SOD1 (superoxide dismutase 1) - Rat Genome Database

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Gene: SOD1 (superoxide dismutase 1) Canis lupus familiaris
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Symbol: SOD1
Name: superoxide dismutase 1
RGD ID: 12246481
Description: ENCODES a protein that exhibits chaperone binding (ortholog); copper ion binding (ortholog); enzyme binding (ortholog); INVOLVED IN aging (ortholog); anterograde axonal transport (ortholog); apoptotic process (ortholog); PARTICIPATES IN amyotrophic lateral sclerosis pathway; forkhead class A signaling pathway; hypertension pathway; ASSOCIATED WITH spinal cord disease; acute kidney failure (ortholog); Alcoholic Fatty Liver (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic vesicle (ortholog); cytosol (ortholog); INTERACTS WITH 2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid; nafenopin; phenobarbital
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cu/Zn superoxide dismutase; superoxide dismutase 1 soluble; superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)); superoxide dismutase [Cu-Zn]
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13126,540,291 - 26,544,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3126,486,274 - 26,662,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3126,528,080 - 26,536,169 (+)NCBI
ROS_Cfam_1.03126,654,922 - 26,662,986 (+)NCBI
ROS_Cfam_1.0 Ensembl3126,654,409 - 26,782,319 (+)Ensembl
UMICH_Zoey_3.13126,600,785 - 26,608,887 (+)NCBI
UNSW_CanFamBas_1.03126,612,632 - 26,620,712 (+)NCBI
UU_Cfam_GSD_1.03127,118,829 - 27,126,937 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alcoholic Fatty Liver  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
Aortic Calcification  (ISO)
aortic disease  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
cardiac arrest  (ISO)
cardiomyopathy  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystitis  (ISO)
developmental coordination disorder  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
Down syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fatigue  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
fragile X-associated tremor/ataxia syndrome  (ISO)
Gliosis  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Hemolysis  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
high grade glioma  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
immunodeficiency 28  (ISO)
Inflammation  (ISO)
inflammatory bowel disease 25  (ISO)
iron deficiency anemia  (ISO)
ischemia  (ISO)
Kidney Calculi  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
low tension glaucoma  (ISO)
macular degeneration  (ISO)
Marfan syndrome  (ISO)
MELAS syndrome  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (ISO)
motor neuron disease  (ISO)
Muscle Weakness  (ISO)
muscular atrophy  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrosis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neurologic Gait Disorders  (ISO)
newborn respiratory distress syndrome  (ISO)
non-alcoholic steatohepatitis  (ISO)
nutritional deficiency disease  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
Paralysis  (ISO)
Parkinson's disease  (ISO)
Parkinson's disease 20  (ISO)
polycystic kidney disease  (ISO)
Presbycusis  (ISO)
prion disease  (ISO)
progressive supranuclear palsy  (ISO)
Protein Aggregation, Pathological  (ISO)
Protein Deficiency  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
Radiation Injuries, Experimental  (ISO)
renal artery obstruction  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
Schistosomiasis Mansoni  (ISO)
sciatic neuropathy  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
SPASTIC TETRAPLEGIA AND AXIAL HYPOTONIA, PROGRESSIVE  (ISO)
spinal cord disease  (IAGP)
Spinal Cord Injuries  (ISO)
Stroke  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Ureteral Calculi  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
anterograde axonal transport  (ISO)
apoptotic process  (ISO)
auditory receptor cell stereocilium organization  (ISO)
cellular iron ion homeostasis  (ISO)
cellular response to ATP  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to potassium ion  (ISO)
ectopic germ cell programmed cell death  (ISO)
embryo implantation  (ISO)
glutathione metabolic process  (ISO)
heart contraction  (ISO)
hydrogen peroxide biosynthetic process  (ISO)
locomotory behavior  (ISO)
muscle cell cellular homeostasis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cholesterol biosynthetic process  (ISO)
negative regulation of developmental process  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reproductive process  (ISO)
neurofilament cytoskeleton organization  (ISO)
obsolete cell aging  (ISO)
ovarian follicle development  (ISO)
peripheral nervous system myelin maintenance  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of superoxide anion generation  (ISO)
reactive oxygen species metabolic process  (ISS)
regulation of blood pressure  (ISO)
regulation of GTPase activity  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of protein kinase activity  (ISO)
relaxation of vascular associated smooth muscle  (ISO)
removal of superoxide radicals  (IBA,IEA,ISO,ISS)
response to amphetamine  (ISO)
response to antibiotic  (ISO)
response to antipsychotic drug  (ISO)
response to axon injury  (ISO)
response to carbon monoxide  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to nutrient levels  (ISO)
response to organic substance  (ISO)
response to oxidative stress  (ISO)
response to reactive oxygen species  (ISO)
response to superoxide  (ISO)
response to xenobiotic stimulus  (ISO)
retina homeostasis  (ISO)
retrograde axonal transport  (ISO)
sensory perception of sound  (ISO)
spermatogenesis  (ISO)
superoxide anion generation  (ISO)
superoxide metabolic process  (IEA,ISO)
transmission of nerve impulse  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12140271   PMID:15466883   PMID:21848967   PMID:22542607   PMID:23279517   PMID:23328634   PMID:23707216   PMID:24390315   PMID:26162235   PMID:27114170   PMID:27185954   PMID:27917507  
PMID:33494906   PMID:33677640  


