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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N,N-dimethylglycine
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Accession:CHEBI:17724 term browser browse the term
Definition:An N-methylglycine that is glycine carrying two N-methyl substituents.
Synonyms:related_synonym: (dimethylamino)acetic acid;   2-(Dimethylamino)acetic acid;   Dimethylglycine;   Formula=C4H9NO2;   InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7);   InChIKey=FFDGPVCHZBVARC-UHFFFAOYSA-N;   N,N-Dimethylaminoacetic acid;   N-Methylsarcosine;   SMILES=CN(C)CC(O)=O
 alt_id: CHEBI:12426;   CHEBI:14173;   CHEBI:21455;   CHEBI:41993;   CHEBI:7077
 xref: CAS:1118-68-9;   DrugBank:DB02083;   Gmelin:82215;   HMDB:HMDB0000092;   KEGG:C01026
 xref_mesh: MESH:C025138
 xref: MetaCyc:DIMETHYL-GLYCINE;   PDBeChem:DMG;   PMID:17190852;   PMID:21228267;   PMID:22418088;   PMID:22510294;   Reaxys:1700261
 cyclic_relationship: is_tautomer_of CHEBI:58251



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N,N-dimethylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity ISO dimethylglycine results in increased activity of CAT protein CTD PMID:27171376 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
decreases expression
ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GPT protein]
dimethylglycine results in decreased expression of GPT protein
CTD PMID:27171376 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity
ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of GSR protein]
dimethylglycine results in increased activity of GSR protein
CTD PMID:27171376 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SIRT1 mRNA] CTD PMID:27171376 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions
ISO dimethylglycine results in increased activity of SOD2 protein
dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of SOD2 protein]
CTD PMID:27171376 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                amino acid derivative 11117
                  N-methyl-amino acid 16
                    N,N-dimethylglycine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        amino acid 14872
                                          alpha-amino acid 12865
                                            L-alpha-amino acid 11583
                                              serine family amino acid 2556
                                                glycine 1599
                                                  glycine derivative 1586
                                                    N-alkylglycine 5
                                                      N-methylglycines 5
                                                        N,N-dimethylglycine 5
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