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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glutaric acid
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Accession:CHEBI:17859 term browser browse the term
Definition:An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.
Synonyms:related_synonym: 1,3-Propanedicarboxylic acid;   1,5-pentanedioic acid;   Formula=C5H8O4;   Glutarsaeure;   InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9);   InChIKey=JFCQEDHGNNZCLN-UHFFFAOYSA-N;   Pentanedioic acid;   SMILES=OC(=O)CCCC(O)=O
 alt_id: CHEBI:24330;   CHEBI:43097;   CHEBI:5434
 xref: Beilstein:1209725;   CAS:110-94-1;   DrugBank:DB03553;   Gmelin:26809;   HMDB:HMDB0000661;   KEGG:C00489;   KNApSAcK:C00001184;   LIPID_MAPS_instance:LMFA01170046
 xref_mesh: MESH:C035736
 xref: PDBeChem:GUA;   PMID:24297153;   PMID:24587932;   PMID:24900967;   Reaxys:1209725;   Wikipedia:Glutaric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:24329;   is_conjugate_acid_of CHEBI:35907


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glutaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of glutaric acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases import
increases activity
ISO glutaric acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 results in increased export of p-Aminohippuric Acid]
SLC22A6 protein results in increased import of glutaric acid
glutaric acid results in increased activity of SLC22A6 protein
CTD PMID:15284288 PMID:19643159 PMID:28629854 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases import
multiple interactions
increases activity
ISO SLC22A8 protein results in increased import of glutaric acid
glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]
glutaric acid results in increased activity of SLC22A8 protein
CTD PMID:28629854 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
2-hydroxyglutaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH2 protein CTD PMID:28269980 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914
JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH3 protein CTD PMID:28269980 NCBI chr 3:79,939,515...79,972,820
Ensembl chr 3:79,939,600...79,972,000
JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase increases metabolic processing ISO D2HGDH protein results in increased metabolism of alpha-hydroxyglutarate CTD PMID:15609246 NCBI chr 9:94,350,555...94,368,384
Ensembl chr 9:94,350,576...94,368,382
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO [epigallocatechin gallate results in decreased expression of GLUD1 protein] which results in decreased abundance of alpha-hydroxyglutarate CTD PMID:31857147 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 affects abundance ISO IDH1 gene mutant form affects the abundance of alpha-hydroxyglutarate CTD PMID:22057236 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G L2hgdh L-2-hydroxyglutarate dehydrogenase increases abundance ISO L2HGDH gene mutant form results in increased abundance of alpha-hydroxyglutarate CTD PMID:25800467 NCBI chr 6:88,164,429...88,205,585
Ensembl chr 6:88,164,440...88,205,578
JBrowse link
glutaryl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot4 acyl-CoA thioesterase 4 affects hydrolysis ISO ACOT4 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acot8 acyl-CoA thioesterase 8 affects hydrolysis ISO ACOT8 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              animal metabolite 18892
                mammalian metabolite 18891
                  human metabolite 18351
                    glutaric acid 12
                      (2S)-2-(3-\{2-bromo-5-[(2,4-diaminopyrimidin-1-ium-5-yl)methyl]-3-methoxyphenoxy\}propyl)pentanedioate 0
                      (R)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester + 0
                      (S)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester + 0
                      1-(2-\{4-[(4-carboxybutanoyl)amino]phenyl\}ethyl)-1-methylpiperidinium 0
                      1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine 0
                      2-formylglutaric acid 0
                      2-hydroxyglutaric acid + 7
                      2-hydroxymethylglutaric acid + 0
                      2-methylglutaric acid 0
                      2-methylideneglutaric acid 0
                      2-oxoglutaric acid + 0
                      3,3-dimethylglutaric acid 0
                      3-hydroxy-3-methylglutaric acid + 0
                      3-hydroxyglutaric acid 0
                      3-methylglutaric acid + 0
                      4-(4-styrylphenylcarbamoyl)butyric acid 0
                      4-hydroxy-2-oxoglutaric acid + 0
                      4-hydroxy-4-methyl-2-oxoglutaric acid 0
                      5-(\{4-[2-(1-oxidopiperidin-1-yl)ethyl]phenyl\}amino)-5-oxopentanoic acid 0
                      5-\{[4-(\{hydroxy[(4-nitrophenyl)amino]phosphoryl\}methyl)phenyl]amino\}-5-oxopentanoic acid 0
                      8-benzyl-7-hydroxy-4,10-dioxo-1-phenyl-6-oxa-3,9-diaza-7-phosphatetradecan-14-oic acid 7-oxide 0
                      N-formylisoglutamic acid 0
                      O-glutaroyl-L-carnitine 0
                      O-glutarylcarnitine 0
                      diethyl glutarate 0
                      glutaramic acid + 0
                      glutaric anhydride 0
                      glutaryl-CoAs + 2
                      isoglutamic acid 0
                      monomethyl glutaric acid 0
                      p-nitrobenzyl glutaryl glycinic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      dicarboxylic acids and O-substituted derivatives 10366
                                        dicarboxylic acid 10358
                                          alpha,omega-dicarboxylic acid 2796
                                            glutaric acid 12
                                              (2S)-2-(3-\{2-bromo-5-[(2,4-diaminopyrimidin-1-ium-5-yl)methyl]-3-methoxyphenoxy\}propyl)pentanedioate 0
                                              (R)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester + 0
                                              (S)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester + 0
                                              1-(2-\{4-[(4-carboxybutanoyl)amino]phenyl\}ethyl)-1-methylpiperidinium 0
                                              1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine 0
                                              2-formylglutaric acid 0
                                              2-hydroxyglutaric acid + 7
                                              2-hydroxymethylglutaric acid + 0
                                              2-methylglutaric acid 0
                                              2-methylideneglutaric acid 0
                                              2-oxoglutaric acid + 0
                                              3,3-dimethylglutaric acid 0
                                              3-hydroxy-3-methylglutaric acid + 0
                                              3-hydroxyglutaric acid 0
                                              3-methylglutaric acid + 0
                                              4-(4-styrylphenylcarbamoyl)butyric acid 0
                                              4-hydroxy-2-oxoglutaric acid + 0
                                              4-hydroxy-4-methyl-2-oxoglutaric acid 0
                                              5-(\{4-[2-(1-oxidopiperidin-1-yl)ethyl]phenyl\}amino)-5-oxopentanoic acid 0
                                              5-\{[4-(\{hydroxy[(4-nitrophenyl)amino]phosphoryl\}methyl)phenyl]amino\}-5-oxopentanoic acid 0
                                              8-benzyl-7-hydroxy-4,10-dioxo-1-phenyl-6-oxa-3,9-diaza-7-phosphatetradecan-14-oic acid 7-oxide 0
                                              N-formylisoglutamic acid 0
                                              O-glutaroyl-L-carnitine 0
                                              O-glutarylcarnitine 0
                                              diethyl glutarate 0
                                              glutaramic acid + 0
                                              glutaric anhydride 0
                                              glutaryl-CoAs + 2
                                              isoglutamic acid 0
                                              monomethyl glutaric acid 0
                                              p-nitrobenzyl glutaryl glycinic acid 0
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