Genomics

Comparative Map Data
SOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13126,540,291 - 26,544,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3126,486,274 - 26,662,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3126,528,080 - 26,536,169 (+)NCBI
ROS_Cfam_1.03126,654,922 - 26,662,986 (+)NCBI
ROS_Cfam_1.0 Ensembl3126,654,409 - 26,782,319 (+)Ensembl
UMICH_Zoey_3.13126,600,785 - 26,608,887 (+)NCBI
UNSW_CanFamBas_1.03126,612,632 - 26,620,712 (+)NCBI
UU_Cfam_GSD_1.03127,118,829 - 27,126,937 (+)NCBI
SOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382131,659,693 - 31,668,931 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2131,659,666 - 31,668,931 (+)EnsemblGRCh38hg38GRCh38
GRCh372133,032,006 - 33,041,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,953,806 - 31,963,115 (+)NCBINCBI36hg18NCBI36
Build 342131,953,805 - 31,963,112NCBI
Celera2118,215,252 - 18,224,561 (+)NCBI
Cytogenetic Map21q22.11ENTREZGENE
HuRef2118,441,963 - 18,451,272 (+)NCBIHuRef
CHM1_12132,593,921 - 32,603,230 (+)NCBICHM1_1
T2T-CHM13v2.02130,027,677 - 30,036,914 (+)NCBI
Sod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,017,650 - 90,023,221 (+)NCBIGRCm39mm39
GRCm39 Ensembl1690,017,642 - 90,023,217 (+)Ensembl
GRCm381690,220,762 - 90,226,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,220,754 - 90,226,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv371690,220,987 - 90,226,569 (+)NCBIGRCm37mm9NCBIm37
MGSCv361690,109,601 - 90,115,183 (+)NCBImm8
Celera1690,416,380 - 90,421,958 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.56NCBI
Sod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21129,456,673 - 29,462,249 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1129,456,558 - 29,462,249 (+)Ensembl
Rnor_6.01130,363,282 - 30,368,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,982,764 - 33,988,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,810,766 - 29,816,342 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11129,810,765 - 29,816,342 (-)NCBI
Celera1129,143,740 - 29,149,316 (+)NCBICelera
Cytogenetic Map11q11NCBI
Sod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540731,263,863 - 31,267,727 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540731,261,451 - 31,267,657 (+)NCBIChiLan1.0ChiLan1.0
SOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12131,411,702 - 31,419,432 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02118,029,831 - 18,037,526 (+)NCBIMhudiblu_PPA_v0panPan3
Sod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497127,114,944 - 27,122,669 (+)NCBI
SpeTri2.0NW_00493650010,345,154 - 10,352,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13195,326,649 - 195,337,729 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113195,326,573 - 195,335,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,620,994 - 205,629,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1260,461,219 - 60,472,999 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660713,004,172 - 3,013,463 (-)NCBIVero_WHO_p1.0
Sod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474520,032,011 - 20,037,958 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474520,032,003 - 20,037,958 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1 1
Medium 5 5 21 6 6 6 6 6 12 8 10 5
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014065   ⟹   ENSCAFP00000013012
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3126,486,274 - 26,544,514 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000065394   ⟹   ENSCAFP00000054366
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3126,486,274 - 26,662,815 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040105   ⟹   ENSCAFP00845031406
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3126,654,409 - 26,782,319 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040157   ⟹   ENSCAFP00845031451
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3126,657,031 - 26,782,319 (+)Ensembl
RefSeq Acc Id: NM_001003035   ⟹   NP_001003035
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13126,540,291 - 26,544,212 (+)NCBI
Dog10K_Boxer_Tasha3126,528,080 - 26,536,169 (+)NCBI
ROS_Cfam_1.03126,654,922 - 26,662,986 (+)NCBI
UMICH_Zoey_3.13126,600,785 - 26,608,887 (+)NCBI
UNSW_CanFamBas_1.03126,612,632 - 26,620,712 (+)NCBI
UU_Cfam_GSD_1.03127,118,829 - 27,126,937 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003035 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL61608 (Get FASTA)   NCBI Sequence Viewer  
  ANF06965 (Get FASTA)   NCBI Sequence Viewer  
  Q8WNN6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003035   ⟸   NM_001003035
- UniProtKB: Q8WNN6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000013012   ⟸   ENSCAFT00000014065
RefSeq Acc Id: ENSCAFP00000054366   ⟸   ENSCAFT00000065394
RefSeq Acc Id: ENSCAFP00845031451   ⟸   ENSCAFT00845040157
RefSeq Acc Id: ENSCAFP00845031406   ⟸   ENSCAFT00845040105
Protein Domains
Sod_Cu


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008859 Ensembl
  ENSCAFG00845022725 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845031406.1 UniProtKB/TrEMBL
  ENSCAFP00845031451.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845040105.1 UniProtKB/TrEMBL
  ENSCAFT00845040157.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SOD-like_Cu/Zn_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu/Zn_/chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu/Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu_Zn_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403559 UniProtKB/Swiss-Prot
NCBI Gene SOD1 ENTREZGENE
PANTHER PTHR10003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sod_Cu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CUZNDISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_CU_ZN_1 UniProtKB/TrEMBL
  SOD_CU_ZN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49329 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A172WBY9_CANLF UniProtKB/TrEMBL
  A0A8I3PS52_CANLF UniProtKB/TrEMBL
  A0A8I3S396_CANLF UniProtKB/TrEMBL
  Q8WNN6 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:46653 ENTREZGENE