Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:9352 term browser browse the term
Definition:A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Synonyms:exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
 related_synonym: (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;   Clinoril;   Formula=C20H17FO3S;   InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-;   InChIKey=MLKXDPUZXIRXEP-MFOYZWKCSA-N;   SMILES=CC1=C(CC(O)=O)c2cc(F)ccc2C\\1=C/c1ccc(cc1)S(C)=O;   Sulindacum;   cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;   cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid;   sulindaco
 xref: Beilstein:2951842;   CAS:38194-50-2;   DrugBank:DB00605;   Drug_Central:2534;   HMDB:HMDB0014743;   KEGG:C01531;   KEGG:D00120
 xref_mesh: MESH:D013467
 xref: PDBeChem:SUZ;   PMID:11569947;   PMID:11927004;   PMID:12406542;   PMID:15020200;   PMID:15123337;   PMID:19884509;   PMID:23689354;   PMID:23804703;   Patent:DE2039426;   Patent:US3654349;   Reaxys:2951842;   Wikipedia:Sulindac

show annotations for term's descendants           Sort by:
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Sulindac results in decreased expression of PTGS2 protein CTD PMID:12857884 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases localization EXP Sulindac results in decreased localization of RELA protein CTD PMID:12857884 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 402
    role 402
      biological role 402
        pharmacological role 163
          analgesic 18
            sulindac 2
              nitrosulindac 0
              sulindac sulfide 0
              sulindac sulfone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 402
    subatomic particle 402
      composite particle 402
        hadron 402
          baryon 402
            nucleon 402
              atomic nucleus 402
                atom 402
                  main group element atom 395
                    p-block element atom 395
                      carbon group element atom 384
                        carbon atom 383
                          organic molecular entity 383
                            organic group 313
                              organic divalent group 312
                                organodiyl group 312
                                  carbonyl group 312
                                    carbonyl compound 312
                                      carboxylic acid 276
                                        monocarboxylic acid 92
                                          acetic acid 22
                                            sulindac 2
                                              nitrosulindac 0
                                              sulindac sulfide 0
                                              sulindac sulfone 0
paths to the root