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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carnosine
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Accession:CHEBI:15727 term browser browse the term
Definition:A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.
Synonyms:exact_synonym: N(alpha)-(beta-alanyl)-L-histidine
 related_synonym: Formula=C9H14N4O3;   InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1;   InChIKey=CQOVPNPJLQNMDC-ZETCQYMHSA-N;   Nalpha-(beta-alanyl)-L-histidine;   SMILES=NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O
 alt_id: CHEBI:13948;   CHEBI:23040;   CHEBI:3428
 xref: CAS:305-84-0;   HMDB:HMDB0000033;   KEGG:C00386
 xref_mesh: MESH:D002336
 xref: MetaCyc:CARNOSINE;   PMID:16804013;   PMID:18019400;   PMID:18076890;   PMID:18773880;   PMID:24398899;   Reaxys:87671;   Wikipedia:Carnosine
 cyclic_relationship: is_conjugate_acid_of CHEBI:66874;   is_tautomer_of CHEBI:57485


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carnosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein] CTD PMID:28266762 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Carnosine results in decreased expression of APP protein modified form CTD PMID:21423579 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases abundance ISO ARNTL gene mutant form results in increased abundance of Carnosine CTD PMID:27056296 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Glucose results in increased expression of BAX mRNA]
CTD PMID:28266762, PMID:28833918, PMID:30802477 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]
CTD PMID:28266762, PMID:30802477 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Carnosine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Carnosine inhibits the reaction [Glucose results in increased activity of CASP3 protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]
CTD PMID:19748544, PMID:28833918, PMID:29191451, PMID:30802477 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein] CTD PMID:29191451 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Carnosine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Carnosine inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA] CTD PMID:19748544, PMID:19799668, PMID:29191451 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of CCL2 mRNA] CTD PMID:19799668, PMID:29191451 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Crp C-reactive protein multiple interactions ISO
EXP
Carnosine inhibits the reaction [Acetaminophen results in increased expression of CRP protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein]
CTD PMID:19799668, PMID:28266762, PMID:28833918 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein] CTD PMID:19799668 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Carnosine results in increased expression of FOS protein CTD PMID:17628717 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in decreased expression of GPX1 mRNA] CTD PMID:19799668 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein] CTD PMID:28266762 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP Carnosine results in increased expression of HSPA1B protein CTD PMID:16984587 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased expression of ICAM1 mRNA] CTD PMID:29191451 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of IL10 mRNA] CTD PMID:19799668, PMID:29191451 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL1B protein]
CTD PMID:30802477 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL6 protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]
CTD PMID:19799668, PMID:28266762, PMID:30802477 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Carnosine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:30802477 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Carnosine inhibits the reaction [Cadmium Chloride results in increased activity of MPO protein] CTD PMID:19748544 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:29191451 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] CTD PMID:30802477 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carnosine inhibits the reaction [Cisplatin affects the localization of RELA protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] CTD PMID:29191451, PMID:30802477 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein] CTD PMID:28266762 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein] CTD PMID:28266762 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
CTD PMID:19799668, PMID:28266762, PMID:29191451, PMID:30802477 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein] CTD PMID:28266762 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        antioxidant 14211
          carnosine 32
            N-acetylcarnosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                peptide 9392
                                                  oligopeptide 1196
                                                    dipeptide 372
                                                      carnosine 32
                                                        N-acetylcarnosine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.