G Sphk1 sphingosine kinase 1 decreases expression ISO Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Ouabain results in decreased expression of TGFB1 mRNA CTD PMID:28795476 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO Ouabain results in decreased expression of TGFB2 mRNA CTD PMID:28795476 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression ISO Ouabain results in decreased expression of TGFB3 mRNA CTD PMID:28795476 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 increases expression ISO Ouabain results in increased expression of TGFBR3 mRNA CTD PMID:28795476 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Tln1 talin 1 decreases expression ISO Ouabain results in decreased expression of TLN1 mRNA CTD PMID:28795476 NCBI chr 5:59,033,635...59,063,592
Ensembl chr 5:59,033,636...59,063,592
JBrowse link
G Tln2 talin 2 decreases expression ISO Ouabain results in decreased expression of TLN2 mRNA CTD PMID:28795476 NCBI chr 8:73,009,980...73,441,536
Ensembl chr 8:73,014,137...73,194,837
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Ouabain results in increased expression of TNFRSF10A protein CTD PMID:31436044 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein CTD PMID:31436044 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects expression ISO Ouabain affects the expression of TPI1 protein CTD PMID:17268060 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects expression ISO Ouabain affects the expression of TPT1 protein CTD PMID:17268060 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO [Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA CTD PMID:21139329 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP Ouabain results in increased expression of TRPC1 protein CTD PMID:19897708 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression
multiple interactions
EXP Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]
CTD PMID:19897708 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Txn1 thioredoxin 1 affects expression ISO Ouabain affects the expression of TXN protein CTD PMID:17268060 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Zfhx3 zinc finger homeobox 3 decreases expression ISO Ouabain results in decreased expression of ZFHX3 mRNA CTD PMID:16412265 NCBI chr19:42,753,983...42,925,794
Ensembl chr19:42,758,127...42,920,344
JBrowse link
peruvoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO cannogenin thevetoside inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] CTD PMID:23104431 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
rofecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 affects expression ISO rofecoxib affects the expression of ADAMTS8 mRNA CTD PMID:17070997 NCBI chr 8:32,017,684...32,037,529
Ensembl chr 8:32,018,560...32,037,531
JBrowse link
G Adgrf1 adhesion G protein-coupled receptor F1 affects expression ISO rofecoxib affects the expression of ADGRF1 mRNA CTD PMID:17070997 NCBI chr 9:20,343,730...20,378,686 JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 affects expression ISO rofecoxib affects the expression of ADGRG6 mRNA CTD PMID:17070997 NCBI chr 1:8,593,342...8,751,540
Ensembl chr 1:8,593,075...8,751,198
JBrowse link
G Afdn afadin, adherens junction formation factor affects expression ISO rofecoxib affects the expression of AFDN mRNA CTD PMID:17070997 NCBI chr 1:53,713,873...53,861,918
Ensembl chr 1:53,715,693...53,802,658
JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B affects expression ISO rofecoxib affects the expression of ALOX15B mRNA CTD PMID:17070997 NCBI chr10:55,773,748...55,783,489
Ensembl chr10:55,774,006...55,783,489
JBrowse link
G Angpt1 angiopoietin 1 decreases expression ISO rofecoxib results in decreased expression of ANGPT1 mRNA CTD PMID:17070997 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO rofecoxib results in decreased expression of ANGPTL1 mRNA CTD PMID:17070997 NCBI chr13:74,456,487...74,463,031
Ensembl chr13:74,410,010...74,474,681
JBrowse link
G Anxa1 annexin A1 affects expression ISO rofecoxib affects the expression of ANXA1 mRNA CTD PMID:17070997 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa3 annexin A3 increases expression ISO rofecoxib results in increased expression of ANXA3 mRNA CTD PMID:17070997 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa9 annexin A9 decreases expression ISO rofecoxib results in decreased expression of ANXA9 mRNA CTD PMID:17070997 NCBI chr 2:196,470,318...196,481,568
Ensembl chr 2:196,470,858...196,479,770
JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression ISO rofecoxib results in decreased expression of AOX1 mRNA CTD PMID:17070997 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO rofecoxib results in decreased expression of ARHGAP29 mRNA CTD PMID:17070997 NCBI chr 2:225,552,075...225,613,349
Ensembl chr 2:225,552,148...225,613,359
JBrowse link
G C2cd4a C2 calcium-dependent domain containing 4A affects expression ISO rofecoxib affects the expression of NLF1 mRNA CTD PMID:17070997 NCBI chr 8:73,671,516...73,686,344
Ensembl chr 8:73,672,295...73,673,317
JBrowse link
G C3 complement C3 increases expression ISO rofecoxib results in increased expression of C3 mRNA CTD PMID:17070997 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 decreases expression ISO rofecoxib results in decreased expression of CACNA2D3 mRNA CTD PMID:17070997 NCBI chr16:4,871,348...5,795,825
Ensembl chr16:4,871,650...5,795,825
