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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monomethoxyflavone
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Accession:CHEBI:25401 term browser browse the term
Definition:Any methoxyflavone with a single methoxy substituent.
Synonyms:related_synonym: monomethoxyflavones


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4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Il6 interleukin 6 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding ISO chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding ISO chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
5,7-dihydroxy-4'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
decreases activity
ISO CYP1A1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1A1 mRNA
acacetin results in decreased activity of CYP1A1 protein
CTD PMID:10781868, PMID:21053930, PMID:21482471, PMID:31621310 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO acacetin results in decreased activity of CYP1A2 protein CTD PMID:21053930 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
multiple interactions
ISO CYP1B1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1B1 mRNA
acacetin results in decreased activity of CYP1B1 protein
acacetin binds to and results in decreased activity of CYP1B1 protein
CTD PMID:10781868, PMID:21053930, PMID:21482471, PMID:31621310 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
multiple interactions
ISO acacetin results in increased activity of NR1I2 protein
acacetin results in increased expression of NR1I2 mRNA
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforafan inhibits the reaction [acacetin results in increased activity of NR1I2 protein]
CTD PMID:25455453, PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO acacetin results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
diosmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO diosmetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1A1 protein CTD PMID:10781868, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO diosmetin results in decreased activity of CYP1A2 protein CTD PMID:28867436 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1B1 protein CTD PMID:10781868, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO diosmetin results in decreased activity of CYP2C19 protein CTD PMID:28867436 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO diosmetin results in decreased activity of CYP2C8 protein CTD PMID:28867436 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP2E1 protein CTD PMID:28867436 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:16934226 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:16934226 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO diosmetin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:28867436 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:28867436 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16934226 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]
CTD PMID:21477647, PMID:32061149 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]
CTD PMID:21477647, PMID:23665045, PMID:32061149 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647, PMID:23665045 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]
CTD PMID:23665045, PMID:32061149 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]
CTD PMID:23665045, PMID:32061149 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647, PMID:23665045 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]
CTD PMID:23665045, PMID:32061149 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
genkwanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
decreases activity
ISO CYP1A1 protein results in increased metabolism of genkwanin
genkwanin results in decreased activity of CYP1A1 protein
CTD PMID:19666078, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of genkwanin CTD PMID:19666078 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions
ISO CYP1B1 protein results in increased metabolism of genkwanin
[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin
CTD PMID:19666078 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Ins2 insulin 2 multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity
EXP [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344
JBrowse link
G Syn1 synapsin I affects response to substance ISO SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
isorhamnetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
increases expression
ISO ABCB1 protein results in increased transport of 3-methylquercetin
3-methylquercetin results in increased expression of ABCB1 mRNA
CTD PMID:15969930, PMID:26238175 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO 3-methylquercetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:27151496 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions EXP 3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein] CTD PMID:17374653 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein] CTD PMID:19794518 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO
EXP
3-methylquercetin results in decreased phosphorylation of AKT1 protein
3-methylquercetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]
CTD PMID:12826665, PMID:19222219 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 3-methylquercetin results in decreased expression of BCL2 mRNA; 3-methylquercetin results in decreased expression of BCL2 protein CTD PMID:22992727 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 3-methylquercetin results in decreased expression of BCL2L1 mRNA; 3-methylquercetin results in decreased expression of BCL2L1 protein CTD PMID:22992727 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases activity
ISO
EXP
3-methylquercetin results in decreased expression of CASP3 protein
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
3-methylquercetin results in increased activity of CASP3 protein
CTD PMID:12826665, PMID:19222219, PMID:22992727 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 decreases expression ISO 3-methylquercetin results in decreased expression of CASP9 protein CTD PMID:22992727 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein CTD PMID:19222219, PMID:25716194 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA CTD PMID:20579867 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 3-methylquercetin results in decreased expression of CCND1 mRNA; 3-methylquercetin results in decreased expression of CCND1 protein CTD PMID:22992727 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27151496 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO 3-methylquercetin results in decreased expression of CYP1B1 mRNA CTD PMID:19794518 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO 3-methylquercetin binds to ESR1 protein CTD PMID:14706564 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO 3-methylquercetin binds to ESR2 protein CTD PMID:14706564 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein
3-methylquercetin results in increased expression of GCLC mRNA; 3-methylquercetin results in increased expression of GCLC protein
CTD PMID:24211276, PMID:25716194 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:27151496 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein
3-methylquercetin results in increased expression of HMOX1 mRNA; 3-methylquercetin results in increased expression of HMOX1 protein
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 mRNA]; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein
CTD PMID:24211276, PMID:24337631, PMID:25716194, PMID:27151496 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL1B protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA
CTD PMID:20579867, PMID:23774260 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL6 protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA
CTD PMID:20579867, PMID:23774260 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] CTD PMID:19222219 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mir155 microRNA 155 multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of MIR155 mRNA] CTD PMID:20579867 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP 3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:17374653, PMID:18436224 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance
multiple interactions
affects localization
increases activity
ISO NFE2L2 protein affects the susceptibility to 3-methylquercetin
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 3-methylquercetin affects the localization of and results in increased phosphorylation of and results in increased activity of NFE2L2 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
3-methylquercetin affects the localization of NFE2L2 protein
[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [3-methylquercetin results in decreased susceptibility to tert-Butylhydroperoxide]
CTD PMID:24211276, PMID:27151496 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:23774260 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of NOS2 mRNA CTD PMID:16213685, PMID:18178435, PMID:18274639, PMID:20579867, PMID:23774260 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipids results in decreased expression of NOS3] CTD PMID:16891912 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA CTD PMID:24211276 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO 3-methylquercetin binds to and results in increased activity of NR1I2 protein
3-methylquercetin results in increased activity of NR1I2 protein
CTD PMID:26238175 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1] CTD PMID:16891912 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO 3-methylquercetin results in increased cleavage of PARP1 protein CTD PMID:22992727 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO 3-methylquercetin results in decreased expression of PECAM1 protein CTD PMID:22992727 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pon1 paraoxonase 1 increases expression ISO 3-methylquercetin results in increased expression of PON1 mRNA CTD PMID:20228421 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon2 paraoxonase 2 increases expression ISO 3-methylquercetin results in increased expression of PON2 mRNA CTD PMID:19865538 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases activity ISO 3-methylquercetin results in increased activity of PPARD protein CTD PMID:22992727 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [3-methylquercetin results in increased activity of PPARG protein]; 3-methylquercetin binds to and results in increased activity of PPARG protein
3-methylquercetin results in increased expression of PPARG protein
CTD PMID:22992727 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkcd protein kinase C, delta increases phosphorylation ISO 3-methylquercetin results in increased phosphorylation of PRKCD protein CTD PMID:24211276 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] CTD PMID:21341175 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
ISO
EXP
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; tin protoporphyrin IX inhibits the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]
3-methylquercetin results in decreased activity of PTGS2 protein
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein]
CTD PMID:15292928, PMID:21341175, PMID:24337631 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18274639, PMID:20579867, PMID:23774260 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]
CTD PMID:27151496 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA CTD PMID:24211276 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:27151496 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 3-methylquercetin results in increased expression of TFF1 mRNA CTD PMID:14706564 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:20579867, PMID:23774260 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tyr tyrosinase increases expression ISO 3-methylquercetin results in increased expression of TYR protein CTD PMID:24853321 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO 3-methylquercetin results in increased expression of TYRP1 protein CTD PMID:24853321 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
kaempferide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO kaempferide results in decreased expression of SLC2A1 mRNA CTD PMID:21865046 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO kaempferide results in increased expression of VEGFA mRNA CTD PMID:21865046 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
oroxylin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
decreases activity
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCB1 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of and results in decreased activity of ABCB1 protein; diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA]
CTD PMID:23470866, PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases activity
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCG2 protein
