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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tryptophan
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Accession:CHEBI:27897 term browser browse the term
Definition:An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.
Synonyms:related_synonym: 2-amino-3-(1H-indol-3-yl)propanoic acid;   Formula=C11H12N2O2;   Htrp;   InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15);   InChIKey=QIVBCDIJIAJPQS-UHFFFAOYSA-N;   SMILES=NC(Cc1c[nH]c2ccccc12)C(O)=O;   Trp;   W;   alpha-Amino-beta-(3-indolyl)-propionic acid;   alpha-amino-beta-3-indolepropionic acid;   beta-3-indolylalanine;   triptofano;   tryptophane
 alt_id: CHEBI:27163;   CHEBI:9769
 xref: Beilstein:86196;   CAS:54-12-6;   Gmelin:4532;   KEGG:C00806;   KNApSAcK:C00001396;   LINCS:LSM-36836;   PMID:17439666;   PMID:22264337;   Reaxys:86196;   Wikipedia:Tryptophan
 cyclic_relationship: is_conjugate_acid_of CHEBI:32727;   is_conjugate_base_of CHEBI:32728;   is_tautomer_of CHEBI:64554


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1-methyltryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido2 indoleamine 2,3-dioxygenase 2 decreases activity ISO 1-methyltryptophan results in decreased activity of IDO2 protein CTD PMID:32289347 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
5-hydroxytryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
ilomastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 multiple interactions EXP ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein] CTD PMID:18852015 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA] CTD PMID:18837084 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein] CTD PMID:18837084 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
L-tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
violacein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 increases activity ISO violacein results in increased activity of CASP2 protein CTD PMID:20416285 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity ISO violacein results in increased activity of CASP3 protein CTD PMID:20416285 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO violacein results in increased activity of CASP9 protein CTD PMID:20416285 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        refrigerant 17511
          ammonia 17039
            organic amino compound 17038
              amino acid 14119
                polar amino acid 10661
                  tryptophan 9
                    1-tryptophano group + 0
                    D-tryptophan + 0
                    L-tryptophan + 7
                    tryptophan derivative + 6
                    tryptophan residue + 0
                    tryptophano group + 0
                    tryptophanyl radical + 0
                    tryptophanyl radical cation + 0
                    tryptophyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        amino acid 14119
                                          polar amino acid 10661
                                            tryptophan 9
                                              1-tryptophano group + 0
                                              D-tryptophan + 0
                                              L-tryptophan + 7
                                              tryptophan derivative + 6
                                              tryptophan residue + 0
                                              tryptophano group + 0
                                              tryptophanyl radical + 0
                                              tryptophanyl radical cation + 0
                                              tryptophyl group + 0
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