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP rofecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of CALCA protein] CTD PMID:16690336 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cat catalase multiple interactions EXP rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] CTD PMID:20043943 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO rofecoxib results in increased expression of CCL2 mRNA CTD PMID:17070997 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions
increases expression
ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein]
rofecoxib results in increased expression of CCL20 mRNA; rofecoxib results in increased expression of CCL20 protein
CTD PMID:17667525 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions
ISO rofecoxib results in increased expression of CCL3 mRNA; rofecoxib results in increased expression of CCL3 protein
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL3 protein]
CTD PMID:17667525 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein]
rofecoxib results in increased expression of CCL5 mRNA; rofecoxib results in increased expression of CCL5 protein
CTD PMID:17667525 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO rofecoxib inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 protein] CTD PMID:17565644 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdh2 cadherin 2 affects expression ISO rofecoxib affects the expression of CDH2 mRNA CTD PMID:17070997 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh3 cadherin 3 increases expression ISO rofecoxib results in increased expression of CDH3 mRNA CTD PMID:17070997 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdsn corneodesmosin affects expression ISO rofecoxib affects the expression of CDSN mRNA CTD PMID:17070997 NCBI chr20:3,704,626...3,707,266 JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 affects expression ISO rofecoxib affects the expression of CEACAM1 mRNA CTD PMID:17070997 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Clu clusterin increases expression ISO rofecoxib results in increased expression of CLU mRNA CTD PMID:17070997 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col14a1 collagen type XIV alpha 1 chain decreases expression ISO rofecoxib results in decreased expression of COL14A1 mRNA CTD PMID:17070997 NCBI chr 7:95,054,877...95,274,073
Ensembl chr 7:95,074,236...95,273,298
JBrowse link
G Colec12 collectin sub-family member 12 decreases expression ISO rofecoxib results in decreased expression of COLEC12 mRNA CTD PMID:17070997 NCBI chr18:867,048...1,054,047
Ensembl chr18:867,048...1,052,606
JBrowse link
G Crisp3 cysteine-rich secretory protein 3 increases expression ISO rofecoxib results in increased expression of CRISP3 mRNA CTD PMID:17070997 NCBI chr 9:24,047,405...24,088,066
Ensembl chr 9:24,066,303...24,088,064
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CX3CL1 mRNA CTD PMID:17070997 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]
rofecoxib results in decreased activity of CYP1A2 protein
CTD PMID:15834531, PMID:16934051, PMID:18816299 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Defb4 defensin beta 4 increases expression ISO rofecoxib results in increased expression of DEFB4 mRNA CTD PMID:17070997 NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789
JBrowse link
G Dsc1 desmocollin 1 affects expression ISO rofecoxib affects the expression of DSC1 mRNA CTD PMID:17070997 NCBI chr18:11,877,918...11,906,828
Ensembl chr18:11,877,561...11,906,827
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB] CTD PMID:12126971 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO rofecoxib results in decreased expression of EPHA3 mRNA CTD PMID:17070997 NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954
JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO rofecoxib results in decreased expression of EPHB6 mRNA CTD PMID:17070997 NCBI chr 4:70,903,253...70,918,514
Ensembl chr 4:70,903,253...70,918,514
JBrowse link
G Etv5 ETS variant transcription factor 5 decreases expression ISO rofecoxib results in decreased expression of ETV5 mRNA CTD PMID:17070997 NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO rofecoxib results in decreased expression of FABP4 mRNA CTD PMID:17070997 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Faf1 Fas associated factor 1 affects expression ISO rofecoxib affects the expression of FAF1 mRNA CTD PMID:17070997 NCBI chr 5:129,370,767...129,738,393
Ensembl chr 5:129,448,879...129,738,252
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO rofecoxib results in decreased expression of FAIM2 mRNA CTD PMID:17070997 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Flnb filamin B increases expression ISO rofecoxib results in increased expression of FLNB mRNA CTD PMID:17070997 NCBI chr15:18,750,152...18,883,019
Ensembl chr15:18,750,118...18,883,005
JBrowse link
G Foxd1 forkhead box D1 decreases expression ISO rofecoxib results in decreased expression of FOXD1 mRNA CTD PMID:17070997 NCBI chr 2:28,460,068...28,462,488
Ensembl chr 2:28,460,068...28,462,488
JBrowse link
G Frzb frizzled-related protein affects expression ISO rofecoxib affects the expression of FRZB mRNA CTD PMID:17070997 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO rofecoxib results in decreased expression of GATA3 mRNA CTD PMID:17070997 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO rofecoxib results in decreased expression of HGF mRNA CTD PMID:17070997 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression ISO rofecoxib results in decreased expression of HPGD mRNA CTD PMID:17070997 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Il1a interleukin 1 alpha affects expression ISO rofecoxib affects the expression of IL1A mRNA CTD PMID:17070997 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
