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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway
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Accession:GO:0097193 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
Comment:The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595.
Synonyms:exact_synonym: intrinsic apoptotic pathway;   intrinsic apoptotic signalling pathway;   mitochondrial-mediated apoptotic pathway
 narrow_synonym: intrinsic apoptosis
 related_synonym: induction of apoptosis by intracellular signals
 alt_id: GO:0008629


show annotations for term's descendants           Sort by:
intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:18676776)		 UniProt
RGD		 PMID:18676776 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:22006182) RGD PMID:22006182 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of		 ISS
ISO		 GO_REF:0000024
MGI:2158306 (MGI:3692043|PMID:14502238)
(PMID:16462759), (PMID:9219694)		 UniProt
RGD		 PMID:9219694 PMID:14502238 PMID:16462759 GO_REF:0000024 MGI:3692043 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l10 Bcl2-like 10 acts_upstream_of ISO (MGI:1326939|PMID:9878060) RGD PMID:9878060 MGI:1326939 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bnip3 BCL2 interacting protein 3 acts_upstream_of_or_within ISO MGI:96224 (MGI:3696331|PMID:16954213) RGD PMID:16954213 MGI:3696331 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase acts_upstream_of ISO MGI:3793294 (MGI:3790365|PMID:17938250) RGD PMID:17938250 MGI:3790365 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Casp12 caspase 12 involved_in IMP PMID:10638761 ParkinsonsUK-UCL PMID:10638761 RGD:10047306 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 involved_in ISO (PMID:15565177) RGD PMID:15565177 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 involved_in ISO (PMID:15123740) RGD PMID:15123740 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp9 caspase 9 involved_in ISO (PMID:35446120) RGD PMID:35446120 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Clu clusterin involved_in ISO
ISS		 (PMID:21567405)
GO_REF:0000024		 RGD
UniProt		 PMID:21567405 GO_REF:0000024 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Coa8 cytochrome c oxidase assembly factor 8 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3694393|PMID:16782708)
GO_REF:0000002		 RGD
InterPro		 PMID:16782708 GO_REF:0000002 MGI:3694393 NCBI chr 6:130,772,218...130,797,081
Ensembl chr 6:130,771,199...130,797,081 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:16301996) RGD PMID:16301996 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Flcn folliculin acts_upstream_of ISO MGI:4348628 (MGI:5050037|PMID:21258407) RGD PMID:21258407 MGI:5050037 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
G Hras HRas proto-oncogene, GTPase acts_upstream_of_or_within ISO MGI:109326 (MGI:3696331|PMID:16954213) RGD PMID:16954213 MGI:3696331 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Htra2 HtrA serine peptidase 2 acts_upstream_of_or_within ISO MGI:3512633 (MGI:3511636|PMID:15509788) RGD PMID:15509788 MGI:3511636 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Ivns1abp influenza virus NS1A binding protein acts_upstream_of ISO MGI:4820513 (MGI:4819697|PMID:15485691) RGD PMID:15485691 MGI:4819697 NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701 		JBrowse link
G Lgals12 galectin 12 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(PMID:11435439)		 RGD PMID:11435439 PMID:21873635 RGD:13792537 NCBI chr 1:204,832,065...204,842,759
Ensembl chr 1:204,832,065...204,842,759 		JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor involved_in ISO
ISS		 (PMID:18852119)
GO_REF:0000024		 RGD
UniProt		 PMID:18852119 GO_REF:0000024 NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO MGI:2151803 (MGI:2677657|PMID:14632208) RGD PMID:14632208 MGI:2677657 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Nbn nibrin involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3027036 (MGI:3805397|PMID:18614044)		 Ensembl
RGD		 PMID:18614044 GO_REF:0000107 MGI:3805397 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5573029|PMID:24312627)		 Ensembl
RGD		 PMID:24312627 GO_REF:0000107 MGI:5573029 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Plscr1 phospholipid scramblase 1 involved_in ISO (MGI:5315351|PMID:15863367) RGD PMID:15863367 MGI:5315351 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:14500711) RGD PMID:14500711 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F involved_in ISO
ISS		 (PMID:11559703)
GO_REF:0000024		 RGD
UniProt		 PMID:11559703 GO_REF:0000024 NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340 		JBrowse link
G Prkca protein kinase C, alpha acts_upstream_of_or_within ISO MGI:3029711 (MGI:2671671|PMID:12928424) RGD PMID:12928424 MGI:2671671 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1932564|PMID:10859351)
GO_REF:0000107		 RGD
Ensembl		 PMID:10859351 GO_REF:0000107 MGI:1932564 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:23313858) RGD PMID:23313858 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor NOT|involved_in ISO (PMID:12011449) RGD PMID:12011449 NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690 		JBrowse link
intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO (MGI:1344924|PMID:10479688) RGD PMID:10479688 MGI:1344924 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (PMID:15102863) RGD PMID:15102863 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp6 caspase 6 involved_in ISO
IEA
ISS		 (PMID:22858542)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22858542 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Cep63 centrosomal protein 63 acts_upstream_of ISO MGI:98834 (MGI:5662131|PMID:26158450) RGD PMID:26158450 MGI:5662131 NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177 		JBrowse link
G Ddx5 DEAD-box helicase 5 involved_in ISO (PMID:15660129) RGD PMID:15660129 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283 		JBrowse link
G E2f1 E2F transcription factor 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1927703|PMID:11095619)
GO_REF:0000107		 RGD
Ensembl		 PMID:11095619 GO_REF:0000107 MGI:1927703 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 acts_upstream_of_or_within ISO (MGI:1927703|PMID:11095619) RGD PMID:11095619 MGI:1927703 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G Eda2r ectodysplasin A2 receptor acts_upstream_of_or_within ISO MGI:98834 (MGI:4454200|PMID:20434500) RGD PMID:20434500 MGI:4454200 NCBI chr  X:62,224,763...62,269,333
Ensembl chr  X:62,228,229...62,269,268 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit acts_upstream_of_or_within ISO MGI:2183949 (MGI:3798119|PMID:18545656) RGD PMID:18545656 MGI:3798119 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase involved_in IBA
IEA
ISO
ISS		 PMID:21873635
GO_REF:0000107
(PMID:15313915)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:15313915 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 involved_in ISO
ISS		 (PMID:16835243)
GO_REF:0000024		 RGD
UniProt		 PMID:16835243 GO_REF:0000024 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Jmy junction mediating and regulatory protein, p53 cofactor involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:1891484|PMID:10518217)		 RGD PMID:10518217 PMID:21873635 MGI:1891484, RGD:13792537 NCBI chr 2:24,662,104...24,730,955
Ensembl chr 2:24,668,854...24,731,006 		JBrowse link
G Mybbp1a MYB binding protein 1a involved_in ISO
IEA		 (PMID:21471221)
GO_REF:0000107		 RGD
Ensembl		 PMID:21471221 GO_REF:0000107 NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISO
IEA		 (PMID:22123926)
GO_REF:0000107		 RGD
Ensembl		 PMID:22123926 GO_REF:0000107 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 acts_upstream_of_or_within ISO (MGI:1929912|PMID:10733530) RGD PMID:10733530 MGI:1929912 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15102863)
(MGI:2679929|PMID:14500851)		 RGD PMID:14500851 PMID:15102863 MGI:2679929 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold acts_upstream_of_or_within ISO (MGI:3034149|PMID:14992722) RGD PMID:14992722 MGI:3034149 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pou4f1 POU class 4 homeobox 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5825431|PMID:17145718)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17145718 GO_REF:0000024 GO_REF:0000107 MGI:5825431 NCBI chr15:81,253,714...81,260,057
Ensembl chr15:81,257,781...81,259,728 		JBrowse link
G Pou4f2 POU class 4 homeobox 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5825431|PMID:17145718)		 UniProt
RGD		 PMID:17145718 GO_REF:0000024 MGI:5825431 NCBI chr19:29,486,686...29,490,327
Ensembl chr19:29,486,686...29,490,327 		JBrowse link
G Ppp1r13b protein phosphatase 1, regulatory subunit 13B involved_in ISO (PMID:11684014) RGD PMID:11684014 NCBI chr 6:130,890,682...130,963,845
Ensembl chr 6:130,890,679...130,963,330 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor acts_upstream_of ISO MGI:3584037 (MGI:3583493|PMID:15989966) RGD PMID:15989966 MGI:3583493 NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663 		JBrowse link
G Rrp8 ribosomal RNA processing 8 involved_in ISO
IEA		 (PMID:21471221)
GO_REF:0000107		 RGD
Ensembl		 PMID:21471221 GO_REF:0000107 NCBI chr 1:160,081,092...160,088,709
Ensembl chr 1:160,084,295...160,089,331 		JBrowse link
G Shisa5 shisa family member 5 acts_upstream_of_or_within ISO (MGI:2183272|PMID:12135983) RGD PMID:12135983 MGI:2183272 NCBI chr 8:109,691,504...109,706,411
Ensembl chr 8:109,691,522...109,706,408 		JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO
ISS		 (PMID:11430832)
GO_REF:0000024		 RGD
UniProt		 PMID:11430832 GO_REF:0000024 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO (PMID:12172011), (PMID:16322561), (PMID:17310983)
