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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N,N-dimethylglycine
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Accession:CHEBI:17724 term browser browse the term
Definition:An N-methylglycine that is glycine carrying two N-methyl substituents.
Synonyms:related_synonym: (dimethylamino)acetic acid;   2-(Dimethylamino)acetic acid;   Dimethylglycine;   Formula=C4H9NO2;   InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7);   InChIKey=FFDGPVCHZBVARC-UHFFFAOYSA-N;   N,N-Dimethylaminoacetic acid;   N-Methylsarcosine;   SMILES=CN(C)CC(O)=O
 alt_id: CHEBI:12426;   CHEBI:14173;   CHEBI:21455;   CHEBI:41993;   CHEBI:7077
 xref: CAS:1118-68-9;   DrugBank:DB02083;   Gmelin:82215;   HMDB:HMDB0000092;   KEGG:C01026
 xref_mesh: MESH:C025138
 xref: MetaCyc:DIMETHYL-GLYCINE;   PDBeChem:DMG;   PMID:17190852;   PMID:21228267;   PMID:22418088;   PMID:22510294;   Reaxys:1700261
 cyclic_relationship: is_tautomer_of CHEBI:58251



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N,N-dimethylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity ISO dimethylglycine results in increased activity of CAT protein CTD PMID:27171376 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
decreases expression
ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GPT protein]
dimethylglycine results in decreased expression of GPT protein
CTD PMID:27171376 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity
ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of GSR protein]
dimethylglycine results in increased activity of GSR protein
CTD PMID:27171376 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SIRT1 mRNA] CTD PMID:27171376 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions
ISO dimethylglycine results in increased activity of SOD2 protein
dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of SOD2 protein]
CTD PMID:27171376 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    chemical entity 19846
      atom 19846
        nonmetal atom 19784
          nitrogen atom 18965
            nitrogen molecular entity 18965
              organonitrogen compound 18816
                amino acid derivative 12503
                  N-methyl-amino acid 16
                    N,N-dimethylglycine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        amino acid 15954
                                          alpha-amino acid 13872
                                            L-alpha-amino acid 12862
                                              serine family amino acid 5573
                                                glycine 3106
                                                  glycine derivative 3096
                                                    N-alkylglycine 5
                                                      N-methylglycines 5
                                                        N,N-dimethylglycine 5
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