rofecoxib promotes the reaction [Acetic Acid results in increased expression of IL1B protein]
CTD PMID:11376495, PMID:12126971, PMID:14762100, PMID:15705740 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO rofecoxib results in increased expression of IL1RN mRNA CTD PMID:17070997 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 increases expression ISO rofecoxib results in increased expression of IL6 mRNA; rofecoxib results in increased expression of IL6 protein CTD PMID:17070997 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insm1 INSM transcriptional repressor 1 decreases expression ISO rofecoxib results in decreased expression of INSM1 mRNA CTD PMID:17070997 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Itgbl1 integrin subunit beta like 1 affects expression ISO rofecoxib affects the expression of ITGBL1 mRNA CTD PMID:17070997 NCBI chr15:110,114,148...110,378,970
Ensembl chr15:110,114,148...110,378,969
JBrowse link
G Klf12 Kruppel-like factor 12 affects expression ISO rofecoxib affects the expression of KLF12 mRNA CTD PMID:17070997 NCBI chr15:84,316,986...84,748,549
Ensembl chr15:84,324,470...84,748,525
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP rofecoxib inhibits the reaction [Dimethoate results in increased expression of LHB protein] CTD PMID:19579042 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO rofecoxib results in decreased expression of LIFR mRNA CTD PMID:17070997 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha increases expression ISO rofecoxib results in increased expression of LMX1A mRNA CTD PMID:17070997 NCBI chr13:85,916,753...86,061,534
Ensembl chr13:85,918,252...86,061,176
JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO rofecoxib results in increased expression of MAL mRNA CTD PMID:17070997 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO rofecoxib results in decreased expression of MAPRE2 mRNA CTD PMID:17070997 NCBI chr18:14,814,149...15,780,290 JBrowse link
G Mbtd1 mbt domain containing 1 decreases expression ISO rofecoxib results in decreased expression of MBTD1 mRNA CTD PMID:17070997 NCBI chr10:81,588,233...81,645,532
Ensembl chr10:81,592,114...81,642,663
JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression ISO rofecoxib affects the expression of MEF2C mRNA CTD PMID:17070997 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Meox2 mesenchyme homeobox 2 decreases expression ISO rofecoxib results in decreased expression of MEOX2 mRNA CTD PMID:17070997 NCBI chr 6:56,625,768...56,689,195
Ensembl chr 6:56,625,650...56,689,238
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO rofecoxib results in increased expression of MMP1 mRNA CTD PMID:16580899 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO rofecoxib results in increased expression of MMP3 mRNA CTD PMID:16580899 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO rofecoxib affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Mta2 metastasis associated 1 family, member 2 decreases expression ISO rofecoxib results in decreased expression of MTA2 mRNA CTD PMID:17070997 NCBI chr 1:225,140,863...225,149,584
Ensembl chr 1:225,140,863...225,149,583
JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO rofecoxib results in decreased expression of NAALADL2 mRNA CTD PMID:17070997 NCBI chr 2:109,092,931...110,424,885 JBrowse link
G Nfasc neurofascin decreases expression ISO rofecoxib results in decreased expression of NFASC mRNA CTD PMID:17070997 NCBI chr13:49,335,407...49,522,474
Ensembl chr13:49,335,408...49,522,415
JBrowse link
G Ngf nerve growth factor multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein] CTD PMID:16879691 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO rofecoxib affects the expression of NOS1 mRNA CTD PMID:17070997 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:16879691 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP rofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; rofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682, PMID:25596430 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Npas3 neuronal PAS domain protein 3 increases expression ISO rofecoxib results in increased expression of NPAS3 mRNA CTD PMID:17070997 NCBI chr 6:74,081,995...74,913,025 JBrowse link
G Npr2 natriuretic peptide receptor 2 decreases expression ISO rofecoxib results in decreased expression of NPR2 mRNA CTD PMID:17070997 NCBI chr 5:59,128,186...59,147,321
Ensembl chr 5:59,128,315...59,147,255
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression ISO rofecoxib affects the expression of NQO1 mRNA CTD PMID:17070997 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha decreases expression ISO rofecoxib results in decreased expression of PI4KA mRNA CTD PMID:17070997 NCBI chr11:87,858,323...87,975,549
Ensembl chr11:87,858,453...87,973,422
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects expression ISO rofecoxib affects the expression of PLA2G2A mRNA CTD PMID:17070997 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO rofecoxib results in increased expression of PLAT mRNA CTD PMID:16580899 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pml PML nuclear body scaffold increases expression ISO rofecoxib results in increased expression of PML mRNA CTD PMID:17070997 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Postn periostin affects expression ISO rofecoxib affects the expression of POSTN mRNA CTD PMID:17070997 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Prrx1 paired related homeobox 1 affects expression ISO rofecoxib affects the expression of PRRX1 mRNA CTD PMID:17070997 NCBI chr13:81,147,038...81,215,559