MGI:2442860 (MGI:2183272|PMID:12135983), (MGI:3589512|PMID:16107883), (MGI:4454200|PMID:20434500)
(MGI:5883206|PMID:22262176)		 RGD PMID:12135983 PMID:12172011 PMID:16107883 PMID:16322561 PMID:17310983 More... MGI:2183272 MGI:3589512 MGI:4454200 MGI:5883206 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 involved_in ISO (PMID:11684014) RGD PMID:11684014 NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432 		JBrowse link
G Wwox WW domain-containing oxidoreductase acts_upstream_of_or_within ISO MGI:98834 (MGI:1930321|PMID:11058590) RGD PMID:11058590 MGI:1930321 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391 		JBrowse link
G Zfp385b zinc finger protein 385B involved_in ISO (PMID:22945289) RGD PMID:22945289 NCBI chr 3:62,355,182...62,640,417
Ensembl chr 3:62,355,196...62,640,510 		JBrowse link
intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:1328356|MGI:88138 (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Atm ATM serine/threonine kinase acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:109337|MGI:1933746 (MGI:1926715|PMID:11040211), (MGI:3652689|PMID:16777961), (MGI:3714678|PMID:17476307)
PMID:21873635		 RGD PMID:11040211 PMID:16777961 PMID:17476307 PMID:21873635 MGI:1926715 MGI:3652689 MGI:3714678, RGD:13792537 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bad BCL2-associated agonist of cell death acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:3029528 (MGI:3029504|PMID:12431371), (MGI:3057092|PMID:15231831)
GO_REF:0000107		 RGD
Ensembl		 PMID:12431371 PMID:15231831 GO_REF:0000107 MGI:3029504 MGI:3057092 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:1197519|MGI:99702 (MGI:3581932|PMID:15967824), (MGI:3689797|PMID:15901672)
PMID:21873635		 RGD PMID:15901672 PMID:15967824 PMID:21873635 MGI:3581932 MGI:3689797, RGD:13792537 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1097161|MGI:1197519|MGI:1857429 (MGI:2675761|PMID:12952892), (MGI:3581932|PMID:15967824), (MGI:3689797|PMID:15901672)		 RGD PMID:12952892 PMID:15901672 PMID:15967824 PMID:21873635 MGI:2675761 MGI:3581932 MGI:3689797, RGD:13792537 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
MGI:2442925 (MGI:3584078|PMID:15983387)		 Ensembl
RGD		 PMID:15983387 PMID:21873635 GO_REF:0000107 MGI:3584078, RGD:13792537 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:2158303 (MGI:2677658|PMID:14517295)		 RGD PMID:14517295 PMID:21873635 MGI:2677658, RGD:13792537 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l10 Bcl2-like 10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1097161|MGI:99702 (MGI:3581932|PMID:15967824)
GO_REF:0000107
(PMID:11546872)		 RGD
Ensembl		 PMID:11546872 PMID:15967824 GO_REF:0000107 MGI:3581932 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Brca1 BRCA1, DNA repair associated acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14654789)
GO_REF:0000107		 RGD
Ensembl		 PMID:14654789 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated acts_upstream_of_or_within ISO MGI:107202 (MGI:3714678|PMID:17476307) RGD PMID:17476307 MGI:3714678 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Casp2 caspase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp9 caspase 9 involved_in IBA
ISO		 PMID:21873635
(PMID:15657060)		 RGD PMID:15657060 PMID:21873635 RGD:13792537 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Chek2 checkpoint kinase 2 involved_in ISO (PMID:12402044), (PMID:12717439), (PMID:18644861) RGD PMID:12402044 PMID:12717439 PMID:18644861 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Crip1 cysteine rich protein 1 involved_in ISS
ISO
IBA		 PMID:20415737
(PMID:20415737)
PMID:21873635		 RGD PMID:20415737 PMID:20415737 PMID:21873635 RGD:8553326, RGD:13792537 NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620 		JBrowse link
G E2f1 E2F transcription factor 1 involved_in ISO
IEA
ISS		 (PMID:12717439)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:12717439 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein acts_upstream_of_or_within ISO (MGI:1350723|PMID:10594026) RGD PMID:10594026 MGI:1350723 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571 		JBrowse link
G Epha2 Eph receptor A2 involved_in ISO (PMID:18339848) RGD PMID:18339848 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor acts_upstream_of_or_within ISO MGI:1932102 (MGI:1913261|PMID:11005836) RGD PMID:11005836 MGI:1913261 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G Fnip2 folliculin interacting protein 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5284752|PMID:19137017)		 UniProt
RGD		 PMID:19137017 GO_REF:0000024 MGI:5284752 NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901 		JBrowse link
G Hic1 HIC ZBTB transcriptional repressor 1 involved_in ISO (PMID:16269335)
(MGI:5297787|PMID:16269335)		 RGD PMID:16269335 MGI:5297787 NCBI chr10:60,014,520...60,019,475
Ensembl chr10:60,011,528...60,019,475 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:11854317 RGD:625692 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Htra2 HtrA serine peptidase 2 involved_in ISO (PMID:11602612) RGD PMID:11602612 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (MGI:3775338|PMID:11753682) RGD PMID:11753682 MGI:3775338 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in ISO (PMID:20188669) RGD PMID:20188669 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Mael maelstrom spermatogenic transposon silencer acts_upstream_of_or_within ISO MGI:3795667 (MGI:3813746|PMID:18694567) RGD PMID:18694567 MGI:3813746 NCBI chr13:78,457,073...78,496,657
Ensembl chr13:78,457,073...78,496,657 		JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase acts_upstream_of_or_within ISO MGI:2183491 (MGI:2678630|PMID:14562041) RGD PMID:14562041 MGI:2678630 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3689797|PMID:15901672)		 RGD PMID:15901672 PMID:21873635 MGI:3689797, RGD:13792537 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857946 (MGI:2678630|PMID:14562041)		 Ensembl
RGD		 PMID:14562041 GO_REF:0000107 MGI:2678630 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within ISO MGI:1858055|MGI:2680817 (MGI:1334080|PMID:10097137), (MGI:3029112|PMID:14744764) RGD PMID:10097137 PMID:14744764 MGI:1334080 MGI:3029112 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO MGI:1858014 (MGI:3053495|PMID:15324697) RGD PMID:15324697 MGI:3053495 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor acts_upstream_of_or_within ISO MGI:2447604 (MGI:2677658|PMID:14517295) RGD PMID:14517295 MGI:2677658 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 acts_upstream_of_or_within ISO MGI:97583 (MGI:3709926|PMID:17242187) RGD PMID:17242187 MGI:3709926 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Pcbp4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) RGD PMID:10891498 NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:104798|MGI:2149414 (MGI:3709926|PMID:17242187)		 Ensembl
RGD		 PMID:17242187 GO_REF:0000107 MGI:3709926 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO MGI:2678372 (MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:2675761 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:12402044)
PMID:21873635
MGI:104662|MGI:2429949 (MGI:1306978|PMID:9806545), (MGI:3580934|PMID:15626733)		 RGD PMID:9806545 PMID:12402044 PMID:15626733 PMID:21873635 MGI:1306978 MGI:3580934, RGD:13792537 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO (MGI:1334987|PMID:10197627) RGD PMID:10197627 MGI:1334987 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1857113 (MGI:2450507|PMID:12604618)		 RGD PMID:12604618 PMID:21873635 MGI:2450507, RGD:13792537 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A acts_upstream_of ISO MGI:2442925 (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Sfn stratifin involved_in ISO (PMID:11574543) RGD PMID:11574543 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:5297787|PMID:16269335) RGD PMID:16269335 MGI:5297787 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Skil SKI-like proto-oncogene acts_upstream_of ISO MGI:2387096 (MGI:1858539|PMID:10811619) RGD PMID:10811619 MGI:1858539 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857480 (MGI:3691744|PMID:15642323) RGD PMID:15642323 MGI:3691744 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO (MGI:3709926|PMID:17242187) RGD PMID:17242187 MGI:3709926 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A acts_upstream_of_or_within ISO (MGI:3709926|PMID:17242187) RGD PMID:17242187 MGI:3709926 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3709926|PMID:17242187)		 RGD PMID:17242187 PMID:21873635 MGI:3709926, RGD:13792537 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase involved_in ISO (PMID:20188669) RGD PMID:20188669 NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937 		JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats acts_upstream_of_or_within ISO MGI:3043446 (MGI:3056865|PMID:15271982) RGD PMID:15271982 MGI:3056865 NCBI chr 8:61,259,415...61,347,789
Ensembl chr 8:61,259,477...61,347,789 		JBrowse link
G Usp47 ubiquitin specific peptidase 47 acts_upstream_of ISO MGI:4130032 (MGI:4839431|PMID:19966869) RGD PMID:19966869 MGI:4839431 NCBI chr 1:166,152,104...166,235,312
Ensembl chr 1:166,152,199...166,235,312 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor acts_upstream_of_or_within ISO MGI:1857939 (MGI:1913261|PMID:11005836) RGD PMID:11005836 MGI:1913261 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aen apoptosis enhancing nuclease involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:18264133)		 UniProt
RGD		 PMID:18264133 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:1336991|MGI:98834 (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17403783)		 UniProt
Ensembl
RGD		 PMID:17403783 GO_REF:0000024 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bbc3 Bcl-2 binding component 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2681654 (MGI:3603103|PMID:16151013)
GO_REF:0000107		 RGD
Ensembl		 PMID:16151013 GO_REF:0000107 MGI:3603103 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO (PMID:16384933) RGD PMID:16384933 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Brca2 BRCA2, DNA repair associated involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2429691|MGI:3052655|MGI:98834 (MGI:3579926|PMID:15735671), (MGI:3714678|PMID:17476307)		 Ensembl
RGD		 PMID:15735671 PMID:17476307 GO_REF:0000107 MGI:3579926 MGI:3714678 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Cdip1 cell death-inducing p53 target 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:17599062)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:17599062 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A acts_upstream_of_or_within ISO MGI:1933751 (MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:2675761 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek2 checkpoint kinase 2 acts_upstream_of_or_within ISO MGI:2386905 (MGI:1354114|PMID:10710310) RGD PMID:10710310 MGI:1354114 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5298149|PMID:21896779)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21896779 GO_REF:0000024 GO_REF:0000107 MGI:5298149 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 involved_in ISO (PMID:17349958) RGD PMID:17349958 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 acts_upstream_of
involved_in		 ISO
IEA		 (MGI:5438719|PMID:22768269)
GO_REF:0000107		 RGD
Ensembl		 PMID:22768269 GO_REF:0000107 MGI:5438719 NCBI chr 3:108,413,035...108,417,181
Ensembl chr 3:108,410,448...108,417,132 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:17403783) RGD PMID:17403783 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 PMID:21873635
MGI:1314872|MGI:98834 (MGI:3619785|PMID:16537918)
GO_REF:0000107		 RGD
Ensembl		 PMID:16537918 PMID:21873635 GO_REF:0000107 MGI:3619785, RGD:13792537 NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 acts_upstream_of_or_within ISO MGI:1314872|MGI:98834 (MGI:3619785|PMID:16537918) RGD PMID:16537918 MGI:3619785 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:98834 (MGI:1334080|PMID:10097137)		 Ensembl
RGD		 PMID:10097137 GO_REF:0000107 MGI:1334080 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator acts_upstream_of_or_within ISO MGI:3784016 (MGI:3784021|PMID:11896600) RGD PMID:11896600 MGI:3784021 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 involved_in ISO
ISS
IBA		 (PMID:19203586)
GO_REF:0000024
PMID:21873635		 RGD
UniProt		 PMID:19203586 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1858284|PMID:10807576)
GO_REF:0000107		 RGD
Ensembl		 PMID:10807576 GO_REF:0000107 MGI:1858284 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:3580934 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma involved_in ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rps27l ribosomal protein S27-like involved_in ISO
IEA		 (PMID:17057733), (PMID:18056458)
GO_REF:0000107		 RGD
Ensembl		 PMID:17057733 PMID:18056458 GO_REF:0000107 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418 		JBrowse link
G Shisa5 shisa family member 5 acts_upstream_of_or_within ISO (MGI:2183272|PMID:12135983) RGD PMID:12135983 MGI:2183272 NCBI chr 8:109,691,504...109,706,411
Ensembl chr 8:109,691,522...109,706,408 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:20100829)
GO_REF:0000107		 RGD
Ensembl		 PMID:20100829 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Snw1 SNW domain containing 1 involved_in ISO (PMID:21460037) RGD PMID:21460037 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536 		JBrowse link
G Tmem109 transmembrane protein 109 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
MGI:4453832 (MGI:4437179|PMID:20060811)		 Ensembl
RGD		 PMID:20060811 PMID:21873635 GO_REF:0000107 MGI:4437179, RGD:13792537 NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215 		JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase acts_upstream_of_or_within ISO (MGI:3578084|PMID:15735665) RGD PMID:15735665 MGI:3578084 NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:4944151|PMID:20818388), (MGI:5882892|PMID:16213212)
GO_REF:0000107
(PMID:14654789), (PMID:14744935)
(PMID:16213212), (PMID:17403783)
MGI:109337|MGI:1096393|MGI:1336991|MGI:1857263|MGI:1926340|MGI:2442925 (MGI:2183272|PMID:12135983), (MGI:2675761|PMID:12952892), (MGI:3584078|PMID:15983387), (MGI:3652689|PMID:16777961), (MGI:3690827|PMID:16286009), (MGI:3714678|PMID:17476307)		 RGD
Ensembl		 PMID:12135983 PMID:12952892 PMID:14654789 PMID:14744935 PMID:15983387 More... GO_REF:0000107 MGI:2183272 MGI:2675761 MGI:3584078 MGI:3652689 MGI:3690827 MGI:3714678 MGI:4944151 MGI:5882892 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 acts_upstream_of_or_within ISO MGI:1934269 (MGI:3693137|PMID:17122775) RGD PMID:17122775 MGI:3693137 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 involved_in
acts_upstream_of		 ISO (PMID:18174154), (PMID:19490146)
MGI:2442925|MGI:98834 (MGI:3584078|PMID:15983387)		 RGD PMID:15983387 PMID:18174154 PMID:19490146 MGI:3584078 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 involved_in ISO
ISS		 (PMID:16901786)
GO_REF:0000024		 RGD
UniProt		 PMID:16901786 GO_REF:0000024 NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229 		JBrowse link
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07005775.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Aifm1 apoptosis inducing factor, mitochondria associated 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3774040|PMID:18056262)		 UniProt
RGD		 PMID:18056262 GO_REF:0000024 MGI:3774040 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 involved_in ISO (MGI:5621265|PMID:16407291) RGD PMID:16407291 MGI:5621265 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4879048|PMID:21159964), (MGI:5496937|PMID:23624402)		 UniProt
RGD		 PMID:21159964 PMID:23624402 GO_REF:0000024 MGI:4879048 MGI:5496937 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO
IEA		 (PMID:19061639)
GO_REF:0000107		 RGD
Ensembl		 PMID:19061639 GO_REF:0000107 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 involved_in ISO
IEA		 (PMID:16725111)
GO_REF:0000107		 RGD
Ensembl		 PMID:16725111 GO_REF:0000107 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3774040|PMID:18056262)		 UniProt
Ensembl
RGD		 PMID:18056262 GO_REF:0000024 GO_REF:0000107 MGI:3774040 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 acts_upstream_of_or_within ISO MGI:99702|UniProtKB:P10415 (MGI:2667259|PMID:12847083), (MGI:3575207|PMID:15776018) RGD PMID:12847083 PMID:15776018 MGI:2667259 MGI:3575207 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:1097161|UniProtKB:P10415 (MGI:2667259|PMID:12847083), (MGI:3575207|PMID:15776018)
(PMID:16645094)		 UniProt
RGD		 PMID:12847083 PMID:15776018 PMID:16645094 GO_REF:0000024 MGI:2667259 MGI:3575207 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in IBA
IEA
ISO
ISS		 PMID:21873635
GO_REF:0000107
(PMID:16407291)
(MGI:4879048|PMID:21159964), (MGI:5448480|PMID:22761832), (MGI:5621265|PMID:16407291)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:16407291 PMID:21159964 PMID:22761832 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:4879048 MGI:5448480 MGI:5621265, RGD:13792537 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15776018)
GO_REF:0000107		 RGD
Ensembl		 PMID:15776018 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Brsk2 BR serine/threonine kinase 2 involved_in ISO
IEA		 (PMID:22713462)
GO_REF:0000107		 RGD
Ensembl		 PMID:22713462 GO_REF:0000107 NCBI chr 1:197,035,505...197,088,624
Ensembl chr 1:197,035,633...197,088,092 		JBrowse link
G Casp12 caspase 12 involved_in
acts_upstream_of_or_within		 NAS
IEA
ISO		 PMID:10638761
GO_REF:0000107
(MGI:1351404|PMID:10638761), (MGI:5634893|PMID:12097332)
MGI:1097161|MGI:99702 (MGI:2667259|PMID:12847083)		 Ensembl
RGD		 PMID:10638761 PMID:12097332 PMID:12847083 PMID:10638761 GO_REF:0000107 MGI:1351404 MGI:2667259 MGI:5634893, RGD:10047306 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp4 caspase 4 involved_in ISO (PMID:15123740) RGD PMID:15123740 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta involved_in ISO
IEA		 (MGI:1335331|PMID:9531536)
GO_REF:0000107		 RGD
Ensembl		 PMID:9531536 GO_REF:0000107 MGI:1335331 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 involved_in ISO (PMID:19109178) RGD PMID:19109178 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO
IEA		 (MGI:3796479|PMID:18281285)
GO_REF:0000107		 RGD
Ensembl		 PMID:18281285 GO_REF:0000107 MGI:3796479 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
MGI:2179046 (MGI:2158984|PMID:11854325)
(MGI:1335331|PMID:9531536), (MGI:4879048|PMID:21159964), (MGI:5496937|PMID:23624402)
PMID:21873635
(PMID:15322075), (PMID:18940792), (PMID:20829347)		 UniProt
Ensembl
RGD		 PMID:9531536 PMID:11854325 PMID:15322075 PMID:18940792 PMID:20829347 More... GO_REF:0000024 GO_REF:0000107 MGI:1335331 MGI:2158984 MGI:4879048 MGI:5496937, RGD:13792537 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 involved_in ISO (PMID:19122239) RGD PMID:19122239 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO MGI:2177666 (MGI:2136067|PMID:11430819) RGD PMID:11430819 MGI:2136067 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:1929557|PMID:11146108)
(MGI:3840374|PMID:19328063)		 RGD PMID:11146108 PMID:19328063 PMID:21873635 MGI:1929557 MGI:3840374, RGD:13792537 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:1346198|PMID:9755171)		 RGD PMID:9755171 PMID:21873635 MGI:1346198, RGD:13792537 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha involved_in ISS
ISO		 GO_REF:0000024
