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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway in response to DNA damage
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Accession:GO:0008630 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
Synonyms:related_synonym: DNA damage response, signal transduction resulting in induction of apoptosis


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intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:1328356|MGI:88138 (PMID:15983387) RGD PMID:15983387 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Atm ATM serine/threonine kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:109337|MGI:1933746 (PMID:11040211), (PMID:16777961), (PMID:17476307)		 GO_Central
RGD		 PMID:11040211 PMID:16777961 PMID:17476307 GO_REF:0000033 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bad BCL2-associated agonist of cell death involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3029528 (PMID:12431371), (PMID:15231831)		 Ensembl
RGD		 PMID:12431371 PMID:15231831 GO_REF:0000107 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1197519|MGI:99702 (PMID:15901672), (PMID:15967824)		 GO_Central
RGD		 PMID:15901672 PMID:15967824 GO_REF:0000033 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 IBA
ISO
ISS		 GO_REF:0000033
MGI:1097161|MGI:1197519|MGI:1857429 (PMID:12952892), (PMID:15901672), (PMID:15967824)
(PMID:11912183)
GO_REF:0000024		 GO_Central
RGD
UniProt		 PMID:11912183 PMID:12952892 PMID:15901672 PMID:15967824 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
MGI:2442925 (PMID:15983387)		 Ensembl
GO_Central
RGD		 PMID:15983387 GO_REF:0000033 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2158303 (PMID:14517295)		 GO_Central
RGD		 PMID:14517295 GO_REF:0000033 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l10 Bcl2-like 10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11546872)
MGI:1097161|MGI:99702 (PMID:15967824)
GO_REF:0000107		 RGD
Ensembl		 PMID:11546872 PMID:15967824 GO_REF:0000107 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Brca1 BRCA1, DNA repair associated acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14654789)
GO_REF:0000107		 RGD
Ensembl		 PMID:14654789 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated acts_upstream_of_or_within ISO MGI:107202 (PMID:17476307) RGD PMID:17476307 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Casp2 caspase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp9 caspase 9 involved_in ISO
IBA		 (PMID:15657060)
GO_REF:0000033		 RGD
GO_Central		 PMID:15657060 GO_REF:0000033 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Casp9_v1 caspase-9-carboxyl-terminal divergent involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Chek2 checkpoint kinase 2 involved_in ISO (PMID:12402044), (PMID:12717439), (PMID:18644861) RGD PMID:12402044 PMID:12717439 PMID:18644861 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Crip1 cysteine rich protein 1 involved_in ISS
IBA
ISO		 PMID:20415737
GO_REF:0000033
(PMID:20415737)		 GO_Central
RGD		 PMID:20415737 PMID:20415737 GO_REF:0000033, RGD:8553326 NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620 		JBrowse link
G E2f1 E2F transcription factor 1 involved_in ISO
IEA
ISS		 (PMID:12717439)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:12717439 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein acts_upstream_of_or_within ISO (PMID:10594026) RGD PMID:10594026 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571 		JBrowse link
G Epha2 Eph receptor A2 involved_in ISO (PMID:18339848) RGD PMID:18339848 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor acts_upstream_of_or_within ISO MGI:1932102 (PMID:11005836) RGD PMID:11005836 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G Fnip2 folliculin interacting protein 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5284752|PMID:19137017)		 UniProt
RGD		 PMID:19137017 GO_REF:0000024 MGI:5284752 NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901 		JBrowse link
G Hic1 HIC ZBTB transcriptional repressor 1 involved_in ISO (PMID:16269335)
(MGI:5297787|PMID:16269335)		 RGD PMID:16269335 MGI:5297787 NCBI chr10:60,014,520...60,019,475
Ensembl chr10:60,011,528...60,019,475 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:11854317 RGD:625692 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Htra2 HtrA serine peptidase 2 involved_in ISO (PMID:11602612) RGD PMID:11602612 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (PMID:11753682) RGD PMID:11753682 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in ISO (PMID:20188669) RGD PMID:20188669 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Mael maelstrom spermatogenic transposon silencer acts_upstream_of_or_within ISO MGI:3795667 (PMID:18694567) RGD PMID:18694567 NCBI chr13:78,457,073...78,496,657
Ensembl chr13:78,457,073...78,496,657 		JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase acts_upstream_of_or_within ISO MGI:2183491 (PMID:14562041) RGD PMID:14562041 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:15901672)		 GO_Central
