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Gene: Mbd4 (methyl-CpG binding domain 4 DNA glycosylase) Rattus norvegicus
Symbol: Mbd4
Name: methyl-CpG binding domain 4 DNA glycosylase
Description: Predicted to have DNA binding activity and pyrimidine-specific mismatch base pair DNA N-glycosylase activity. Involved in response to estradiol. Predicted to localize to the chromatin; cytoplasm; and nuclear speck. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus squamous cell carcinoma; lung cancer; and rheumatoid arthritis. Orthologous to human MBD4 (methyl-CpG binding domain 4, DNA glycosylase); PARTICIPATES IN altered DNA modification pathway; DNA modification pathway; base excision repair pathway; INTERACTS WITH decabromodiphenyl ether; quercetin; tetrachloromethane.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC680915; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; similar to Methyl-CpG-binding domain protein 4 (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase)
Homo sapiens (human) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)  HGNC  Alliance
Mus musculus (house mouse) : Mbd4 (methyl-CpG binding domain protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mbd4 (methyl-CpG binding domain 4, DNA glycosylase)
Pan paniscus (bonobo/pygmy chimpanzee) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)
Canis lupus familiaris (dog) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mbd4 (methyl-CpG binding domain 4, DNA glycosylase)
Sus scrofa (pig) : MBD4 (methyl-CpG binding domain 4, DNA glycosylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04147,744,673 - 147,756,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04211,028,384 - 211,040,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,972,272 - 151,981,633 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4137,783,059 - 137,794,850 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mbd4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1585874
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.