(MGI:4366390|PMID:19752026)		 UniProt
RGD		 PMID:19752026 GO_REF:0000024 MGI:4366390 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO (MGI:5619738|PMID:23028846) RGD PMID:23028846 MGI:5619738 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ins2 insulin 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1857572 (MGI:2158984|PMID:11854325)
GO_REF:0000107		 RGD
Ensembl		 PMID:11854325 GO_REF:0000107 MGI:2158984 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:4366390|PMID:19752026)		 UniProt
Ensembl
RGD		 PMID:19752026 GO_REF:0000024 GO_REF:0000107 MGI:4366390 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in ISO (MGI:5616327|PMID:12050113) RGD PMID:12050113 MGI:5616327 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 acts_upstream_of ISO MGI:2181360 (MGI:4836774|PMID:20811152) RGD PMID:20811152 MGI:4836774 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO
IEA		 (MGI:5621265|PMID:16407291)
GO_REF:0000107		 RGD
Ensembl		 PMID:16407291 GO_REF:0000107 MGI:5621265 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold acts_upstream_of_or_within ISO (MGI:4849347|PMID:21030605) RGD PMID:21030605 MGI:4849347 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Rnf186 ring finger protein 186 involved_in ISO
IBA		 (PMID:23896122)
PMID:21873635		 RGD PMID:23896122 PMID:21873635 RGD:13792537 NCBI chr 5:151,210,492...151,211,716
Ensembl chr 5:151,210,492...151,211,716 		JBrowse link
G Selenok selenoprotein K involved_in ISO (PMID:20692228) RGD PMID:20692228 NCBI chr16:5,152,066...5,160,648
Ensembl chr16:5,152,066...5,159,188 		JBrowse link
G Spop speckle type BTB/POZ protein acts_upstream_of ISO MGI:102851 (MGI:4836774|PMID:20811152) RGD PMID:20811152 MGI:4836774 NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955 		JBrowse link
G Syvn1 synoviolin 1 acts_upstream_of ISO MGI:2679656 (MGI:3575050|PMID:15611074) RGD PMID:15611074 MGI:3575050 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 acts_upstream_of_or_within ISO MGI:3052422 (MGI:3050914|PMID:15304216) RGD PMID:15304216 MGI:3050914 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
G Tmem117 transmembrane protein 117 involved_in ISO (PMID:28285135) RGD PMID:28285135 NCBI chr 7:125,757,591...126,219,692
Ensembl chr 7:125,757,591...126,219,690 		JBrowse link
G Tmem238l transmembrane protein 238 like involved_in ISO (PMID:33112233) RGD PMID:33112233 NCBI chr10:51,647,871...51,662,206 JBrowse link
G Tp53 tumor protein p53 involved_in ISO
IEA		 (MGI:5621265|PMID:16407291)
GO_REF:0000107		 RGD
Ensembl		 PMID:16407291 GO_REF:0000107 MGI:5621265 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trib3 tribbles pseudokinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15775988)		 UniProt
RGD		 PMID:15775988 GO_REF:0000024 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K acts_upstream_of_or_within IMP PMID:18710920 MGI PMID:18710920 RGD:8554156 NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (MGI:3840374|PMID:19328063) RGD PMID:19328063 MGI:3840374 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k4 mitogen activated protein kinase kinase 4 involved_in ISO (MGI:5770039|PMID:24705900) RGD PMID:24705900 MGI:5770039 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Pdcd10 programmed cell death 10 involved_in ISO
IEA		 UniProtKB:O00506 (PMID:22652780)
GO_REF:0000107		 RGD
Ensembl		 PMID:22652780 GO_REF:0000107 NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018 		JBrowse link
G Stk25 serine/threonine kinase 25 involved_in ISO UniProtKB:Q9BUL8 (PMID:22652780) RGD PMID:22652780 NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244 		JBrowse link
intrinsic apoptotic signaling pathway in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
IEA		 MGI:1857283 (MGI:3700897|PMID:17189429)
GO_REF:0000107		 RGD
Ensembl		 PMID:17189429 GO_REF:0000107 MGI:3700897 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:20436456) RGD PMID:20436456 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4867601|PMID:20935145)
GO_REF:0000107		 RGD
Ensembl		 PMID:20935145 GO_REF:0000107 MGI:4867601 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
intrinsic apoptotic signaling pathway in response to nitrosative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 involved_in ISO (MGI:5784990|PMID:14752510) RGD PMID:14752510 MGI:5784990 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 involved_in ISO (PMID:21716255)
(MGI:5474549|PMID:21716255)		 RGD PMID:21716255 MGI:5474549 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 acts_upstream_of_or_within
involved_in		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
MGI:2180186 (MGI:2179539|PMID:10827969)		 UniProt
Ensembl
RGD		 PMID:10827969 GO_REF:0000024 GO_REF:0000107 MGI:2179539 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 acts_upstream_of
involved_in		 ISO
IEA		 MGI:98834|MGI:99702 (MGI:3654719|PMID:16571598)
GO_REF:0000107		 RGD
Ensembl		 PMID:16571598 GO_REF:0000107 MGI:3654719 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
intrinsic apoptotic signaling pathway in response to oxidative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member IMP protein:altered expression:liver (rat) RGD PMID:29589772 RGD:14975297 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 involved_in ISO
IEA		 (PMID:18387645)
GO_REF:0000107		 RGD
Ensembl		 PMID:18387645 GO_REF:0000107 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2679141|PMID:12855558)
GO_REF:0000107		 RGD
Ensembl		 PMID:12855558 GO_REF:0000107 MGI:2679141 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5492227|PMID:23568032), (MGI:5544856|PMID:23979599)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:23568032 PMID:23979599 GO_REF:0000024 GO_REF:0000107 MGI:5492227 MGI:5544856 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein acts_upstream_of_or_within
involved_in		 ISO
IBA		 (MGI:3587135|PMID:16085184)
PMID:21873635		 RGD PMID:16085184 PMID:21873635 MGI:3587135, RGD:13792537 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Diablol1 diablo, IAP-binding mitochondrial protein like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:141,744,994...141,746,345
Ensembl chr 5:141,744,961...141,746,356 		JBrowse link
G Gpx1 glutathione peroxidase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2158814 (MGI:2153292|PMID:11562367), (MGI:3613414|PMID:15663476)
MGI:2158814 (MGI:3698597|PMID:16373599)
GO_REF:0000107		 RGD
Ensembl		 PMID:11562367 PMID:15663476 PMID:16373599 GO_REF:0000107 MGI:2153292 MGI:3613414 MGI:3698597 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gskip GSK3B interacting protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:25920809)		 UniProt
Ensembl
RGD		 PMID:25920809 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:124,586,087...124,609,106
Ensembl chr 6:124,586,070...124,609,100 		JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:15659221 RGD:1641883 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3829088|PMID:18948261)
(PMID:21771788), (PMID:26095851)		 RGD PMID:18948261 PMID:21771788 PMID:26095851 PMID:21873635 MGI:3829088, RGD:13792537 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapt microtubule-associated protein tau IDA RGD PMID:12420308 RGD:8158111 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Melk maternal embryonic leucine zipper kinase acts_upstream_of_or_within ISO (MGI:3829088|PMID:18948261) RGD PMID:18948261 MGI:3829088 NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937 		JBrowse link
G Nox1 NADPH oxidase 1 acts_upstream_of
involved_in		 ISO
IEA		 MGI:3616995 (MGI:4881403|PMID:19661248)
GO_REF:0000107		 RGD
Ensembl		 PMID:19661248 GO_REF:0000107 MGI:4881403 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18541534)		 UniProt
Ensembl
RGD		 PMID:18541534 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pml PML nuclear body scaffold acts_upstream_of_or_within ISO (MGI:4849347|PMID:21030605) RGD PMID:21030605 MGI:4849347 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Rnf7 ring finger protein 7 acts_upstream_of_or_within ISO (MGI:1333612|PMID:10082581) RGD PMID:10082581 MGI:1333612 NCBI chr 8:97,038,845...97,048,080
Ensembl chr 8:97,038,840...97,047,824 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857480 (MGI:3691744|PMID:15642323) RGD PMID:15642323 MGI:3691744 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stk24 serine/threonine kinase 24 involved_in ISO
ISS		 (PMID:19604147)
GO_REF:0000024		 RGD
UniProt		 PMID:19604147 GO_REF:0000024 NCBI chr15:98,363,707...98,458,940
Ensembl chr15:98,365,791...98,460,553 		JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats acts_upstream_of_or_within ISO MGI:3043446 (MGI:3056865|PMID:15271982) RGD PMID:15271982 MGI:3056865 NCBI chr 8:61,259,415...61,347,789
Ensembl chr 8:61,259,477...61,347,789 		JBrowse link
G Zfp622 zinc finger protein 622 involved_in ISO (PMID:21771788) RGD PMID:21771788 NCBI chr 2:76,479,605...76,494,405
Ensembl chr 2:76,335,609...76,493,898 		JBrowse link
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 involved_in ISO
ISS		 (PMID:29507230)
GO_REF:0000024		 RGD
UniProt		 PMID:29507230 GO_REF:0000024 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO (PMID:16940180) RGD PMID:16940180 NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 involved_in IMP
ISO		 PMID:15665855
(MGI:5616321|PMID:15665855)		 RGD PMID:15665855 PMID:15665855 MGI:5616321, RGD:1558627 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1341830|MGI:99682 (MGI:5525071|PMID:22240901)
GO_REF:0000107		 RGD
Ensembl		 PMID:22240901 GO_REF:0000107 MGI:5525071 NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO
IBA		 (PMID:15102845)