Ensembl chr13:81,147,348...81,214,546
JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO rofecoxib results in decreased expression of PTGER3 mRNA CTD PMID:17070997 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO rofecoxib results in decreased expression of PTGIS mRNA CTD PMID:17175104 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression
ISO rofecoxib analog results in decreased activity of PTGS1 protein; rofecoxib results in decreased activity of PTGS1 protein
rofecoxib results in decreased expression of PTGS1 mRNA
CTD PMID:16141368, PMID:17175104 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases response to substance
multiple interactions
decreases expression
decreases activity
increases expression
ISO
EXP
PTGS2 promoter SNP results in increased susceptibility to rofecoxib
[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Lipopolysaccharides; Dinoprostone results in decreased susceptibility to [rofecoxib results in decreased activity of PTGS2 protein]
rofecoxib results in decreased expression of PTGS2 mRNA
PTGS2 inhibits the reaction [rofecoxib results in increased uptake of Hexoses]
rofecoxib results in increased expression of PTGS2 mRNA
[rofecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
CTD PMID:10594344, PMID:11245490, PMID:11321505, PMID:11703585, PMID:12110471, PMID:12417326, PMID:15705740, PMID:15718289, PMID:16249722, PMID:16447059, PMID:16678543, PMID:16944022, PMID:17070997, PMID:17164136 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rasa1 RAS p21 protein activator 1 affects expression ISO rofecoxib affects the expression of RASA1 mRNA CTD PMID:17070997 NCBI chr 2:13,617,021...13,696,531
Ensembl chr 2:13,616,822...13,696,426
JBrowse link
G Rnf144b ring finger protein 144B increases expression ISO rofecoxib results in increased expression of RNF144B mRNA CTD PMID:17070997 NCBI chr17:17,817,122...17,947,777
Ensembl chr17:17,817,100...17,947,777
JBrowse link
G Rorc RAR-related orphan receptor C decreases expression ISO rofecoxib results in decreased expression of RORC mRNA CTD PMID:17070997 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO rofecoxib results in increased expression of SCD mRNA CTD PMID:17070997 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO rofecoxib results in increased expression of SERPINA3 mRNA CTD PMID:17070997 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Sh2d1a SH2 domain containing 1A decreases expression ISO rofecoxib results in decreased expression of SH2D1A mRNA CTD PMID:17070997 NCBI chr  X:128,897,053...128,925,408
Ensembl chr  X:128,897,181...128,925,407
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO SLC2A1 inhibits the reaction [rofecoxib results in increased uptake of Hexoses] CTD PMID:16447059 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions
ISO rofecoxib results in increased expression of SLC2A4 mRNA; rofecoxib results in increased expression of SLC2A4 protein
[rofecoxib results in increased expression of SLC2A4 protein] which results in increased uptake of Hexoses
CTD PMID:16447059 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO rofecoxib results in increased expression of SOCS3 mRNA; rofecoxib results in increased expression of SOCS3 protein CTD PMID:17070997 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO rofecoxib results in increased expression of SOD2 mRNA CTD PMID:17070997 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO rofecoxib results in increased expression of STAT3 mRNA CTD PMID:17070997 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO rofecoxib results in increased expression of TAC1 protein CTD PMID:16449370 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tead4 TEA domain transcription factor 4 increases expression ISO rofecoxib results in increased expression of TEAD4 mRNA CTD PMID:17070997 NCBI chr 4:161,542,566...161,619,848
Ensembl chr 4:161,540,130...161,587,222
JBrowse link
G Tfrc transferrin receptor affects expression ISO rofecoxib affects the expression of TFRC mRNA CTD PMID:17070997 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO rofecoxib results in decreased expression of TIMP3 mRNA CTD PMID:16580899 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO rofecoxib results in increased expression of TMPRSS4 mRNA CTD PMID:17070997 NCBI chr 8:49,469,804...49,503,304
Ensembl chr 8:49,469,503...49,502,647
JBrowse link
G Tnc tenascin C increases expression ISO rofecoxib results in increased expression of TNC mRNA CTD PMID:17070997 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
rofecoxib promotes the reaction [Acetic Acid results in increased expression of TNF protein]
rofecoxib results in decreased expression of TNF protein
CTD PMID:11376495, PMID:17878525 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trim17 tripartite motif-containing 17 affects expression ISO rofecoxib affects the expression of TRIM17 mRNA CTD PMID:17070997 NCBI chr10:45,307,007...45,314,823
Ensembl chr10:45,297,937...45,314,837
JBrowse link
G Tspan2 tetraspanin 2 decreases expression ISO rofecoxib results in decreased expression of TSPAN2 mRNA CTD PMID:17070997 NCBI chr 2:205,160,405...205,202,766
Ensembl chr 2:205,160,405...205,202,764
