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Gene: Topors (TOP1 binding arginine/serine rich protein) Rattus norvegicus
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Symbol: Topors
Name: TOP1 binding arginine/serine rich protein
Description: Predicted to have several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of macromolecule metabolic process; and protein modification by small protein conjugation. Predicted to colocalize with the PML body. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; cadmium dichloride; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase Topors; LOC362501; topoisomerase I binding, arginine/serine-rich; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Orthologs:
Homo sapiens (human) : TOPORS (TOP1 binding arginine/serine rich protein)  HGNC  Alliance
Mus musculus (house mouse) : Topors (topoisomerase I binding, arginine/serine-rich)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Topors (TOP1 binding arginine/serine rich protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TOPORS (TOP1 binding arginine/serine rich protein)
Canis lupus familiaris (dog) : TOPORS (TOP1 binding arginine/serine rich protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Topors (TOP1 binding arginine/serine rich protein)
Sus scrofa (pig) : TOPORS (TOP1 binding arginine/serine rich protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0556,554,956 - 56,566,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,554,969 - 56,567,320 (-)Ensembl
Rnor_5.0561,098,846 - 61,110,393 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4557,663,121 - 57,676,619 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1557,663,337 - 57,676,660 (-)NCBI
Celera554,004,376 - 54,015,952 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Topors
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305270
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.