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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ursolic acid
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Accession:CHEBI:9908 term browser browse the term
Definition:A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Synonyms:exact_synonym: 3beta-hydroxyurs-12-en-28-oic acid
 related_synonym: (3beta)-3-hydroxyurs-12-en-28-oic acid;   Formula=C30H48O3;   InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1;   InChIKey=WCGUUGGRBIKTOS-GPOJBZKASA-N;   SMILES=[H][C@@]12[C@@H](C)[C@H](C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O;   malol;   prunol;   urson
 xref: Beilstein:2228563;   CAS:77-52-1;   DrugBank:DB15588;   FooDB:FDB014373;   HMDB:HMDB0002395;   KEGG:C08988;   KNApSAcK:C00003558;   LIPID_MAPS_instance:LMPR0106180007
 xref_mesh: MESH:C005466
 xref: PDBeChem:6Q5;   PMID:17516089;   PMID:28493531;   PMID:30496629;   Reaxys:2228563;   Wikipedia:Ursolic_acid



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ursolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO ursolic acid results in decreased expression of ABCB1 mRNA; ursolic acid results in decreased expression of ABCB1 protein
ABCB1 protein inhibits the reaction [ursolic acid results in increased susceptibility to Doxorubicin]
CTD PMID:33009882 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO ursolic acid results in increased phosphorylation of ACACA protein CTD PMID:24802810 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases response to substance
increases localization
ISO AIFM1 mutant form results in decreased susceptibility to ursolic acid
ursolic acid results in increased localization of AIFM1 protein
CTD PMID:20630652 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ursolic acid results in decreased phosphorylation of AKT1 protein CTD PMID:19344998 PMID:24802810 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO ursolic acid results in increased activity of BAK1 protein CTD PMID:20630652 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ursolic acid results in increased expression of BAX protein CTD PMID:16012738 PMID:24051192 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases phosphorylation
ISO ursolic acid results in decreased expression of BCL2 protein
[ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; ursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein]
CTD PMID:16012738 PMID:24802810 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 multiple interactions ISO [ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; ursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein] CTD PMID:24802810 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [ursolic acid results in increased cleavage of and results in increased activity of CASP3 protein]; ursolic acid results in increased cleavage of and results in increased activity of CASP3 protein
ursolic acid results in increased expression of CASP3 protein
ursolic acid results in increased activity of CASP3 protein
CTD PMID:16012738 PMID:19329757 PMID:20005942 PMID:24051192 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO ursolic acid results in increased activity of CASP7 protein CTD PMID:19329757 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO ursolic acid results in increased activity of CASP8 protein CTD PMID:20005942 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase increases activity ISO ursolic acid results in increased activity of CAT protein CTD PMID:24051192 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ursolic acid results in decreased expression of CCND1 mRNA; ursolic acid results in decreased expression of CCND1 protein CTD PMID:24566423 PMID:24802810 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO ursolic acid results in decreased expression of CCND3 protein CTD PMID:24802810 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO ursolic acid results in decreased expression of CCNE1 protein CTD PMID:24802810 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO ursolic acid results in decreased expression of CDK4 protein CTD PMID:24802810 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ursolic acid results in increased expression of CDKN1A protein CTD PMID:24802810 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO ursolic acid results in increased expression of CDKN1B protein CTD PMID:24802810 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO ursolic acid results in increased phosphorylation of and results in increased degradation of CTNNB1 protein CTD PMID:24566423 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO ursolic acid affects the localization of CYCS protein CTD PMID:16012738 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO ursolic acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
ursolic acid results in decreased activity of CYP2C19 protein
CTD PMID:15043991 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein] CTD PMID:24802810 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased expression of EDN1 protein] CTD PMID:27567547 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]] CTD PMID:26100520 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]; ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]
ursolic acid results in increased phosphorylation of EIF2AK3 protein
CTD PMID:24802810 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein] CTD PMID:24802810 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression ISO ursolic acid results in decreased expression of EIF4EBP1 protein CTD PMID:24802810 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases activity ISO ursolic acid results in increased activity of ERN1 protein CTD PMID:24802810 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased activity of GPT protein] CTD PMID:27567547 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein] CTD PMID:24802810 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO ursolic acid results in decreased expression of ICAM1 mRNA; ursolic acid results in decreased expression of ICAM1 protein CTD PMID:20005942 PMID:21539908 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO ursolic acid results in decreased expression of IL6 protein
[Glucaric Acid co-treated with ursolic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]
CTD PMID:20869956 PMID:23835587 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Glucaric Acid co-treated with ursolic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]] CTD PMID:23835587 PMID:26100520 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lep leptin increases expression ISO ursolic acid results in increased expression of LEP protein CTD PMID:20869956 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein] CTD PMID:27274199 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein] CTD PMID:27274199 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein] CTD PMID:27274199 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein] CTD PMID:27274199 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO
EXP
ursolic acid results in decreased expression of MMP2 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]
CTD PMID:21539908 PMID:27274199 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO
EXP
ursolic acid results in decreased expression of MMP9 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]
CTD PMID:21539908 PMID:27274199 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO ursodoxicoltaurine inhibits the reaction [ursolic acid results in decreased phosphorylation of MTOR protein] CTD PMID:24802810 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [ursolic acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKB1 protein] CTD PMID:23835587 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO ursolic acid analog results in decreased phosphorylation of and results in increased expression of NFKBIA protein CTD PMID:26134000 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO ursolic acid results in decreased expression of NOS2 protein CTD PMID:24051192 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased expression of NOS3 protein] CTD PMID:27567547 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO ursolic acid results in increased cleavage of PARP1 protein CTD PMID:16012738 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein] CTD PMID:27274199 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [ursolic acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]] CTD PMID:23835587 PMID:26100520 PMID:26513295 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO ursolic acid results in decreased activity of PTPN1 protein CTD PMID:27085377 PMID:29175190 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO ursolic acid analog results in decreased expression of RELA mRNA; ursolic acid analog results in decreased expression of RELA protein CTD PMID:26134000 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO ursolic acid results in decreased expression of RPS6KB1 protein CTD PMID:24802810 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]] CTD PMID:26100520 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; ursolic acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]] CTD PMID:26100520 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO ursolic acid results in decreased expression of TGFB1 protein CTD PMID:21539908 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein] CTD PMID:27274199 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO ursolic acid results in decreased expression of TNF protein CTD PMID:24051192 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO ursolic acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO ursolic acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO ursolic acid results in decreased expression of VEGFA protein CTD PMID:24051192 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            protective agent 17739
              geroprotector 16520
                ursolic acid 60
                  23-hydroxyursolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        hydroxy carboxylic acid 3656
                                          hydroxy monocarboxylic acid 3656
                                            ursolic acid 60
                                              23-hydroxyursolic acid + 0
paths to the root