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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Daphnia magna metabolite
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Accession:CHEBI:83056 term browser browse the term
Definition:A Daphnia metabolite produced by the species Daphnia magna.
Synonyms:related_synonym: Daphnia magna metabolites


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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions		 EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
1-stearoyl-2-arachidonoylphosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Estradiol CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740 		JBrowse link
G ESR1 estrogen receptor 1 affects expression EXP Estradiol affects the expression of ESR1 protein CTD PMID:16483645 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544 		JBrowse link
17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
17beta-hydroxy-5alpha-androstan-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD2 superoxide dismutase 2 multiple interactions EXP Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] CTD PMID:16682413 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
2-hydroxypropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCT secretin decreases abundance EXP SCT protein results in decreased abundance of Lactic Acid CTD PMID:2418308
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603 		JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Aspirin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G SCT secretin multiple interactions EXP Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] CTD PMID:3562434
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects export EXP ABCC1 protein affects the export of calcein AM CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
carmustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MGMT O-6-methylguanine-DNA methyltransferase decreases response to substance
multiple interactions		 EXP MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine
MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]		 CTD PMID:14617759 PMID:15053863 NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380 		JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 increases expression EXP Clofibrate results in increased expression of ACAA2 mRNA CTD PMID:19952500 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain increases expression EXP Clofibrate results in increased expression of ACADVL protein CTD PMID:19952500 NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990 		JBrowse link
G AGXT alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression EXP Clofibrate results in decreased expression of AGXT protein CTD PMID:19952500 NCBI chr25:50,968,291...50,976,089 JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Clofibrate results in decreased expression of AHCY protein CTD PMID:19952500 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767 		JBrowse link
G ASL argininosuccinate lyase increases expression EXP Clofibrate results in increased expression of ASL protein CTD PMID:19952500 NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424 		JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression EXP Clofibrate results in decreased expression of ASS1 protein CTD PMID:19952500 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 increases expression EXP Clofibrate results in increased expression of CPS1 protein CTD PMID:19952500 NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697 		JBrowse link
G CPT2 carnitine palmitoyltransferase 2 increases expression EXP Clofibrate results in increased expression of CPT2 mRNA CTD PMID:19952500 NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression EXP Clofibrate results in decreased expression of CYP1A2 mRNA CTD PMID:19952500 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 decreases expression EXP Clofibrate results in decreased expression of CYP2A13 mRNA CTD PMID:19952500 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350 		JBrowse link
G CYP2B6 cytochrome P450 2B11 decreases expression EXP Clofibrate results in decreased expression of CYP2B6 mRNA CTD PMID:19952500 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
G CYP2C18 cytochrome P450 2C21 decreases expression EXP Clofibrate results in decreased expression of CYP2C18 mRNA CTD PMID:19952500 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression EXP Clofibrate results in increased expression of CYP2E1 protein CTD PMID:19952500 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
G CYP3A12 cytochrome P-450 3A12 decreases expression EXP Clofibrate results in decreased expression of CYP3A12 mRNA CTD PMID:19952500
G CYP3A26 cytochrome P450 3A26 decreases expression EXP Clofibrate results in decreased expression of CYP3A26 mRNA CTD PMID:19952500 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352 		JBrowse link
G CYP4A37 cytochrome P450 4A37 increases expression EXP Clofibrate results in increased expression of CYP4A11 mRNA CTD PMID:19952500 NCBI chr15:13,604,130...13,623,797 JBrowse link
G DLST dihydrolipoamide S-succinyltransferase increases expression EXP Clofibrate results in increased expression of DLST protein CTD PMID:19952500 NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999 		JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 increases expression EXP Clofibrate results in increased expression of ECHS1 protein CTD PMID:19952500 NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167 		JBrowse link
G GDI1 GDP dissociation inhibitor 1 increases expression EXP Clofibrate results in increased expression of GDI1 protein CTD PMID:19952500 NCBI chr  X:122,141,633...122,146,724
Ensembl chr  X:122,141,566...122,146,824 		JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases expression EXP Clofibrate results in decreased expression of GSTA4 mRNA CTD PMID:19952500 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200 		JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP Clofibrate results in decreased expression of GSTK1 mRNA CTD PMID:19952500 NCBI chr16:6,411,678...6,416,135 JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Clofibrate results in decreased expression of GSTO1 mRNA CTD PMID:19952500 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880 		JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase increases expression EXP Clofibrate results in increased expression of HADH mRNA CTD PMID:19952500 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clofibrate results in increased expression of HSPD1 protein CTD PMID:19952500 NCBI chr37:7,010,421...7,025,912 JBrowse link
G KRT1 keratin 1 increases expression EXP Clofibrate results in increased expression of KRT1 protein CTD PMID:19952500 NCBI chr27:2,422,150...2,427,160 JBrowse link
G KRT18 keratin 18 decreases expression EXP Clofibrate results in decreased expression of KRT18 protein CTD PMID:19952500 NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368 		JBrowse link
G LOC474938 glutathione S-transferase A2 decreases expression EXP Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein CTD PMID:19952500 NCBI chr12:20,349,133...20,365,023 JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Clofibrate results in increased expression of MGST1 mRNA CTD PMID:19952500 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778 		JBrowse link
G PC pyruvate carboxylase increases expression EXP Clofibrate results in increased expression of PC protein CTD PMID:19952500 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669 		JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial increases expression EXP Clofibrate results in increased expression of PCK2 protein CTD PMID:19952500 NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865 		JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP Clofibrate results in decreased expression of PRDX6 protein CTD PMID:19952500 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754 		JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Clofibrate results in decreased expression of SELENBP1 protein CTD PMID:19952500 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 decreases expression EXP Clofibrate results in decreased expression of SHMT1 protein CTD PMID:19952500 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166 		JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases expression EXP Clofibrate results in decreased expression of UGP2 protein CTD PMID:19952500 NCBI chr10:63,532,366...63,598,362
Ensembl chr10:63,533,171...63,597,452 		JBrowse link
G UQCRC1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP Clofibrate results in increased expression of UQCRC1 protein CTD PMID:19952500 NCBI chr20:40,507,767...40,515,854
Ensembl chr20:40,506,907...40,520,110 		JBrowse link
G UROC1 urocanate hydratase 1 decreases expression EXP Clofibrate results in decreased expression of UROC1 protein CTD PMID:19952500 NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141 		JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C18 cytochrome P450 2C21 increases hydroxylation EXP CYP2C19 protein results in increased hydroxylation of Diclofenac CTD PMID:15677349 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587 		JBrowse link
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
dihexadecanoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 multiple interactions
increases activity		 EXP dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Glyburide results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Indomethacin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]
ochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 protein		 CTD PMID:33543323 NCBI chr26:38,700,434...38,714,915
Ensembl chr26:38,700,480...38,711,753 		JBrowse link
G B9D2 B9 domain containing 2 increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of TGFB1 mRNA; ochratoxin A results in increased expression of TGFB1 protein
CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]		 CTD PMID:33543323 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G CASP4 caspase 4, apoptosis-related cysteine peptidase increases expression
multiple interactions
increases cleavage		 EXP ochratoxin A results in increased expression of CASP1 mRNA
CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]		 CTD PMID:33543323 NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736 		JBrowse link
G GSDMD gasdermin D multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]
ochratoxin A results in increased expression of GSDMD mRNA; ochratoxin A results in increased expression of GSDMD protein		 CTD PMID:33543323 NCBI chr13:37,221,219...37,226,912
Ensembl chr13:37,193,022...37,228,360 		JBrowse link
G IL18 interleukin 18 multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA] CTD PMID:33543323 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]
ochratoxin A results in increased expression of IL1B mRNA; ochratoxin A results in increased expression of IL1B protein		 CTD PMID:33543323 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 increases secretion
increases expression		 EXP ochratoxin A results in increased secretion of IL6 protein
ochratoxin A results in increased expression of IL6 mRNA		 CTD PMID:33543323 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions
increases expression		 EXP N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]
ochratoxin A results in increased expression of NLRP3 mRNA; ochratoxin A results in increased expression of NLRP3 protein		 CTD PMID:33543323 NCBI chr 8:251,776...313,290
Ensembl chr 8:253,407...313,059 		JBrowse link
G PYCARD PYD and CARD domain containing increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of PYCARD mRNA; ochratoxin A results in increased expression of PYCARD protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]		 CTD PMID:33543323 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240 		JBrowse link
G TNF tumor necrosis factor increases secretion
increases expression		 EXP ochratoxin A results in increased secretion of TNF protein
ochratoxin A results in increased expression of TNF mRNA		 CTD PMID:33543323 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G VIM vimentin multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of VIM protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]
ochratoxin A results in increased expression of VIM mRNA; ochratoxin A results in increased expression of VIM protein		 CTD PMID:33543323 NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466 		JBrowse link
phenacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects metabolic processing EXP CYP1A2 protein affects the metabolism of Phenacetin CTD PMID:15801540 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Phenacetin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
phorbol 13-acetate 12-myristate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein CTD PMID:12639917 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G SLC6A9 solute carrier family 6 member 9 multiple interactions
affects localization		 EXP Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]
Tetradecanoylphorbol Acetate affects the localization of SLC6A9 protein		 CTD PMID:19473961 NCBI chr15:16,235,342...16,267,161
Ensembl chr15:16,235,482...16,267,933 		JBrowse link
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Tetradecanoylphorbol Acetate CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
prochloraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
rac-lactic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCT secretin decreases abundance EXP SCT protein results in decreased abundance of Lactic Acid CTD PMID:2418308
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Ritonavir results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
saquinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Saquinavir CTD PMID:12702717 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740 		JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Sulindac results in decreased expression of PTGS2 protein CTD PMID:12857884 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases localization EXP Sulindac results in decreased localization of RELA protein CTD PMID:12857884 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
testosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 increases expression EXP Testosterone results in increased expression of TGFB1 mRNA CTD PMID:17157324 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 increases expression EXP Testosterone results in increased expression of KCND3 protein CTD PMID:17054656 NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035 		JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 increases expression EXP Testosterone results in increased expression of KCNJ2 protein CTD PMID:17054656 NCBI chr 9:16,468,938...16,475,722
Ensembl chr 9:16,468,938...16,475,722 		JBrowse link
tetradecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 decreases activity EXP Myristic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Troleandomycin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G SCT secretin multiple interactions EXP Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] CTD PMID:3562434
urea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Urea results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Urea results in increased expression of SOD2 protein CTD PMID:22718889 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
UTP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions
increases activity		 EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases export
multiple interactions
affects response to substance		 EXP ABCB1 protein results in increased export of Vincristine
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]		 CTD PMID:24975508 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Vincristine CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:1618819 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501
    role 501
      biological role 501
        biochemical role 460
          metabolite 451
            eukaryotic metabolite 429
              animal metabolite 418
                crustacean metabolite 82
                  Daphnia metabolite 82
                    Daphnia magna metabolite 82
                      15alpha-hydroxytestosterone 0
                      16beta-hydroxytestosterone 0
                      17beta-estradiol + 3
                      17beta-hydroxy-5alpha-androstan-3-one + 1
                      2-hydroxypropanoic acid + 1
                      2alpha-hydroxytestosterone 0
                      5alpha-androstane-3alpha,17beta-diol + 0
                      5alpha-androstane-3alpha-glcosyl-17beta-diol 0
                      5alpha-androstane-3beta,17beta-diol + 0
                      6beta-hydroxytestosterone + 0
                      7alpha -hydroxytestosterone 0
                      D-ribonic acid + 0
                      L-ascorbate + 0
                      L-citrulline zwitterion + 0
                      L-threonic acid + 0
                      N,N-dimethylglycine 0
                      acetic acid + 23
                      adenine + 0
                      aminomalonic acid 0
                      androst-4-ene-3,17-dione + 0
                      asparagine + 1
                      cadaverine + 0
                      carnosine + 0
                      choline + 1
                      citrulline + 0
                      glucosyl-6beta-hydroxytestosterone 0
                      glucosyltestosterone 0
                      glucuronolactone + 0
                      glutaric acid + 0
                      heptadecanoic acid + 0
                      hexadecanoic acid + 1
                      isobutyric acid + 36
                      isoleucine + 0
                      leucine + 0
                      lysine + 0
                      methionine + 0
                      myo-inositol + 0
                      nonanoic acid + 0
                      octadecanoic acid + 1
                      ornithine + 0
                      p-aminohippuric acid 0
                      pentadecanoic acid + 0
                      phenylalanine + 11
                      pimelic acid + 0
                      proline + 0
                      pyrazine 0
                      pyrimidine 0
                      ribitol + 0
                      sodium ascorbate 0
                      talose + 0
                      testosterone + 3
                      tetradecanoic acid + 6
                      threonine + 0
                      tricosanoic acid + 0
                      tryptophan + 0
                      turanose 0
                      tyrosine + 0
                      uracil + 1
                      urea + 9
                      valine + 2
paths to the root