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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-acetyl-L-cysteine
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Accession:CHEBI:28939 term browser browse the term
Definition:An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Synonyms:related_synonym: (2R)-2-acetylamino-3-sulfanylpropanoic acid;   (R)-2-acetylamino-3-mercaptopropanoic acid;   (R)-mercapturic acid;   Acetylcysteine;   Formula=C5H9NO3S;   InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1;   InChIKey=PWKSKIMOESPYIA-BYPYZUCNSA-N;   L-acetylcysteine;   L-alpha-acetamido-beta-mercaptopropionic acid;   N-acetylcysteine;   NAC;   SMILES=CC(=O)N[C@@H](CS)C(O)=O;   acetilcisteina;   acetylcysteinum;   mercapturic acid
 alt_id: CHEBI:21548;   CHEBI:2418;   CHEBI:45481
 xref: Beilstein:1724426;   CAS:616-91-1;   DrugBank:DB06151;   Drug_Central:66;   Gmelin:142554;   HMDB:HMDB0001890;   KEGG:C06809;   KEGG:D00221;   LINCS:LSM-4672
 xref_mesh: MESH:D000111
 xref: MetaCyc:CPD-9175;   PDBeChem:SC2;   PMID:10651166;   PMID:11544433;   PMID:12057717;   PMID:15025780;   PMID:15647642;   PMID:17174578;   PMID:19580823;   PMID:2026726;   PMID:20819793;   PMID:24119926;   PMID:25553484;   PMID:9624310;   PMID:9711192;   Reaxys:1724426;   Wikipedia:Acetylcysteine
 cyclic_relationship: is_conjugate_acid_of CHEBI:78236



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N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 400
    role 402
      chemical role 326
        antioxidant 43
          N-acetyl-L-cysteine 5
            N-acetyl-L-cysteinyl residue 0
            S-substituted N-acetyl-L-cysteine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 400
    subatomic particle 400
      composite particle 402
        hadron 400
          baryon 400
            nucleon 400
              atomic nucleus 400
                atom 400
                  main group element atom 395
                    p-block element atom 395
                      carbon group element atom 382
                        carbon atom 383
                          organic molecular entity 381
                            organic group 311
                              organic divalent group 310
                                organodiyl group 310
                                  carbonyl group 310
                                    carbonyl compound 310
                                      carboxylic acid 275
                                        carboacyl group 215
                                          univalent carboacyl group 215
                                            carbamoyl group 213
                                              carboxamide 213
                                                acetamides 8
                                                  N-acetyl-amino acid 5
                                                    N-acetyl-L-amino acid 5
                                                      N-acetyl-L-cysteine 5
                                                        N-acetyl-L-cysteinyl residue 0
                                                        S-substituted N-acetyl-L-cysteine + 0
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