Insm1 (INSM transcriptional repressor 1) - Rat Genome Database

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Gene: Insm1 (INSM transcriptional repressor 1) Rattus norvegicus
Analyze
Symbol: Insm1
Name: INSM transcriptional repressor 1
RGD ID: 6486258
Description: Predicted to enable several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and cyclin binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; nervous system development; and norepinephrine biosynthetic process. Predicted to act upstream of or within enteroendocrine cell differentiation; positive regulation of cell migration; and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Orthologous to human INSM1 (INSM transcriptional repressor 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: insulinoma-associated 1; insulinoma-associated protein 1; insulinoma-associated protein 1-like; LOC100912563
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83154,093,310 - 154,096,243 (+)NCBIGRCr8
mRatBN7.23133,640,030 - 133,642,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3133,639,580 - 133,643,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3137,549,595 - 137,552,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03146,133,699 - 146,136,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03143,836,848 - 143,839,791 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03140,427,961 - 140,430,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03146,847,005 - 146,849,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03145,430,571 - 145,431,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3132,503,442 - 132,506,973 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Welcker JE, etal., Development. 2013 Dec;140(24):4947-58. doi: 10.1242/dev.097642. Epub 2013 Nov 13.
Additional References at PubMed
PMID:11842116   PMID:12079283   PMID:16511571   PMID:16569215   PMID:16951258   PMID:18094025   PMID:18417529   PMID:19124461   PMID:25053427  


Genomics

Comparative Map Data
Insm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83154,093,310 - 154,096,243 (+)NCBIGRCr8
mRatBN7.23133,640,030 - 133,642,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3133,639,580 - 133,643,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3137,549,595 - 137,552,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03146,133,699 - 146,136,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03143,836,848 - 143,839,791 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03140,427,961 - 140,430,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03146,847,005 - 146,849,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03145,430,571 - 145,431,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3132,503,442 - 132,506,973 (+)NCBICelera
Cytogenetic Map3q41NCBI
INSM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382020,368,104 - 20,370,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2020,368,104 - 20,370,949 (+)EnsemblGRCh38hg38GRCh38
GRCh372020,348,748 - 20,351,593 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362020,296,765 - 20,299,593 (+)NCBINCBI36Build 36hg18NCBI36
Build 342020,296,764 - 20,299,590NCBI
Celera2020,422,836 - 20,425,664 (+)NCBICelera
Cytogenetic Map20p11.23NCBI
HuRef2020,312,192 - 20,314,947 (+)NCBIHuRef
CHM1_12020,349,234 - 20,352,014 (+)NCBICHM1_1
T2T-CHM13v2.02020,426,632 - 20,429,477 (+)NCBIT2T-CHM13v2.0
Insm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,064,021 - 146,066,940 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2146,063,841 - 146,066,940 (+)EnsemblGRCm39 Ensembl
GRCm382146,221,997 - 146,225,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2146,221,921 - 146,225,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv372146,047,733 - 146,050,756 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362145,913,552 - 145,916,461 (+)NCBIMGSCv36mm8
MGSCv362147,254,133 - 147,257,764 (+)NCBIMGSCv36mm8
Celera2147,455,140 - 147,457,656 (+)NCBICelera
Cytogenetic Map2G1NCBI
cM Map271.33NCBI
Insm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541528,396,176 - 28,398,114 (+)NCBIChiLan1.0ChiLan1.0
INSM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22121,246,668 - 21,250,789 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12021,243,803 - 21,247,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02020,317,060 - 20,320,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12020,277,885 - 20,281,143 (+)NCBIpanpan1.1PanPan1.1panPan2
INSM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,008,387 - 3,011,186 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha243,036,625 - 3,039,359 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0243,416,209 - 3,418,945 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1243,012,583 - 3,015,318 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0243,115,662 - 3,118,396 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0243,393,687 - 3,396,423 (-)NCBIUU_Cfam_GSD_1.0
Insm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640151,635,539 - 151,638,432 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648568,004 - 69,596 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648566,889 - 69,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1728,379,880 - 28,381,427 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11728,379,529 - 28,382,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21732,161,045 - 32,163,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INSM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1249,360,307 - 49,363,136 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl249,360,448 - 49,361,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660784,147,498 - 4,150,393 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474120,863,088 - 20,864,584 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474120,862,835 - 20,866,176 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Insm1
1 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat


Expression


Sequence


Ensembl Acc Id: ENSRNOT00000114149   ⟹   ENSRNOP00000091867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3133,639,580 - 133,643,003 (+)Ensembl
RefSeq Acc Id: NM_001399746   ⟹   NP_001386675
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83154,093,310 - 154,096,243 (+)NCBI
mRatBN7.23133,640,030 - 133,642,963 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091867.1
Ensembl Acc Id: ENSRNOP00000091867   ⟸   ENSRNOT00000114149
RefSeq Acc Id: NP_001386675   ⟸   NM_001399746
- UniProtKB: A0A8I6GJX9 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6486258 AgrOrtholog
BioCyc Gene G2FUF-47572 BioCyc
Ensembl Genes ENSRNOG00000068937 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000114149.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro INSM1/2 UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene LOC100912563 ENTREZGENE
PANTHER INSULINOMA-ASSOCIATED PROTEIN 1 UniProtKB/TrEMBL
  PTHR15065 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Insm1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000068937 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6GJX9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Insm1  INSM transcriptional repressor 1  Insm1  INSM transcriptional repressor 1  Data merged from RGD:149736401 737654 PROVISIONAL
2021-08-09 Insm1  INSM transcriptional repressor 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2016-05-11 Insm1  INSM transcriptional repressor 1  Insm1  insulinoma-associated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-10-27 Insm1  insulinoma-associated 1  LOC100912563  insulinoma-associated protein 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912563  insulinoma-associated protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL