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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:colistin
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Accession:CHEBI:37943 term browser browse the term
Definition:A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Synonyms:related_synonym: Formula=C52H97N16O13R;   SMILES=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)CCC[C@@H](C*)C;   colistina;   colistine;   colistinum;   polymyxin E
 alt_id: CHEBI:34651;   CHEBI:472593;   CHEBI:560465;   CHEBI:566816;   CHEBI:596826;   CHEBI:597111;   CHEBI:600596;   CHEBI:659853
 xref: CAS:1066-17-7;   CAS:1264-72-8;   DrugBank:DB00803;   KEGG:C13768;   KEGG:D02138
 xref_mesh: MESH:D003091
 xref: PMID:15825037;   PMID:16931410;   PMID:17145797;   PMID:17562800;   PMID:17576842;   PMID:17606684;   PMID:17620384;   PMID:17646423;   PMID:17846127;   PMID:17876007;   PMID:18625681;   PMID:25322351;   PMID:26252512;   PMID:26415906;   PMID:26488563;   PMID:26730548;   PMID:27160031;   PMID:27411324;   PMID:27480806;   PMID:27524102;   PMID:27552304;   PMID:27684296;   PMID:27743779;   PMID:27790432;   PMID:27793510;   PMID:27891118;   PMID:27917926;   PMID:28018876;   PMID:28029008;   PMID:28215823;   PMID:28257552;   PMID:28267594;   PMID:28267779;   PMID:28300674;   PMID:28315729;   PMID:28321410


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colistin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Colistin results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]
CTD PMID:28465020 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein] CTD PMID:28465020 PMID:28842171 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases phosphorylation
multiple interactions
EXP Colistin results in decreased expression of BCL2 protein
Colistin results in increased phosphorylation of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]
CTD PMID:28465020 PMID:28842171 PMID:30138604 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
EXP Colistin results in increased expression of BECN1 protein
Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]
CTD PMID:28842171 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; [Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Colistin results in increased activity of and results in increased cleavage of CASP3 protein; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:28465020 PMID:28842171 PMID:30138604 PMID:30273961 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions
EXP Colistin results in decreased expression of CAT protein
Colistin results in decreased activity of CAT protein
chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]
CTD PMID:30138604 PMID:30273961 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein] CTD PMID:30138604 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
EXP chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] CTD PMID:30273961 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mrgprx2 MAS related GPR family member X2 multiple interactions
increases response to substance
ISO MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]
MRGPRX2 protein results in increased susceptibility to Colistin
CTD PMID:31132327 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Oga O-GlcNAcase increases secretion
multiple interactions
ISO Colistin results in increased secretion of OGA protein
MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]
CTD PMID:31132327 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein CTD PMID:28842171 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sqstm1 sequestosome 1 increases degradation
multiple interactions
EXP Colistin results in increased degradation of SQSTM1 protein
Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein]
CTD PMID:28842171 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions
EXP
ISO
Colistin results in increased expression of TNF protein
Colistin results in increased secretion of TNF protein
Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]
CTD PMID:30138604 PMID:31132327 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
EXP Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein] CTD PMID:28842171 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          peptide antibiotic 1690
            colistin 14
              colistimethate 0
              colistimethate sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                peptide 9450
                                                  cyclic peptide 8771
                                                    heterodetic cyclic peptide 1462
                                                      polymyxin 54
                                                        colistin A 14
                                                          colistin 14
                                                            colistimethate 0
                                                            colistimethate sodium 0
paths to the root