PMID:21873635		 RGD PMID:15102845 PMID:21873635 RGD:13792537 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:12150907), (PMID:20625543) RGD PMID:12150907 PMID:20625543 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:12150907), (PMID:20625543) RGD PMID:12150907 PMID:20625543 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISO (MGI:5495588|PMID:23453807) RGD PMID:23453807 MGI:5495588 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:21857923) RGD PMID:21857923 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Ngf nerve growth factor involved_in NAS PMID:21266243 ParkinsonsUK-UCL PMID:21266243 RGD:10047230 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5495588|PMID:23453807)
UniProtKB:P58281 (PMID:23453807)		 ParkinsonsUK-UCL
Ensembl
RGD		 PMID:23453807 GO_REF:0000024 GO_REF:0000107 MGI:5495588 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO
IEA		 UniProtKB:Q99LX0 (PMID:14652021)
GO_REF:0000107
(MGI:5613479|PMID:14652021)		 RGD
Ensembl		 PMID:14652021 GO_REF:0000107 MGI:5613479 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 acts_upstream_of_or_within ISO MGI:2181360 (MGI:4836774|PMID:20811152) RGD PMID:20811152 MGI:4836774 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISS
ISO		 GO_REF:0000024
(MGI:5433837|PMID:21113145)
(PMID:10973942), (PMID:11439185), (PMID:12150907), (PMID:21113145), (PMID:23453807)		 ParkinsonsUK-UCL
RGD		 PMID:10973942 PMID:11439185 PMID:12150907 PMID:21113145 PMID:23453807 GO_REF:0000024 MGI:5433837 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:5619464 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA		 (PMID:17210132)
GO_REF:0000107		 RGD
Ensembl		 PMID:17210132 GO_REF:0000107 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Syvn1 synoviolin 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:12459480), (PMID:17059562)
MGI:2679656 (MGI:3575050|PMID:15611074)		 RGD PMID:12459480 PMID:15611074 PMID:17059562 MGI:3575050 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:21075086)
MGI:1913418 (MGI:5525071|PMID:22240901)		 RGD PMID:21075086 PMID:22240901 MGI:5525071 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
G Txndc12 thioredoxin domain containing 12 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:18628206)
GO_REF:0000107		 RGD
Ensembl		 PMID:18628206 GO_REF:0000107 NCBI chr 5:123,587,854...123,612,886
Ensembl chr 5:123,586,781...123,612,870 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (MGI:3629256|PMID:16571599) RGD PMID:16571599 MGI:3629256 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
IEA
IMP		 (PMID:19135031)
GO_REF:0000107
PMID:20625543		 RGD
Ensembl		 PMID:19135031 PMID:20625543 GO_REF:0000107, RGD:10047191 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyou1 hypoxia up-regulated 1 involved_in ISO
IEA		 (MGI:3697528|PMID:17116640)
GO_REF:0000107		 RGD
Ensembl		 PMID:17116640 GO_REF:0000107 MGI:3697528 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA		 UniProtKB:O15354 (MGI:3697528|PMID:17116640), (MGI:5495588|PMID:23453807)
GO_REF:0000107		 RGD
Ensembl		 PMID:17116640 PMID:23453807 GO_REF:0000107 MGI:3697528 MGI:5495588 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISO
IEA		 UniProtKB:Q99LX0 (PMID:14652021)
GO_REF:0000107
(MGI:5613479|PMID:14652021)		 RGD
Ensembl		 PMID:14652021 GO_REF:0000107 MGI:5613479 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:21177249), (PMID:23261939) RGD PMID:21177249 PMID:23261939 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eno1 enolase 1 involved_in ISO UniProtKB:Q01986 (PMID:15459207) RGD PMID:15459207 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Hyou1 hypoxia up-regulated 1 involved_in IDA
IBA
IEA
ISO		 PMID:11231630
PMID:21873635
GO_REF:0000107
(PMID:10037731)		 Ensembl
RGD		 PMID:10037731 PMID:11231630 PMID:21873635 GO_REF:0000107, RGD:10047348, RGD:13792537 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Kdm6a lysine demethylase 6A IMP RGD PMID:30887465 RGD:151665136 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 involved_in IGI
IMP		 PMID:15459207 CAFA PMID:15459207 PMID:15459207 RGD:12793039, RGD:12793039 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IDA PMID:10590251 UniProt PMID:10590251 RGD:10047155 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in IEA
ISO		 GO_REF:0000107
(MGI:6444553|PMID:30496354)		 Ensembl
RGD		 PMID:30496354 GO_REF:0000107 MGI:6444553 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (MGI:5558956|PMID:24553947) RGD PMID:24553947 MGI:5558956 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in ISO (PMID:21075086) RGD PMID:21075086 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO
IEA		 (MGI:4999711|PMID:19911006)
GO_REF:0000107		 RGD
Ensembl		 PMID:19911006 GO_REF:0000107 MGI:4999711 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in ISO
IEA
IBA		 (PMID:11684014)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:11684014 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO
IBA		 (PMID:12011449)
PMID:21873635
(PMID:21567405)		 RGD PMID:12011449 PMID:21567405 PMID:21873635 RGD:13792537 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l10 Bcl2-like 10 acts_upstream_of_or_within ISO (MGI:1326939|PMID:9878060) RGD PMID:9878060 MGI:1326939 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl2l2 Bcl2-like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:21883093) RGD PMID:21883093 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Fignl1 fidgetin-like 1 acts_upstream_of_or_within ISO (MGI:4944122|PMID:20886204) RGD PMID:20886204 MGI:4944122 NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455 		JBrowse link
G G2e3 G2/M-phase specific E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:3808723 (MGI:3807157|PMID:18511420) RGD PMID:18511420 MGI:3807157 NCBI chr 6:68,763,847...68,795,305
Ensembl chr 6:68,764,185...68,793,924 		JBrowse link
G Gcg glucagon involved_in ISO (MGI:4453294|PMID:19915011) RGD PMID:19915011 MGI:4453294 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Hdac1 histone deacetylase 1 acts_upstream_of_or_within ISO MGI:1097691 (MGI:4889029|PMID:21093383) RGD PMID:21093383 MGI:4889029 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 acts_upstream_of_or_within ISO MGI:108086 (MGI:4889029|PMID:21093383) RGD PMID:21093383 MGI:4889029 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hells helicase, lymphoid specific acts_upstream_of_or_within ISO MGI:2178586 (MGI:2178571|PMID:11325543) RGD PMID:11325543 MGI:2178571 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO UniProtKB:P37840 (PMID:22045699) RGD PMID:22045699 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Ivns1abp influenza virus NS1A binding protein acts_upstream_of_or_within ISO MGI:4820513 (MGI:4819697|PMID:15485691) RGD PMID:15485691 MGI:4819697 NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1332866|PMID:10098834)
GO_REF:0000107		 RGD
Ensembl		 PMID:10098834 GO_REF:0000107 MGI:1332866 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22984561)		 Ensembl
RGD		 PMID:22984561 GO_REF:0000107 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 involved_in ISO (PMID:16826196) RGD PMID:16826196 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 involved_in ISO (PMID:16826196) RGD PMID:16826196 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Noc2l NOC2-like nucleolar associated transcriptional repressor involved_in ISO (PMID:16322561) RGD PMID:16322561 NCBI chr 5:166,820,150...166,831,949
Ensembl chr 5:166,820,161...166,831,949 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IMP
IBA		 PMID:15383280
PMID:21873635		 UniProt
GO_Central		 PMID:15383280 PMID:21873635 RGD:10047289, RGD:13792537 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISO (MGI:3692706|PMID:16839884) RGD PMID:16839884 MGI:3692706 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Parl presenilin associated, rhomboid-like involved_in ISS
ISO		 GO_REF:0000024
(MGI:3692706|PMID:16839884)		 ParkinsonsUK-UCL
RGD		 PMID:16839884 GO_REF:0000024 MGI:3692706 NCBI chr11:80,594,059...80,620,506
Ensembl chr11:80,593,192...80,620,506 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:15087508) RGD PMID:15087508 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO
IEA		 (PMID:22984561)
GO_REF:0000107		 RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Ppif peptidylprolyl isomerase F involved_in ISO
ISS		 (PMID:19228691)
GO_REF:0000024		 RGD
UniProt		 PMID:19228691 GO_REF:0000024 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Rtkn2 rhotekin 2 involved_in ISO (PMID:26124677) RGD PMID:26124677 NCBI chr20:20,536,628...20,609,951
Ensembl chr20:20,525,256...20,609,951 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in IBA
ISO		 PMID:21873635
(PMID:19767770)		 RGD PMID:19767770 PMID:21873635 RGD:13792537 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Uri1 URI1, prefoldin-like chaperone involved_in ISO (PMID:17936702) RGD PMID:17936702 NCBI chr 1:90,646,392...90,704,811
Ensembl chr 1:90,646,393...90,709,026 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 involved_in ISO
IEA		 (MGI:5315363|PMID:12881569)
GO_REF:0000107		 RGD
Ensembl		 PMID:12881569 GO_REF:0000107 MGI:5315363 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Armc10 armadillo repeat containing 10 involved_in IBA
ISO		 PMID:21873635
(PMID:17904127)		 RGD PMID:17904127 PMID:21873635 RGD:13792537 NCBI chr 4:13,399,004...13,414,594
Ensembl chr 4:13,395,207...13,414,548 		JBrowse link
G Cep63 centrosomal protein 63 acts_upstream_of_or_within ISO MGI:98834 (MGI:5662131|PMID:26158450) RGD PMID:26158450 MGI:5662131 NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:17310983) RGD PMID:17310983 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mdm4 MDM4 regulator of p53 involved_in ISO (MGI:2182884|PMID:12101245) RGD PMID:12101245 MGI:2182884 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:18829576) RGD PMID:18829576 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA		 (PMID:23985028)