JBrowse link
G Vcan versican decreases expression ISO rofecoxib results in decreased expression of VCAN mRNA CTD PMID:17070997 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
strophanthidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of Strophanthidin CTD PMID:26708294 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions
ISO Strophanthidin results in increased expression of G6PC mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC promoter]
CTD PMID:29981919 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il17f interleukin 17F multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219
JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression
multiple interactions
ISO Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]
CTD PMID:29981919 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions
increases expression
ISO RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] CTD PMID:29981919 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
triptonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO triptonide results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:28666825 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO triptonide results in decreased expression of BCL2 protein CTD PMID:28666825 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases cleavage ISO triptonide results in increased cleavage of CASP3 protein CTD PMID:28666825 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO triptonide results in decreased expression of GLI1 mRNA; triptonide results in decreased expression of GLI1 protein CTD PMID:30610878 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases expression
multiple interactions
ISO triptonide results in decreased expression of LYN mRNA
triptonide results in decreased expression of and results in decreased phosphorylation of LYN protein
CTD PMID:28666825 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO triptonide results in decreased phosphorylation of MAPK1 protein CTD PMID:28666825 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO triptonide results in decreased phosphorylation of MAPK3 protein CTD PMID:28666825 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO triptonide results in increased cleavage of PARP1 protein CTD PMID:28666825 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptch1 patched 1 increases expression ISO triptonide results in increased expression of PTCH1 protein CTD PMID:30610878 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO triptonide results in decreased expression of SHH protein CTD PMID:30610878 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          oxygen atom 19353
            oxygen molecular entity 19353
              organooxygen compound 18809
                oxacycle 17200
                  furans 4136
                    butenolide 361
                      (-)-microperfuranone 0
                      (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate 0
                      (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate 0
                      (5Z)-3-(4-chlorophenyl)-4-hydroxy-5-(naphthalen-1-ylmethylidene)furan-2(5H)-one 0
                      (E)-ascladiol 0
                      (Z)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-furanone 0
                      (Z)-6,6',7,3'a-Diligustilide 0
                      (Z)-ligustilide 28
                      2,5-Dichloro-carboxymethylenebut-2-en-4-olide 0
                      2-Chloro-5-methyl-cis-dienelactone 0
                      2-chloro-4-carboxy(chloro)methylenebut-2-en-4-olide 0
                      2-chloro-4-carboxymethylenebut-2-en-1,4-olide + 0
                      2-oxo-3-(5-oxofuran-2-ylidene)propanoic acid 0
                      3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 0
                      3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone 9
                      3-hydroxymethyl-4-methyl-furan-2(5H)-one 0
                      3-o-Ethyl-L-ascorbic acid 0
                      4-Fluoromuconolactone 0
                      4-carboxymethylenebut-2-en-4-olide + 0
                      4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one + 0
                      5-Fluoromuconolactone 0
                      5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone 0
                      5-hydroxy-4-methoxy-5-(1-methylethenyl)-2-furanone 0
                      5-oxo-2-furylacetic acid + 0
                      Ajugarin I 0
                      Anemonin 1
                      BE-23372M 0
                      Isomuronic acid 0
                      LSM-4499 0
                      Lichesterinic acid 0
                      Maklamicin, (rel)- 0
                      N-butan-2-yl-3,8-dimethyl-2-oxo-1-oxaspiro[4.5]dec-3-ene-4-carboxamide 0
                      Pulvinic acid 0
                      Pulvinic acid dilactone 0
                      Vulpinic acid 0
                      [4-(6-methylheptanoyl)-5-oxo-2,5-dihydrofuran-3-yl]methyl phosphate 0
                      agglomerin F 0
                      aglaiabbreviatin A 0
                      aglaiabbreviatin B 0
                      ajugaciliatin A 0
                      ajugaciliatin B 0
                      ajugaciliatin C 0
                      ajugaciliatin D 0
                      ajugaciliatin E 0
                      ajugaciliatin F 0
                      ajugaciliatin G 0
                      ajugaciliatin H 0
                      ajugaciliatin I 0
                      ajugaciliatin J 0