RGD		 PMID:15901672 GO_REF:0000033 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857946 (PMID:14562041)		 Ensembl
RGD		 PMID:14562041 GO_REF:0000107 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within ISO MGI:1858055|MGI:2680817 (PMID:10097137), (PMID:14744764) RGD PMID:10097137 PMID:14744764 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO MGI:1858014 (PMID:15324697) RGD PMID:15324697 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor acts_upstream_of_or_within ISO MGI:2447604 (PMID:14517295) RGD PMID:14517295 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 acts_upstream_of_or_within ISO MGI:97583 (PMID:17242187) RGD PMID:17242187 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Pcbp4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) RGD PMID:10891498 NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:104798|MGI:2149414 (PMID:17242187)		 Ensembl
RGD		 PMID:17242187 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO MGI:2678372 (PMID:12952892) RGD PMID:12952892 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:12402044)
MGI:104662|MGI:2429949 (PMID:15626733), (PMID:9806545)
GO_REF:0000033		 RGD
GO_Central		 PMID:9806545 PMID:12402044 PMID:15626733 GO_REF:0000033 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO (PMID:10197627) RGD PMID:10197627 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1857113 (PMID:12604618)		 GO_Central
RGD		 PMID:12604618 GO_REF:0000033 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A acts_upstream_of ISO MGI:2442925 (PMID:15983387) RGD PMID:15983387 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Sfn stratifin involved_in ISO (PMID:11574543) RGD PMID:11574543 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (MGI:5297787|PMID:16269335)
GO_REF:0000107		 RGD
Ensembl		 PMID:16269335 GO_REF:0000107 MGI:5297787 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Skil SKI-like proto-oncogene acts_upstream_of ISO MGI:2387096 (PMID:10811619) RGD PMID:10811619 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857480 (PMID:15642323) RGD PMID:15642323 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO (PMID:17242187) RGD PMID:17242187 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A acts_upstream_of_or_within ISO (PMID:17242187) RGD PMID:17242187 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:17242187)		 GO_Central
RGD		 PMID:17242187 GO_REF:0000033 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase involved_in ISO (PMID:20188669) RGD PMID:20188669 NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937 		JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats acts_upstream_of_or_within ISO MGI:3043446 (PMID:15271982) RGD PMID:15271982 NCBI chr 8:61,259,415...61,347,789
Ensembl chr 8:61,259,477...61,347,789 		JBrowse link
G Usp47 ubiquitin specific peptidase 47 acts_upstream_of ISO MGI:4130032 (PMID:19966869) RGD PMID:19966869 NCBI chr 1:166,152,104...166,235,312
Ensembl chr 1:166,152,199...166,235,312 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor acts_upstream_of_or_within ISO MGI:1857939 (PMID:11005836) RGD PMID:11005836 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aen apoptosis enhancing nuclease involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:18264133)		 UniProt
GO_Central
RGD		 PMID:18264133 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:1336991|MGI:98834 (PMID:15983387) RGD PMID:15983387 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17403783)		 UniProt
Ensembl
RGD		 PMID:17403783 GO_REF:0000024 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2681654 (PMID:16151013)		 Ensembl
RGD		 PMID:16151013 GO_REF:0000107 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO (PMID:16384933) RGD PMID:16384933 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Brca2 BRCA2, DNA repair associated involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2429691|MGI:3052655|MGI:98834 (PMID:15735671), (PMID:17476307)		 Ensembl
RGD		 PMID:15735671 PMID:17476307 GO_REF:0000107 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Cdip1 cell death-inducing p53 target 1 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:17599062)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:17599062 GO_REF:0000033 GO_REF:0000107 NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A acts_upstream_of_or_within ISO MGI:1933751 (PMID:12952892) RGD PMID:12952892 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek2 checkpoint kinase 2 acts_upstream_of_or_within ISO MGI:2386905 (PMID:10710310) RGD PMID:10710310 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5298149|PMID:21896779)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21896779 GO_REF:0000024 GO_REF:0000107 MGI:5298149 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 involved_in ISO (PMID:17349958) RGD PMID:17349958 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:22768269)		 Ensembl
RGD		 PMID:22768269 GO_REF:0000107 NCBI chr 3:108,413,035...108,417,181
