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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:wogonin
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Accession:CHEBI:10043 term browser browse the term
Definition:A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.
Synonyms:exact_synonym: 5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one
 related_synonym: 5,7-Dihydroxy-8-methoxyflavone;   5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3;   InChIKey=XLTFNNCXVBYBSX-UHFFFAOYSA-N;   Norwogonin 8-methyl ether;   SMILES=COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1
 xref: CAS:632-85-9;   KEGG:C10197;   KNApSAcK:C00001111;   LIPID_MAPS_instance:LMPK12111330
 xref_mesh: MESH:C085514
 xref: MetaCyc:CPD-12727;   PMID:10724177;   PMID:11322923;   PMID:19438509;   PMID:22419433;   PMID:23371323;   Reaxys:287152;   Wikipedia:Wogonin
 cyclic_relationship: is_conjugate_acid_of CHEBI:78338


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wogonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO wogonin analog results in increased expression of ADIPOQ protein; wogonin results in increased expression of ADIPOQ protein CTD PMID:30445784 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression		 ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of and results in increased phosphorylation of AKT1 protein]
wogonin results in decreased phosphorylation of AKT1 protein
wogonin results in decreased expression of AKT1 mRNA		 CTD PMID:37004399 PMID:38134066 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO wogonin inhibits the reaction [Hydrogen Peroxide results in increased uptake of ALB protein] CTD PMID:23246481 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [wogonin co-treated with Fluorouracil] results in increased expression of BAX protein
wogonin results in increased expression of BAX protein		 CTD PMID:20570612 PMID:21457722 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein
wogonin results in decreased expression of BCL2 protein		 CTD PMID:20570612 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression		 ISO
EXP		 wogonin results in increased activity of CASP3 protein
[wogonin co-treated with Fluorouracil] results in increased activity of CASP3 protein
wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP3 protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein]
wogonin results in increased expression of CASP3 mRNA		 CTD PMID:20570612 PMID:26756871 PMID:31103702 PMID:38134066 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein] CTD PMID:26756871 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of CAT protein]
wogonin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]		 CTD PMID:26213241 PMID:31103702 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein]; wogonin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein] CTD PMID:23246481 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO wogonin results in decreased expression of CCNA2 protein CTD PMID:21457722 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO
EXP		 wogonin results in decreased expression of CCND1 protein CTD PMID:21457722 PMID:23872260 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO
EXP		 wogonin results in decreased expression of CDK2 protein CTD PMID:23872260 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO
EXP		 wogonin results in decreased expression of CDK4 protein CTD PMID:23872260 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk7 cyclin-dependent kinase 7 decreases activity ISO wogonin results in decreased activity of CDK7 protein CTD PMID:37515497 NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases activity ISO wogonin results in decreased activity of CDK9 protein CTD PMID:37515497 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO wogonin results in increased expression of CDKN1A mRNA; wogonin results in increased expression of CDKN1A protein CTD PMID:32671444 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO
EXP		 wogonin results in increased expression of CDKN1B protein CTD PMID:23872260 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO wogonin results in increased expression of CDKN2A mRNA; wogonin results in increased expression of CDKN2A protein CTD PMID:32671444 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO wogonin analog results in increased expression of CEBPA protein; wogonin results in increased expression of CEBPA protein CTD PMID:30445784 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in decreased expression of CHRM4 mRNA] CTD PMID:37004399 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
increases expression
multiple interactions		 ISO
EXP		 wogonin results in decreased expression of CTNNB1 protein
wogonin results in increased expression of CTNNB1 protein modified form
Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]
Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; wogonin inhibits the reaction [Cisplatin results in increased expression of CTNNB1 protein]		 CTD PMID:23872260 PMID:31103702 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO wogonin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]; wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; wogonin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; wogonin results in decreased expression of and results in decreased activity of CYP1A1 protein
wogonin results in decreased expression of CYP1A1 mRNA		 CTD PMID:18451504 PMID:37515497 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of DIO1 mRNA] CTD PMID:37004399 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO wogonin results in decreased expression of DPYD mRNA CTD PMID:20570612 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of GABRA1 mRNA] CTD PMID:37004399 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 ISO
EXP		 Lithium Chloride inhibits the reaction [wogonin results in increased expression of GFAP protein] CTD PMID:23872260 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Glb1 galactosidase, beta 1 increases expression ISO wogonin results in increased expression of GLB1 protein CTD PMID:32671444 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
increases expression		 ISO
EXP		 wogonin results in decreased expression of GSK3B protein modified form
wogonin results in increased expression of GSK3B protein		 CTD PMID:23872260 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO wogonin results in increased expression of H2AX protein
wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]		 CTD PMID:32671444 PMID:37515497 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HIF1A protein] CTD PMID:26213241 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of HTR3A mRNA] CTD PMID:37004399 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Ifng interferon gamma multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] CTD PMID:23362215 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of and results in increased phosphorylation of IKBKB protein] CTD PMID:37004399 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of IL13 protein] CTD PMID:37004399 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of IL17A protein] CTD PMID:37004399 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]		 CTD PMID:26213241 PMID:31103702 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of IL5 protein] CTD PMID:37004399 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases expression
increases secretion		 ISO wogonin results in increased expression of IL6 protein
wogonin results in increased expression of IL6 mRNA; wogonin results in increased expression of IL6 protein
wogonin results in increased secretion of IL6 protein		 CTD PMID:32671444 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 increases secretion