                      ajugacumbin A 0
                      ajugacumbin A chlorohydrin 0
                      ajugacumbin F 0
                      ajugalide B 0
                      ajugalide C 0
                      ajugamarin A1 0
                      ajugamarin A1 chlorohydrin 0
                      ajugamarin A2 0
                      ajugamarin A2 chlorohydrin 0
                      ajugamarin B1 0
                      ajugamarin G1 0
                      ajugamarin H1 0
                      ajuganipponin A 0
                      ajuganipponin B 0
                      ajugapantin A 0
                      ajugatakasin A 0
                      ajugatakasin B 0
                      alpha-angelica lactone 0
                      aplysinoplide A 0
                      aplysinoplide B 0
                      aplysinoplide C 0
                      asperlactone 0
                      aspulvinone + 0
                      azadiradionolide 0
                      beta-angelica lactone + 0
                      but-2-en-4-olide + 1
                      but-3-en-4-olide + 0
                      cardenolides + 235
                      carlosic acid + 0
                      carlosic acid methyl ester 0
                      daibulactone A, (rel)- 0
                      daibulactone B, (rel)- 0
                      dysolenticin B 0
                      dysolenticin C 0
                      elaeodendroside B 0
                      elaeodendroside F 0
                      elaeodendroside G 0
                      elaeodendroside T 0
                      eutypoid B 0
                      eutypoid C 0
                      eutypoid D 0
                      eutypoid E 0
                      firocoxib 0
                      flupyradifurone 0
                      gigantetronenin 0
                      gigantrionenin 0
                      hedychilactone D 0
                      leucosesterlactone 0
                      linderalactone 0
                      manoalide 3
                      penicillic acid 0
                      protoanemonin 0
                      pseudoneolinderane 0
                      rofecoxib 110
                      sarmentologenin + 0
                      scutebarbatine C 0
                      scutebarbatine D 0
                      scutebarbatine E 0
                      sotolone 0
                      spiromesifen 0
                      strigolactone + 0
                      trilobacin 0
                      triptonide 10
                      viteagnusin I 0
                      vitexilactone 0
                      yadanziolide V 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic ester 14367
                                        lactone 5988
                                          gamma-lactone 1220
                                            butenolide 361
                                              (-)-microperfuranone 0
                                              (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate 0
                                              (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate 0
                                              (5Z)-3-(4-chlorophenyl)-4-hydroxy-5-(naphthalen-1-ylmethylidene)furan-2(5H)-one 0
                                              (E)-ascladiol 0
                                              (Z)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-furanone 0
                                              (Z)-6,6',7,3'a-Diligustilide 0
                                              (Z)-ligustilide 28
                                              2,5-Dichloro-carboxymethylenebut-2-en-4-olide 0
                                              2-Chloro-5-methyl-cis-dienelactone 0
                                              2-chloro-4-carboxy(chloro)methylenebut-2-en-4-olide 0
                                              2-chloro-4-carboxymethylenebut-2-en-1,4-olide + 0
                                              2-oxo-3-(5-oxofuran-2-ylidene)propanoic acid 0
                                              3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 0
                                              3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone 9
                                              3-hydroxymethyl-4-methyl-furan-2(5H)-one 0
                                              3-o-Ethyl-L-ascorbic acid 0
                                              4-Fluoromuconolactone 0
                                              4-carboxymethylenebut-2-en-4-olide + 0
                                              4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one + 0
                                              5-Fluoromuconolactone 0
                                              5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone 0
                                              5-hydroxy-4-methoxy-5-(1-methylethenyl)-2-furanone 0
                                              5-oxo-2-furylacetic acid + 0
                                              Ajugarin I 0
                                              Anemonin 1
                                              BE-23372M 0
                                              Isomuronic acid 0
                                              LSM-4499 0
                                              Lichesterinic acid 0
                                              Maklamicin, (rel)- 0
