Adamts8 (ADAM metallopeptidase with thrombospondin type 1 motif, 8) - Rat Genome Database

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Gene: Adamts8 (ADAM metallopeptidase with thrombospondin type 1 motif, 8) Rattus norvegicus
Analyze
Symbol: Adamts8
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 8
RGD ID: 1308511
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 8; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8; LOC300475
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,607,001 - 37,626,597 (+)NCBIGRCr8
mRatBN7.2829,349,078 - 29,368,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,349,114 - 29,368,404 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0832,017,684 - 32,037,529 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,018,560 - 32,037,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0832,044,601 - 32,064,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4830,732,584 - 30,743,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1830,732,857 - 30,751,947 (+)NCBI
Celera830,811,122 - 30,830,962 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21257285   PMID:37424113  


Genomics

Comparative Map Data
Adamts8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,607,001 - 37,626,597 (+)NCBIGRCr8
mRatBN7.2829,349,078 - 29,368,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,349,114 - 29,368,404 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0832,017,684 - 32,037,529 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,018,560 - 32,037,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0832,044,601 - 32,064,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4830,732,584 - 30,743,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1830,732,857 - 30,751,947 (+)NCBI
Celera830,811,122 - 30,830,962 (+)NCBICelera
Cytogenetic Map8q13NCBI
ADAMTS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811130,404,923 - 130,428,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11130,404,923 - 130,428,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3711130,274,818 - 130,298,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611129,780,028 - 129,803,749 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411129,780,424 - 129,804,098NCBI
Celera11127,443,759 - 127,467,479 (-)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11126,229,030 - 126,252,351 (-)NCBIHuRef
CHM1_111130,160,628 - 130,184,367 (-)NCBICHM1_1
T2T-CHM13v2.011130,440,731 - 130,464,423 (-)NCBIT2T-CHM13v2.0
Adamts8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39930,853,858 - 30,875,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl930,853,858 - 30,875,134 (+)EnsemblGRCm39 Ensembl
GRCm38930,942,562 - 30,963,838 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl930,942,562 - 30,963,838 (+)EnsemblGRCm38mm10GRCm38
MGSCv37930,750,148 - 30,770,443 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36930,687,184 - 30,712,421 (+)NCBIMGSCv36mm8
Celera928,185,167 - 28,221,160 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map916.49NCBI
Adamts8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541231,296,051 - 31,314,835 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541231,295,436 - 31,336,781 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29131,087,001 - 131,110,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111132,197,650 - 132,221,389 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011125,220,258 - 125,244,841 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111129,111,542 - 129,135,851 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11129,112,176 - 129,136,928 (-)Ensemblpanpan1.1panPan2
ADAMTS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.154,479,874 - 4,517,211 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl54,496,791 - 4,516,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha54,558,176 - 4,578,151 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.054,451,384 - 4,478,246 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl54,457,509 - 4,478,240 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.154,492,670 - 4,512,668 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.054,494,163 - 4,521,090 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.054,528,207 - 4,548,223 (+)NCBIUU_Cfam_GSD_1.0
Adamts8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947112,450,935 - 112,471,947 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365721,978,642 - 1,999,411 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl957,090,617 - 57,110,414 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1957,090,313 - 57,113,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2963,360,903 - 63,383,712 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,465,341 - 121,491,301 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,465,883 - 121,489,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660434,619,200 - 4,643,818 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248124,775,240 - 4,795,841 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts8
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000007358
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)82815732330848259Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 1 1 11 1
Low 3 31 11 3 19 3 6 9 66 35 30 6
Below cutoff 40 32 32 1 1 8 11 1

Sequence


RefSeq Acc Id: ENSRNOT00000007358   ⟹   ENSRNOP00000007358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl829,349,114 - 29,368,404 (+)Ensembl
Rnor_6.0 Ensembl832,018,560 - 32,037,531 (+)Ensembl
RefSeq Acc Id: NM_001427178   ⟹   NP_001414107
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,607,001 - 37,626,597 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414107 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83320 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007358.7
RefSeq Acc Id: ENSRNOP00000007358   ⟸   ENSRNOT00000007358
RefSeq Acc Id: NP_001414107   ⟸   NM_001427178
- Peptide Label: precursor
- UniProtKB: D4AAT1 (UniProtKB/TrEMBL)
Protein Domains
Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAT1-F1-model_v2 AlphaFold D4AAT1 1-788 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308511 AgrOrtholog
BioCyc Gene G2FUF-31267 BioCyc
Ensembl Genes ENSRNOG00000005574 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007358.8 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS8 UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report rno:300475 UniProtKB/TrEMBL
NCBI Gene 300475 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamts8 PhenoGen
PRINTS ADAMTS8 UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005574 RatGTEx
SMART ACR UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
UniProt D4AAT1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts8  ADAM metallopeptidase with thrombospondin type 1 motif, 8  Adamts8  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Adamts8  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8   Adamts8_predicted  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Adamts8_predicted  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (predicted)    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Adamts8_predicted  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED