Insm1 (INSM transcriptional repressor 1) - Rat Genome Database

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Gene: Insm1 (INSM transcriptional repressor 1) Rattus norvegicus
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Symbol: Insm1
Name: INSM transcriptional repressor 1
RGD ID: 6486258
Description: Predicted to enable several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and cyclin binding activity. Predicted to be involved in several processes, including negative regulation of nitrogen compound metabolic process; nervous system development; and norepinephrine biosynthetic process. Predicted to act upstream of or within enteroendocrine cell differentiation; positive regulation of cell migration; and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Orthologous to human INSM1 (INSM transcriptional repressor 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: insulinoma-associated 1; insulinoma-associated protein 1; insulinoma-associated protein 1-like; LOC100912563
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23133,640,030 - 133,642,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3133,639,580 - 133,643,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3137,549,595 - 137,552,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03146,133,699 - 146,136,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03143,836,848 - 143,839,791 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03140,427,961 - 140,430,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03145,430,571 - 145,431,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03146,847,005 - 146,849,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3132,503,442 - 132,506,973 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Welcker JE, etal., Development. 2013 Dec;140(24):4947-58. doi: 10.1242/dev.097642. Epub 2013 Nov 13.
Additional References at PubMed
PMID:11842116   PMID:12079283   PMID:16511571   PMID:16569215   PMID:16951258   PMID:18094025   PMID:18417529   PMID:19124461   PMID:25053427  


Genomics

Comparative Map Data
Insm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23133,640,030 - 133,642,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3133,639,580 - 133,643,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3137,549,595 - 137,552,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03146,133,699 - 146,136,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03143,836,848 - 143,839,791 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03140,427,961 - 140,430,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03145,430,571 - 145,431,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03146,847,005 - 146,849,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3132,503,442 - 132,506,973 (+)NCBICelera
Cytogenetic Map3q41NCBI
INSM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382020,368,104 - 20,370,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2020,368,104 - 20,370,949 (+)EnsemblGRCh38hg38GRCh38
GRCh372020,348,748 - 20,351,593 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362020,296,765 - 20,299,593 (+)NCBINCBI36Build 36hg18NCBI36
Build 342020,296,764 - 20,299,590NCBI
Celera2020,422,836 - 20,425,664 (+)NCBICelera
Cytogenetic Map20p11.23NCBI
HuRef2020,312,192 - 20,314,947 (+)NCBIHuRef
CHM1_12020,349,234 - 20,352,014 (+)NCBICHM1_1
T2T-CHM13v2.02020,426,632 - 20,429,477 (+)NCBIT2T-CHM13v2.0
Insm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,064,021 - 146,066,940 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2146,063,841 - 146,066,940 (+)EnsemblGRCm39 Ensembl
GRCm382146,221,997 - 146,225,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2146,221,921 - 146,225,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv372146,047,733 - 146,050,756 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362145,913,552 - 145,916,461 (+)NCBIMGSCv36mm8
MGSCv362147,254,133 - 147,257,764 (+)NCBIMGSCv36mm8
Celera2147,455,140 - 147,457,656 (+)NCBICelera
Cytogenetic Map2G1NCBI
cM Map271.33NCBI
Insm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541528,396,176 - 28,398,114 (+)NCBIChiLan1.0ChiLan1.0
INSM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12021,243,803 - 21,247,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02020,317,060 - 20,320,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12020,277,885 - 20,281,143 (+)NCBIpanpan1.1PanPan1.1panPan2
INSM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,008,387 - 3,011,186 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha243,036,625 - 3,039,359 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0243,416,209 - 3,418,945 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1243,012,583 - 3,015,318 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0243,115,662 - 3,118,396 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0243,393,687 - 3,396,423 (-)NCBIUU_Cfam_GSD_1.0
Insm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640151,635,539 - 151,638,432 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648568,004 - 69,596 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648566,889 - 69,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1728,379,880 - 28,381,427 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11728,379,529 - 28,382,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21732,161,045 - 32,163,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INSM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1249,360,307 - 49,363,136 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl249,360,448 - 49,361,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660784,147,498 - 4,150,393 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474120,863,088 - 20,864,584 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474120,862,835 - 20,866,176 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Insm1
1 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000114149   ⟹   ENSRNOP00000091867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3133,639,580 - 133,643,003 (+)Ensembl
RefSeq Acc Id: NM_001399746   ⟹   NP_001386675
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23133,640,030 - 133,642,963 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091867
  ENSRNOP00000091867.1
RefSeq Acc Id: ENSRNOP00000091867   ⟸   ENSRNOT00000114149
RefSeq Acc Id: NP_001386675   ⟸   NM_001399746
- UniProtKB: A0A8I6GJX9 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6486258 AgrOrtholog
BioCyc Gene G2FUF-47572 BioCyc
Ensembl Genes ENSRNOG00000068937 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000114149 ENTREZGENE
  ENSRNOT00000114149.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro INSM1/2 UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene LOC100912563 ENTREZGENE
PANTHER INSULINOMA-ASSOCIATED PROTEIN 1 UniProtKB/TrEMBL
  PTHR15065 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Insm1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000068937 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6GJX9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Insm1  INSM transcriptional repressor 1  Insm1  INSM transcriptional repressor 1  Data merged from RGD:149736401 737654 PROVISIONAL
2021-08-09 Insm1  INSM transcriptional repressor 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2016-05-11 Insm1  INSM transcriptional repressor 1  Insm1  insulinoma-associated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-10-27 Insm1  insulinoma-associated 1  LOC100912563  insulinoma-associated protein 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912563  insulinoma-associated protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL