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Pathways
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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
apoptosome assembly +   
cell cycle checkpoint signaling +   
extrinsic apoptotic signaling pathway +   
granzyme-mediated apoptotic signaling pathway  
hippo signaling +   
hormone-mediated apoptotic signaling pathway  
intracellular signaling cassette +   
intrinsic apoptotic signaling pathway +   
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
mitochondrial outer membrane permeabilization +   
negative regulation of apoptotic signaling pathway +   
negative regulation of intracellular signal transduction +   
osmosensory signaling pathway +   
phosphatidylinositol-mediated signaling  
phosphorelay signal transduction system +   
positive regulation of apoptotic signaling pathway +   
positive regulation of intracellular signal transduction +   
protein kinase A signaling +   
protein kinase C signaling +   
RAM/MOR signaling 
regulation of apoptotic signaling pathway +   
regulation of intracellular signal transduction +   
release of cytochrome c from mitochondria +   
signal transduction by p53 class mediator +   
signal transduction in response to DNA damage +   
stress-activated protein kinase signaling cascade +   
TOR signaling +   

Synonyms
Exact Synonyms: intrinsic apoptotic pathway ;   intrinsic apoptotic signalling pathway ;   mitochondrial-mediated apoptotic pathway
Narrow Synonyms: intrinsic apoptosis
Related Synonyms: induction of apoptosis by intracellular signals
Alternate IDs: GO:0008629
Definition Sources: GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119

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