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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N,N-dimethylglycine
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Accession:CHEBI:17724 term browser browse the term
Definition:An N-methylglycine that is glycine carrying two N-methyl substituents.
Synonyms:related_synonym: (dimethylamino)acetic acid;   2-(Dimethylamino)acetic acid;   Dimethylglycine;   Formula=C4H9NO2;   InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7);   InChIKey=FFDGPVCHZBVARC-UHFFFAOYSA-N;   N,N-Dimethylaminoacetic acid;   N-Methylsarcosine;   SMILES=CN(C)CC(O)=O
 alt_id: CHEBI:12426;   CHEBI:14173;   CHEBI:21455;   CHEBI:41993;   CHEBI:7077
 xref: CAS:1118-68-9;   DrugBank:DB02083;   Gmelin:82215;   HMDB:HMDB0000092;   KEGG:C01026
 xref_mesh: MESH:C025138
 xref: MetaCyc:DIMETHYL-GLYCINE;   PDBeChem:DMG;   PMID:17190852;   PMID:21228267;   PMID:22418088;   PMID:22510294;   Reaxys:1700261
 cyclic_relationship: is_tautomer_of CHEBI:58251


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N,N-dimethylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity ISO dimethylglycine results in increased activity of CAT protein CTD PMID:27171376 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
decreases expression
ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GPT protein]
dimethylglycine results in decreased expression of GPT protein
CTD PMID:27171376 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity
ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of GSR protein]
dimethylglycine results in increased activity of GSR protein
CTD PMID:27171376 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SIRT1 mRNA] CTD PMID:27171376 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions
ISO dimethylglycine results in increased activity of SOD2 protein
dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of SOD2 protein]
CTD PMID:27171376 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      atom 19759
        nonmetal atom 19641
          nitrogen atom 18572
            nitrogen molecular entity 18572
              organonitrogen compound 18361
                amino acid derivative 10957
                  N-methyl-amino acid 16
                    N,N-dimethylglycine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        amino acid 14107
                                          alpha-amino acid 11593
                                            L-alpha-amino acid 11428
                                              serine family amino acid 2061
                                                glycine 1215
                                                  glycine derivative 1201
                                                    N-alkylglycine 5
                                                      N-methylglycines 5
                                                        N,N-dimethylglycine 5
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