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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:polymyxin
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Accession:CHEBI:59062 term browser browse the term
Definition:Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium Bacillus polymyxa and are selectively toxic for Gram-negative bacteria.
Synonyms:related_synonym: polymixin;   polymycin;   polymyxins


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colistin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
decreases expression		 EXP
ISO		 Colistin results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]
Colistin results in decreased expression of AKT1 protein modified form		 CTD PMID:28465020 PMID:35378205 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Colistin results in increased expression of APAF1 mRNA; Colistin results in increased expression of APAF1 protein CTD PMID:34560125 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atg12 autophagy related 12 increases expression ISO Colistin results in increased expression of ATG12 mRNA CTD PMID:35378205 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Colistin results in increased expression of ATG5 mRNA CTD PMID:35378205 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg9a autophagy related 9A increases expression ISO Colistin results in increased expression of ATG9A mRNA CTD PMID:35378205 NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]
Colistin results in increased expression of BAX mRNA; Colistin results in increased expression of BAX protein		 CTD PMID:28465020 PMID:28842171 PMID:34560125 PMID:35378205 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases phosphorylation		 EXP
ISO		 Colistin results in decreased expression of BCL2 protein
Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2 protein]
Colistin results in decreased expression of BCL2 mRNA; Colistin results in decreased expression of BCL2 protein
Colistin results in increased phosphorylation of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]		 CTD PMID:28465020 PMID:28842171 PMID:30138604 PMID:34560125 PMID:35378205 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2L1 protein] CTD PMID:35378205 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 EXP
ISO		 Colistin results in increased expression of BECN1 mRNA; Colistin results in increased expression of BECN1 protein
Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]		 CTD PMID:28842171 PMID:30318960 PMID:35378205 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; [Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Colistin results in increased activity of and results in increased cleavage of CASP3 protein; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 protein]; rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]
Colistin results in increased activity of CASP3 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Colistin results in increased activity of CASP3 protein]; MitoTEMPO inhibits the reaction [Colistin results in increased activity of CASP3 protein]; setanaxib inhibits the reaction [Colistin results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP3 protein]
Colistin results in increased cleavage of CASP3 protein
Colistin results in increased expression of CASP3 mRNA; Colistin results in increased expression of CASP3 protein		 CTD PMID:28465020 PMID:28842171 PMID:30138604 PMID:30273961 PMID:30318960 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO Colistin results in increased cleavage of CASP8 protein CTD PMID:34560125 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
increases activity
multiple interactions
increases cleavage		 ISO Colistin results in increased expression of CASP9 mRNA
Colistin results in increased activity of CASP9 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Colistin results in increased activity of CASP9 protein]; MitoTEMPO inhibits the reaction [Colistin results in increased activity of CASP9 protein]; setanaxib inhibits the reaction [Colistin results in increased activity of CASP9 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP9 protein]
Colistin results in increased cleavage of CASP9 protein		 CTD PMID:34560125 PMID:35378205 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions		 EXP
ISO		 Colistin results in decreased expression of CAT protein
Colistin results in decreased activity of CAT protein
chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]		 CTD PMID:30138604 PMID:30273961 PMID:35378205 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit decreases expression ISO Colistin results in decreased expression of DGCR8 protein CTD PMID:34560125 NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO Colistin results in decreased expression of HMOX1 mRNA; Colistin results in decreased expression of HMOX1 protein CTD PMID:34560125 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein] CTD PMID:30138604 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Colistin results in increased expression of KEAP1 mRNA; Colistin results in increased expression of KEAP1 protein CTD PMID:34560125 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]
Colistin results in increased expression of MAP1LC3B mRNA; Colistin results in increased expression of MAP1LC3B protein		 CTD PMID:30273961 PMID:30318960 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Colistin results in decreased expression of METTL3 mRNA; Colistin results in decreased expression of METTL3 protein CTD PMID:34560125 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 multiple interactions
increases response to substance		 ISO MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]
MRGPRX2 protein results in increased susceptibility to Colistin		 CTD PMID:31132327 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Colistin results in decreased expression of MTOR protein modified form CTD PMID:35378205 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Colistin results in decreased expression of NDUFB8 protein CTD PMID:35378205 NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO Colistin results in decreased expression of NFE2L2 protein CTD PMID:34560125 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] CTD PMID:30318960 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Colistin results in increased expression of NOX4 mRNA; Colistin results in increased expression of NOX4 protein CTD PMID:35378205 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Oga O-GlcNAcase increases secretion
multiple interactions		 ISO Colistin results in increased secretion of OGA protein
MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]		 CTD PMID:31132327 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein CTD PMID:28842171 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B decreases expression ISO Colistin results in decreased expression of SDHB protein CTD PMID:35378205 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sqstm1 sequestosome 1 increases degradation
multiple interactions		 EXP Colistin results in increased degradation of SQSTM1 protein
Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein]		 CTD PMID:28842171 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Colistin results in increased expression of TGFB1 mRNA; Colistin results in increased expression of TGFB1 protein CTD PMID:35378205 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions		 EXP
ISO		 Colistin results in increased expression of TNF protein
Colistin results in increased secretion of TNF protein
Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]		 CTD PMID:30138604 PMID:31132327 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 EXP Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein] CTD PMID:28842171 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tsc2 TSC complex subunit 2 increases expression ISO Colistin results in increased expression of TSC2 protein CTD PMID:35378205 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression ISO Colistin results in decreased expression of UQCRC2 protein CTD PMID:35378205 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453 		JBrowse link
polymyxin B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression
multiple interactions		 ISO Polymyxin B results in increased expression of ALOX12 protein
TP53 protein promotes the reaction [Polymyxin B results in increased expression of ALOX12 protein]		 CTD PMID:37088170 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO Polymyxin B promotes the reaction [Particulate Matter results in increased expression of ATF3 mRNA] CTD PMID:21652769 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein] CTD PMID:26882889 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]] CTD PMID:21652769 PMID:26882889 PMID:28555929 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases secretion		 ISO Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]]; Acetylcysteine promotes the reaction [Polymyxin B results in decreased secretion of CCL3 protein]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL3 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of CCL3 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine results in decreased secretion of CCL3 protein] CTD PMID:26882889 PMID:28555929 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL5 protein]
Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein]		 CTD PMID:26882889 PMID:29348435 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein] CTD PMID:26882889 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD80 protein] CTD PMID:14977963 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions		 ISO Polymyxin B results in increased expression of CD86 protein
Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD86 protein]
Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]		 CTD PMID:14977963 PMID:15671028 PMID:30944281 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases expression		 ISO Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 protein]
Polymyxin B results in decreased expression of CSF2 protein		 CTD PMID:31442584 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein]; Polymyxin B promotes the reaction [Cadmium Chloride results in increased expression of CSF3 protein] CTD PMID:26790433 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CXCL2 mRNA] CTD PMID:21652769 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Polymyxin B co-treated with Particulate Matter] results in increased expression of CXCL1 protein; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CXCL1 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of CXCL1 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] CTD PMID:26882889 PMID:28555929 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Polymyxin B promotes the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA] CTD PMID:20801209 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2C11 protein] CTD PMID:18079364 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] CTD PMID:18079364 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO Polymyxin B results in decreased expression of FTH1 protein CTD PMID:37088170 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO Polymyxin B inhibits the reaction [Alpha-Amanitin results in decreased expression of GAPDH mRNA] CTD PMID:26385100 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Polymyxin B results in increased expression of GCLM mRNA CTD PMID:37088170 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpnmb glycoprotein nmb increases secretion ISO Polymyxin B results in increased secretion of GPNMB protein CTD PMID:32905824 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression		 ISO baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SLC7A11 protein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of GPX4 protein]
GPX4 protein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]
Polymyxin B results in decreased expression of GPX4 mRNA; Polymyxin B results in decreased expression of GPX4 protein		 CTD PMID:37088170 PMID:37354967 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases secretion ISO Polymyxin B results in increased secretion of HAVCR1 protein CTD PMID:32905824 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Polymyxin B inhibits the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]]
baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of HMOX1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]
Polymyxin B results in increased expression of HMOX1 mRNA; Polymyxin B results in increased expression of HMOX1 protein		 CTD PMID:28555929 PMID:37088170 PMID:37354967 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Polymyxin B inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] CTD PMID:24080332 PMID:30944281 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of IL10 protein] CTD PMID:14977963 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:26882889 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:9278343 PMID:26882889 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein] CTD PMID:26882889 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA] CTD PMID:21703343 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Polymyxin B inhibits the reaction [Vehicle Emissions results in increased secretion of IL1B protein]
