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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ursolic acid
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Accession:CHEBI:9908 term browser browse the term
Definition:A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Synonyms:exact_synonym: 3beta-hydroxyurs-12-en-28-oic acid
 related_synonym: (3beta)-3-hydroxyurs-12-en-28-oic acid;   Formula=C30H48O3;   InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1;   InChIKey=WCGUUGGRBIKTOS-GPOJBZKASA-N;   SMILES=C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O;   malol;   prunol;   urson
 xref: Beilstein:2228563;   CAS:77-52-1;   KEGG:C08988;   KNApSAcK:C00003558
 xref_mesh: MESH:C005466
 xref: PMID:17516089;   Reaxys:2228563


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ursolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO ursolic acid results in increased phosphorylation of ACACA protein CTD PMID:24802810 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases response to substance
increases localization
ISO AIFM1 mutant form results in decreased susceptibility to ursolic acid
ursolic acid results in increased localization of AIFM1 protein
CTD PMID:20630652 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ursolic acid results in decreased phosphorylation of AKT1 protein CTD PMID:19344998, PMID:24802810 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO ursolic acid results in increased activity of BAK1 protein CTD PMID:20630652 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ursolic acid results in increased expression of BAX protein CTD PMID:16012738, PMID:24051192 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases phosphorylation
ISO ursolic acid results in decreased expression of BCL2 protein
[ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; ursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein]
CTD PMID:16012738, PMID:24802810 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions ISO [ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; ursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein] CTD PMID:24802810 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [ursolic acid results in increased cleavage of and results in increased activity of CASP3 protein]; ursolic acid results in increased cleavage of and results in increased activity of CASP3 protein
ursolic acid results in increased expression of CASP3 protein
ursolic acid results in increased activity of CASP3 protein
CTD PMID:16012738, PMID:19329757, PMID:20005942, PMID:24051192 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO ursolic acid results in increased activity of CASP7 protein CTD PMID:19329757 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO ursolic acid results in increased activity of CASP8 protein CTD PMID:20005942 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase increases activity ISO ursolic acid results in increased activity of CAT protein CTD PMID:24051192 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ursolic acid results in decreased expression of CCND1 mRNA; ursolic acid results in decreased expression of CCND1 protein CTD PMID:24566423, PMID:24802810 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO ursolic acid results in decreased expression of CCND3 protein CTD PMID:24802810 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO ursolic acid results in decreased expression of CCNE1 protein CTD PMID:24802810 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO ursolic acid results in decreased expression of CDK4 protein CTD PMID:24802810 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ursolic acid results in increased expression of CDKN1A protein CTD PMID:24802810 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO ursolic acid results in increased expression of CDKN1B protein CTD PMID:24802810 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO ursolic acid results in increased phosphorylation of and results in increased degradation of CTNNB1 protein CTD PMID:24566423 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO ursolic acid affects the localization of CYCS protein CTD PMID:16012738 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO ursolic acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
ursolic acid results in decreased activity of CYP2C19 protein
CTD PMID:15043991 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein] CTD PMID:24802810 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased expression of EDN1 protein] CTD PMID:27567547 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]] CTD PMID:26100520 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]; ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]
ursolic acid results in increased phosphorylation of EIF2AK3 protein
CTD PMID:24802810 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]; tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein] CTD PMID:24802810 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression ISO ursolic acid results in decreased expression of EIF4EBP1 protein CTD PMID:24802810 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases activity ISO ursolic acid results in increased activity of ERN1 protein CTD PMID:24802810 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased activity of GPT protein] CTD PMID:27567547 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein] CTD PMID:24802810 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO ursolic acid results in decreased expression of ICAM1 mRNA; ursolic acid results in decreased expression of ICAM1 protein CTD PMID:20005942, PMID:21539908 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO ursolic acid results in decreased expression of IL6 protein
[Glucaric Acid co-treated with ursolic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]
CTD PMID:20869956, PMID:23835587 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Glucaric Acid co-treated with ursolic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]] CTD PMID:23835587, PMID:26100520 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lep leptin increases expression ISO ursolic acid results in increased expression of LEP protein CTD PMID:20869956 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein] CTD PMID:27274199 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein] CTD PMID:27274199 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein] CTD PMID:27274199 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein] CTD PMID:27274199 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO
EXP
ursolic acid results in decreased expression of MMP2 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]
CTD PMID:21539908, PMID:27274199 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO
EXP
ursolic acid results in decreased expression of MMP9 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]
CTD PMID:21539908, PMID:27274199 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in decreased phosphorylation of MTOR protein] CTD PMID:24802810 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [ursolic acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKB1 protein] CTD PMID:23835587 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO ursolic acid analog results in decreased phosphorylation of and results in increased expression of NFKBIA protein CTD PMID:26134000 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO ursolic acid results in decreased expression of NOS2 protein CTD PMID:24051192 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased expression of NOS3 protein] CTD PMID:27567547 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO ursolic acid results in increased cleavage of PARP1 protein CTD PMID:16012738 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein] CTD PMID:27274199 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [ursolic acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]] CTD PMID:23835587, PMID:26100520, PMID:26513295 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO ursolic acid results in decreased activity of PTPN1 protein CTD PMID:27085377, PMID:29175190 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO ursolic acid analog results in decreased expression of RELA mRNA; ursolic acid analog results in decreased expression of RELA protein CTD PMID:26134000 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO ursolic acid results in decreased expression of RPS6KB1 protein CTD PMID:24802810 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]] CTD PMID:26100520 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; ursolic acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]] CTD PMID:26100520 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO ursolic acid results in decreased expression of TGFB1 protein CTD PMID:21539908 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein] CTD PMID:27274199 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO ursolic acid results in decreased expression of TNF protein CTD PMID:24051192 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO ursolic acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO ursolic acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO ursolic acid results in decreased expression of VEGFA protein CTD PMID:24051192 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            eukaryotic metabolite 18908
              plant metabolite 17360
                ursolic acid 59
                  23-hydroxyursolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        hydroxy carboxylic acid 3603
                                          hydroxy monocarboxylic acid 3603
                                            ursolic acid 59
                                              23-hydroxyursolic acid + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.