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Gene: Mbd4 (methyl-CpG binding domain 4 DNA glycosylase) Rattus norvegicus
Symbol: Mbd4
Name: methyl-CpG binding domain 4 DNA glycosylase
RGD ID: 1585874
Description: Predicted to have DNA binding activity and pyrimidine-specific mismatch base pair DNA N-glycosylase activity. Involved in response to estradiol. Predicted to localize to chromatin; cytoplasm; and nuclear speck. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus squamous cell carcinoma; lung cancer; and rheumatoid arthritis. Orthologous to human MBD4 (methyl-CpG binding domain 4, DNA glycosylase); PARTICIPATES IN altered DNA modification pathway; DNA modification pathway; base excision repair pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC680915; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; similar to Methyl-CpG-binding domain protein 4 (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase)
Homo sapiens (human) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)  HGNC  Alliance
Mus musculus (house mouse) : Mbd4 (methyl-CpG binding domain protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mbd4 (methyl-CpG binding domain 4, DNA glycosylase)
Pan paniscus (bonobo/pygmy chimpanzee) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)
Canis lupus familiaris (dog) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mbd4 (methyl-CpG binding domain 4, DNA glycosylase)
Sus scrofa (pig) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)
Chlorocebus sabaeus (African green monkey) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)
Heterocephalus glaber (naked mole-rat) : Mbd4 (methyl-CpG binding domain 4, DNA glycosylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04147,744,673 - 147,756,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,746,186 - 147,756,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,028,384 - 211,040,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,972,272 - 151,981,633 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4137,783,059 - 137,794,850 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mbd4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1585874
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.