GO_REF:0000107		 RGD
Ensembl		 PMID:23985028 GO_REF:0000107 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Pttg1ip PTTG1 interacting protein acts_upstream_of_or_within ISO (PMID:24506068) RGD PMID:24506068 NCBI chr20:11,030,013...11,047,742
Ensembl chr20:11,030,015...11,047,316 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B acts_upstream_of_or_within ISO MGI:2672883 (MGI:2670318|PMID:12858174) RGD PMID:12858174 MGI:2670318 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor acts_upstream_of_or_within ISO MGI:3584037 (MGI:3583493|PMID:15989966) RGD PMID:15989966 MGI:3583493 NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 involved_in ISO (MGI:5553386|PMID:24523556) RGD PMID:24523556 MGI:5553386 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 involved_in ISO (PMID:20388803) RGD PMID:20388803 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO (PMID:16608847) RGD PMID:16608847 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:5428930 (MGI:5662300|PMID:26219591)
GO_REF:0000107		 RGD
Ensembl		 PMID:26219591 GO_REF:0000107 MGI:5662300 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 involved_in ISO (PMID:23352644) RGD PMID:23352644 NCBI chr15:45,212,797...45,228,001
Ensembl chr15:45,212,803...45,227,636 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D involved_in ISO (PMID:15750620) RGD PMID:15750620 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16113678)		 UniProt
Ensembl
RGD		 PMID:16113678 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO (PMID:20388803) RGD PMID:20388803 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor involved_in ISO (PMID:24214091) RGD PMID:24214091 NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO (PMID:14561758) RGD PMID:14561758 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:15314165) RGD PMID:15314165 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:15314165) RGD PMID:15314165 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Tmem161a transmembrane protein 161A involved_in ISO (PMID:16551573) RGD PMID:16551573 NCBI chr16:19,237,638...19,248,151
Ensembl chr16:19,238,487...19,248,087 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 acts_upstream_of_or_within ISO (PMID:11598139) RGD PMID:11598139 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Trim32 tripartite motif-containing 32 involved_in ISO (PMID:18632609) RGD PMID:18632609 NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018 		JBrowse link
G Usp47 ubiquitin specific peptidase 47 acts_upstream_of_or_within ISO MGI:4130032 (MGI:4839431|PMID:19966869) RGD PMID:19966869 MGI:4839431 NCBI chr 1:166,152,104...166,235,312
Ensembl chr 1:166,152,199...166,235,312 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 involved_in ISO (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Bcl2l12 Bcl2 like 12 acts_upstream_of_or_within ISO (MGI:4834958|PMID:20837658) RGD PMID:20837658 MGI:4834958 NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) involved_in ISO
IEA		 (PMID:17045821)
GO_REF:0000107
(MGI:3690285|PMID:17045821)		 RGD
Ensembl		 PMID:17045821 GO_REF:0000107 MGI:3690285 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd74 CD74 molecule involved_in ISO
IEA
ISS
IBA		 (PMID:17045821)
GO_REF:0000107
GO_REF:0000024
(MGI:3690285|PMID:17045821)
PMID:21873635		 RGD
Ensembl
BHF-UCL		 PMID:17045821 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3690285, RGD:13792537 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5438719|PMID:22768269)
GO_REF:0000107		 RGD
Ensembl		 PMID:22768269 GO_REF:0000107 MGI:5438719 NCBI chr 3:108,413,035...108,417,181
Ensembl chr 3:108,410,448...108,417,132 		JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (PMID:17805299) RGD PMID:17805299 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:29295817)		 UniProt
Ensembl
RGD		 PMID:29295817 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:17045821) RGD PMID:17045821 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Muc1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (MGI:2152474|PMID:11672522)
GO_REF:0000107		 RGD
Ensembl		 PMID:11672522 GO_REF:0000107 MGI:2152474 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 involved_in ISO (PMID:15735003) RGD PMID:15735003 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042 		JBrowse link
G Zfp385a zinc finger protein 385A involved_in ISO (PMID:17719541) RGD PMID:17719541 NCBI chr 7:134,448,914...134,475,548
Ensembl chr 7:134,448,921...134,475,548 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsph1 heat shock protein family H (Hsp110) member 1 acts_upstream_of_or_within ISO (MGI:3822965|PMID:18681888) RGD PMID:18681888 MGI:3822965 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:24947010)
(MGI:5574514|PMID:24947010)		 RGD PMID:24947010 MGI:5574514 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO
IMP		 (PMID:17579517) RGD PMID:17579517 PMID:17579517 RGD:8693356 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q99497 (MGI:5574514|PMID:24947010)
UniProtKB:Q99497 (PMID:24947010)		 Ensembl
RGD		 PMID:24947010 GO_REF:0000107 MGI:5574514 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Trap1 TNF receptor-associated protein 1 involved_in IMP PMID:17579517 ParkinsonsUK-UCL PMID:17579517 RGD:8693356 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) RGD PMID:22711822 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Bdkrb2 bradykinin receptor B2 acts_upstream_of_or_within ISO MGI:1857135 (MGI:3654719|PMID:16571598) RGD PMID:16571598 MGI:3654719 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Epo erythropoietin involved_in ISO (PMID:14569084) RGD PMID:14569084 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ptger2 prostaglandin E receptor 2 involved_in ISO (PMID:21716255) RGD PMID:21716255 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO (PMID:21716255)
(MGI:5474549|PMID:21716255)		 RGD PMID:21716255 MGI:5474549 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ybx3 Y box binding protein 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22711822)		 Ensembl
RGD		 PMID:22711822 GO_REF:0000107 NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:98834|MGI:99702 (MGI:3654719|PMID:16571598)
GO_REF:0000107		 RGD
Ensembl		 PMID:16571598 GO_REF:0000107 MGI:3654719 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 involved_in ISO (PMID:14752510) RGD PMID:14752510 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO
IEA		 (PMID:14752510)
GO_REF:0000107		 RGD
Ensembl		 PMID:14752510 GO_REF:0000107 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag5 BAG cochaperone 5 involved_in ISO (PMID:24475098) RGD PMID:24475098 NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of ISO (MGI:5780531|PMID:25590961) RGD PMID:25590961 MGI:5780531 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2158814 (MGI:3698597|PMID:16373599)		 Ensembl
RGD		 PMID:16373599 GO_REF:0000107 MGI:3698597 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3581090|PMID:15731106)		 Ensembl
RGD		 PMID:15731106 GO_REF:0000107 MGI:3581090 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 involved_in ISO
IEA		 (PMID:23043106)
GO_REF:0000107		 RGD
Ensembl		 PMID:23043106 GO_REF:0000107 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:19956414) RGD PMID:19956414 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:19956414) RGD PMID:19956414 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (PMID:23043106) RGD PMID:23043106 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nme5 NME/NM23 family member 5 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2664629|PMID:12788088)		 RGD PMID:12788088 PMID:21873635 MGI:2664629, RGD:13792537 NCBI chr18:26,163,558...26,180,742
Ensembl chr18:26,163,555...26,180,794 		JBrowse link
G Nol3 nucleolar protein 3 involved_in ISO (PMID:15004034) RGD PMID:15004034 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of ISO (PMID:22523093)
(MGI:5582151|PMID:22523093)		 RGD PMID:22523093 MGI:5582151 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Ppia peptidylprolyl isomerase A involved_in ISO
ISS		 (PMID:26095851)
GO_REF:0000024		 RGD
UniProt		 PMID:26095851 GO_REF:0000024 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ppial4d peptidylprolyl isomerase A (cyclophilin A)-like 4D involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr14:21,006,522...21,007,284
Ensembl chr14:21,006,538...21,007,310 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:17317627)
GO_REF:0000107		 RGD
Ensembl		 PMID:17317627 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod2 superoxide dismutase 2 involved_in ISO (PMID:12551919) RGD PMID:12551919 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in IMP
ISO		 PMID:23392669
UniProtKB:Q9ES19 (PMID:23392669)		 RGD PMID:23392669 PMID:23392669 RGD:10047168 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5770063|PMID:21752258)		 Ensembl
RGD		 PMID:21752258 GO_REF:0000107 MGI:5770063 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Fbxo7 F-box protein 7 acts_upstream_of
involved_in		 ISO (PMID:26310625)
(PMID:25029497)		 RGD PMID:25029497 PMID:26310625 NCBI chr 7:17,809,224...17,837,549
Ensembl chr 7:17,809,231...17,837,530 		JBrowse link
G Fzd1 frizzled class receptor 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5770063|PMID:21752258)		 Ensembl
RGD		 PMID:21752258 GO_REF:0000107 MGI:5770063 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in ISO
IEA		 (PMID:24899725)
GO_REF:0000107		 RGD
Ensembl		 PMID:24899725 GO_REF:0000107 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Il10 interleukin 10 involved_in ISO ComplexPortal:CPX-1134 (MGI:5291547|PMID:21857966) RGD PMID:21857966 MGI:5291547 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Nono non-POU domain containing, octamer-binding involved_in ISO (PMID:15790595) RGD PMID:15790595 NCBI chr  X:66,554,131...66,571,992
