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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carnosine
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Accession:CHEBI:15727 term browser browse the term
Definition:A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.
Synonyms:exact_synonym: N(alpha)-(beta-alanyl)-L-histidine
 related_synonym: (2S)-2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acid;   Formula=C9H14N4O3;   InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1;   InChIKey=CQOVPNPJLQNMDC-ZETCQYMHSA-N;   Karnozin;   Karnozzn;   L-carnosine;   N-(3-aminopropanoyl)-L-histidine;   N-2-M;   N-beta-alanyl-L-histidine;   Nalpha-(beta-alanyl)-L-histidine;   SMILES=NCCC(=O)N[C@@H](CC1=CNC=N1)C(O)=O;   beta-alanyl-L-histidine;   ignotine
 alt_id: CHEBI:13948;   CHEBI:23040;   CHEBI:3428
 xref: CAS:305-84-0;   Chemspider:388363;   DrugBank:DB11695;   HMDB:HMDB0000033;   KEGG:C00386;   KNApSAcK:C00052222
 xref_mesh: MESH:D002336
 xref: PDBeChem:8V0;   PMID:10841274;   PMID:10951105;   PMID:10951108;   PMID:11470131;   PMID:11707898;   PMID:11911459;   PMID:11976203;   PMID:12139778;   PMID:15853927;   PMID:15878720;   PMID:15941308;   PMID:16162015;   PMID:16181134;   PMID:16287364;   PMID:16406688;   PMID:16804013;   PMID:17031479;   PMID:1735411;   PMID:17443912;   PMID:18019400;   PMID:18076890;   PMID:18773880;   PMID:19309105;   PMID:20017611;   PMID:24398899;   PMID:2674258;   PMID:29463897;   PMID:31951767;   PMID:33586561;   PMID:33704575;   PMID:34067694;   PMID:8689392;   PMID:9029640;   PMID:9928418;   Reaxys:87671;   Wikipedia:Carnosine
 cyclic_relationship: is_conjugate_acid_of CHEBI:66874;   is_tautomer_of CHEBI:57485



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carnosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Carnosine inhibits the reaction [cupric chloride results in decreased activity of ACHE protein] CTD PMID:32745495 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein] CTD PMID:28266762 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Carnosine results in decreased expression of APP protein modified form CTD PMID:21423579 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases abundance ISO ARNTL gene mutant form results in increased abundance of Carnosine CTD PMID:27056296 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Glucose results in increased expression of BAX mRNA]
CTD PMID:28266762 PMID:28833918 PMID:30802477 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]
CTD PMID:28266762 PMID:30802477 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Carnosine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Carnosine inhibits the reaction [Glucose results in increased activity of CASP3 protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]
CTD PMID:19748544 PMID:28833918 PMID:29191451 PMID:30802477 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein] CTD PMID:29191451 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Carnosine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Carnosine inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]
Carnosine inhibits the reaction [cupric chloride results in decreased activity of CAT protein]
CTD PMID:19748544 PMID:19799668 PMID:29191451 PMID:32745495 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of CCL2 mRNA] CTD PMID:19799668 PMID:29191451 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Crp C-reactive protein multiple interactions ISO
EXP
Carnosine inhibits the reaction [Acetaminophen results in increased expression of CRP protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein]
CTD PMID:19799668 PMID:28266762 PMID:28833918 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein] CTD PMID:19799668 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Carnosine results in increased expression of FOS protein CTD PMID:17628717 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO Carnosine inhibits the reaction [cupric chloride results in decreased activity of G6PD protein] CTD PMID:32745495 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in decreased expression of GPX1 mRNA] CTD PMID:19799668 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Carnosine inhibits the reaction [cupric chloride results in decreased activity of GSR protein] CTD PMID:32745495 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein] CTD PMID:28266762 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP Carnosine results in increased expression of HSPA1B protein CTD PMID:16984587 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased expression of ICAM1 mRNA] CTD PMID:29191451 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of IL10 mRNA] CTD PMID:19799668 PMID:29191451 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL1B protein]
CTD PMID:30802477 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL6 protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]
CTD PMID:19799668 PMID:28266762 PMID:30802477 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Carnosine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:30802477 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Carnosine inhibits the reaction [Cadmium Chloride results in increased activity of MPO protein] CTD PMID:19748544 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:29191451 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] CTD PMID:30802477 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carnosine inhibits the reaction [Cisplatin affects the localization of RELA protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] CTD PMID:29191451 PMID:30802477 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein] CTD PMID:28266762 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Carnosine inhibits the reaction [cupric chloride results in decreased activity of SOD1 protein] CTD PMID:32745495 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein] CTD PMID:28266762 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
CTD PMID:19799668 PMID:28266762 PMID:29191451 PMID:30802477 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein] CTD PMID:28266762 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      chemical role 19332
        antioxidant 14440
          carnosine 36
            N-acetylcarnosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic acid 18361
                                        carboacyl group 17481
                                          univalent carboacyl group 17481
                                            carbamoyl group 17297
                                              carboxamide 17297
                                                peptide 9444
                                                  oligopeptide 1264
                                                    dipeptide 375
                                                      carnosine 36
                                                        N-acetylcarnosine 0
paths to the root