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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:calcein am
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Accession:CHEBI:3303 term browser browse the term
Definition:An organic heteropentacyclic compound that is calcein in which all four carboxy group hydrogens have been substituted by (acetyloxy)methoxy groups and the hyrodgens of the two hydroxy groups have been substituted by acetyl groups. It is a a non-fluorescent probe cleaved to a fluorescent probe by non-specific intracellular esterases.
Synonyms:exact_synonym: tetrakis[(acetyloxy)methyl] 2,2',2'',2'''-{[3',6'-bis(acetyloxy)-3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-2',7'-diyl]bis(methanediylnitrilo)}tetraacetate
 related_synonym: Formula=C46H46N2O23;   InChI=1S/C46H46N2O23/c1-25(49)60-21-64-41(55)17-47(18-42(56)65-22-61-26(2)50)15-31-11-35-39(13-37(31)68-29(5)53)70-40-14-38(69-30(6)54)32(12-36(40)46(35)34-10-8-7-9-33(34)45(59)71-46)16-48(19-43(57)66-23-62-27(3)51)20-44(58)67-24-63-28(4)52/h7-14H,15-24H2,1-6H3;   InChIKey=BQRGNLJZBFXNCZ-UHFFFAOYSA-N;   SMILES=O(C1=C(C=C2C3(OC(C4=C3C=CC=C4)=O)C=5C(OC2=C1)=CC(=C(C5)CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)OC(C)=O)CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(C)=O;   [({[3',6'-bis(acetyloxy)-3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-2',7'-diyl]bis(methylene)nitrilo}bis[(1-oxoethane-2,1-diyl)oxy]methylene)] tetraacetate;   calcein O,O'-diacetate tetrakis(acetoxymethyl) ester
 alt_id: CHEBI:51904
 xref: CAS:148504-34-1;   KEGG:C11257
 xref_mesh: MESH:C085925
 xref: PMID:30925062;   PMID:31188648;   PMID:31489142;   PMID:8107502

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calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects export EXP ABCC1 protein affects the export of calcein AM CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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Path 1
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  CHEBI ontology 400
    role 402
      application 360
        dye 6
          xanthene dye 2
            calcein am 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 400
    subatomic particle 400
      composite particle 402
        hadron 400
          baryon 400
            nucleon 400
              atomic nucleus 400
                atom 400
                  main group element atom 395
                    p-block element atom 395
                      carbon group element atom 382
                        carbon atom 383
                          organic molecular entity 381
                            organic group 311
                              organic divalent group 310
                                organodiyl group 310
                                  carbonyl group 310
                                    carbonyl compound 310
                                      carboxylic acid 275
                                        monocarboxylic acid 91
                                          acetic acid 22
                                            acetate ester 12
                                              calcein am 1
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