CTD PMID:32305507 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of BCL2 protein CTD PMID:19135124 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP3 protein CTD PMID:19135124 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased cleavage of CASP8 protein CTD PMID:19135124 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP9 protein CTD PMID:19135124 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CCL2 protein] CTD PMID:32464219 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdh5 cadherin 5 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of CDH5 protein] CTD PMID:32464219 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form
diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form]
CTD PMID:23470866 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ece1 endothelin converting enzyme 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 protein] CTD PMID:26694894 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]] CTD PMID:26694894 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]] CTD PMID:29476730 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of FOS protein CTD PMID:22245252 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]] CTD PMID:29476730 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of CXCL15 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of and affects the localization of HIF1A protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]
CTD PMID:29476730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein] CTD PMID:32464219 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with endotoxin, Escherichia coli] results in increased expression of IL10 protein CTD PMID:32464219 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL1B protein]
CTD PMID:22101131, PMID:23236370, PMID:32464219 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]
CTD PMID:22101131, PMID:23236370, PMID:29476730, PMID:32464219 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IRAK4 protein] CTD PMID:32464219 NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK1 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
CTD PMID:22245252 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK3 protein
CTD PMID:22245252 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 protein CTD PMID:22245252 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]
CTD PMID:22245252 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:22101131 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22101131, PMID:23236370, PMID:26694894 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased degradation of PARP1 protein CTD PMID:19135124 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]] CTD PMID:29476730 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein] CTD PMID:22245252 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22101131 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
CTD PMID:22101131, PMID:26694894 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of RHOA protein] CTD PMID:26694894 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein] CTD PMID:26694894 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]] CTD PMID:29476730 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 multiple interactions ISO [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Ethanol] results in decreased expression of SCD protein CTD PMID:29476730 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A6 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD PMID:32305507 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A8 protein
CTD PMID:32159797, PMID:32305507 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases uptake ISO SLCO1B3 protein results in increased uptake of 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one CTD PMID:32305507 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]] CTD PMID:29476730 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:23236370 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TIMP2 protein CTD PMID:22245252 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of TJP1 protein] CTD PMID:32464219 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]
CTD PMID:22101131, PMID:29476730, PMID:32464219 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TP53 protein modified form] CTD PMID:23470866 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of VCAM1 protein] CTD PMID:32464219 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
pedalitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pedalitin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO pedalitin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
tamarixetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO tamarixetin results in increased expression of ABCB1 mRNA CTD PMID:26238175 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tamarixetin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:17090139 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO tamarixetin results in decreased phosphorylation of AKT1 protein CTD PMID:12826665 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 increases activity ISO tamarixetin results in increased activity of CASP3 protein CTD PMID:12826665 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO tamarixetin results in increased expression of CYP1A2 mRNA CTD PMID:19034627 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO tamarixetin results in increased expression of CYP3A5 mRNA CTD PMID:26238175 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO tamarixetin binds to and results in increased activity of NR1I2 protein
tamarixetin results in increased activity of NR1I2 protein
CTD PMID:26238175 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO tamarixetin results in decreased activity of PTGS2 protein CTD PMID:15292928 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
tectochrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO tectochrysin results in decreased activity of ABCG2 protein CTD PMID:15930306 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
wogonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO wogonin inhibits the reaction [Hydrogen Peroxide results in increased uptake of ALB protein] CTD PMID:23246481 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [wogonin co-treated with Fluorouracil] results in increased expression of BAX protein
wogonin results in increased expression of BAX protein
CTD PMID:20570612, PMID:21457722 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein
wogonin results in decreased expression of BCL2 protein
CTD PMID:20570612 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
wogonin results in increased activity of CASP3 protein
wogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein]
wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP3 protein]
