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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6beta-hydroxytestosterone
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Accession:CHEBI:34477 term browser browse the term
Definition:A 17beta-hydroxy steroid that is testosterone bearing an additional hydroxy substituent at the 6beta-position.
Synonyms:related_synonym: (6beta,17beta)-6,17-dihydroxyandrost-4-en-3-one;   4-androsten-6beta,17beta-diol-3-one;   6beta,17beta-Dihydroxyandrost-4-en-3-one;   6beta,17beta-dihydroxy-4-androsten-3-one;   Formula=C19H28O3;   InChI=1S/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1;   InChIKey=XSEGWEUVSZRCBC-ZVBLRVHNSA-N;   SMILES=[H][C@@]12C[C@@H](O)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]
 alt_id: CHEBI:63819
 xref: CAS:62-99-7;   HMDB:HMDB0006259;   KEGG:C14497;   LIPID_MAPS_instance:LMST02020054
 xref_mesh: MESH:C025591
 xref: PMID:10574192;   PMID:15203039;   PMID:22822673;   Reaxys:2625776


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6beta-hydroxytestosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [[ABCC1 gene mutant form results in increased susceptibility to Testosterone deficiency] which results in decreased hydroxylation of Testosterone] which results in decreased chemical synthesis of 6 beta-hydroxytestosterone CTD PMID:22522787 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases chemical synthesis
multiple interactions
ISO
EXP
CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone
[[CYP3A4 protein co-treated with NADP] results in increased oxidation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone; [CYP3A4 mRNA results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone; [CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone; [CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone; [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 6 beta-hydroxytestosterone; fipronil promotes the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; notopterol inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; obeticholic acid inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]
[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone; isobavachalcone inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]
CTD PMID:12401345 PMID:16595712 PMID:17084830 PMID:19135037 PMID:20233841 PMID:20863320 PMID:21915887 PMID:23850985 PMID:26239802 PMID:26739624 PMID:27836570 PMID:27939613 PMID:28238727 PMID:29555536 PMID:30914192 PMID:31102695 PMID:31870919 PMID:32198085 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis
multiple interactions
ISO CYP3A5 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone
[CYP3A5 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone; Meclizine inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]
CTD PMID:26239802 PMID:31102695 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      group 19767
        organic group 18550
          3-oxo-Delta(4)-steroid group 7947
            3-oxo-Delta(4) steroid 7947
              6beta-hydroxytestosterone 3
                glucosyl-6beta-hydroxytestosterone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic group 18550
                              organic divalent group 18541
                                organodiyl group 18541
                                  carbonyl group 18447
                                    carbonyl compound 18447
                                      ketone 16192
                                        oxo steroid 9293
                                          3-oxo steroid 8819
                                            3-oxo-Delta(4) steroid 7947
                                              testosterone 2849
                                                6beta-hydroxytestosterone 3
                                                  glucosyl-6beta-hydroxytestosterone 0
paths to the root