Ensembl chr 3:108,410,448...108,417,132 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:17403783) RGD PMID:17403783 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:1314872|MGI:98834 (PMID:16537918)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:16537918 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 acts_upstream_of_or_within ISO MGI:1314872|MGI:98834 (PMID:16537918) RGD PMID:16537918 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:98834 (PMID:10097137)		 Ensembl
RGD		 PMID:10097137 GO_REF:0000107 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator acts_upstream_of_or_within ISO MGI:3784016 (PMID:11896600) RGD PMID:11896600 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 involved_in ISO
IBA
ISS		 (PMID:19203586)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:19203586 GO_REF:0000024 GO_REF:0000033 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:10807576)		 Ensembl
RGD		 PMID:10807576 GO_REF:0000107 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:3580934 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma involved_in ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rps27l ribosomal protein S27-like involved_in ISO (PMID:17057733), (PMID:18056458) RGD PMID:17057733 PMID:18056458 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418 		JBrowse link
G Shisa5 shisa family member 5 acts_upstream_of_or_within ISO (PMID:12135983) RGD PMID:12135983 NCBI chr 8:109,691,504...109,706,411
Ensembl chr 8:109,691,522...109,706,408 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:20100829) RGD PMID:20100829 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Snw1 SNW domain containing 1 involved_in ISO (PMID:21460037) RGD PMID:21460037 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536 		JBrowse link
G Tmem109 transmembrane protein 109 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:4453832 (PMID:20060811)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:20060811 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215 		JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase acts_upstream_of_or_within ISO (PMID:15735665) RGD PMID:15735665 NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:4944151|PMID:20818388), (MGI:5882892|PMID:16213212)
MGI:109337|MGI:1096393|MGI:1336991|MGI:1857263|MGI:1926340|MGI:2442925 (PMID:12135983), (PMID:12952892), (PMID:15983387), (PMID:16286009), (PMID:16777961), (PMID:17476307)
GO_REF:0000107
(PMID:14654789), (PMID:14744935)
(PMID:16213212), (PMID:17403783)		 RGD
Ensembl		 PMID:12135983 PMID:12952892 PMID:14654789 PMID:14744935 PMID:15983387 More... GO_REF:0000107 MGI:4944151 MGI:5882892 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 acts_upstream_of_or_within ISO MGI:1934269 (PMID:17122775) RGD PMID:17122775 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 involved_in
acts_upstream_of		 ISO (PMID:18174154), (PMID:19490146)
MGI:2442925|MGI:98834 (PMID:15983387)		 RGD PMID:15983387 PMID:18174154 PMID:19490146 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 involved_in ISO
ISS		 (PMID:16901786)
GO_REF:0000024		 RGD
UniProt		 PMID:16901786 GO_REF:0000024 NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 involved_in ISO (PMID:20388803) RGD PMID:20388803 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO (PMID:15983387) RGD PMID:15983387 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO (PMID:16608847) RGD PMID:16608847 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5428930 (PMID:26219591)		 Ensembl
RGD		 PMID:26219591 GO_REF:0000107 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 involved_in ISO (PMID:23352644) RGD PMID:23352644 NCBI chr15:45,212,797...45,228,001
Ensembl chr15:45,212,803...45,227,636 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D involved_in ISO (PMID:15750620) RGD PMID:15750620 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Clu clusterin involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16113678)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16113678 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO (PMID:20388803) RGD PMID:20388803 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor involved_in ISO (PMID:24214091) RGD PMID:24214091 NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO (PMID:14561758) RGD PMID:14561758 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:15314165) RGD PMID:15314165 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:15314165) RGD PMID:15314165 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Tmem161a transmembrane protein 161A involved_in ISO (PMID:16551573) RGD PMID:16551573 NCBI chr16:19,237,638...19,248,151
Ensembl chr16:19,238,487...19,248,087 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 acts_upstream_of_or_within ISO (PMID:11598139) RGD PMID:11598139 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Trim32 tripartite motif-containing 32 involved_in ISO (PMID:18632609) RGD PMID:18632609 NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018 		JBrowse link
G Usp47 ubiquitin specific peptidase 47 acts_upstream_of_or_within ISO MGI:4130032 (PMID:19966869) RGD PMID:19966869 NCBI chr 1:166,152,104...166,235,312
