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Accession:CHEBI:37943 term browser browse the term
Definition:A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Synonyms:related_synonym: Formula=C52H97N16O13R;   SMILES=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)CCC[C@@H](C*)C;   colistina;   colistine;   colistinum;   polymyxin E
 alt_id: CHEBI:34651;   CHEBI:472593;   CHEBI:560465;   CHEBI:566816;   CHEBI:596826;   CHEBI:597111;   CHEBI:600596;   CHEBI:659853
 xref: CAS:1066-17-7;   CAS:1264-72-8;   DrugBank:DB00803;   KEGG:C13768;   KEGG:D02138
 xref_mesh: MESH:D003091
 xref: PMID:15825037;   PMID:16931410;   PMID:17145797;   PMID:17562800;   PMID:17576842;   PMID:17606684;   PMID:17620384;   PMID:17646423;   PMID:17846127;   PMID:17876007;   PMID:18625681;   PMID:25322351;   PMID:26252512;   PMID:26415906;   PMID:26488563;   PMID:26730548;   PMID:27160031;   PMID:27411324;   PMID:27480806;   PMID:27524102;   PMID:27552304;   PMID:27684296;   PMID:27743779;   PMID:27790432;   PMID:27793510;   PMID:27891118;   PMID:27917926;   PMID:28018876;   PMID:28029008;   PMID:28215823;   PMID:28257552;   PMID:28267594;   PMID:28267779;   PMID:28300674;   PMID:28315729;   PMID:28321410

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colistin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:6480464
G Mrgprx2 MAS related GPR family member X2 JBrowse link 1 103,743,746 103,760,945 RGD:6480464
G Oga O-GlcNAcase JBrowse link 1 265,506,752 265,542,452 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      biological role 19726
        antimicrobial agent 17315
          peptide antibiotic 1665
            colistin 14
              colistimethate 0
              colistimethate sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            organic group 18463
                              organic divalent group 18456
                                organodiyl group 18456
                                  carbonyl group 18356
                                    carbonyl compound 18356
                                      carboxylic acid 18027
                                        carboacyl group 17185
                                          univalent carboacyl group 17185
                                            carbamoyl group 16924
                                              carboxamide 16924
                                                peptide 9367
                                                  cyclic peptide 8720
                                                    heterodetic cyclic peptide 1440
                                                      polymyxin 48
                                                        colistin A 14
                                                          colistin 14
                                                            colistimethate 0
                                                            colistimethate sodium 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.