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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glutaric acid
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Accession:CHEBI:17859 term browser browse the term
Definition:An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.
Synonyms:related_synonym: 1,3-Propanedicarboxylic acid;   1,5-pentanedioic acid;   Formula=C5H8O4;   Glutarsaeure;   InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9);   InChIKey=JFCQEDHGNNZCLN-UHFFFAOYSA-N;   Pentanedioic acid;   SMILES=OC(=O)CCCC(O)=O
 alt_id: CHEBI:24330;   CHEBI:43097;   CHEBI:5434
 xref: Beilstein:1209725;   CAS:110-94-1;   DrugBank:DB03553;   Gmelin:26809;   HMDB:HMDB0000661;   KEGG:C00489;   KNApSAcK:C00001184;   LIPID_MAPS_instance:LMFA01170046
 xref_mesh: MESH:C035736
 xref: PDBeChem:GUA;   PMID:24297153;   PMID:24587932;   PMID:24900967;   Reaxys:1209725;   Wikipedia:Glutaric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:24329;   is_conjugate_acid_of CHEBI:35907


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glutaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of glutaric acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases import
increases activity
ISO glutaric acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 results in increased export of p-Aminohippuric Acid]
SLC22A6 protein results in increased import of glutaric acid
glutaric acid results in increased activity of SLC22A6 protein
CTD PMID:15284288, PMID:19643159, PMID:28629854 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases import
multiple interactions
increases activity
ISO SLC22A8 protein results in increased import of glutaric acid
glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]
glutaric acid results in increased activity of SLC22A8 protein
CTD PMID:28629854 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
2-hydroxyglutaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH2 protein CTD PMID:28269980 NCBI chr12:48,257,575...48,262,244
Ensembl chr12:48,257,609...48,262,243
JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH3 protein CTD PMID:28269980 NCBI chr 3:82,874,242...82,907,467
Ensembl chr 3:82,874,248...82,906,581
JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase increases metabolic processing ISO D2HGDH protein results in increased metabolism of alpha-hydroxyglutarate CTD PMID:15609246 NCBI chr 9:100,956,570...100,974,393
Ensembl chr 9:100,956,477...100,974,551
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO [epigallocatechin gallate results in decreased expression of GLUD1 protein] which results in decreased abundance of alpha-hydroxyglutarate CTD PMID:31857147 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 affects abundance ISO IDH1 gene mutant form affects the abundance of alpha-hydroxyglutarate CTD PMID:22057236 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G L2hgdh L-2-hydroxyglutarate dehydrogenase increases abundance ISO L2HGDH gene mutant form results in increased abundance of alpha-hydroxyglutarate CTD PMID:25800467 NCBI chr 6:92,016,560...92,057,643
Ensembl chr 6:92,016,622...92,057,816
JBrowse link
glutaryl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot4 acyl-CoA thioesterase 4 affects hydrolysis ISO ACOT4 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 NCBI chr 6:107,517,668...107,522,952
Ensembl chr 6:107,517,668...107,522,952
JBrowse link
G Acot8 acyl-CoA thioesterase 8 affects hydrolysis ISO ACOT8 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 NCBI chr 3:161,260,837...161,272,495
Ensembl chr 3:161,259,735...161,272,460
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          metabolite 19218
            eukaryotic metabolite 18842
              animal metabolite 18569
                mammalian metabolite 18558
                  human metabolite 18231
                    glutaric acid 12
                      (2S)-2-(3-\{2-bromo-5-[(2,4-diaminopyrimidin-1-ium-5-yl)methyl]-3-methoxyphenoxy\}propyl)pentanedioate 0
                      (R)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester + 0
                      (S)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester + 0
                      1-(2-\{4-[(4-carboxybutanoyl)amino]phenyl\}ethyl)-1-methylpiperidinium 0
                      1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine 0
                      2-formylglutaric acid 0
                      2-hydroxyglutaric acid + 7
                      2-hydroxymethylglutaric acid + 0
                      2-methylglutaric acid 0
                      2-methylideneglutaric acid 0
                      2-oxoglutaric acid + 0
                      3,3-dimethylglutaric acid 0
                      3-hydroxy-3-methylglutaric acid + 0
                      3-hydroxyglutaric acid 0
                      3-methylglutaric acid + 0
                      4-(4-styrylphenylcarbamoyl)butyric acid 0
                      4-hydroxy-2-oxoglutaric acid + 0
                      4-hydroxy-4-methyl-2-oxoglutaric acid 0
                      5-(\{4-[2-(1-oxidopiperidin-1-yl)ethyl]phenyl\}amino)-5-oxopentanoic acid 0
                      5-\{[4-(\{hydroxy[(4-nitrophenyl)amino]phosphoryl\}methyl)phenyl]amino\}-5-oxopentanoic acid 0
                      8-benzyl-7-hydroxy-4,10-dioxo-1-phenyl-6-oxa-3,9-diaza-7-phosphatetradecan-14-oic acid 7-oxide 0
                      N-formylisoglutamic acid 0
                      O-glutaroyl-L-carnitine 0
                      O-glutarylcarnitine 0
                      diethyl glutarate 0
                      glutaramic acid + 0
                      glutaryl-CoAs + 2
                      isoglutamic acid 0
                      monomethyl glutaric acid 0
                      p-nitrobenzyl glutaryl glycinic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      dicarboxylic acids and O-substituted derivatives 10278
                                        dicarboxylic acid 10271
                                          alpha,omega-dicarboxylic acid 2777
                                            glutaric acid 12
                                              (2S)-2-(3-\{2-bromo-5-[(2,4-diaminopyrimidin-1-ium-5-yl)methyl]-3-methoxyphenoxy\}propyl)pentanedioate 0
                                              (R)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester + 0
                                              (S)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester + 0
                                              1-(2-\{4-[(4-carboxybutanoyl)amino]phenyl\}ethyl)-1-methylpiperidinium 0
                                              1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine 0
                                              2-formylglutaric acid 0
                                              2-hydroxyglutaric acid + 7
                                              2-hydroxymethylglutaric acid + 0
                                              2-methylglutaric acid 0
                                              2-methylideneglutaric acid 0
                                              2-oxoglutaric acid + 0
                                              3,3-dimethylglutaric acid 0
                                              3-hydroxy-3-methylglutaric acid + 0
                                              3-hydroxyglutaric acid 0
                                              3-methylglutaric acid + 0
                                              4-(4-styrylphenylcarbamoyl)butyric acid 0
                                              4-hydroxy-2-oxoglutaric acid + 0
                                              4-hydroxy-4-methyl-2-oxoglutaric acid 0
                                              5-(\{4-[2-(1-oxidopiperidin-1-yl)ethyl]phenyl\}amino)-5-oxopentanoic acid 0
                                              5-\{[4-(\{hydroxy[(4-nitrophenyl)amino]phosphoryl\}methyl)phenyl]amino\}-5-oxopentanoic acid 0
                                              8-benzyl-7-hydroxy-4,10-dioxo-1-phenyl-6-oxa-3,9-diaza-7-phosphatetradecan-14-oic acid 7-oxide 0
                                              N-formylisoglutamic acid 0
                                              O-glutaroyl-L-carnitine 0
                                              O-glutarylcarnitine 0
                                              diethyl glutarate 0
                                              glutaramic acid + 0
                                              glutaryl-CoAs + 2
                                              isoglutamic acid 0
                                              monomethyl glutaric acid 0
                                              p-nitrobenzyl glutaryl glycinic acid 0
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