Ensembl chr  X:66,554,098...66,571,952 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO		 GO_REF:0000024
(MGI:5575789|PMID:24899725)
(PMID:15790595), (PMID:16632486), (PMID:23743200)		 ParkinsonsUK-UCL
RGD		 PMID:15790595 PMID:16632486 PMID:23743200 PMID:24899725 GO_REF:0000024 MGI:5575789 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:16632486) RGD PMID:16632486 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA
IGI
ISS		 (PMID:17314283)
GO_REF:0000107
PMID:23392669
(MGI:5543313|PMID:23858059)
GO_REF:0000024		 RGD
Ensembl
ParkinsonsUK-UCL		 PMID:17314283 PMID:23858059 PMID:23392669 GO_REF:0000024 GO_REF:0000107 MGI:5543313, RGD:10047168 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 involved_in ISO (PMID:23743200) RGD PMID:23743200 NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549 		JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (MGI:5770063|PMID:21752258) RGD PMID:21752258 MGI:5770063 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmbim6 transmembrane BAX inhibitor motif containing 6 acts_upstream_of_or_within ISO MGI:3052422 (MGI:3050914|PMID:15304216) RGD PMID:15304216 MGI:3050914 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
neuron intrinsic apoptotic signaling pathway in response to oxidative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Daxx death-domain associated protein involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q99683 (PMID:15983381)		 Ensembl
RGD		 PMID:15983381 GO_REF:0000107 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in ISO UniProtKB:Q9UER7 (PMID:15983381) RGD PMID:15983381 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO		 GO_REF:0000024
(MGI:5648772|PMID:26015568), (MGI:5796067|PMID:26949185)		 UniProt
RGD		 PMID:26015568 PMID:26949185 GO_REF:0000024 MGI:5648772 MGI:5796067 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO MGI:1913418 (MGI:5525071|PMID:22240901) RGD PMID:22240901 MGI:5525071 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA		 (PMID:14676213)
PMID:21873635
UniProtKB:O55033 (MGI:5613475|PMID:16835242)		 RGD PMID:14676213 PMID:16835242 PMID:21873635 MGI:5613475, RGD:13792537 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA		 UniProtKB:Q99M51 (MGI:5613475|PMID:16835242)
PMID:21873635		 RGD PMID:16835242 PMID:21873635 MGI:5613475, RGD:13792537 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA		 (MGI:5619464|PMID:21216966)
GO_REF:0000107		 RGD
Ensembl		 PMID:21216966 GO_REF:0000107 MGI:5619464 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Rnf183 ring finger protein 183 involved_in ISO
IBA		 (PMID:29507230)
PMID:21873635		 RGD PMID:29507230 PMID:21873635 RGD:13792537 NCBI chr 5:75,877,111...75,886,253
Ensembl chr 5:75,876,003...75,886,191 		JBrowse link
G Serinc3 serine incorporator 3 acts_upstream_of_or_within ISO (MGI:2671011|PMID:12486168) RGD PMID:12486168 MGI:2671011 NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (MGI:5607229|PMID:20955178)
GO_REF:0000107		 RGD
Ensembl		 PMID:20955178 GO_REF:0000107 MGI:5607229 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Spop speckle type BTB/POZ protein acts_upstream_of_or_within ISO MGI:102851 (MGI:4836774|PMID:20811152) RGD PMID:20811152 MGI:4836774 NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 IDA MMO:0000679 RGD PMID:23729662 RGD:329403056 NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2158306 (MGI:3692043|PMID:14502238)
(PMID:14963330), (PMID:21199865), (PMID:21262771)		 UniProt
RGD		 PMID:14502238 PMID:14963330 PMID:21199865 PMID:21262771 GO_REF:0000024 MGI:3692043 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in IMP
IEA
ISO
ISS		 PMID:27031958
GO_REF:0000107
(PMID:17289999), (PMID:27031958)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17289999 PMID:27031958 PMID:27031958 GO_REF:0000024 GO_REF:0000107, RGD:14390051 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO (PMID:21183955) RGD PMID:21183955 NCBI chr  X:151,397,567...151,429,666
Ensembl chr  X:151,397,576...151,428,506 		JBrowse link
G Bcl2l11 Bcl2-like 11 involved_in ISO (PMID:21671007) RGD PMID:21671007 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 involved_in ISO (PMID:17938203) RGD PMID:17938203 NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832 		JBrowse link
G Becn1 beclin 1 involved_in IMP
ISO
ISS		 PMID:27031958
(PMID:27031958)
GO_REF:0000024		 RGD
UniProt		 PMID:27031958 PMID:27031958 GO_REF:0000024, RGD:14390051 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
(PMID:21262771)		 Ensembl
RGD		 PMID:21262771 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO		 GO_REF:0000024
(MGI:5705719|PMID:23429263)		 UniProt
RGD		 PMID:23429263 GO_REF:0000024 MGI:5705719 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase acts_upstream_of_or_within ISO MGI:3793294 (MGI:3790365|PMID:17938250) RGD PMID:17938250 MGI:3790365 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Cav1 caveolin 1 involved_in ISO
IEA		 (PMID:21382479)
GO_REF:0000107		 RGD
Ensembl		 PMID:21382479 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Clu clusterin involved_in ISS
ISO		 GO_REF:0000024
(PMID:21567405)		 UniProt
RGD		 PMID:21567405 GO_REF:0000024 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cyct cytochrome c, testis acts_upstream_of_or_within ISO (MGI:3652666|PMID:16757556) RGD PMID:16757556 MGI:3652666 NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
PMID:21873635
(PMID:27031958)		 UniProt
Ensembl
RGD		 PMID:27031958 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dnm1l dynamin 1-like involved_in ISO (PMID:20850011) RGD PMID:20850011 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein acts_upstream_of_or_within ISO (MGI:3764759|PMID:17981155) RGD PMID:17981155 MGI:3764759 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571 		JBrowse link
G Fis1 fission, mitochondrial 1 involved_in ISO
IEA		 (PMID:21183955)
GO_REF:0000107		 RGD
Ensembl		 PMID:21183955 GO_REF:0000107 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Flcn folliculin acts_upstream_of_or_within ISO MGI:4348628 (MGI:5050037|PMID:21258407) RGD PMID:21258407 MGI:5050037 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:21522185) RGD PMID:21522185 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Il19 interleukin 19 acts_upstream_of_or_within ISO MGI:3605069 (MGI:5491082|PMID:23468852) RGD PMID:23468852 MGI:5491082 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473 		JBrowse link
G Il20ra interleukin 20 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1890472 (MGI:5491082|PMID:23468852) RGD PMID:23468852 MGI:5491082 NCBI chr 1:14,424,215...14,494,226
Ensembl chr 1:14,451,228...14,493,602 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase involved_in ISO
IEA		 (PMID:16116473)
GO_REF:0000107		 RGD
Ensembl		 PMID:16116473 GO_REF:0000107 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Mir16 microRNA 16 involved_in ISO RNAcentral:URS00003D1AE3_9606 (PMID:16166262) RGD PMID:16166262 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443 		JBrowse link
G Mir27b microRNA 27b acts_upstream_of_or_within ISO UniProtKB:P01375 (PMID:31124343) RGD PMID:31124343 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 involved_in ISO (PMID:20012548) RGD PMID:20012548 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Nkx3-1 NK3 homeobox 1 involved_in ISO (PMID:17486276) RGD PMID:17486276 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISO
ISS
IMP		 (PMID:27031958)
GO_REF:0000024		 RGD
UniProt		 PMID:27031958 PMID:27031958 GO_REF:0000024, RGD:14390051 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Plagl2 PLAG1 like zinc finger 2 acts_upstream_of_or_within ISO (MGI:2179174|PMID:11832486) RGD PMID:11832486 MGI:2179174 NCBI chr 3:141,695,322...141,708,516
Ensembl chr 3:141,695,322...141,708,503 		JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (MGI:3611133|PMID:16188880)
PMID:21873635		 RGD PMID:16188880 PMID:21873635 MGI:3611133, RGD:13792537 NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:21454712) RGD PMID:21454712 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:2386461|PMID:12181197)		 Ensembl
RGD		 PMID:12181197 GO_REF:0000107 MGI:2386461 NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:19767770) RGD PMID:19767770 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 acts_upstream_of_or_within ISO (MGI:1345788|PMID:10490590) RGD PMID:10490590 MGI:1345788 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G S100a8 S100 calcium binding protein A8 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19935772)		 UniProt
RGD		 PMID:19935772 GO_REF:0000024 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:19935772)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:19935772 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Septin4 septin 4 involved_in ISO (PMID:21185211) RGD PMID:21185211 NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 involved_in ISO
IEA		 (PMID:21185211)
GO_REF:0000107		 RGD
Ensembl		 PMID:21185211 GO_REF:0000107 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 involved_in ISO
IBA		 (PMID:21262771), (PMID:24709986)
PMID:21873635		 RGD PMID:21262771 PMID:24709986 PMID:21873635 RGD:13792537 NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752 		JBrowse link
G Taf6 TATA-box binding protein associated factor 6 involved_in ISO (PMID:20096117) RGD PMID:20096117 NCBI chr12:17,055,864...17,064,244
Ensembl chr12:17,055,873...17,064,247 		JBrowse link
G Tp53 tumor protein p53 involved_in ISS
IEA
ISO
IMP		 GO_REF:0000024
GO_REF:0000107
(PMID:14963330), (PMID:27031958)		 UniProt
Ensembl
