Topors (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase) - Rat Genome Database

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Gene: Topors (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase) Rattus norvegicus
Analyze
Symbol: Topors
Name: TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
RGD ID: 1305270
Description: Predicted to enable several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; maintenance of protein location in nucleus; and protein modification by small protein conjugation. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of DNA-templated transcription; and regulation of cell population proliferation. Predicted to be located in PML body; centriole; and spindle pole. Predicted to be part of gamma-tubulin complex and ubiquitin ligase complex. Predicted to be active in ciliary basal body; nuclear speck; and photoreceptor connecting cilium. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase Topors; LOC362501; TOP1 binding arginine/serine rich protein; topoisomerase I binding, arginine/serine-rich; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,184,076 - 60,195,979 (-)NCBIGRCr8
mRatBN7.2555,388,033 - 55,399,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,387,632 - 55,399,937 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx557,354,241 - 57,365,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,173,382 - 59,184,966 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,145,077 - 59,156,688 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0556,554,956 - 56,566,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,554,969 - 56,567,320 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0561,098,846 - 61,110,393 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4557,663,121 - 57,676,619 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1557,663,337 - 57,676,660 (-)NCBI
Celera554,004,376 - 54,015,952 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10352183   PMID:10415337   PMID:11278651   PMID:14516784   PMID:15247280   PMID:15735665   PMID:17803295   PMID:18077445   PMID:19473992   PMID:20188669   PMID:21159800   PMID:26872363  


Genomics

Comparative Map Data
Topors
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,184,076 - 60,195,979 (-)NCBIGRCr8
mRatBN7.2555,388,033 - 55,399,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,387,632 - 55,399,937 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx557,354,241 - 57,365,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,173,382 - 59,184,966 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,145,077 - 59,156,688 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0556,554,956 - 56,566,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,554,969 - 56,567,320 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0561,098,846 - 61,110,393 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4557,663,121 - 57,676,619 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1557,663,337 - 57,676,660 (-)NCBI
Celera554,004,376 - 54,015,952 (-)NCBICelera
Cytogenetic Map5q22NCBI
TOPORS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38932,540,544 - 32,552,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl932,540,544 - 32,552,586 (-)EnsemblGRCh38hg38GRCh38
GRCh37932,540,542 - 32,552,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,530,542 - 32,542,601 (-)NCBINCBI36Build 36hg18NCBI36
Build 34932,530,542 - 32,542,601NCBI
Celera932,471,749 - 32,483,828 (-)NCBICelera
Cytogenetic Map9p21.1NCBI
HuRef932,496,996 - 32,509,408 (-)NCBIHuRef
CHM1_1932,540,543 - 32,552,661 (-)NCBICHM1_1
T2T-CHM13v2.0932,556,707 - 32,568,751 (-)NCBIT2T-CHM13v2.0
Topors
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,259,606 - 40,269,841 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,259,601 - 40,269,850 (-)EnsemblGRCm39 Ensembl
GRCm38440,259,606 - 40,269,841 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,259,601 - 40,269,850 (-)EnsemblGRCm38mm10GRCm38
MGSCv37440,206,639 - 40,216,874 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36440,443,970 - 40,458,496 (-)NCBIMGSCv36mm8
Celera439,922,611 - 39,932,846 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.24NCBI
Topors
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554723,073,090 - 3,076,607 (+)NCBIChiLan1.0ChiLan1.0
TOPORS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21192,062,236 - 92,074,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1992,068,174 - 92,091,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0932,314,850 - 32,327,067 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1933,124,730 - 33,136,923 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl933,124,730 - 33,135,129 (-)Ensemblpanpan1.1panPan2
TOPORS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11149,809,156 - 49,821,224 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1149,809,465 - 49,821,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1148,431,713 - 48,443,289 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01150,750,269 - 50,761,842 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1150,750,578 - 50,761,831 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,413,336 - 49,424,903 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,279,886 - 49,291,445 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,038,557 - 50,050,130 (-)NCBIUU_Cfam_GSD_1.0
Topors
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947164,671,640 - 164,682,295 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,219,907 - 1,229,723 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,219,101 - 1,229,937 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOPORS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,865,959 - 33,879,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11033,865,967 - 33,878,135 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21038,119,298 - 38,131,555 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOPORS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11247,702,638 - 47,714,309 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1247,702,995 - 47,714,338 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603844,594,963 - 44,606,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Topors
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473637,210,291 - 37,221,747 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473637,209,709 - 37,221,921 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Topors
109 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:50
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000066081
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat

Markers in Region
AW105885  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2555,388,138 - 55,388,251 (+)MAPPERmRatBN7.2
Rnor_6.0556,555,062 - 56,555,174NCBIRnor6.0
Rnor_5.0561,098,952 - 61,099,064UniSTSRnor5.0
RGSC_v3.4557,663,227 - 57,663,339UniSTSRGSC3.4
Celera554,004,482 - 54,004,594UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000066081   ⟹   ENSRNOP00000063561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,388,041 - 55,398,684 (-)Ensembl
Rnor_6.0 Ensembl556,554,969 - 56,567,320 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116027   ⟹   ENSRNOP00000095797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,388,049 - 55,399,937 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119019   ⟹   ENSRNOP00000077956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,387,632 - 55,398,560 (-)Ensembl
RefSeq Acc Id: NM_001108658   ⟹   NP_001102128
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,184,076 - 60,195,979 (-)NCBI
mRatBN7.2555,388,033 - 55,399,937 (-)NCBI
Rnor_6.0556,554,956 - 56,566,503 (-)NCBI
Rnor_5.0561,098,846 - 61,110,393 (-)NCBI
RGSC_v3.4557,663,121 - 57,676,619 (-)RGD
Celera554,004,376 - 54,015,952 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102128 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063561.2
  ENSRNOP00000077956.1
  ENSRNOP00000095797.1
RefSeq Acc Id: NP_001102128   ⟸   NM_001108658
- UniProtKB: D3ZZE0 (UniProtKB/TrEMBL),   A0A8I6ANV8 (UniProtKB/TrEMBL),   A6IIQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063561   ⟸   ENSRNOT00000066081
Ensembl Acc Id: ENSRNOP00000077956   ⟸   ENSRNOT00000119019
Ensembl Acc Id: ENSRNOP00000095797   ⟸   ENSRNOT00000116027
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZE0-F1-model_v2 AlphaFold D3ZZE0 1-1042 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693629
Promoter ID:EPDNEW_R4154
Type:initiation region
Name:Topors_1
Description:TOP1 binding arginine/serine rich protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0556,566,461 - 56,566,521EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305270 AgrOrtholog
BioCyc Gene G2FUF-41603 BioCyc
Ensembl Genes ENSRNOG00000006485 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066081.3 UniProtKB/TrEMBL
  ENSRNOT00000116027.1 UniProtKB/TrEMBL
  ENSRNOT00000119019.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Znf_C3HC4_RING-type UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:362501 UniProtKB/TrEMBL
NCBI Gene 362501 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TOPORS UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE TOPORS UniProtKB/TrEMBL
Pfam zf-C3HC4 UniProtKB/TrEMBL
PhenoGen Topors PhenoGen
PROSITE ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006485 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8I5Y285_RAT UniProtKB/TrEMBL
  A0A8I6ANV8 ENTREZGENE, UniProtKB/TrEMBL
  A6IIQ9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZE0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-28 Topors  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase  Topors  TOP1 binding arginine/serine rich protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-27 Topors  TOP1 binding arginine/serine rich protein  Topors  topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Topors  topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase  Topors  topoisomerase I binding, arginine/serine-rich  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Topors  topoisomerase I binding, arginine/serine-rich   Topors_predicted  topoisomerase I binding, arginine/serine-rich (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Topors_predicted  topoisomerase I binding, arginine/serine-rich (predicted)      Symbol and Name status set to approved 70820 APPROVED