decreases secretion		 EXP wogonin analog results in increased secretion of INS1 protein
wogonin results in decreased secretion of INS1 protein		 CTD PMID:30445784 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 increases response to substance ISO wogonin results in increased susceptibility to INS protein CTD PMID:28854906 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO wogonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein]
wogonin results in decreased expression of JUN mRNA		 CTD PMID:17570322 PMID:38134066 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions ISO wogonin inhibits the reaction [angiotensin II increases expression of KLF4 protein in vascular smooth muscle cells] RGD PMID:29127880 RGD:155230825 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Lep leptin decreases expression ISO wogonin analog results in decreased expression of LEP protein; wogonin results in decreased expression of LEP protein CTD PMID:30445784 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] CTD PMID:23362215 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein] CTD PMID:23362215 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
wogonin results in decreased phosphorylation of MAPK1 protein
wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]		 CTD PMID:21295103 PMID:23362215 PMID:26892447 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
wogonin results in decreased phosphorylation of MAPK3 protein
wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21295103 PMID:23362215 PMID:26892447 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:23362215 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein] CTD PMID:23362215 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO wogonin results in decreased expression of MKI67 protein CTD PMID:32671444 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO wogonin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:21295103 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO		 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased activity of MMP9 protein]
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wogonin results in decreased expression of and results in decreased activity of MMP9 protein		 CTD PMID:14700523 PMID:21295103 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases expression ISO wogonin results in decreased expression of NAT1 mRNA; wogonin results in decreased expression of NAT1 protein CTD PMID:15816529 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of NCOA2 mRNA] CTD PMID:37004399 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of NFKBIA protein] CTD PMID:26213241 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NOS2 protein]		 CTD PMID:14700523 PMID:17570322 PMID:23362215 PMID:26892447 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO wogonin inhibits the reaction [Etoposide results in decreased expression of OGG1 mRNA] CTD PMID:23872129 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of PIK3CA protein] CTD PMID:37004399 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO wogonin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP wogonin inhibits the reaction [Cisplatin results in decreased expression of PPARG protein] CTD PMID:31103702 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkci protein kinase C, iota multiple interactions ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein] CTD PMID:21295103 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prss1 serine protease 1 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of PRSS1 mRNA] CTD PMID:37004399 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of PTGS1 mRNA] CTD PMID:37004399 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:23362215 PMID:26892447 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO wogonin analog results in decreased expression of RBP4 protein; wogonin results in decreased expression of RBP4 protein CTD PMID:30445784 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 ISO
EXP		 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of RELA protein]
wogonin results in increased phosphorylation of RELA protein		 CTD PMID:23362215 PMID:26213241 PMID:31103702 PMID:32671444 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 multiple interactions ISO wogonin inhibits the reaction [Ovalbumin results in increased expression of RUNX1T1 mRNA] CTD PMID:37004399 NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases activity		 ISO [wogonin results in decreased activity of SLC22A6 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I CTD PMID:32159797 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
multiple interactions		 ISO wogonin results in decreased activity of SLC22A8 protein
[wogonin results in decreased activity of SLC22A8 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I		 CTD PMID:32159797 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO wogonin analog results in increased expression of SLC2A4 protein; wogonin results in increased expression of SLC2A4 protein CTD PMID:30445784 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] CTD PMID:23362215 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO wogonin results in decreased phosphorylation of STAT3 protein CTD PMID:32671444 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; wogonin inhibits the reaction [Ovalbumin results in increased expression of TNF protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
wogonin analog results in decreased expression of TNF protein; wogonin results in decreased expression of TNF protein
wogonin results in decreased expression of TNF mRNA		 CTD PMID:26213241 PMID:30445784 PMID:31103702 PMID:37004399 PMID:38134066 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO wogonin results in increased expression of TP53 protein CTD PMID:21457722 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression ISO wogonin results in decreased expression of TXNRD2 mRNA; wogonin results in decreased expression of TXNRD2 protein CTD PMID:32671444 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Tyms thymidylate synthetase multiple interactions
increases expression		 ISO [wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA
wogonin results in increased expression of TYMS mRNA		 CTD PMID:20570612 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Umps uridine monophosphate synthetase multiple interactions
decreases expression		 ISO Fluorouracil inhibits the reaction [wogonin results in decreased expression of UMPS mRNA] CTD PMID:20570612 NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO wogonin results in decreased expression of VEGFA mRNA CTD PMID:38134066 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        pharmaceutical 19518
          drug 19538
            antineoplastic agent 17812
              wogonin 78
                wogonin 7-O-beta-D-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            organic molecule 19714
                              organic cyclic compound 19485
                                organic heterocyclic compound 18881
                                  oxacycle 17917
                                    benzopyran 11984
                                      1-benzopyran 11737
                                        flavonoid 7229
                                          anthoxanthin 4587
                                            flavones 4587
                                              methoxyflavone 494
                                                monomethoxyflavone 201
                                                  wogonin 78
                                                    wogonin 7-O-beta-D-glucuronide 0
paths to the root