RGD		 PMID:14963330 PMID:27031958 PMID:27031958 GO_REF:0000024 GO_REF:0000107, RGD:14390051 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif5a eukaryotic translation initiation factor 5A involved_in ISO (PMID:15371445) RGD PMID:15371445 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656 		JBrowse link
G Mir186 microRNA 186 acts_upstream_of ISO (PMID:27714074) RGD PMID:27714074 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Msx1 msh homeobox 1 involved_in ISO (PMID:15705871) RGD PMID:15705871 NCBI chr14:72,961,036...72,964,970
Ensembl chr14:72,961,148...72,964,966 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO (PMID:10962037) RGD PMID:10962037 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Rpl11 ribosomal protein L11 involved_in ISO (MGI:5883206|PMID:22262176) RGD PMID:22262176 MGI:5883206 NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599 		JBrowse link
G Rps7 ribosomal protein S7 involved_in ISO (PMID:17310983) RGD PMID:17310983 NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 involved_in ISO (MGI:5553386|PMID:24523556) RGD PMID:24523556 MGI:5553386 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
G Ubb ubiquitin B acts_upstream_of_or_within ISO (PMID:17571083) RGD PMID:17571083 NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbh1 F-box DNA helicase 1 acts_upstream_of_or_within ISO (PMID:23361013) RGD PMID:23361013 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590 		JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO MGI:2449949|MGI:5566664 (MGI:5662300|PMID:26219591) RGD PMID:26219591 MGI:5662300 NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189 		JBrowse link
G Nacc2 NACC family member 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22926524)		 Ensembl
RGD		 PMID:22926524 GO_REF:0000107 NCBI chr 3:8,879,952...8,946,660
Ensembl chr 3:8,883,065...8,946,660 		JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 acts_upstream_of_or_within ISO (MGI:5009403|PMID:16816390) RGD PMID:16816390 MGI:5009403 NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808 		JBrowse link
G Plscr1 phospholipid scramblase 1 acts_upstream_of_or_within ISO (MGI:5284813|PMID:12509439) RGD PMID:12509439 MGI:5284813 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A acts_upstream_of_or_within ISO MGI:2442925 (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:22510408) RGD PMID:22510408 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Skil SKI-like proto-oncogene acts_upstream_of_or_within ISO MGI:2387096 (MGI:1858539|PMID:10811619) RGD PMID:10811619 MGI:1858539 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 involved_in ISO (PMID:16213212)
(MGI:5882892|PMID:16213212)		 RGD PMID:16213212 MGI:5882892 NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO MGI:4398911 (MGI:4367682|PMID:18617898) RGD PMID:18617898 MGI:4367682 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within ISO MGI:2442925|MGI:98834 (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in ISO
IEA		 (PMID:21716255)
GO_REF:0000107
(MGI:5474549|PMID:21716255)		 RGD
Ensembl		 PMID:21716255 GO_REF:0000107 MGI:5474549 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nox1 NADPH oxidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3616995 (MGI:4881403|PMID:19661248)		 Ensembl
RGD		 PMID:19661248 GO_REF:0000107 MGI:4881403 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (MGI:5543357|PMID:22555455) RGD PMID:22555455 MGI:5543357 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Sfpq splicing factor proline and glutamine rich involved_in ISO (PMID:15790595) RGD PMID:15790595 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472 		JBrowse link
G Sod1 superoxide dismutase 1 involved_in ISO
IEA		 (PMID:12551919)
GO_REF:0000107		 RGD
Ensembl		 PMID:12551919 GO_REF:0000107 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Vnn1 vanin 1 involved_in ISO (MGI:3052282|PMID:15282320) RGD PMID:15282320 MGI:3052282 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395 		JBrowse link
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 IMP RGD PMID:28386847 RGD:329337357 NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISO (PMID:23858059)
(MGI:5543313|PMID:23858059)		 RGD PMID:23858059 MGI:5543313 NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in ISO UniProtKB:Q9WVS6 (PMID:23858059)
(MGI:5543313|PMID:23858059)		 RGD PMID:23858059 MGI:5543313 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IMP RGD PMID:27614125 RGD:329961568 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Ralbp1 ralA binding protein 1 IMP RGD PMID:23788031 RGD:12904719 NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707 		JBrowse link
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (PMID:23000344) RGD PMID:23000344 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 involved_in ISO (MGI:5613446|PMID:24370996) RGD PMID:24370996 MGI:5613446 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (MGI:5613477|PMID:15147274) RGD PMID:15147274 MGI:5613477 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:23921129) RGD PMID:23921129 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Fcgr2b Fc gamma receptor 2B involved_in IMP
ISO		 PMID:23921129
(MGI:5514474|PMID:23921129)		 RGD PMID:23921129 PMID:23921129 MGI:5514474, RGD:12910988 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
regulation of intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO
IBA		 (PMID:21525013)
PMID:21873635		 RGD PMID:21525013 PMID:21873635 RGD:13792537 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Dapk2 death-associated protein kinase 2 involved_in ISO (PMID:10376525) RGD PMID:10376525 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 involved_in ISO
IEA		 UniProtKB:Q9Y6J8 (PMID:24709986)
GO_REF:0000107		 RGD
Ensembl		 PMID:24709986 GO_REF:0000107 NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 involved_in ISO UniProtKB:Q8WUK0 (PMID:24709986) RGD PMID:24709986 NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752 		JBrowse link
regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd2 ankyrin repeat domain 2 acts_upstream_of_or_within ISO (MGI:3796961|PMID:18302940) RGD PMID:18302940 MGI:3796961 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3818156|PMID:17571083)
GO_REF:0000107		 RGD
Ensembl		 PMID:17571083 GO_REF:0000107 MGI:3818156 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpk heterogeneous nuclear ribonucleoprotein K acts_upstream_of_or_within ISO (MGI:4881379|PMID:20673990) RGD PMID:20673990 MGI:4881379 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tifab TIFA inhibitor acts_upstream_of_or_within ISO (MGI:6415433|PMID:32101751) RGD PMID:32101751 MGI:6415433 NCBI chr17:8,433,406...8,436,541
Ensembl chr17:8,431,635...8,436,592 		JBrowse link
G Usp15 ubiquitin specific peptidase 15 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6415433|PMID:32101751)
GO_REF:0000107		 RGD
Ensembl		 PMID:32101751 GO_REF:0000107 MGI:6415433 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721 		JBrowse link
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P4hb prolyl 4-hydroxylase subunit beta involved_in ISO (PMID:12095988) RGD PMID:12095988 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:12095988)
GO_REF:0000107		 HGNC
RGD
Ensembl		 PMID:12095988 GO_REF:0000024 GO_REF:0000107 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:15983381) RGD PMID:15983381 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP RGD PMID:17347665 RGD:10414071 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prodh proline dehydrogenase involved_in ISO (PMID:23743200) RGD PMID:23743200 NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6458378|PMID:30684126) RGD PMID:30684126 MGI:6458378 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    cellular process 18252
      signal transduction 6999
        apoptotic signaling pathway 670
          intrinsic apoptotic signaling pathway 336
            intrinsic apoptotic signaling pathway by p53 class mediator + 87
            intrinsic apoptotic signaling pathway in response to DNA damage + 110
            intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + 70
            intrinsic apoptotic signaling pathway in response to hypoxia + 11
            intrinsic apoptotic signaling pathway in response to nitrosative stress + 3
            intrinsic apoptotic signaling pathway in response to osmotic stress + 11
            intrinsic apoptotic signaling pathway in response to oxidative stress + 65
            negative regulation of intrinsic apoptotic signaling pathway + 119
            positive regulation of intrinsic apoptotic signaling pathway + 77
            regulation of intrinsic apoptotic signaling pathway + 206
Path 2
Term Annotations click to browse term
  biological_process 19574
    biological regulation 13203
      regulation of biological process 12829
        regulation of cellular process 12310
          signal transduction 6999
            apoptotic signaling pathway 670
              intrinsic apoptotic signaling pathway 336
                intrinsic apoptotic signaling pathway by p53 class mediator + 87
                intrinsic apoptotic signaling pathway in response to DNA damage + 110
                intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + 70
                intrinsic apoptotic signaling pathway in response to hypoxia + 11
                intrinsic apoptotic signaling pathway in response to nitrosative stress + 3
                intrinsic apoptotic signaling pathway in response to osmotic stress + 11
                intrinsic apoptotic signaling pathway in response to oxidative stress + 65
                negative regulation of intrinsic apoptotic signaling pathway + 119
                positive regulation of intrinsic apoptotic signaling pathway + 77
                regulation of intrinsic apoptotic signaling pathway + 206
paths to the root