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL1B protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of IL1B mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]		 CTD PMID:14993811 PMID:18406506 PMID:26882889 PMID:27393915 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein] CTD PMID:26882889 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]
Dextran Sulfate inhibits the reaction [Polymyxin B results in decreased expression of IL6 protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of IL6 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]
Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL6]		 CTD PMID:8886760 PMID:12185005 PMID:20549640 PMID:21784459 PMID:26882889 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK1 protein
Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]]; Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15671028 PMID:28555929 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK3 protein
Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]]; Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15671028 PMID:28555929 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]] CTD PMID:18986645 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein] CTD PMID:30891624 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 increases response to substance
multiple interactions		 ISO MRGPRX2 protein results in increased susceptibility to Polymyxin B
MRGPRX2 protein affects the reaction [Polymyxin B results in increased secretion of OGA protein]		 CTD PMID:31132327 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein; [Particulate Matter co-treated with Polymyxin B] results in increased secretion of MYD88 protein; MYD88 protein affects the reaction [[Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]] CTD PMID:28555929 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 Polymyxin B inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:12568917 PMID:23500011 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Oga O-GlcNAcase increases secretion
multiple interactions		 ISO Polymyxin B results in increased secretion of OGA protein
MRGPRX2 protein affects the reaction [Polymyxin B results in increased secretion of OGA protein]		 CTD PMID:31132327 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO baicalein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; GPX4 protein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; Polymyxin B affects the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]]
Polymyxin B promotes the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]		 CTD PMID:21652769 PMID:23500011 PMID:27393915 PMID:28555929 PMID:37088170 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rig1 RNA sensor RIG-1 multiple interactions ISO Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of RIGI mRNA] CTD PMID:27183587 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G Sele selectin E multiple interactions ISO Polymyxin B promotes the reaction [Particulate Matter results in increased expression of SELE mRNA] CTD PMID:21652769 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions		 ISO Polymyxin B results in decreased expression of SIRT1 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]		 CTD PMID:37354967 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions		 ISO Polymyxin B results in decreased expression of SLC7A11 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SLC7A11 protein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]		 CTD PMID:37088170 PMID:37354967 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions		 ISO Polymyxin B results in increased expression of TFRC mRNA; Polymyxin B results in increased expression of TFRC protein
TP53 protein promotes the reaction [Polymyxin B results in increased expression of TFRC protein]		 CTD PMID:37088170 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
decreases expression		 ISO
EXP		 Dextran Sulfate inhibits the reaction [Polymyxin B results in decreased expression of TNF protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]]; Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]
Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [Vehicle Emissions results in increased secretion of TNF protein]
Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF]
Polymyxin B results in increased secretion of TNF protein		 CTD PMID:8886760 PMID:12185005 PMID:18406506 PMID:26882889 PMID:28555929 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]; Polymyxin B results in increased expression of and results in increased acetylation of TP53 protein; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; TP53 protein promotes the reaction [Polymyxin B results in increased expression of ALOX12 protein]; TP53 protein promotes the reaction [Polymyxin B results in increased expression of TFRC protein] CTD PMID:37088170 PMID:37354967 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion ISO Polymyxin B results in increased secretion of VEGFA protein CTD PMID:32905824 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          polymyxin 80
            colistimethate 0
            colistimethate A + 0
            colistimethate B + 0
            colistimethate sodium 0
            colistin + 34
            colistin A + 34
            colistin A sodium methanesulfonate + 0
            colistin B + 34
            colistin B sodium methanesulfonate + 0
            polymyxin B1 0
            polymyxin B2 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              peptide 11122
                                                cyclic peptide 8873
                                                  heterodetic cyclic peptide 1644
                                                    polymyxin 80
                                                      colistimethate 0
                                                      colistimethate A + 0
                                                      colistimethate B + 0
                                                      colistimethate sodium 0
                                                      colistin + 34
                                                      colistin A + 34
                                                      colistin A sodium methanesulfonate + 0
                                                      colistin B + 34
                                                      colistin B sodium methanesulfonate + 0
                                                      polymyxin B1 0
                                                      polymyxin B2 52
paths to the root