Ensembl chr 1:166,152,199...166,235,312 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 involved_in ISO (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Bcl2l12 Bcl2 like 12 acts_upstream_of_or_within ISO (PMID:20837658) RGD PMID:20837658 NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991 		JBrowse link
G Cd44 CD44 molecule involved_in ISO
IEA		 (PMID:17045821)
GO_REF:0000107
(MGI:3690285|PMID:17045821)		 RGD
Ensembl		 PMID:17045821 GO_REF:0000107 MGI:3690285 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd74 CD74 molecule involved_in ISO
IBA
IEA
ISS		 (PMID:17045821)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
(MGI:3690285|PMID:17045821)		 RGD
GO_Central
Ensembl
BHF-UCL		 PMID:17045821 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3690285 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:22768269)		 Ensembl
RGD		 PMID:22768269 GO_REF:0000107 NCBI chr 3:108,413,035...108,417,181
Ensembl chr 3:108,410,448...108,417,132 		JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (PMID:17805299) RGD PMID:17805299 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:29295817)		 UniProt
Ensembl
RGD		 PMID:29295817 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:17045821) RGD PMID:17045821 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Muc1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (MGI:2152474|PMID:11672522)
GO_REF:0000107		 RGD
Ensembl		 PMID:11672522 GO_REF:0000107 MGI:2152474 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 involved_in ISO (PMID:15735003) RGD PMID:15735003 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042 		JBrowse link
G Zfp385a zinc finger protein 385A involved_in ISO (PMID:17719541) RGD PMID:17719541 NCBI chr 7:134,448,914...134,475,548
Ensembl chr 7:134,448,921...134,475,548 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbh1 F-box DNA helicase 1 acts_upstream_of_or_within ISO (PMID:23361013) RGD PMID:23361013 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590 		JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO MGI:2449949|MGI:5566664 (PMID:26219591) RGD PMID:26219591 NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189 		JBrowse link
G Nacc2 NACC family member 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22926524)		 Ensembl
RGD		 PMID:22926524 GO_REF:0000107 NCBI chr 3:8,879,952...8,946,660
Ensembl chr 3:8,883,065...8,946,660 		JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 acts_upstream_of_or_within ISO (PMID:16816390) RGD PMID:16816390 NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808 		JBrowse link
G Plscr1 phospholipid scramblase 1 acts_upstream_of_or_within ISO (PMID:12509439) RGD PMID:12509439 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A acts_upstream_of_or_within ISO MGI:2442925 (PMID:15983387) RGD PMID:15983387 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:22510408) RGD PMID:22510408 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Skil SKI-like proto-oncogene acts_upstream_of_or_within ISO MGI:2387096 (PMID:10811619) RGD PMID:10811619 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 involved_in ISO (PMID:16213212)
(MGI:5882892|PMID:16213212)		 RGD PMID:16213212 MGI:5882892 NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO MGI:4398911 (PMID:18617898) RGD PMID:18617898 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within ISO MGI:2442925|MGI:98834 (PMID:15983387) RGD PMID:15983387 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpk heterogeneous nuclear ribonucleoprotein K involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:20673990)		 Ensembl
RGD		 PMID:20673990 GO_REF:0000107 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G LOC100359916 heterogeneous nuclear ribonucleoprotein K-like involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:58,668,326...58,670,222
Ensembl chr 5:58,668,327...58,670,220 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    response to stimulus 10517
      response to stress 4181
        cellular response to stress 1993
          DNA damage response 860
            intrinsic apoptotic signaling pathway in response to DNA damage 112
              intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 45
              negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 27
              positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 11
              regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 40
Path 2
Term Annotations click to browse term
  biological_process 19694
    biological regulation 13309
      regulation of biological process 12906
        regulation of cellular process 12363
          signal transduction 7020
            apoptotic signaling pathway 671
              intrinsic apoptotic signaling pathway 338
                intrinsic apoptotic signaling pathway in response to DNA damage 112
                  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 45
                  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 27
                  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 11
                  regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 40
paths to the root