[wogonin co-treated with Fluorouracil] results in increased activity of CASP3 protein
CTD PMID:20570612, PMID:26756871, PMID:31103702 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein] CTD PMID:26756871 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions ISO
EXP
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of CAT protein]
wogonin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD PMID:26213241, PMID:31103702 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein]; wogonin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein] CTD PMID:23246481 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO wogonin results in decreased expression of CCNA2 protein CTD PMID:21457722 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO
EXP
wogonin results in decreased expression of CCND1 protein CTD PMID:21457722, PMID:23872260 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO
EXP
wogonin results in decreased expression of CDK2 protein CTD PMID:23872260 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO
EXP
wogonin results in decreased expression of CDK4 protein CTD PMID:23872260 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO wogonin results in increased expression of CDKN1A mRNA; wogonin results in increased expression of CDKN1A protein CTD PMID:32671444 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO
EXP
wogonin results in increased expression of CDKN1B protein CTD PMID:23872260 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO wogonin results in increased expression of CDKN2A mRNA; wogonin results in increased expression of CDKN2A protein CTD PMID:32671444 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
increases expression
ISO
EXP
wogonin results in decreased expression of CTNNB1 protein
Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; wogonin inhibits the reaction [Cisplatin results in increased expression of CTNNB1 protein]
wogonin results in increased expression of CTNNB1 protein modified form
CTD PMID:23872260, PMID:31103702 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO wogonin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
wogonin results in decreased expression of CYP1A1 mRNA
CTD PMID:18451504 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO wogonin results in decreased expression of DPYD mRNA CTD PMID:20570612 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression
ISO
EXP
Lithium Chloride inhibits the reaction [wogonin results in increased expression of GFAP protein] CTD PMID:23872260 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glb1 galactosidase, beta 1 increases expression ISO wogonin results in increased expression of GLB1 protein CTD PMID:32671444 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
increases expression
ISO
EXP
wogonin results in decreased expression of GSK3B protein modified form
wogonin results in increased expression of GSK3B protein
CTD PMID:23872260 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HIF1A protein] CTD PMID:26213241 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Ifng interferon gamma multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] CTD PMID:23362215 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD PMID:26213241, PMID:31103702 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
ISO wogonin results in increased expression of IL6 protein
wogonin results in increased secretion of IL6 protein
wogonin results in increased expression of IL6 mRNA; wogonin results in increased expression of IL6 protein
CTD PMID:32671444 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO wogonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] CTD PMID:17570322 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] CTD PMID:23362215 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein] CTD PMID:23362215 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
wogonin results in decreased phosphorylation of MAPK1 protein
CTD PMID:21295103, PMID:23362215, PMID:26892447 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
wogonin results in decreased phosphorylation of MAPK3 protein
CTD PMID:21295103, PMID:23362215, PMID:26892447 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:23362215 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein] CTD PMID:23362215 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO wogonin results in decreased expression of MKI67 protein CTD PMID:32671444 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO wogonin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:21295103 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased activity of MMP9 protein]
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wogonin results in decreased expression of and results in decreased activity of MMP9 protein
CTD PMID:14700523, PMID:21295103 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nat1 N-acetyltransferase 1 decreases expression ISO wogonin results in decreased expression of NAT1 mRNA; wogonin results in decreased expression of NAT1 protein CTD PMID:15816529 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of NFKBIA protein] CTD PMID:26213241 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NOS2 protein]
CTD PMID:14700523, PMID:17570322, PMID:23362215, PMID:26892447 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO wogonin inhibits the reaction [Etoposide results in decreased expression of OGG1 mRNA] CTD PMID:23872129 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO wogonin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP wogonin inhibits the reaction [Cisplatin results in decreased expression of PPARG protein] CTD PMID:31103702 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkci protein kinase C, iota multiple interactions ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein] CTD PMID:21295103 NCBI chr 2:115,941,998...116,002,550
Ensembl chr 2:115,941,993...116,002,561
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:23362215, PMID:26892447 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO
EXP
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]
wogonin results in increased phosphorylation of RELA protein
wogonin inhibits the reaction [Cisplatin results in increased expression of RELA protein]
CTD PMID:23362215, PMID:26213241, PMID:31103702, PMID:32671444 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases activity
ISO [wogonin results in decreased activity of SLC22A6 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I CTD PMID:32159797 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
multiple interactions