                                              N-butan-2-yl-3,8-dimethyl-2-oxo-1-oxaspiro[4.5]dec-3-ene-4-carboxamide 0
                                              Pulvinic acid 0
                                              Pulvinic acid dilactone 0
                                              Vulpinic acid 0
                                              [4-(6-methylheptanoyl)-5-oxo-2,5-dihydrofuran-3-yl]methyl phosphate 0
                                              agglomerin F 0
                                              aglaiabbreviatin A 0
                                              aglaiabbreviatin B 0
                                              ajugaciliatin A 0
                                              ajugaciliatin B 0
                                              ajugaciliatin C 0
                                              ajugaciliatin D 0
                                              ajugaciliatin E 0
                                              ajugaciliatin F 0
                                              ajugaciliatin G 0
                                              ajugaciliatin H 0
                                              ajugaciliatin I 0
                                              ajugaciliatin J 0
                                              ajugacumbin A 0
                                              ajugacumbin A chlorohydrin 0
                                              ajugacumbin F 0
                                              ajugalide B 0
                                              ajugalide C 0
                                              ajugamarin A1 0
                                              ajugamarin A1 chlorohydrin 0
                                              ajugamarin A2 0
                                              ajugamarin A2 chlorohydrin 0
                                              ajugamarin B1 0
                                              ajugamarin G1 0
                                              ajugamarin H1 0
                                              ajuganipponin A 0
                                              ajuganipponin B 0
                                              ajugapantin A 0
                                              ajugatakasin A 0
                                              ajugatakasin B 0
                                              alpha-angelica lactone 0
                                              aplysinoplide A 0
                                              aplysinoplide B 0
                                              aplysinoplide C 0
                                              asperlactone 0
                                              aspulvinone + 0
                                              azadiradionolide 0
                                              beta-angelica lactone + 0
                                              but-2-en-4-olide + 1
                                              but-3-en-4-olide + 0
                                              cardenolides + 235
                                              carlosic acid + 0
                                              carlosic acid methyl ester 0
                                              daibulactone A, (rel)- 0
                                              daibulactone B, (rel)- 0
                                              dysolenticin B 0
                                              dysolenticin C 0
                                              elaeodendroside B 0
                                              elaeodendroside F 0
                                              elaeodendroside G 0
                                              elaeodendroside T 0
                                              eutypoid B 0
                                              eutypoid C 0
                                              eutypoid D 0
                                              eutypoid E 0
                                              firocoxib 0
                                              flupyradifurone 0
                                              gigantetronenin 0
                                              gigantrionenin 0
                                              hedychilactone D 0
                                              leucosesterlactone 0
                                              linderalactone 0
                                              manoalide 3
                                              penicillic acid 0
                                              protoanemonin 0
                                              pseudoneolinderane 0
                                              rofecoxib 110
                                              sarmentologenin + 0
                                              scutebarbatine C 0
                                              scutebarbatine D 0
                                              scutebarbatine E 0
                                              sotolone 0
                                              spiromesifen 0
                                              strigolactone + 0
                                              trilobacin 0
                                              triptonide 10
                                              viteagnusin I 0
                                              vitexilactone 0
                                              yadanziolide V 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.