ISO wogonin results in decreased activity of SLC22A8 protein
[wogonin results in decreased activity of SLC22A8 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I
CTD PMID:32159797 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] CTD PMID:23362215 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO wogonin results in decreased phosphorylation of STAT3 protein CTD PMID:32671444 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:26213241, PMID:31103702 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO wogonin results in increased expression of TP53 protein CTD PMID:21457722 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression ISO wogonin results in decreased expression of TXNRD2 mRNA; wogonin results in decreased expression of TXNRD2 protein CTD PMID:32671444 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Tyms thymidylate synthetase multiple interactions
increases expression
ISO [wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA
wogonin results in increased expression of TYMS mRNA
CTD PMID:20570612 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Umps uridine monophosphate synthetase multiple interactions
decreases expression
ISO Fluorouracil inhibits the reaction [wogonin results in decreased expression of UMPS mRNA] CTD PMID:20570612 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          oxygen atom 19361
            oxygen molecular entity 19361
              organooxygen compound 18816
                ether 16076
                  methoxyflavone 416
                    monomethoxyflavone 138
                      2''-O-(4-sinapoylarabinosyl)isoscoparin 0
                      2''-O-alpha-L-arabinopyranosylisoscoparin 0
                      2''-O-beta-D-glucosylisoscoparin 0
                      2''-O-rhamnosylscoparin 0
                      2-(2-amino-3-methoxyphenyl)chromen-4-one 0
                      3',4',5,7-tetrahydroxy-3-methoxyflavone + 0
                      3'-O-methyltricetin + 0
                      3'-O-methyltricetin 3-O-alpha-L-rhamnopyranoside 0
                      3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                      3-O-methyl-8-prenylgalangin 0
                      3-O-methylquercetin 7-O-beta-glucopyranosyl-4'-O-beta-D-glucopyranoside 0
                      3-methoxyapigenin 0
                      3-methylgalangin 0
                      4',5,7-trihydroxy-3'-methoxyflavone + 11
                      4',5,7-trihydroxy-3-methoxyflavone-7-O-alpha-L-arabinofuranosyl(1->6)-beta-D-glucopyranoside 0
                      4',5,7-trihydroxy-3-methoxyflavone-7-O-beta-D-glucopyranoside 0
                      4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside 0
                      5,7,2'-trihydroxy-6-methoxyflavone 0
                      5,7-dihydroxy-4'-methoxyflavone + 5
                      6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol 0
                      6-desmethylsideroxylin 0
                      6-hydroxy-2'-methoxyflavone 0
                      6-methoxyluteolin 7-alpha-L-rhamnoside 0
                      7-O-(6-p-coumaroylglucosyl)chrysoeriol 0
                      7-O-(6-sinapoylglucosyl)isoscoparin 0
                      7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol 0
                      7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoscoparin 0
                      7-O-beta-D-glucosylisoscoparin 0
                      7-O-methoxy gossypetin 3-O-rutinoside 0
                      7-O-methylmyricetin 0
                      7-O-methylvitexin 2''-O-alpha-L-rhamnoside 0
                      7-O-methylvitexin 2''-O-beta-L-rhamnoside 0
                      7-hydroxy-5-methoxy-6,8-dimethylflavone 0
                      8-(1,1-dimethylallyl)-3-methylgalangin 0
                      8-(1,1-dimethylallyl)kaempferide 0
                      8-desmethylsideroxylin 0
                      acacetin-7-O-beta-D-galactopyranoside 0
                      acacetin-8-C-neohesperidoside 0
                      artocarpin 0
                      azaleatin 0
                      chrysoeriol 7-O-gentiobioside 0
                      diandraflavone 0
                      diosmetin + 32
                      diosmin 20
                      genkwanin 3
                      geraldone 0
                      hispidulin 8
                      isorhamnetin + 53
                      isorhamnetin 3-O-alpha-L-[6''''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside] 0
                      isorhamnetin 3-O-beta-D-galactopyranoside 0
                      isorhamnetin 3-O-beta-D-glucopyranoside 0
                      isorhamnetin 3-O-beta-L-galactopyranoside 0
                      isorhamnetin 3-O-beta-L-glucopyranoside 0
                      isorhamnetin 3-O-robinobioside 0
                      isorhamnetin 4'-O-beta-D-glucopyranoside 0
                      isorhamnetin 4'-O-beta-L-glucopyranoside 0
                      isorhamnetin 7-O-beta-D-glucopyranoside 0
                      isorhamnetin 7-O-beta-L-glucopyranoside 0
                      isorhamnetin-3-O-rutinoside 0
                      isoscoparin + 0
                      isoscoparin 2''-O-[6-(E)-feruloylglucoside] 0
                      kaempferide + 2
                      laricitrin 0
                      laricitrin 3-glucoside 0
                      macaranone B 0
                      myricitrin-5-methyl ether 0
                      nigrasin j 0
                      oroxylin A + 45
                      oroxylin A 7-O-beta-D-glucuronide 0
                      patuletin 0
                      pedalitin 2
                      phyllospadine 0
                      rhamnetin 0
                      rhamnocitrin 0
                      sexangularetin 0
                      sideroxylin + 0
                      spinosin 0
                      swertiajaponin 0
                      swertisin 0
                      tamarixetin 8
                      tectochrysin 1
                      wogonin + 52
                      wogonin 7-O-beta-D-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  oxacycle 17200
                                    benzopyran 10142
                                      1-benzopyran 9858
                                        flavonoid 6376
                                          flavones 4169
                                            methoxyflavone 416
                                              monomethoxyflavone 138
                                                2''-O-(4-sinapoylarabinosyl)isoscoparin 0
                                                2''-O-alpha-L-arabinopyranosylisoscoparin 0
                                                2''-O-beta-D-glucosylisoscoparin 0
                                                2''-O-rhamnosylscoparin 0
                                                2-(2-amino-3-methoxyphenyl)chromen-4-one 0
                                                3',4',5,7-tetrahydroxy-3-methoxyflavone + 0
                                                3'-O-methyltricetin + 0
                                                3'-O-methyltricetin 3-O-alpha-L-rhamnopyranoside 0
                                                3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                                                3-O-methyl-8-prenylgalangin 0
                                                3-O-methylquercetin 7-O-beta-glucopyranosyl-4'-O-beta-D-glucopyranoside 0
                                                3-methoxyapigenin 0
                                                3-methylgalangin 0
                                                4',5,7-trihydroxy-3'-methoxyflavone + 11
                                                4',5,7-trihydroxy-3-methoxyflavone-7-O-alpha-L-arabinofuranosyl(1->6)-beta-D-glucopyranoside 0
                                                4',5,7-trihydroxy-3-methoxyflavone-7-O-beta-D-glucopyranoside 0
                                                4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside 0
                                                5,7,2'-trihydroxy-6-methoxyflavone 0
                                                5,7-dihydroxy-4'-methoxyflavone + 5
                                                6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol 0
                                                6-desmethylsideroxylin 0
                                                6-hydroxy-2'-methoxyflavone 0
                                                6-methoxyluteolin 7-alpha-L-rhamnoside 0
                                                7-O-(6-p-coumaroylglucosyl)chrysoeriol 0
                                                7-O-(6-sinapoylglucosyl)isoscoparin 0
                                                7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol 0
                                                7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoscoparin 0
                                                7-O-beta-D-glucosylisoscoparin 0
                                                7-O-methoxy gossypetin 3-O-rutinoside 0
                                                7-O-methylmyricetin 0
                                                7-O-methylvitexin 2''-O-alpha-L-rhamnoside 0
                                                7-O-methylvitexin 2''-O-beta-L-rhamnoside 0
                                                7-hydroxy-5-methoxy-6,8-dimethylflavone 0
                                                8-(1,1-dimethylallyl)-3-methylgalangin 0
                                                8-(1,1-dimethylallyl)kaempferide 0
                                                8-desmethylsideroxylin 0
                                                acacetin-7-O-beta-D-galactopyranoside 0
                                                acacetin-8-C-neohesperidoside 0
                                                artocarpin 0
                                                azaleatin 0
                                                chrysoeriol 7-O-gentiobioside 0
                                                diandraflavone 0
                                                diosmetin + 32
                                                diosmin 20
                                                genkwanin 3
                                                geraldone 0
                                                hispidulin 8
                                                isorhamnetin + 53
                                                isorhamnetin 3-O-alpha-L-[6''''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside] 0
                                                isorhamnetin 3-O-beta-D-galactopyranoside 0
                                                isorhamnetin 3-O-beta-D-glucopyranoside 0
                                                isorhamnetin 3-O-beta-L-galactopyranoside 0
                                                isorhamnetin 3-O-beta-L-glucopyranoside 0
                                                isorhamnetin 3-O-robinobioside 0
                                                isorhamnetin 4'-O-beta-D-glucopyranoside 0
                                                isorhamnetin 4'-O-beta-L-glucopyranoside 0
                                                isorhamnetin 7-O-beta-D-glucopyranoside 0
                                                isorhamnetin 7-O-beta-L-glucopyranoside 0
                                                isorhamnetin-3-O-rutinoside 0
                                                isoscoparin + 0
                                                isoscoparin 2''-O-[6-(E)-feruloylglucoside] 0
                                                kaempferide + 2
                                                laricitrin 0
                                                laricitrin 3-glucoside 0
                                                macaranone B 0
                                                myricitrin-5-methyl ether 0
                                                nigrasin j 0
                                                oroxylin A + 45
                                                oroxylin A 7-O-beta-D-glucuronide 0
                                                patuletin 0
                                                pedalitin 2
                                                phyllospadine 0
                                                rhamnetin 0
                                                rhamnocitrin 0
                                                sexangularetin 0
                                                sideroxylin + 0
                                                spinosin 0
                                                swertiajaponin 0
                                                swertisin 0
                                                tamarixetin 8
                                                tectochrysin 1
                                                wogonin + 52
                                                wogonin 7-O-beta-D-glucuronide 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.